Polymer dressings used in surgery for repair of soft tissue defects after organolead operations and correction of congenital anomalies. The material is made from a polymeric composition comprising acrylamide, N, N-methylenebisacrylamide, potassium neccersarily or ammonium neccersarily, triethanolamine and distilled water in certain proportions. Applying a new dressing material indicates no allergenic, irritant, General toxic and carcinogenic actions. 6 Il. The invention relates to medicine, in particular to surgery, and can be used as a dressing material for repair of soft tissue defects after organolead operations and correction of congenital malformations.A method of obtaining soft contact lenses (P. 2104675, RU, IPC6: A 61 F 2/16). Source components for the production of soft contact lenses take in the following ratio: acrylamide 25-60%; a crosslinking agent 0,07-1,20%; potassium persulfate or sodium 0,05-0,40%; N,N,N',N'-tetramethylethylenediamine 0,08-0,30%; distilled water - the rest is up to 100%.Also known composition for injektilo PAG Interfall, containing tetramethylethylenediamine of 0.001 to 1.0%; acrylamide 3,5-9,0%; methylene-bis-acrylamide 0,01-1,0%; ammonium persulfate of 0.001 to 1.0%; distilled water - the rest is up to 100%.However, the described compositions cannot be used because of toxicity.The task of the invention is the elimination of toxic reactions.The problem is solved in that the inventive polymer material use ready-made polymer composition comprising acrylamide, N, N-methylenebisacrylamide, potassium neccersarily or ammonium neccersarily, N,N, N,N-tetramethylaniline or triethanolamine in the following ratio, wt.%: Acrylamide - 15-20 N,N-methylenebisacrylamide - 0,019-0,132 Potassium neccersarily or ammonium neccersarily - 0,084-0,1 N,N,N,N-tetramethylaniline or triethanolamine - 0,075-0,106 Distilled water - the Rest of the starting components is prepared polymerizing composition as follows.Preparation of solution 1 is Weighed 3.1 g of ammonium nadsemeistvo, placed in a beaker with 800 ml, measure cylinder 460 ml of distilled water and poured into a glass. The solution is stirred.Preparation of solutions 2 and 3 Weigh 0.75 g of N,N-methylenebisacrylamide, placed in a bottle with a capacity of 3 liters Measure cylindroma prepare a 40% aqueous solution as follows: weigh 800 g of acrylamide, placed in a volumetric flask or cylinder capacity of 2 liters, the volume was adjusted with distilled water to a 2 l stirred until complete dissolution of acrylamide and filtered through a funnel with a paper filter.Weighed 3.1 g of triethanolamine, placed in the bottle. Measure the cylinder 1287 ml of distilled water and placed in the bottle. Get the solution 2, which is thoroughly mixed manually or with the help of a mixer and filtered through a Buechner funnel with a paper filter in the suction flask, after which the solution 2 is transferred back into the bottle and poured up to the same solution 1. Get the solution of 3. Solutions 1 and 2 merge immediately before the loading of the reactor.The reactor is disassembled thoroughly washed under running water using detergent and rinsed with distilled water. After drying, the reactor is collected.Solution 3 is poured into the reactor for polymerization. The polymerization is carried out at ambient temperature for 405 minutes At the end of the polymerization process block plates are removed and dismantled: sever forms and strip, of the forms removed, the plates of the gel and transmit them to the purification step.The obtained plates were washed off the residual monomers, linear acrylic polymer is batrouney compressed air are shaded in the following way: 1-I wash - plates filled with distilled water at the rate of 50 ml per plate of rectangular shape (i.e., 10 l, 200 plates). Leaching lead for 30 min, the washing water is drained;
2-I and 3-I wash - just like the first;
4-I and 5-I wash - plate pour distilled water at the rate of 80 ml of a rectangle and are shaded in the same conditions for one hour.The linear dimensions of the obtained plates after washing the increase 1.5 times, the volume - 3.24 times in comparison with the appropriate parameters before washing.The obtained plate control:
(a) appearance (visual);
C) mass fraction of ash;
g) the presence of heavy metals;
d) the presence of residual monomers.The resulting plates are placed in plastic bags and sterilized by the method of tyndallization water termopane at a temperature of 65oC for 60 min twice with an interval of 24 hours.The obtained plate used in clinical practice as a dressing (self and therapeutic) of the material of the carrier of various biological substances. Depending on the destination environment, varying the ratio of components, it can be obtained with different densities and pore sizes, and in different temperatur, radiation and UV exposure, biologically inert, capable enough of all nutrients derived nutrient medium can be sterilized by heat or radiation method. For clinical practice (surgery, dermatology, plastic surgery and others) it is produced in various forms by customer order. The finished forms are supplied sealed in plastic bags and sterile. Shelf life 2 years.It is established that upon contact of the inventive polymeric material from various tissues and organs of experimental animals pathology was not detected. The remote results of the studies indicate no allergogennym, irritation and General toxic action, as well as carcinogenic effects.Clinical approbation of the proposed use of the plates as a dressing material was conducted in the clinic of hospital surgery of the Siberian state medical University, Tomsk).Properties of the polymer material used in the treatment of trophic ulcers:
