A method for predicting the dynamics of the inflammatory process and device for its implementation

 

The invention relates to medicine and is designed to measure and evaluate the electrochemical properties of the biological environment and can be used to predict the dynamics of the inflammatory process. The method is carried out by passing through the biological environment, placed in the interelectrode space of the sensor constant electric current, to measure changes in electrode potential for a certain period of time from the zero level to the bottom defined by the beginning of the formation of the plateau and the registration of the dynamics of work spent on the electrochemical reaction at the change of the electrode potential from the lower level to the top for a certain period of time. Then produce decomposition of the generalized values of work on four separate components and conduct the registration of the dynamics of each of them. Positive dynamics of each of the four papers forecast the progression of the inflammatory process at the negative of its devolution. The device for implementing the method of predicting the dynamics of the inflammatory process contains the area with the sensor electrodes, the current source control circuit containing the button is a, the meter zero voltage level, the meter works, ADC, ALU and indicators. The use of the invention allows to improve forecasting accuracy by obtaining multidimensional measurement parameters characterizing the linear and nonlinear properties of biological environment. 2 C. p. F.-ly, 3 ill.

The invention relates to medical equipment and can be used to measure and evaluate the biological environment in order to predict the dynamics of the inflammatory process.

Known Electrochemical method for determination of organic impurities in the water and the sensor for its implementation" (AB. St. SU 1158913, CL 4 C 01 N 27/48, 30.05.85).

The method consists of passing an electric current through the tested fluid is placed in the interelectrode space of the sensor, for measuring the electrode potential from the zero level to the top, in which the content of impurities is judged by the magnitude of the time interval, it is necessary to measure the electrode potential from one level to another after changing the polarity of the current.

Sensor for implementing the method includes the indicator and auxiliary electrodes with leads separated by the ion-exchange membrane. Where the local electrode made of platinum wire.

The sensor design has the disadvantage conductivity of the membrane, which is an electrolyte, has a limited size, which affects the accuracy and reliability of the measurement result.

The method is based on the same principle of adsorption and elektrookislenie organic impurities on the platinum electrode. When changing the polarity of the DC potential of the electrode changes and restoration of the electrode surface and the adsorption of organic impurities.

The disadvantage of this method when applied to the study of biological environment, such as fluid is low accuracy and reliability, because the error is at 30%, since the current passing through the biological fluid electrochemical reaction is accompanied by: capacitive accumulation of charge in the electrical double layer, which is characterized by non-linear voltage increase; Faraday process, characterized by a linear change of voltage, decreasing the concentration of ionic groups. Because biological fluid significant influence related charges (ionic groups of proteins, lipids, and so on), quantifying the accumulation of charge boundary not information nirosha. In addition, when transmitting current change occurs in the concentration of ionic groups of the biological fluid. As a consequence, the value of the time required to change the potential from one level to another will depend on the volume of the studied biological fluid.

The method also requires the selection of patients biological fluid sample, which complicates the diagnostic process.

Closest to the claimed method and apparatus, that is, the prototype is a method for predicting the dynamics of the inflammatory process and device for its implementation (patent RU 2033606, CL G 01 N 33/48, 20.04.95).

The method includes the following operations (steps): 1) passing electric current through a biological environment, placed in the interelectrode space of the sensor; 2) measurement of changes in electrode potential from the zero level to the bottom defined by the beginning of the formation of a plateau on the curve of the dependence of the electrode potential from time to time; 3) the registration of the dynamics of work spent on the electrochemical reaction at the change in electrode potential biological environment, placed in the interelectrode space from the bottom level to the top defined by the end RIT probe with first and second ploskoparallel the sensor electrodes, the constant current source, control circuit, key, meter, intervals, two threshold element, click "start" and two sections of the circuit connected to the electrodes of the probe.

If this is the source of constant current connected to the first output with a common bus, a second output with the first input key, the output of which is connected to the input of the first threshold element and through the first circuit to the first electrode of the probe. The second electrode of the probe through a second circuit connected to the shared bus. Control circuit input connected to the start button, the first output to the second input key, a second output to the second input of measuring time intervals. The first output of the first threshold element connected to the first input of the measuring time intervals, the first input of the second threshold element through the first circuit to the first electrode of the probe, and the output to the third input of the measuring time intervals.

