The method of diagnostics of the functional state of the body and the device for its implementation
The invention relates to biomedical measurements, namely the means of control of the functional state of the organism on the parameters of the kinetics of hydroxy - and deoxygenate blood, and may find application in laboratory practice for biological research and in medicine for diagnostic purposes, including for the diagnosis of the functional state of the organism as a whole. For this purpose, with the help of the device investigated the kinetics of oxygenation and deoxygenation blood by measuring the time of its optical characteristics. The processes of oxygenation (deoxygenation) blood perform repeatedly in a significantly small amount (one drop) on a substrate placed in the cavity thermally sealed chamber filled with a gas mixture with a fixed partial pressure of oxygen. Efficient gas exchange in the blood samples with a gas mixture in a sealed cavity ensure through periodic changes in the surface area of the blood in contact with the gas environment, and/or updates that are made using a special mechanism. This produces a continuous registration of the optical signal, which characterizes the degree of saturation of blood oxygen throughout votem changes in the composition of the gas mixture, the filling chamber, and the evaluation of the functional state of an organism produced by comparing the data obtained in this simulation. Device for controlling the functional state of the organism on the parameters of the kinetics of hydroxy - and deoxygenate blood contains sealed vegetatively chamber made in the form of a cavity formed by the cover placed on the top plate of the casing is cooled substrate for a blood sample. The cavity is connected to the supply system of the gas mixture with the regulator of its composition. The device is equipped with a mechanism for updating the surface of contact of the blood with the gas mixture and changing the area of contact. In the device integrated optical oximeter, optically associated with the blood sample. The device is also equipped with temperature control systems of the substrate, pressure and humidity in the working cavity, with sensors measuring each of these parameters are placed in the working cavity and connected to the logger. The invention allows to detect deviations from the norm of the functional state of the organism (illness, stress, fatigue), to establish the ability to adapt and restore on quantitative parameters characterises>Description text in facsimile form (see graphic part).
Claims1. The method of diagnostics of the functional state of the organism, which means that the control parameters of oxygenation and deoxygenation blood by measuring changes over time its optical characteristics when placing the blood sample in a sealed thermal and vegetatively the chamber filled with a gas mixture with a fixed partial pressure of oxygen, and oxygen exchange of the analyzed blood samples from a gas mixture in the chamber at a continuous contact of blood with the gas mixture and the continuous reception of the optical signal, which characterizes the degree of saturation of blood with oxygen during the entire process of gas exchange blood with contacting a gas mixture, characterized in that the processes of gas exchange in the blood is carried out in several stages alternately repeated oxygenation and/or deoxygenate blood samples in considerably small amount, thus when measuring the optical characteristics of blood perform simulation of various conditions studied blood samples by changing the composition of the gas mixture filling the chamber, and the evaluation of the functional state of the organism, proizvodyaschiesya fact, effective gas exchange blood samples with a gas mixture in a sealed cavity ensure through periodic changes in the surface area of the blood in contact with a gas environment, ensuring its update.3. The method according to p. 1, characterized in that the changing composition of the gas mixture model for the studied blood samples of the normal gas exchange in the lungs and stress (fatigue) of the disease with depleted in the body's functional reserves and/or, on the contrary, when the supply of functional reserves maximum.4. The method according to PP.1 and 3, wherein comparing the measured characteristics of the optical signal in time, obtained at different stages of oxygenation and deoxygenation, and functional state of the organism characterize quantitatively the difference in these characteristics, in particular, by the difference between the saturation levels of the measured characteristics make the conclusion that “the degree of fatigue” and “the reserve forces”.5. The device for diagnostics of functional state of organism, containing a sealed vegetatively the camera attached to the system feed gas mixture with the regulator of its composition, optical oximeter made with the possibility of optical and contact of blood with the gas mixture and changing the area of contact, characterized in that tight vegetatively camera placed on the top panel of the casing and is made in the form of a cavity formed by a sealed cover placed on the top plate of the casing is cooled substrate for a blood sample, and the supply of the gas