Polymer dressings


Polymer dressings used in surgery for repair of soft tissue defects after organolead operations and correction of congenital anomalies. The material is made from a polymeric composition comprising acrylamide, N, N-methylenebisacrylamide, potassium neccersarily or ammonium neccersarily, triethanolamine and distilled water in certain proportions. Applying a new dressing material indicates no allergenic, irritant, General toxic and carcinogenic actions. 6 Il.

The invention relates to medicine, in particular to surgery, and can be used as a dressing material for repair of soft tissue defects after organolead operations and correction of congenital malformations.

A method of obtaining soft contact lenses (P. 2104675, RU, IPC6: A 61 F 2/16). Source components for the production of soft contact lenses take in the following ratio: acrylamide 25-60%; a crosslinking agent 0,07-1,20%; potassium persulfate or sodium 0,05-0,40%; N,N,N',N'-tetramethylethylenediamine 0,08-0,30%; distilled water - the rest is up to 100%.

Also known composition for injektilo PAG Interfall, containing tetramethylethylenediamine of 0.001 to 1.0%; acrylamide 3,5-9,0%; methylene-bis-acrylamide 0,01-1,0%; ammonium persulfate of 0.001 to 1.0%; distilled water - the rest is up to 100%.

However, the described compositions cannot be used because of toxicity.

The task of the invention is the elimination of toxic reactions.

The problem is solved in that the inventive polymer material use ready-made polymer composition comprising acrylamide, N, N-methylenebisacrylamide, potassium neccersarily or ammonium neccersarily, N,N, N,N-tetramethylaniline or triethanolamine in the following ratio, wt.%: Acrylamide - 15-20 N,N-methylenebisacrylamide - 0,019-0,132 Potassium neccersarily or ammonium neccersarily - 0,084-0,1 N,N,N,N-tetramethylaniline or triethanolamine - 0,075-0,106 Distilled water - the Rest of the starting components is prepared polymerizing composition as follows.

Preparation of solution 1 is Weighed 3.1 g of ammonium nadsemeistvo, placed in a beaker with 800 ml, measure cylinder 460 ml of distilled water and poured into a glass. The solution is stirred.

Preparation of solutions 2 and 3 Weigh 0.75 g of N,N-methylenebisacrylamide, placed in a bottle with a capacity of 3 liters Measure cylindroma prepare a 40% aqueous solution as follows: weigh 800 g of acrylamide, placed in a volumetric flask or cylinder capacity of 2 liters, the volume was adjusted with distilled water to a 2 l stirred until complete dissolution of acrylamide and filtered through a funnel with a paper filter.

Weighed 3.1 g of triethanolamine, placed in the bottle. Measure the cylinder 1287 ml of distilled water and placed in the bottle. Get the solution 2, which is thoroughly mixed manually or with the help of a mixer and filtered through a Buechner funnel with a paper filter in the suction flask, after which the solution 2 is transferred back into the bottle and poured up to the same solution 1. Get the solution of 3. Solutions 1 and 2 merge immediately before the loading of the reactor.

The reactor is disassembled thoroughly washed under running water using detergent and rinsed with distilled water. After drying, the reactor is collected.

Solution 3 is poured into the reactor for polymerization. The polymerization is carried out at ambient temperature for 405 minutes At the end of the polymerization process block plates are removed and dismantled: sever forms and strip, of the forms removed, the plates of the gel and transmit them to the purification step.

The obtained plates were washed off the residual monomers, linear acrylic polymer is batrouney compressed air are shaded in the following way: 1-I wash - plates filled with distilled water at the rate of 50 ml per plate of rectangular shape (i.e., 10 l, 200 plates). Leaching lead for 30 min, the washing water is drained;
2-I and 3-I wash - just like the first;
4-I and 5-I wash - plate pour distilled water at the rate of 80 ml of a rectangle and are shaded in the same conditions for one hour.

The linear dimensions of the obtained plates after washing the increase 1.5 times, the volume - 3.24 times in comparison with the appropriate parameters before washing.

The obtained plate control:
(a) appearance (visual);
b) color;
C) mass fraction of ash;
g) the presence of heavy metals;
d) the presence of residual monomers.

The resulting plates are placed in plastic bags and sterilized by the method of tyndallization water termopane at a temperature of 65oC for 60 min twice with an interval of 24 hours.

The obtained plate used in clinical practice as a dressing (self and therapeutic) of the material of the carrier of various biological substances. Depending on the destination environment, varying the ratio of components, it can be obtained with different densities and pore sizes, and in different temperatur, radiation and UV exposure, biologically inert, capable enough of all nutrients derived nutrient medium can be sterilized by heat or radiation method. For clinical practice (surgery, dermatology, plastic surgery and others) it is produced in various forms by customer order. The finished forms are supplied sealed in plastic bags and sterile. Shelf life 2 years.

It is established that upon contact of the inventive polymeric material from various tissues and organs of experimental animals pathology was not detected. The remote results of the studies indicate no allergogennym, irritation and General toxic action, as well as carcinogenic effects.