The General features of the proposed method and device for its implementation are all signs of a method and a device selected as a prototype.

The disadvantage of this method and device, taken as a prototype, is that they allow you to get a measurement parameter, characterizing that the biological environment eliminates option (uninformative plot OA on the graph) non-linear change in voltage on the electrodes of the probe.

The technical problem solved by the claimed method and device is receiving a multidimensional measurement parameters characterizing the linear and nonlinear properties of biological environment, which improves the accuracy of predicting the dynamics of the inflammatory process by comparing several parameters characterizing the biological environment in health and disease.

The problem is solved by the fact that in the method for predicting the dynamics of the inflammatory process comprising passing electric current through a biological environment, placed in the interelectrode space of the sensor, the measurement changes the electrode potential from the zero level to the bottom defined by the beginning of the formation of a plateau on the curve of the dependence of the electrode potential from the time registration of the dynamics of work spent on the electrochemical reaction at the change in electrode potential biological environment, placed in the interelectrode space, from the bottom level to the top defined by the end of the linear relationship between the change in electrode potential and time, according to the invention includes the following: conduct the decomposition of the overall work, perfect shock for even the each of the four papers forecast the progression of the inflammatory process, negative - its devolution.

A device for predicting the dynamics of the inflammatory process, containing the probe with the first and second sensor electrodes, a source of constant current connected to the first output with a common bus, a second output with the first input key, the output of which is connected to the input of the first threshold element and through the first circuit to the first electrode of the probe, the second electrode of the probe through a second circuit connected to the shared bus, the control circuit is connected by the entrance to the "start" button, the first output to the second input key, a second output to the second input of measuring time intervals, moreover, the first output of the first threshold element connected to the first input of the measuring time intervals, the input of the second threshold element through the first circuit to the first electrode of the probe, and the output to the third input of the measuring time intervals, according to the invention includes the following: the device is further provided with four storage devices, measuring current, the meter zero voltage level, the meter works, analog-to-digital Converter, four arithmetic-logical units and four indicators, phod second storage device connected to the second output of the measuring time intervals, the input current meter connected to the second output of the constant current source, the first input of the measuring work is connected to the first output of the measuring current, the second input to the output of the key, the third input to the third output of the control circuit; the first input of the meter zero voltage level connected to the fourth output of the control circuit, the second input to the first circuit; the analog-digital Converter connected to the meter output; the first input of the third storage device connected to the first output of the analog-to-digital Converter, a second input to the first output of the first threshold element; the first input of the fourth storage device connected to the second output of the analog-to-digital Converter, the second input to the output of the second threshold element; the first input of the first arithmetic-logical unit connected to the output of the first storage device, the second input to the output of the second storage device, the third input to the output of the fourth storage device, the fourth input to the second output of the measuring current, the fifth input to the second output of the first threshold element; the first input of the second arithmetic-logical unit connected to jihovychod meter zero voltage level, the fourth input to the second output of the measuring current, the fifth input to the second output of the first threshold element; the first input of the third arithmetic-logical unit connected to the output of the first storage device, the second input to the meter output zero voltage level, the third input to the output of the third storage device, the fourth input to the second output of the current meter; the first input of the fourth arithmetic-logical unit connected to the output of the second storage device, the second input to the meter output zero voltage level, the third input to the second output of the measuring current; input the first indicator connected to the output of the first arithmetic-logical unit; the input of the second indicator connected to the output of the second arithmetic-logical unit; the third indicator connected to the output of the third arithmetic-logical unit; the input of the fourth indicator connected to the output of the fourth arithmetic-logical unit.

Introduction to forecasting new operations - decomposition of the overall work on four components, calculate each of them and check each of them, as well as the introduction of a device for the implementation of FPIC is, to improve the method and the technical features of the claimed device, to increase the number of parameters to assess the status of biological environment, to increase the accuracy and reliability of prediction.

