Fiorello "nephrolith for the treatment and prevention of urolithiasis

 

The invention relates to medicine, in particular to plants with nephrolithiasis action, and can be used for the treatment and prevention of urolithiasis. The proposed tool containing bearberry leaves, rhizomes and roots of madder, a grass of a horsetail grass knotweed, wild rose hips, peppermint leaves, leaves of kidney tea or birch with a specific ratio of ingredients. The technical result of the invention is expressed in enhancing therapeutic effect while reducing side effects. table 4.

The invention relates to medicine, namely to the creation of drugs of plant origin with nephrolithiasis action, and can be used for the treatment and prevention of kidney stones.

Urolithiasis is one of the leading places in the structure of urologic diseases on the frequency distribution of hospitalized morbidity and among the most common surgical diseases in patients presenting to emergency and acting urgently to hospital.

Urolithiasis, or urolithiasis, meetings what altiazem constitute 30-40% of the entire cohort urological hospitals.

Currently, in developed countries 10 million 400 thousand suffer from urolithiasis. Annually 85 thousand diseases urolithiasis, with 62 thousand of them - recurrent stones.

In the origin and development of urolithiasis great role for metabolic disorders: calcium, uric and oxalic acids, rare amino acids. Important factors in the formation of urinary stones are violations of hemo - and urodynamics of the upper urinary tract, reducing blood flow and mechetka kidney infection, climatic factors, as well as the high content of mineral salts in drinking water and other

Due to these reasons is the deposition of concretions in the kidneys and upper urinary tract. In addition to the most common urate stones are stones, the main components of which are other salts: oxalates, phosphates, and combinations of these salts. Urates precipitate in an acidic environment; their education contributes to an excess of purine bases in food. Phosphates are formed in an alkaline medium and observed under the excessive consumption of vegetables and fruits. The oxalate precipitate in urine pH ~5.5 and the concentration of calcium ions; obrazovaniya oxalates as a result of metabolism (for example, taking large doses of ascorbic acid).

Currently there are several approaches in the treatment of urolithiasis. Among them surgical, physiotherapy, chemotherapy and phytotherapy, as well as their combination (combination therapy); sometimes used homeopathic remedies.

During chemo - and phytotherapeutic treatment in the case of formation of concretions containing urates, conduct activities aimed at alkalinization of urine. Means providing for the maintenance of urine pH from 6.2 to 6.6, can serve as "Uralic And, Makulit", "Bimaran" etc.

For the treatment and prevention of recurrence of concrements, consisting of phosphates of calcium and magnesium, in contrast, achieve acidification of urine, which is achieved by the use of the extract of the rhizomes and roots of madder, at the same time eliminate microbial factor, using antibiotics and other drugs.

Preventing the formation of oxalate stones is a diet that excludes foods rich in oxalic, ascorbic acid and salts of calcium.

There are a number of herbal remedies, including combination used for the treatment and prevention of urolithiasis.

In the patent EP 0101849, 1984 describes a tool for the prevention of the art of the calcium salts of polymerized carboxylic acids and/or their sulfate esters, the carboxylic acids used polygalacturonase, polyglucoronic and other acids, as well as salts of calcium - alginate and/or pectin calcium.

Known drug "Urolesan used for the treatment of kidney stones containing oil fir needle, peppermint, castor and extracts from seeds of wild carrot, hop cones and herbs oregano at a certain content of components (M. D. Mashkovsky. Medicinal product. - T. 1, Kharkov: Torching" 1997, S. 507).

Known drug Vitalizing used for the treatment of urolithiasis, containing extracts of parsley root, rhizomes of couch grass, herb horsetail, birch leaves, grass knotweed and mint oil, sage, pine, orange and vanilla. The drug has diuretic, anti-inflammatory and antispasmodic; loosening of the concretions is slow (S. 507).

Known for the comprehensive preparation "Marelin used for the treatment of urolithiasis, which contains dry extracts of madder, herb horsetail, goldenrod, magnesium phosphate, Collison, kellin and salicylamide at a certain content of ingredients and has antispasmodic and FR is phosphate (ibid, S. 505-506).

Known urological (diuretic) collection used in decoction urolithiasis containing bearberry leaves, calendula flowers, fruits dill, rhizomes and koreni of Siberian ginseng and peppermint leaves at a certain ratio of the components; the collection has diuretic, anti-inflammatory, antispasmodic and antimicrobial effects (RLS Russia, 9th edition, 2002, S. 873).

You know the tool used for urolithiasis in the presence of concrements oxalate calcium nature, which is obtained by extraction of the leaves of Eriobotrya japonica and subsequent treatment. Means effective when used over an extended period of time (EP 0652761, 1995).

Known fitokontsentrat treatment-and-prophylactic actions used in diseases of the kidneys and bladder, including urolithiasis, including quercetin, or dihydroquercetin, or routines, or askorutin, grass knotweed, a sheet of birch, columns with stigmas of maize, grass Bidens tripartite, concentrate, meat, or chicken, or vegetable at a certain content of components (patent RU 2122421, 1997).