mixture is connected to the logger.6. The device under item 5, characterized in that it is equipped with temperature control systems of the substrate, pressure and humidity in the working cavity, with sensors measuring each of these parameters are placed in the working cavity and connected to the respective controllers, the outputs of which are connected with actuators systems.7. The device under item 5, characterized in that the mechanism provides updates to the surface of contact of the blood with the gas mixture and changing the area of this contact is made in the form of a plunger with the ability to do periodic reciprocating motion by the drive, including horizontal and/or vertical direction, and the working surface of which is constantly in contact with the surface of the blood samples.8. The device according to PP.5 and 7, characterized in that the working surface of the plunger is made of a mother with a sample of blood, the surface of the substrate made of a material with high wettability for blood.10. The device according to PP.5 and 7-9, wherein the contacting with a sample of blood to the surface of the substrate and/or the working surface of the plunger has a flat or a more complex geometric shape, e.g. spherical, cylindrical.11. The device according to PP.5, 7 and 10, characterized in that the plunger is made in the form immersed in a blood sample of a cylindrical shaft, the long axis of which is parallel to the substrate plane, and the drive for rolling the shaft on its surface provides periodic reciprocating motion of the shaft in the horizontal direction.12. The device according to PP.5, 7 and 10, characterized in that the plunger is made in the form immersed in a blood sample of a ball connected to the actuator, which provides periodic reciprocating motion of the ball in the horizontal or vertical direction.13. The device according to PP.5, 7, 11 and 12, characterized in that the surface of the plunger has a spherical, cylindrical, or other geometric shape and is made of a material with low wettability for blood.14. The device according to PP.5, 7 and 11-13, wherein the contacting with a sample of blood to the surface of the substrate made of a material with low wettability for blood.15.RMU horizontal plane or a more complex geometric shape, for example, the inner surface of the spherical segment.16. The device according to PP.5, 7, 11 and 13-15, characterized in that the surface of the substrate and/or the working surface of the plunger is made from a material without injuring the blood.17. The device according to PP.5 and 7, characterized in that the mechanism for updating the surface of contact of the blood with the gas mixture and changing the area of this contact is made in the form of a capillary tube, one end of which is immersed in the blood sample on the substrate, and the other is paired with a pump, for example, the type of dropper-dispenser, which provides periodic involvement in capillary whole blood samples or part thereof and the return on a substrate of blood samples with updated contact surface with a gas environment.18. The device according to PP.5 and 17, characterized in that as the capillary mechanism to update the surface of contact of the blood with the gas mixture and changing the area of this contact is used for capillary sampling blood samples from the patient.19. The device according to PP.5, 17 and 18, characterized in that the inner surface of the capillary is covered with a preservative for blood.20. The device under item 5, wherein the sensitive elements of the oximeter placed inside or outside the housing and/or the specified cavity and provided with light is trichomania fact, the substrate for placement of the blood sample is made of translucent material.22. The device according to PP.5 and 6, characterized in that it comprises sensor pCO2in the working cavity and embedded in the substrate for blood samples the sensors RNO2and Rho2and pH electrode in contact with a sample of blood.23. The device according to PP.5 and 6, characterized in that it contains mechanisms to feed into the working cavity and/or a sample of blood chemicals, including gaseous, liquid and powder.
SUBSTANCE: method involves carrying out ultrasonic scanning examination of subclavian artery over its whole extent in physiological arm position with arterial blood pressure being measured in the middle one third of the arm. Next, when applying compression tests, blood circulation parameters variations are recorded in distal segment of the subclavian artery with arterial blood pressure being concurrently measured. Three degrees of superior thorax aperture syndrome severity are diagnosed depending on reduction of linear blood circulation velocity and arterial blood pressure compared to their initial values. Mild one takes place when linear blood circulation velocity reduction reaches 40% and arterial blood pressure 20% of initial level, moderate one when linear blood circulation velocity reduction reaches 70% and arterial blood pressure 50% and heavy one when linear blood circulation velocity reduction is greater than 70% of initial level and arterial blood pressure is greater than 50% to the extent of no blood circulation manifestation being observed in the subclavian artery.