Clinical approbation of the proposed use of the plates as a dressing material was conducted in the clinic of hospital surgery of the Siberian state medical University, Tomsk).

Properties of the polymer material used in the treatment of trophic ulcers:
1. Synthetic material is biologically inert material.

2. Ease of preparation and ligation.

3. Hydrophilic.

4. The ability of n is, the considering stage of the wound healing process and the sensitivity of microflora.

6. Osmotically active on the wound, making forms medication active gel.

7. Has a smooth surface, so it does not injure granulation and skin transplants.

Drugs used for saturation:
1. Dioksidina Solution 1%.

2. Solutions Of Trypsin.

3. Soccerer.

4. Gentamicin.

Method of application.

The polymeric material is supplied sterile, Packed in a plastic bag, having maglalatik texture, transparent, in the form of a plate.

The plate is removed from the package and immersed in the prepared solution for 48 hours in a sterile container, for easy retrieval on the gauze cloth.

The maximum saturation of the plate is in the first day, significantly slowing down in the next. The material is placed on gauze and placed in a container of saturated liquid.

Plate increases in size, becomes a jelly-like consistency, while maintaining its transparency, starting with the second day the plate is practically not increased in size (Fig.1).

The best option of cooking plate: saturation plates for 24-48 h is niruetsya size of the ulcer or stacked several plates depending on the size of the ulcers. Modeled plate on the gauze cloth, with which the drug is placed over the ulcer, followed by fixation to the tibia several rounds of gauze bandage and partially adhesive fixation.

Ligation in the stage of purulent-necrotic process is done daily. The plate is removed from the wound undergoes mechanical blast cleaning water from the tap, and then placed in a solution of furacin 1/5000 for a few hours and dried in air. Re-sterilization by autoclaving. According to this scheme the plate in the dressings can be used up to 3 times. After that, the plate loses its elastic and hydrophilic properties.

In the process of liquidation of purulent-necrotic complications between the wound surface and the plate is formed a layer of pus and necrotic tissue, which during the dressing is removed mechanically (Fig.2).

Under stimulation of reparative processes used in combination with the ointment: between the plate and the wound is placed solcoseryl jelly or ointment and bandaging is done through the day. Between the surface of the ulcer and the plate is formed of a gel layer with active regenerative properties. This layer while removing the plate not traveroes riminals on the wound after closure of the skin. In most cases, the plastic skin was performed on Yanovich-Chainsaw-Davis. Immediately after surgery the wound is placed a plate, rich in anti-bacterial solution. The first ligation was carried out for 2-3 days. Gauze bandage was removed from the wound and the wound looked through the plate, if between the wound and plate no local accumulations of blood, exudate, the plate is left for another day. In the case of accumulation of fluid under the plate the plate is changed. Having a smooth surface, the plate does not injure skin graft and granulation of the wound, promoting their engraftment and epithelization of the wound. In Fig.4 depicts the ligation after the plastic skin on the 4th day.

The main advantage of dressing in the clinic is that between the smooth plate surface and an ulcer is formed of wound gel, so while bandaging, and after bandaging the patient is not experiencing pain. This factor and the presence of wound gel favorably affect the healing process of ulcers (Fig.5).

Trophic ulcers cleansed of necrotic tissue in 1.7 times faster than in the control group (mechanical purification of hydrogen peroxide 3% solution of furacin 1:5000, dressing Malia lion for arthroplasty was used as follows.

Patient K. hospitalized in November 2000 in the surgical hospital clinic. A. Savinykh, Siberian state medical University, Tomsk).

Complaints about cosmetic defect of the chest (Fig.6) and emotional depression.

From the anamnesis: in 1999 performed a mastectomy on Halstead about breast cancer. Postoperative period was unremarkable.

Objectively: on the front wall of the right half of the thorax (in place of the removal of the breast) postoperative scar 15 cm, soft, elastic, healing by primary intention. Signs of recurrence of the disease was not found.

The patient had been proposed several types of breast prostheses. Due to the high cost of implants sick of them refused. Pronounced depressive syndrome, due to the cosmetic defect of the chest, allowed to offer her our implant breast of the inventive polymeric material that has been investigated in the experiment, the negative effects on the body is not revealed.

November 15 was performed implantation developed breast prosthesis of the proposed material under the skin. The implant had forms the feces without features. For two years the implant has increased in volume by a factor of two.

The patient at the time of a follow-up visit no complaints, mental condition is satisfactory.


Polymer dressings made from polymer compositions comprising acrylamide, N, N-methylenebisacrylamide, potassium neccersarily or ammonium neccersarily, triethanolamine and distilled water in the following ratio, wt. %:
Acrylamide - 15-20
N, N-methylenebisacrylamide - 0,019-0,132
Potassium neccersarily or ammonium neccersarily - 0,084-0,1
Triethanolamine - 0,075-0,106
Distilled water - the Rest


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< / BR>
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< / BR>
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