Closest to the claimed means, achieved technical rez is Onosma bracteatum, Verninia cinerea, Shilajeet and Hayrul yahood bhasma at a certain content of components; regulates drug Cristallo-colloid balance of urine and is indicated for the treatment and prevention of urolithiasis (RLS Russia, 6th ed., 1999, S. 823).

The drug has a pronounced therapeutic effect when used over a long period of time 4-5 months and, in addition, contains a remote tropical raw materials.

The present invention is the creation of a more effective Fiorella for the treatment and prevention of kidney stones and reduce treatment time.

The problem is solved by the creation of funds for treatment and prevention of kidney stones containing bearberry leaves, rhizomes and roots of madder, a grass of a horsetail grass knotweed, wild rose hips, peppermint leaves, leaves of kidney tea or leaves of Betula pendula in the following ratio of ingredients, parts: bearberry Leaves - 1-6 Rhizomes and roots of the madder - 1-6 Grass horsetail - 1-6 Grass knotweed - 1-6 hips - 1-6 peppermint Leaves - 1-6 kidney tea Leaves or the leaves of Betula pendula - 1-6 Technical result obtained by icii negative side effects and the reduction of treatment time.

Stated the vehicle was prepared as follows. Ingredients crushed respectively to the sizes, mm: bearberry Leaves - 3
Other leaves - 7
Grass - 7
Rhizomes and roots - 7
Fruits - 7
Then the crushed components are mixed in the stated proportions and Packed.

It was experimentally confirmed that the claimed qualitative and quantitative composition of the collection ensures the achievement of the claimed technical result.

The invention is illustrated by the following examples.

Example 1.

The composition of the funds when the contents of the ingredients, in parts:
The bearberry leaves - 5
Rhizomes and roots of the madder - 4
The herb horsetail - 3
Grass knotweed (knotweed) - 2
Rosehips - 2
Peppermint leaves - 2
The leaves of kidney tea - 2
Example 2.

The composition of the funds when the contents of the ingredients, in parts:
The bearberry leaves - 4
Rhizomes and roots of the madder - 3
The herb horsetail - 2
Grass knotweed (knotweed) - 3
Rosehips - 3
Peppermint leaves - 2
The leaves of Betula pendula - 3
Example 3.

The composition of the funds when the soda is 2
The herb horsetail - 1
Grass knotweed (knotweed) - 4
Rosehips - 5
Peppermint leaves - 1
The leaves of kidney tea - 1
The proposed collection is used as follows. 10 grams (2 tablespoons) of the collection is placed in an enamel bowl, pour 200 ml (1 Cup) of boiling water, heated in a boiling water bath for 15 minutes to infuse at room temperature for 45 minutes, filtered, the remaining raw materials press. The amount received infusions bring boiled water to 200 ml With curative intent take 100 ml 3 times a day, from prevention to 50 ml 3 times a day.

In the course of the research work was carried out to study the specific effect of the stated means of its safety and subacute toxicity.

Specific action was studied on the basis of the study, excretion of water and electrolytes (diuretic effect).

Harmlessness and subacute toxicity was studied on the basis of the study of the dynamics of body weight, General clinical and clinical studies of urine (the functional state of the kidneys) and biochemical indices of blood serum of rats.

Experimental studies were conducted in accordance with the recommendations of the Pharmacological Committee of Ministry of health of Russia and great the statistical processing of experimental data was performed by the method of variation statistics using coefficient t-test. The results of the experiments are presented in tables 1-4. To obtain experimental and clinical data of the studied recipes funds described in examples 1, 2, 3.

During the experiment the animals ' death is not marked.

The experimental group of animals all studies were divided into 3 subgroups based on 4 animals in the group, each of which has been declared the tool in the following ingredients, in parts:
I subgroup experimental group:
The bearberry leaves - 5
Rhizomes and roots of the madder - 4
The herb horsetail - 3
Grass knotweed (knotweed) - 2
Rosehips - 2
Peppermint leaves - 2
The leaves of kidney tea - 2
II subgroup experimental group:
The bearberry leaves - 4
Rhizomes and roots of the madder - 3
The herb horsetail - 2
Grass knotweed (knotweed) - 3
Rosehips - 3
Peppermint leaves - 2
The leaves of Betula pendula - 3
III subgroup experimental group:
The bearberry leaves - 6
Rhizomes and roots of the madder - 2
The herb horsetail - 1
Grass knotweed (knotweed) - 4
Rosehips - 5
Peppermint leaves - 1
The leaves of kidney tea - 1
Varejao 12 animals in group 3 sub-group 4 rats in the experimental group), functional renal activity judged by diuresis, as defined in 18 hours on the background of the water load. Animals of the experimental group received intragastric 8 ml of the stated means in the form of infusion, the control group - the water in the same amounts. The data presented in table 1.

