Pills, having a core coated with an antifungal agent and a polymer

 

The invention relates to tablets comprising a Central, rounded or spherical core diameter of 250-355 Ám (45-60 mesh), the coating film of the water soluble polymer and Itraconazole, and a layer of protective polymer coatings for pharmaceutical dosage form, as well as to a method for the specified bean. The technical result of pharmaceutical dosage forms, one of which would contain the required daily dose of the active ingredient instead of two such units. 3 S. and 6 C.p. f-crystals, 1 table.

Description text in facsimile form (see graphic part).

Claims

1. Pills, including (a) a Central, rounded or spherical core; b) a film coating of a water-soluble polymer and Itraconazole, and C) a layer of protective polymer coating, wherein the core has a diameter of about 250-355 Ám (45-60 mesh).

2. Bean p. 1, comprising by weight calculated on the total weight of bean: a) 10-25 wt.% substance core; b) 39-60 wt.% water-soluble polymer; (c) 26-40 wt.% Itraconazole; (d) 4-7 wt.% polymer protective coating.

3. Bean p. 2, where a water-soluble polymer is a hypromellose.

4. Die under item 2, where the polymer of the protective coating is a polyethylene glycol.

6. Bean p. 3, comprising about a) of 16.5-19 wt.% sugar cores; (b) 43-48 wt.% hydroxypropylmethylcellulose 2910 5 MPaC; c) 29-33 wt.% Itraconazole; (d) 5-6 wt.% polyethylene glycol 20000.

7. Pharmaceutical dosage form comprising an effective amount of antifungal agents in the form of pellets according to any one of paragraphs.1-6.

8. Dosage form under item 7, which is hard gelatin capsule.

9. The method of obtaining the pills according to any one of paragraphs.1-6, comprising the following stages: a) applying the coating onto the sugar spheres with a size of 250-355 Ám (45-60 mesh) by spraying them solution of Itraconazole and water-soluble polymer in an organic solvent consisting of methylene chloride and ethanol, the pellet fluidized bed, equipped with a Wurster (bottom spray) inset; (b) drying the obtained coated cores; (C) applying a protective coating on the dried kernel spray on them of a solution of the polymer of the protective coating in an organic solvent consisting of methylene chloride and ethanol, the pellet fluidized bed, equipped with a Wurster (bottom spray) insert.

 

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