1. Synthetic material is biologically inert material.2. Ease of preparation and ligation.3. Hydrophilic.4. The ability of n is, the considering stage of the wound healing process and the sensitivity of microflora.6. Osmotically active on the wound, making forms medication active gel.7. Has a smooth surface, so it does not injure granulation and skin transplants.Drugs used for saturation:
1. Dioksidina Solution 1%.2. Solutions Of Trypsin.3. Soccerer.4. Gentamicin.Method of application.The polymeric material is supplied sterile, Packed in a plastic bag, having maglalatik texture, transparent, in the form of a plate.The plate is removed from the package and immersed in the prepared solution for 48 hours in a sterile container, for easy retrieval on the gauze cloth.The maximum saturation of the plate is in the first day, significantly slowing down in the next. The material is placed on gauze and placed in a container of saturated liquid.Plate increases in size, becomes a jelly-like consistency, while maintaining its transparency, starting with the second day the plate is practically not increased in size (Fig.1).The best option of cooking plate: saturation plates for 24-48 h is niruetsya size of the ulcer or stacked several plates depending on the size of the ulcers. Modeled plate on the gauze cloth, with which the drug is placed over the ulcer, followed by fixation to the tibia several rounds of gauze bandage and partially adhesive fixation.Ligation in the stage of purulent-necrotic process is done daily. The plate is removed from the wound undergoes mechanical blast cleaning water from the tap, and then placed in a solution of furacin 1/5000 for a few hours and dried in air. Re-sterilization by autoclaving. According to this scheme the plate in the dressings can be used up to 3 times. After that, the plate loses its elastic and hydrophilic properties.In the process of liquidation of purulent-necrotic complications between the wound surface and the plate is formed a layer of pus and necrotic tissue, which during the dressing is removed mechanically (Fig.2).Under stimulation of reparative processes used in combination with the ointment: between the plate and the wound is placed solcoseryl jelly or ointment and bandaging is done through the day. Between the surface of the ulcer and the plate is formed of a gel layer with active regenerative properties. This layer while removing the plate not traveroes riminals on the wound after closure of the skin. In most cases, the plastic skin was performed on Yanovich-Chainsaw-Davis. Immediately after surgery the wound is placed a plate, rich in anti-bacterial solution. The first ligation was carried out for 2-3 days. Gauze bandage was removed from the wound and the wound looked through the plate, if between the wound and plate no local accumulations of blood, exudate, the plate is left for another day. In the case of accumulation of fluid under the plate the plate is changed. Having a smooth surface, the plate does not injure skin graft and granulation of the wound, promoting their engraftment and epithelization of the wound. In Fig.4 depicts the ligation after the plastic skin on the 4th day.The main advantage of dressing in the clinic is that between the smooth plate surface and an ulcer is formed of wound gel, so while bandaging, and after bandaging the patient is not experiencing pain. This factor and the presence of wound gel favorably affect the healing process of ulcers (Fig.5).Trophic ulcers cleansed of necrotic tissue in 1.7 times faster than in the control group (mechanical purification of hydrogen peroxide 3% solution of furacin 1:5000, dressing Malia lion for arthroplasty was used as follows.Patient K. hospitalized in November 2000 in the surgical hospital clinic. A. Savinykh, Siberian state medical University, Tomsk).Complaints about cosmetic defect of the chest (Fig.6) and emotional depression.From the anamnesis: in 1999 performed a mastectomy on Halstead about breast cancer. Postoperative period was unremarkable.Objectively: on the front wall of the right half of the thorax (in place of the removal of the breast) postoperative scar 15 cm, soft, elastic, healing by primary intention. Signs of recurrence of the disease was not found.The patient had been proposed several types of breast prostheses. Due to the high cost of implants sick of them refused. Pronounced depressive syndrome, due to the cosmetic defect of the chest, allowed to offer her our implant breast of the inventive polymeric material that has been investigated in the experiment, the negative effects on the body is not revealed.November 15 was performed implantation developed breast prosthesis of the proposed material under the skin. The implant had forms the feces without features. For two years the implant has increased in volume by a factor of two.The patient at the time of a follow-up visit no complaints, mental condition is satisfactory.
