The method of diagnostics of the functional state of the body and the device for its implementation

 

The invention relates to biomedical measurements, namely the means of control of the functional state of the organism on the parameters of the kinetics of hydroxy - and deoxygenate blood, and may find application in laboratory practice for biological research and in medicine for diagnostic purposes, including for the diagnosis of the functional state of the organism as a whole. For this purpose, with the help of the device investigated the kinetics of oxygenation and deoxygenation blood by measuring the time of its optical characteristics. The processes of oxygenation (deoxygenation) blood perform repeatedly in a significantly small amount (one drop) on a substrate placed in the cavity thermally sealed chamber filled with a gas mixture with a fixed partial pressure of oxygen. Efficient gas exchange in the blood samples with a gas mixture in a sealed cavity ensure through periodic changes in the surface area of the blood in contact with the gas environment, and/or updates that are made using a special mechanism. This produces a continuous registration of the optical signal, which characterizes the degree of saturation of blood oxygen throughout votem changes in the composition of the gas mixture, the filling chamber, and the evaluation of the functional state of an organism produced by comparing the data obtained in this simulation. Device for controlling the functional state of the organism on the parameters of the kinetics of hydroxy - and deoxygenate blood contains sealed vegetatively chamber made in the form of a cavity formed by the cover placed on the top plate of the casing is cooled substrate for a blood sample. The cavity is connected to the supply system of the gas mixture with the regulator of its composition. The device is equipped with a mechanism for updating the surface of contact of the blood with the gas mixture and changing the area of contact. In the device integrated optical oximeter, optically associated with the blood sample. The device is also equipped with temperature control systems of the substrate, pressure and humidity in the working cavity, with sensors measuring each of these parameters are placed in the working cavity and connected to the logger. The invention allows to detect deviations from the norm of the functional state of the organism (illness, stress, fatigue), to establish the ability to adapt and restore on quantitative parameters characterises>Description text in facsimile form (see graphic part).

Claims

1. The method of diagnostics of the functional state of the organism, which means that the control parameters of oxygenation and deoxygenation blood by measuring changes over time its optical characteristics when placing the blood sample in a sealed thermal and vegetatively the chamber filled with a gas mixture with a fixed partial pressure of oxygen, and oxygen exchange of the analyzed blood samples from a gas mixture in the chamber at a continuous contact of blood with the gas mixture and the continuous reception of the optical signal, which characterizes the degree of saturation of blood with oxygen during the entire process of gas exchange blood with contacting a gas mixture, characterized in that the processes of gas exchange in the blood is carried out in several stages alternately repeated oxygenation and/or deoxygenate blood samples in considerably small amount, thus when measuring the optical characteristics of blood perform simulation of various conditions studied blood samples by changing the composition of the gas mixture filling the chamber, and the evaluation of the functional state of the organism, proizvodyaschiesya fact, effective gas exchange blood samples with a gas mixture in a sealed cavity ensure through periodic changes in the surface area of the blood in contact with a gas environment, ensuring its update.

3. The method according to p. 1, characterized in that the changing composition of the gas mixture model for the studied blood samples of the normal gas exchange in the lungs and stress (fatigue) of the disease with depleted in the body's functional reserves and/or, on the contrary, when the supply of functional reserves maximum.

4. The method according to PP.1 and 3, wherein comparing the measured characteristics of the optical signal in time, obtained at different stages of oxygenation and deoxygenation, and functional state of the organism characterize quantitatively the difference in these characteristics, in particular, by the difference between the saturation levels of the measured characteristics make the conclusion that “the degree of fatigue” and “the reserve forces”.

5. The device for diagnostics of functional state of organism, containing a sealed vegetatively the camera attached to the system feed gas mixture with the regulator of its composition, optical oximeter made with the possibility of optical and contact of blood with the gas mixture and changing the area of contact, characterized in that tight vegetatively camera placed on the top panel of the casing and is made in the form of a cavity formed by a sealed cover placed on the top plate of the casing is cooled substrate for a blood sample, and the supply of the gas mixture is connected to the logger.

6. The device under item 5, characterized in that it is equipped with temperature control systems of the substrate, pressure and humidity in the working cavity, with sensors measuring each of these parameters are placed in the working cavity and connected to the respective controllers, the outputs of which are connected with actuators systems.

7. The device under item 5, characterized in that the mechanism provides updates to the surface of contact of the blood with the gas mixture and changing the area of this contact is made in the form of a plunger with the ability to do periodic reciprocating motion by the drive, including horizontal and/or vertical direction, and the working surface of which is constantly in contact with the surface of the blood samples.

8. The device according to PP.5 and 7, characterized in that the working surface of the plunger is made of a mother with a sample of blood, the surface of the substrate made of a material with high wettability for blood.

10. The device according to PP.5 and 7-9, wherein the contacting with a sample of blood to the surface of the substrate and/or the working surface of the plunger has a flat or a more complex geometric shape, e.g. spherical, cylindrical.

11. The device according to PP.5, 7 and 10, characterized in that the plunger is made in the form immersed in a blood sample of a cylindrical shaft, the long axis of which is parallel to the substrate plane, and the drive for rolling the shaft on its surface provides periodic reciprocating motion of the shaft in the horizontal direction.

12. The device according to PP.5, 7 and 10, characterized in that the plunger is made in the form immersed in a blood sample of a ball connected to the actuator, which provides periodic reciprocating motion of the ball in the horizontal or vertical direction.

13. The device according to PP.5, 7, 11 and 12, characterized in that the surface of the plunger has a spherical, cylindrical, or other geometric shape and is made of a material with low wettability for blood.

14. The device according to PP.5, 7 and 11-13, wherein the contacting with a sample of blood to the surface of the substrate made of a material with low wettability for blood.

15.RMU horizontal plane or a more complex geometric shape, for example, the inner surface of the spherical segment.

16. The device according to PP.5, 7, 11 and 13-15, characterized in that the surface of the substrate and/or the working surface of the plunger is made from a material without injuring the blood.

17. The device according to PP.5 and 7, characterized in that the mechanism for updating the surface of contact of the blood with the gas mixture and changing the area of this contact is made in the form of a capillary tube, one end of which is immersed in the blood sample on the substrate, and the other is paired with a pump, for example, the type of dropper-dispenser, which provides periodic involvement in capillary whole blood samples or part thereof and the return on a substrate of blood samples with updated contact surface with a gas environment.

18. The device according to PP.5 and 17, characterized in that as the capillary mechanism to update the surface of contact of the blood with the gas mixture and changing the area of this contact is used for capillary sampling blood samples from the patient.

19. The device according to PP.5, 17 and 18, characterized in that the inner surface of the capillary is covered with a preservative for blood.

20. The device under item 5, wherein the sensitive elements of the oximeter placed inside or outside the housing and/or the specified cavity and provided with light is trichomania fact, the substrate for placement of the blood sample is made of translucent material.

22. The device according to PP.5 and 6, characterized in that it comprises sensor pCO2in the working cavity and embedded in the substrate for blood samples the sensors RNO2and Rho2and pH electrode in contact with a sample of blood.

23. The device according to PP.5 and 6, characterized in that it contains mechanisms to feed into the working cavity and/or a sample of blood chemicals, including gaseous, liquid and powder.

 

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