EFFECT: high accuracy of diagnosis.
FIELD: medicine; medical engineering.
SUBSTANCE: method involves collecting information and storing it in single database or several databases representing parameter values of significance to enable one to carry out the procedures on his/her own, and operations for processing the mentioned single database or several databases to show alternative variants for making selection among two or more actions and values corresponding to each of two or more actions. Device has means for making calculations, required for implementing the method, and computer system and machine-readable carrier having program written on it and capable of implementing the method corresponding to the invention, on computer.
EFFECT: wider range of means accessible to end user.
69 cl, 8 dwg, 1 tbl
SUBSTANCE: method involves measuring intraocular pressure. Static computer-assisted perimetry method is used in a way that luminous spot serves as test object. The spot acts upon eye in various vision field points with threshold brightness and then in growing sequence. Eye retina light-sensitivity is measured in vision field points under study. The number of points is set with patient examination program. Total light-sensitivity is measured in decibels. Medicamentous reduction of intraocular pressure is achieved with 0.5% Ocupress solution introduced as drops twice with 5-6 min long interval. The intraocular pressure being reduced at least by 4 mm of mercury column, repeated static perimetry examination is carried out. Total light-sensitivity being increased less than by 50 dB, individual initial intraocular pressure tolerance conclusion is drawn. Total light-sensitivity being increased by 50 dB or more, individual initial intraocular pressure intolerance conclusion is drawn.
EFFECT: enhanced effectiveness in determining intraocular pressure tolerance/intolerance.
SUBSTANCE: method involves carrying out urological examination for determining hydrodynamic resistance of ureter calculated from formula Z=8Lμ/(πR4), where Z is the hydrodynamic resistance of ureter, L is the ureter length, R is the ureter radius, μ is the urine viscosity. Angle α at which the ureter enters the urinary bladder is determined from formula cosα = 8l1μ/(ZπR4), where l1 is the perpendicular drawn from the upper edge of the ureter to the its exit projection line, μ is the urine viscosity, Z is the hydrodynamic resistance of ureter, R is the ureter radius. Vesicoureteral reflux recidivation is predicted when the angle of α+90° is less than 120°.
EFFECT: enhanced effectiveness in reducing the number of recidivation cases.
2 dwg, 1 tbl
SUBSTANCE: method involves carrying out physiological examination with electroencephalogram recorded. Cognitive evoked potential method is additionally applied as neuropsychological examination for detecting hard and latent organic brain lesions causing central nervous system pathological disorders. An additional psychophysiological examination is carried out with vision analyzer test, visuomotor response test being applied for obtaining estimations of selection, discrimination, noise immunity and muscle endurance index, movement coordination, response to moving object and integral estimation of attention and ability for perceiving significant information, motor analyzer rapid response production estimation, estimation of nature of cardiovascular system response to given psychoemotional loading estimation. The examination is sequentially carried out as primary control when hiring personnel, as intermediate control in following a training course and emergency training. Psychological testing is of multi-purpose nature. To achieve it, a set reliable tests and methods of prognostic and substantial validity are applied, including intellect and project-building tests and standardized self-reports. When making decisions concerning professional validity based on test and examination results, risk group is selected from operation personnel.
EFFECT: enhanced effectiveness of occupational skill assessment.
FIELD: medicine, urology.
SUBSTANCE: the present innovation deals with differential diagnostics of prostatic cancer and other prostatic diseases at the stage of primary inspection. The method includes the detection of PCA and calculation of probability coefficient for prostatic cancer (PCC) by the following formula: where e - the foundation of natural logarithm (e=2.718…), PCA - the level of total blood PCA in ng/ml, V - patient's age in years. At PCC value being above 0.2 one should diagnose prostatic cancer and to establish final diagnosis one should perform polyfocal prostatic biopsy. The method enables to increase accuracy of diagnostics at decreased number of unjustified prostatic biopsies.
EFFECT: higher efficiency of diagnostics.
FIELD: medicine, toxicology.