Polymer dressings made from polymer compositions comprising acrylamide, N, N-methylenebisacrylamide, potassium neccersarily or ammonium neccersarily, triethanolamine and distilled water in the following ratio, wt. %:
Acrylamide - 15-20
N, N-methylenebisacrylamide - 0,019-0,132
Potassium neccersarily or ammonium neccersarily - 0,084-0,1
Triethanolamine - 0,075-0,106
Distilled water - the Rest
< / BR>and the second link has the formula
< / BR>and at least 50% of the units have the formula of the first link
SUBSTANCE: invention relates to dressing materials based on polymeric compositions and can be used in surgery and traumatology for closing wounds of different etiology. The polyol component-base medicinal bandage based on propylene oxide or ethylene oxide comprises water, catalyst for urethane formation and isocyanate complex consisting of isomers of diphenylmethane diisocyanate. High-molecular simple polyetherpolyol with molecular mass 3000-10000 Da is used, and isocyanate complex comprises additionally oligourethane isocyanate based on low-chain oligoetherpolyol with the content of isocyanate groups 26.0-29.5 wt.-%. Also, the bandage comprises activation additive consisting of polyurethane chain lengthener, foam-opening agent and foam-hardening agent. Bandage provides exclusion additional pain senses in the patient, enhancing absorption effect and provides absence of skin sticking.
EFFECT: valuable medicinal properties of bandage.
FIELD: medicine, special additives.
SUBSTANCE: invention relates to hygroscopic additive that represents particles of hygroscopic additive containing particles of hygroscopic resin (α) and additive improving penetrability for liquid (β) wherein particles of hygroscopic resin (α) represent particles of cross-linked polymer formed from a monomer comprising acrylic acid and/or its salt and subjected for treatment resulting to formation of cross-links on its surface. Particles of the proposed hygroscopic additive show average-mass diameter (D50) in the range from 234 to 394 mcm, logarithm standard deviation (σξ) for distribution of particles by sizes in the range from 0.25 to 0.45, absorbing capacity without loading 15 g/g, not less, and the level of the water-extractive component content 15 wt.-%, not above, and, except for, the level of the additive content improving penetrability of liquids (β) in the range from 0.01 to 5 mass parts per 100 mass parts of particles of hygroscopic resin (α). Proposed hygroscopic additive combines exploitation indices describing both capillary absorption strength and penetrability for a liquid.
EFFECT: improved and valuable properties of additive.
8 cl, 7 dwg, 29 ex
SUBSTANCE: the present composition includes nonvolatile, a silicone, fluid substance in the mixture with finely divided silicon dioxide and antibacterial active substance. Pharmaceutically active substance is a nondecomposing one and manifests physical stability in the composition.
EFFECT: higher efficiency.
31 cl, 5 ex, 2 tbl
FIELD: biotechnology, microbiology, medicine.
SUBSTANCE: invention relates to novel probiotic strains of lactobacilli: Lactobacillus acidophilus DSM 14869, Lactobacillus paracasei DSM 14870, Lactobacillus acidophilus DSM 15525, Lactobacillus plantarum DSM 15524, Lactobacillus sp. DSM 11526 and the strain Lactobacillus sp. DSM 15527. Strains shows similar favorable properties used separately or in combination as probiotics or in common with prebiotic as symbiotic. Also, invention relates to pharmaceutical compositions, dairy foodstuffs, functional foodstuffs, nutrient supplements and agents for personal hygiene comprising strains in separately or in combination, and to using strain for prophylaxis or treatment of vaginal infections, urogenital infections and gastrointestinal diseases.
EFFECT: valuable properties of strains.