The set of distinctive features of the proposed method and device for its implementation is not found in the patent and scientific literature.

The method is implemented with the help of the device block diagram is shown in the drawing (Fig.1), and Fig.2, figs.3 shows graphs of changes of the electrode potential on the sensor, placed in a biological environment, by passing a constant current (I const).

The device (Fig. 1) contains the start button, 1 - control circuit, 2 is a source of constant current, 3 - key 4 - meter intervals, 5 - the first threshold element, 6 - second threshold element, 7 - probe, in which the first and second electrodes of the sensor 8 to the first circuit, 9 is a second section of the chain, 10 - current meter, 11 - first storage device 12 to the second storage device 13 of the third storage device 14 to the fourth storage device, 15 - meter zero level voltage, 16 - meter work, 17 - analog-to-digital transformed into the arithmetic and logic unit, 21 - fourth arithmetic-logic device, 22 - the first indicator, 23 - second indicator, 24 - third indicator, 25 - fourth indicator.

While the constant current source 2 is connected to the first output with a common bus, a second output with the first input key 3, the output of which is connected to the input of the first threshold element 5 and through the first section of the circuit 8 to the first electrode of the probe 7, the second electrode of the probe 7 through a second section of the circuit 9 is connected to the shared bus, the control circuit 1 is connected by the entrance to the "start" button, the first output to the second input key 3, a second output to the second input of measuring time intervals 4, the first output of the first threshold element 5 is connected to the first input of the measuring time interval 4, the input of the second threshold element 6 through the first section of the circuit 8 to the first electrode of the probe 7 and the output to the third input of the measuring time interval 4, the input of the first storage device 11 is connected to the first output of the measuring time interval 4, the input of the second storage device 12 is connected to the second output of the measuring time interval 4, the input current meter 10 is connected to the second output of the constant current source 2, the first input of the meter 16 in the control 1, the first input of the meter zero level voltage 15 is connected to the fourth output of the control circuit 1, a second input to the first circuit 8, the input of the analog-to-digital Converter 17 is connected to the output of the meter 16, the first input of the third storage device 13 connected to the first output of the analog-to-digital Converter 17, the second input to the first output of the first threshold element 5, the first input of the fourth storage device 14 is connected to the second output of the analog-to-digital Converter 17, the second input to the output of the second threshold element 6, the first input of the first arithmetic-logical unit 18 is connected to the output of the first storage device 11, the second input to the output of the second storage device 12, the third input to the output of the fourth storage device 14, the fourth input to the second output of the current meter 10, the fifth input to the second output of the first threshold element 5, the first input of the second arithmetic-logical unit 19 is connected to the output of the first storage device 11, the second input to the output of the second storage device 12, the third input to the meter output zero voltage level 15, the fourth input to the second output of the current meter westreich 20 is connected to the output of the first storage device 11, the second input to the meter output zero voltage level 15, the third input to the output of the third storage device 13, the fourth input to the second output of the current meter 10; the first input of the fourth arithmetic-logical unit 21 is connected to the output of the second storage device 12, the second input to the meter output zero voltage level 15, the third input to the second output of the current meter 10; input the first indicator 22 is connected to the output of the first arithmetic-logical unit 18, the input of the second indicator 23 is connected to the output of the second arithmetic-logical unit 19, the entrance to the third indicator 24 is connected to the output of the third arithmetic-logical unit 20, the input of the fourth indicator 25 is connected to the output of the fourth arithmetic-logical unit 21.

Introduction four storage devices 11, 12, 13, 14, current meter 10 meter zero level voltage 15 gauge 16, analog-to-digital Converter 17, the four arithmetic-logic devices 18, 19, 20, 21, and four indicators 22, 23, 24, 25 and appropriate linkages between the functional nodes allows to decompose the overall work of the four components, to calculate each of them isparitelnogo process.

The method is as follows. After opening and installing drainage in the area of inflammation or in an area likely occurrence of inflammation through the drainage tube is inserted probe 7 with the sensor. When a sensor in the focus of inflammation interelectrode space is filled with the biological environment, for example a liquid.

When you click start control circuit 1 resets the meter time intervals 4, meter 16 meter zero voltage level 15.