SUBSTANCE: at patient's hospitalization one should detect the values of patient's state such as: the state of consciousness, availability of spasms, scleral injectivity degree, headache, nystagmus, vertigo, ataxia, respiration frequency, exposure of poisoning substance, patient's age, concentration of carboxyhemoglobin, prothrombin index (PTI), creatinine amount and that of leukocytes, sedimentation rate and patient's body temperature. Each parameter should be evaluated in points to sum them up finally. By the value of summed up points it is possible to evaluate indication for urgent hospitalization into resuscitation department. The method enables to obtain objective evaluation for the necessity in resuscitation aid.
EFFECT: higher accuracy of evaluation.
3 ex, 4 tbl
FIELD: medicine, pediatrics.
SUBSTANCE: in neonatals one should apply control set of risk factors that includes detection of maternal body temperature in the course of delivery, evaluation of neonatal's body weight at birth (g), one should characterize each risk factor and evaluate in points and by the value of the sum of points predict the risk for intrauterine infection, moreover, this set of risk factors includes extragenital pathology and its availability, chronic foci of infection and their exacerbation, acute infectious diseases occurred during pregnancy, prenatal waters, the nature of waters, moreover, if risk factors are characterized, correspondingly: the presence of one pathological disease, the presence of infection at no exacerbation, single acute infectious disease occurred during pregnancy, waters at mature pregnancy, waters color - light, moderate polyhydramnios, maternal body temperature in the course of delivery up to 37.5 C, evaluation by a certain scale being 7-8,neonatal's body weight at birth being above 2500 but below 2900 each of them should be evaluated per 1 point, if risk factors are characterized: combination of pathologies, exacerbation of chronic foci of infection occurred more than once, acute infectious diseases happened twice during pregnancy, prenatal waters at 36-wk-pregnancy, the nature of waters - meconial, pronounced polyhydramnios, maternal body temperature during delivery ranged 37.5-38 C, evaluation by a certain scale being 5-6, neonatal's body weight at birth being 1500-2500 each factor should be evaluated per 2 points, if risk factors are characterized: the presence of three and more pathological diseases, exacerbation of chronic foci of infection in every trimester of pregnancy, acute infectious diseases occurred during pregnancy in every trimester, prenatal waters 6 wk earlier the delivery terms, the nature of waters - turbid, with flavoring, maternal body temperature during delivery being above 38 C, evaluation by a certain scale being below 5, neonatal's body weight at birth being below 1500 every factor should be evaluated per 3 points, moreover, if the sum of points is not above or equal 8 points the risk for intrauterine infection in neonatals ins minimal, at the sum of points ranged 9-13 the risk is average and at the sum of points being 13 or above 13 the risk is maximal. The method takes into account extragenital pathology that creates the foundation for initial shifts in homeostasis and weakens resistance to external impacts.
EFFECT: higher accuracy of prediction.
1 ex, 1 tbl
FIELD: medicine, oncology.
SUBSTANCE: one should study the activity of catalase in the tissue of malignant mammary tumor and its perifocal area, and at ratio coefficient of catalase activity in the tissue of malignant mammary tumor to that in the tissue of perifocal area being equal to 1.0 ± 0.2 one should predict the chance for the development of new foci of lesion before their clinical manifestation, that provides necessary treatment in due time.
EFFECT: higher efficiency of prediction.
1 ex, 1 tbl
SUBSTANCE: before applying substitute hormonal therapy (SHT) on should evaluate antithrombogenic activity of vascular wall in women. For this purpose one should determine quantitative values of ADP-induced aggregation of thrombocytes, activity of antithrombin III in blood and fibrinolytic blood activity both before and after "cuff"-test. Then one should detect the indices calculated as the ratio of mentioned values both before and after carrying out the mentioned test. If mentioned indices are decreased against the norm by 20-40% women should be prescribed to undergo SHT at additional introduction of aspirin and supradin. The method provides prophylaxis of cardio-vascular diseases in this category of female patients due to correcting affected functional activity of vascular endothelium.
EFFECT: higher efficiency of prophylaxis.
1 cl, 1 ex, 4 tbl