43 cl, 12 ex
SUBSTANCE: described bandaging material contains non-volatile silicone fluid mixed with colloidal silicon dioxide, volatile solvent and silicone elastomer. Material is improved composition applied for specific tissue area amenable to pathogenic infections and/or scarring.
EFFECT: has improved composition.
33 cl, 4 tbl, 7 ex
SUBSTANCE: present invention concerns medicine, specifically an absorbent product, such as a diaper, diaper panties, sanitary towel, sanitary tissue, incontinence appliance or similar, containing as specified: a fluid-permeable coat, optionally sub-layer of cloth or porous material, optionally an absorbent layer and a fluid impenetrable coat, differing that at least one part of said absorbent towel contains polymer which is hydrophilic if dry, however shows lowered hydrophilic behaviour after humidifying; and also concerns the related fluid-permeable and impenetrable coat and cloth or porous material.
EFFECT: absorbent product shows optimum hydrophilic/hydrophobic properties to ensure good fluid distribution after humidifying.
SUBSTANCE: invention concerns medicine, namely dressings with polymer compositions and can be used in surgery and traumatology for various wound closing. A medical dressing formed on a wound directly ensures its full sterile closing, provides anaesthetic effect, primary disinfection and exudate absorption from the wound of a patient and medical staff and does not require additional fixation. The dressing consists of a polyol component containing high-molecular simple oligoesterpolyol based on propylene oxide and ethylene oxide, water, an urethane formation activator, an isocyanate component containing mixed isomers of dimethylmethane diisocyanate, an activation additive consisting of the extension of polyurethane chain, a foam opener. The activation additive also contains a foaming agent. The activator is mixed amines and organotin compounds. The isocyanate component has the isocyanate group content 26.0-32 wt % in the following ratio in the composition, weight fractions: high-molecular oligoesterpolyol - 100, water - 2.0-4.0, the foaming agent - 2.0-4.0, the urethane formation activator - 0.05-0.4, the chain extension - 0.2-1.5, the foam opener - 0.2-1.5, the foam hardener - 0.2-1.5, the isocyanate component - 30-60.
EFFECT: extended temperature range of dressing use to 5°C, elimination of collateral pain sensations in patients (reduced temperature of reaction), further improvement of absorption properties and reduced cost price of the dressing.
SUBSTANCE: invention concerns medicine, more specifically to a new method for making a sheet material with interpenetrating polymer networks (IPN). In comparison with the common methods, the offered method shows such advantages as, e.g. a) one-pass making capability for sheet material with IPN, b) the absence of the second liquid polymer coating used as a glue, c) the absence of solvents or other auxiliary materials, d) producibility of the material in the furnace during the required time without elongation, e) higher material traverse and f) applicability of the coating only on one side of a carrier body.
EFFECT: invention concerns particularly making such sheet material and its combination with a protective material to be used as a dressing and as an adhesive plaster.
26 cl, 7 dwg, 3 ex
SUBSTANCE: invention refers to medicine. Described is a multilayer bandage of at least the following structure: nonwoven web 1 which shall contact with a wound, and a membrane 3 which is water-proof and comprises water-insoluble polymer.
EFFECT: multilayer bandage is not adhered to wound and thereby do not interpenetrate with it.
15 cl, 6 dwg
SUBSTANCE: invention relates to field of medicine, in particular, to polymer-based dressings, and can be applied in surgery for closing wounds of various etiology. Described is gel-like coating from elastic foam-polyurethane, which consists of polyol component including highly molecular simple oligoetherpolyol on the basis of propylene and ethylene oxide, water, urethane-formation activator, isocyanate component, which includes mixture of diphenylmethane diisocyanate isomers, activation additive, consisting of polyurethane chain extender, foam-opener, foam-hardener, in activation additive additionally introduced is foaming agent, as activator, used is "mixture of tertiary amines and tin-organic compounds with ratio 1:1 (wt fr.)", isocyanate component with content of isocyanate groups 26.0-32 wt % with the following ratio of ingredients in composition, wt fr.: highly molecular oligoetherpolyol - 100, water - 2.0-4.0, foaming agent - 2.0-4.0, urethane-formation catalyst (mixture of tertiary amines and tin-organic compounds with ratio 1:1 (wt fr.)), - 0.05-0.4, chain extender - 0.2-1.5, foam-opener - 0.2-1.5, foam-hardener - 0.2-1, isocyanate component with content of isocyanate groups 26.0-32 wt % - 30-60, and into composition of polyol component introduced are boehmite nanoparticles with size from 10 to 50 nm with its weight to 10% of polyol component weight.