With the control circuit 1 turns on the key 3, the current from the constant current source 2 flows through the 3 key on the first section of the circuit 8, the probe 7, the second circuit 9, and a common bus. When applying current to the electrodes begins the charging process of the electric double layer to a voltage level defined by the interelectrode resistance of the probe 7. At the moment of switching the meter zero level voltage 15 detects a zero voltage level U0. Upon reaching the probe 7 of the lower voltage level UNfires the first threshold element 5, which starts measuring time intervals 4, the value of measuring time intervals is recorded in the storage device 11. The signal from the about-to-digital Converter 17, which converts the analog signal received from the output of the meter 16 during the formation of the curve interelectrode capacity of the time interval from t0to t1in digital.

Upon reaching the voltage on the probe 7, equal to the top level Uinfires the second threshold element 6, stops the countdown meter intervals 4. The value of measuring time intervals 4 is recorded in the storage device 12. The signal from the second threshold element 6 allows a storage device 14, the recording signal from the analog-to-digital Converter 17 which converts the analog signal received from the output of the meter 16 during the formation of the curve interelectrode capacity of the time interval from t0to ttoin digital.

The signals from the first storage device 11, from the second storage device 12, from the fourth storage device 14, with the current meter 10 from the first threshold element 5 receives the first arithmetic and logic unit 18, is formed where the work is A1, which is displayed on the first display 22.

The signals from the first storage device 11, with drogowego element 5 receives the second arithmetic and logic unit 19, where a work is A2, which is displayed on the second display 23.

The signals from the first storage device 11, from the third storage device 13, with the meter zero voltage level 15, with the current meter 10, proceed to the third arithmetic logic unit 20, which is formed by the work of A3, which is displayed on the second display 24.

The signals from the second storage device 12, with the meter zero voltage level 15, with the current meter 10 arrives at a fourth arithmetic logic unit 21, is formed where the work is A4, which is displayed on the fourth indicator 25.

Improving the prediction accuracy is achieved by the decomposition of the whole work in four parts and use them as independent signs.

As the countdown to the device begins when the switching current when the electrode potential UDOEreaches the value U0in General the work shall be considered work performed by the current during the formation of the portion of the curve from U0to UNthat way the prototype was not taken into account. The introduction of this component is more informative characteristic that affects the accuracy of the output elements, to allow the decomposition of the overall work on the four components.

In Fig.2, the curve I is characterized by a weak inflammatory process, curve II is characterized by severe inflammatory process for the same current I const. In Fig.3 curve characterizes the biological environment in the norm.

If we take the value t'1at the end of the process of electric charge layer for curve I, when the electrode potential UDOEreaches the lower level (UN), t1- at the end of the process of electric charge layer for curve II, the t value of the'k- at the end of the electrochemical reactions for curve I, when the electrode potential UDOEreaches the upper level (Uin), tk- at the end of the electrochemical reactions for the curve II and the value of U0the voltage drop across the electrodes of the probe at the moment of switching current, according to the drawing, the total work done by the current I, const, consists of four components: - for curve I: A1=A1I+A2I+A3I+A4Ifor curve II: AII=A1II+A2II+A3II+A4II.

Each of them can be calculated by ub>2I=(Un-U0)I(tk'-t1'),

for curve II:
A4II=U0Itk",

A2II=(Un-U0)I(tkthe "-t1'),

The calculated work are measured in fractions of a Joule.

After measuring probe 7 is extracted from the drain tube, sterilized and processed by known methods.

After a certain period of time, the probe 7 is re-injected through the drainage tube into the controlled area. Measure work. The obtained values are compared with the previous.

Change work is judged on the dynamics of the inflammatory process: increase in each of the four works shows his progression, and reducing each of the four works on devolution.

Increased activity of the inflammatory process is accompanied by an increase in the concentration yesterdasy molecules in the biological environment. As a consequence, the work spent on the electrochemical reaction increases.

When reducing the activity of the inflammatory process, the concentration yesterdasy molecules in the biological environment is reduced, therefore, emanatory showed the efficiency of the proposed method and device.