As follows from the data presented in table 1, the diuresis in animals in the experimental group increased by 28%, and the excretion of sodium ions Na+increased by 27% compared with the control, at the same time a slight decrease in the concentration of potassium ions (K+in the urine. This allows to conclude that expressed machigonne effect funds, and it acts like potassium-sparing diuretics, not causing hypokalemia.

Harmlessness and subacute toxicity of the drug was determined from the change in body mass in the background of daily injection of funds, as well as on some biochemical parameters in the serum of rats.

Body weight of rats with the introduction of funds experienced group consisted of 12 animals, 3 sub-group 4 rats) was not significantly different from the benchmark during the study period. All groups of animals were well taken food and water, fiziologicheskii presented in table 2. Monitoring respiratory rate abnormalities not revealed.

As follows from the data presented in table 2, no statistically significant differences between the values of body weight of the rats in the control and experimental groups indicates safety funds.

Table 3 presents some biochemical parameters of blood serum of rats treated with the claimed means in the form of infusion for 7 days. Animals were divided into experimental and control group of 12 rats in each group (3 sub-group 4 rats in the experimental group). In the experimental group animals were treated with intragastric infusion of funds in 8 ml 3 times a day, in the control - water according to the same scheme and in the same doses.

After 7 days, animals were killed and examined the serum. As can be seen from table 3, all of the investigated biochemical parameters in experimental group was not significantly different from the control, which confirms the safety and lack of toxicity funds. Due to the fact that the claimed product is intended for treatment of diseases of the urinary system, it seems reasonable determination of its nephrotoxicity. For this he studied indicators functionlity in table 4. As follows from the presented data, the parameters of the control and experimental groups did not significantly differ, indicating the absence of nephrotoxicity in funds.

therapeutic effect of the claimed money was studied in 18 patients with uncomplicated forms of urolithiasis. To explore the tools have been selected patients who have already undergone the course of modern means of treatment using chemotherapy and physiotherapy, but significant improvements in the patients ' condition was not observed, or the remission was short-lived. All patients diagnosed with kidney stones, stones in the renal pelvis of one or both kidneys, chronic pyelonephritis. The composition of the stones oxalates, urates, phosphates and combinations thereof. Surveyed contingent consisted of 10 men aged from 35 to 50 years and 8 women aged 40-65 years. The average disease duration ranged from 3 to 5 years.

All patients were divided into 3 groups of 6 people in each group.

Group I received the claimed means in the form of infusion when the contents of the ingredients in the parts:
The bearberry leaves - 5
Rhizomes and roots of the madder - 4
The herb horsetail - 3
Grass knotweed (knotweed) - 2
Fruit in the form of infusion when the contents of the ingredients in the parts:
The bearberry leaves - 4
Rhizomes and roots of the madder - 3
The herb horsetail - 2
Grass knotweed (knotweed) - 3
Rosehips - 3
Peppermint leaves - 2
The leaves of Betula pendula - 3
Group III received the claimed means in the form of infusion when the contents of the ingredients in the parts:
The bearberry leaves - 6
Rhizomes and roots of the madder - 2
The herb horsetail - 1
Grass knotweed (knotweed) - 4
Rosehips - 5
Peppermint leaves - 1
The leaves of kidney tea - 1
After conducting a two-month course of treatment is objectively and subjectively found no difference in health status between the three groups of patients, this suggests that the proposed qualitative and quantitative compositions of collection provides the achievement of the claimed technical result.

Patients received the claimed means in the form of infusion of 100 ml 3 times a day. The course of treatment was 2 months.

Subjective complaints: before treatment, all patients noted a dull pain in the lumbar region, occasional episodes of renal colic, dull pain was intensified by the long walk and after physical exertion.

Objective: stonoga means marked with the following:

Subjectively: the overall health of all patients improved significantly, they could go for long walks, sometimes on the bike, daily performed simple physical exercises, played with a ball, while none of the surveyed did not feel the aching, the movements become free.

Objective: at the computer and ultrasound examination of the size of large stones with a diameter of 10-15 mm decreased on average by 20%, the proportion of patients diagnosed transformation of stones into separate fragments with a diameter less than 6 mm, small stones not detected; and 12 patients showed disappearance of the stones (as a result of their dissolution).

A control computer and ultrasound examination after 3 and 6 months after treatment did not reveal negative trends, which indicates a sustained remission and possible use of the proposed tools for treatment and prevention of kidney stones.

Thus, the proposed drug collection "Neroli" is an effective therapeutic and prophylactic agent with a stable therapeutic effect, reduce the treatment time up to 2 months and allowing the use of domestic raw materials.

The bearberry leaves 1-6

Rhizomes and roots of the madder 1-6

The herb horsetail 1-6

Grass knotweed 1-6

Rosehips 1-6

Peppermint leaves 1-6

Leaves kidney tea or

the leaves of Betula pendula 1-6

 

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