EFFECT: improvement of sorbing properties of polyurethane coating due to strengthening capillary walls, reduction of their radius and extension of capillary system, which makes it possible to obtain sorbing volume of coating material exceeding 90%.
FIELD: surgical facilities.
SUBSTANCE: invention provides material suitable as hemostatic and wound-healing remedy in low-invasive internal surgery involving endoscopic techniques. Allogenic connective-tissue formations (tendons, fascias, dermis) are subjected to mechanical cleaning to remove the rests of adjoining tissues and foreign bodies, washed with running water during 5-10 min, degreased by cold (+4оС) acetone, placed for 5-10 min in 3% hydrogen peroxide solution to remove blood, and thrice rinsed with 0.9% sodium chloride solution. Treated tissues are frozen in cryogenic chamber at -45оС and dried in vacuo to constant weight using liophilic drying technique. Dried material is then wetted at 1:5 weight ratio in solution containing calculated quantities of hemostatic (fibrinogen), fibrinolysis inhibitor (aminocapronic acid), and antibiotic (cephalexin) for 10-20 min until biomaterial structure is completely and uniformly impregnated. Solution id prepared at +4оС by consecutively dissolving 0.2 g cephalexin and 1 g fibrinogen in 10 ml of 5% aminocapronic acid solution. Thereafter, biomaterial is once again frozen and subjected to liophilic drying, then ground on blade-type mill (e.g. "Cyclotec", Foss Tecator) to particle size 0.1-0.25 mm, which are packaged by 0.5 g doses into glass 20-ml bottles, tightly sealed, and sterilized by gamma radiation in dose 2.5 MRad (25 kGr).
EFFECT: simplified technology, improved quality and structure of material.
FIELD: chemistry of polymers, medicine.
SUBSTANCE: invention describes covers for medicinal device made of metal. Cover comprises polymerized derivative of alkoxysilane bound covalently with surface of medicinal device, lactone polymer bound covalently with functional groups of polymerized derivative of alkoxysilane by the in situ polymerization process accompanying with the cycle opening, and at least one layer of polyester applied on bound lactone. Biologically active agents can be applied together with layers of polyester. Such cover-containing surfaces can be used in medicinal devices, in particular, in stents. Cover is biocompatible and provides prolonged release of biologically active agents for from some weeks to some months.
EFFECT: improved and valuable properties of cover.
49 cl, 8 dwg, 7 tbl, 15 ex
SUBSTANCE: stent includes hyaluronic acid polymer-based coating, and mentioned hyaluronic acid polymer is ester derivative of hyaluronic acid.
EFFECT: effective prevention of restenosis phenomenon.
40 cl, 3 dwg, 7 tbl, 9 ex
SUBSTANCE: are described medical implants which release anthracycline, fluoropyrimidine, antagonist of folic acid, podophyllotoxin, camptotecine, hydroxyurea or platinum complex.
EFFECT: suppressed or reduced rate of implant-associated infections.
83 cl, 1 dwg, 2 tbl, 25 ex
SUBSTANCE: invention relates to method of manufacturing medication-releasing medical device, selected from group consisting of vascular devices, prostheses, probes, catheters, tooth implants or similar, applied in treatment an/or prevention of vessel restenosis, which leads to acute circulatory collapse , conditioned by reduction of circulating blood weight. Claimed method includes application on device by means of submerging into suitable solution or by means of dispersion, of at least one medication layer, when necessary introduced into polymer able to release said medication; polymer which has active functional groups, selected from group consisting of amino groups and sulphhydryl groups capable of chemical binding of biological molecules in one step by means of cold plasma methods; and biological molecules on said polymer surface. Also described is medication-releasing medical device, obtained by said method and application of polymers with reactive functional groups for covering medical devices, preferably vessel stents, by means of cold plasma application.
EFFECT: due to application of definite class of polymers using cold plasma, claimed method is more technological, namely facilitates application of polymer without destroying its functional groups properties and better polymer binding with biomolecules resulting in slower, controlled release of medication from medical device.
36 cl, 1 tbl, 5 ex, 2 dwg