Compared with the prototype of the developed device allows to obtain multi-dimensional parameters of the biological environment and to compare them with the parameters characterizing the biological environment in health and disease, which increases the accuracy of predicting the dynamics of the inflammatory process.


Claims

1. A method for predicting the dynamics of the inflammatory process comprising passing electric current through a biological environment, placed in the interelectrode space of the sensor, the measurement changes the electrode potential from the zero level to the bottom defined by the beginning of the formation of a plateau on the curve of the dependence of the electrode potential from the time registration of the dynamics of work spent on the electrochemical reaction at the change in electrode potential biological environment, placed in the interelectrode space, from the bottom level to the top defined by the end of the linear relationship between the change in electrode potential and time, characterized in that conduct the decomposition of the overall work perfect current to the four components, and calculates each of them, record changes each of them and,and, negative - its devolution.

2. A device for predicting the dynamics of the inflammatory process, containing the probe defined therein first and second sensor electrodes, a source of constant current connected to the first output with a common bus, a second output with the first input key, the output of which is connected to the input of the first threshold element and through the first circuit to the first electrode of the probe, the second electrode of the probe through a second circuit connected to the shared bus, the control circuit is connected by the entrance to the “start” button, the first output to the second input key, a second output to the second input of the measuring time intervals, the first threshold element connected to the first input of the measuring time intervals, the input of the second threshold element through the first circuit to the first electrode of the probe, and the output to the third input of the measuring time intervals, characterized in that it is further provided with four storage devices, measuring current, the meter zero voltage level, the meter works, analog-to-digital Converter, four arithmetic-logical units and the four indicators, and the entrance PE Minusio device connected to the second output of the measuring time intervals, the input current meter connected to the second output of the constant current source, the first input of the measuring work is connected to the first output of the measuring current, the second input to the output of the key, the third input to the third output of the control circuit; the first input of the meter zero voltage level connected to the fourth output of the control circuit, the second input to the first circuit; the analog-digital Converter connected to the meter output; the first input of the third storage device connected to the first output of the analog-to-digital Converter, a second input to the first output of the first threshold element; the first input of the fourth storage device connected to the second output of the analog-to-digital Converter, the second input to the output of the second threshold element; the first input of the first arithmetic-logical unit connected to the output of the first storage device, the second input to the output of the second storage device, the third input to the output of the fourth storage device, the fourth input to the second output of the measuring current, the fifth input to the second output of the first threshold element; the first input of the second arithmetic-logical unit connected to d - the meter output is zero voltage level, the fourth input to the second output of the measuring current, the fifth input to the second output of the first threshold element; the first input of the third arithmetic-logical unit connected to the output of the first storage device, the second input to the meter output zero voltage level, the third input to the output of the third storage device, the fourth input to the second output of the current meter; the first input of the fourth arithmetic-logical unit connected to the output of the second storage device, the second input to the meter output zero voltage level, the third input to the second output of the measuring current; a first indicator connected to the output of the first arithmetic-logical unit; the input of the second indicator connected to the output of the second arithmetic-logical unit; the third indicator connected to the output of the third arithmetic-logical unit; the input of the fourth indicator connected to the output of the fourth arithmetic-logical unit.

 

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15 cl, 10 dwg

FIELD: medical engineering.

SUBSTANCE: device has divider, comparison unit, oscillator, acoustic radiator, controllable current source, stable constant voltage source, perspiration equivalent unit, key member, illumination source, conductivity transducer having two electrodes, the first commutator, delay unit, trigger, inverter, discharge unit, the second commutator and feeding voltage availability indicator unit. The first delay unit inputs and the first commutator inputs are connected to comparison unit output. The first commutator input is connected to the first oscillator input which delay unit, trigger and inverter are connected in series. Inverter output is connected to the second input of the first and the second commutator. The first input of the second commutator is connected to the other conductivity transducer electrode and its output is connected to device body via resistor.

EFFECT: reduced current intensity passing through patient skin; excluded negative influence upon skin during prolonged operation time on patient arm during hypoglycemia attack; low power consumption.

2 cl, 4 dwg

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