The tool pharyngal for the prevention and treatment of infectious - inflammatory diseases of the oropharynx

 

The invention relates to the field of medicine and for the prevention and treatment of infectious and inflammatory diseases of the oral cavity and pharynx. The tool is designed to palatal or cheek introduction, and has the property of snap-in system. The inventive tool contains an active ingredient and excipients. As an active ingredient it contains a dry water-soluble extract of medicinal plants, which is obtained by extraction of medicinal plants herbs St. John's wort, marigold, yarrow, licorice root and rosehips 25% ethyl alcohol. It also contains ascorbic acid, and as excipients contains beet pectin, agar food, sodium carboxymethylcellulose, sugar, calcium stearinovokisly. Technical result: Pharyngal allows to increase the duration of the effects of medicinal substances on mucous membranes of the oropharynx due to slow dissolution in the oral cavity. The tool also normalizes intestinal microflora, increases the immunological reactivity and General nonspecific resistance of the organism. 5 C.p. f-crystals, 2 tab.

The invention of the new cavity and pharynx.

The treatment of infectious-inflammatory diseases of the oral cavity and pharynx is a topical issue due to the wide spread of this disease in adults and children.

The urgency of the problem determines a large assortment of drugs for local and General steps used in the treatment of these conditions (SU 1659054, EN 93041374, US 5248503).

One of the areas of search for such drugs is the creation of dosage forms, which allows to increase the duration of the effects of medicinal substances on mucous membranes of the oropharynx due to slow dissolution in the oral cavity treatment caramels, mints, gum, cheek tablets. In the majority of antimicrobial agents local actions include antiseptics are chemical origin, but they are for the body xenobiotics and therefore on the background of infectious intoxication cause additional stress its metabolizing and eliminating systems, and consequently, a possible cause of adverse reactions, especially in children and patients with chronic diseases. In this regard, the widespread medicines, including herbal components (eucalyptus, mint, sage, etc.). Rusticucci compatible with it. Another advantage of herbal remedies is a normalizing influence on the changed functions of the body in the absence of effects on other indicators. These properties, as well as the use of low doses of plant components, can virtually eliminate the toxic and side effects.

The disadvantage of most common drugs of plant materials is that they have only local effect. Such treatment should be supplemented with total therapy, a large number of other anti-inflammatory drugs, antihistamines, vitamins, etc.

Infectious-inflammatory diseases, along with local antimicrobial and anti-inflammatory action, there is a need to restore homeostasis and mobilization adaptogenic abilities of the body and its immune responses. This purpose can be used multi-component drugs of natural origin, providing a comprehensive therapeutic effect.

The closest in technical essence and the achieved result for the proposed tool is Inhalt containing streptocid soluble norsulfazol, thymol, eucalyptus and peppermint, alcohol, sahasa with tonsillitis, pharyngitis, laryngitis, and ulcer aphthous stomatitis (M. D. Mashkovsky "Drugs" Vilnius, 1993, H. 2, S. 245-246).

The technical result of the proposed tool, called Pharyngal, for the prevention and treatment of infectious-inflammatory diseases of the oropharynx is the creation of new, more efficient, safer and more convenient medicines that may increase the duration of exposure of the drug substance for palatal and cheek introduction to the mucosa of the oropharynx due to slow dissolution in the oral cavity.

To achieve the technical result in the remedy for the prevention and treatment of infectious-inflammatory diseases of the oropharynx, containing the active ingredient and excipients, according to the invention as an active ingredient it contains a dry water-soluble extract of medicinal plants, further comprises ascorbic acid, and as excipients contains beet pectin, agar food, sodium carboxymethylcellulose, sugar, calcium stearinovokisly in the following ratio, wt.%: The beet pectin - 7-23 Sodium carboxymethylcellulose - 8-25 Agar p is - the steel in this active component is obtained by extraction of medicinal plants herbs St. John's wort, marigold, yarrow, licorice root and rosehips 25% ethyl alcohol, taken in the ratio, wt.%: St. John's wort herb - 15-35
Calendula flowers - 15-35
Yarrow herb - 7-20
Licorice root - 5-15
Rosehips - 15-25
The tool is designed to palatal or cheek introduction, and it possesses a snap-in system.

The tool is intended for the prevention and treatment of infectious-inflammatory diseases of the oropharynx: tonsillitis, pharyngitis, chronic tonsillitis, acute respiratory diseases, and can also be used for patients undergoing tonsillectomy, adenotomy.

Dose for adults and children over 12 years of age is 4-6 tablets per day, 1 tablet 4-6 times a day.

Dose for children 7 to 12 years is 2/3 dose adults and children aged 5 to 7 years 1/2 of the adult dose.

The invention is illustrated in the following examples.

Example 1. Get active component by extraction of medicinal plants herbs St. John's wort, marigold, yarrow, licorice root and rosehips 25% ethyl alcohol, taken in the ratio, wt.%, pologitelnui substances: sugar beet pectin, agar food, sodium carboxymethyl cellulose, sugar, calcium stearinovokisly in the following ratio, wt.%, are given in table.2.

The resulting tool, the tablets are light brown in color with multiple inclusions of a dark brown colour is designed for palatal or cheek introduction, and has the property of snap-in system.

Example 2. To obtain a tablet form take the following components, mg 1 tablet weight of 650 mg:
Extract of medicinal plants - 100
The beet pectin - 140
Sodium carboxymethylcellulose - 150
Agar food - 50
Ascorbic acid - 50
Calcium stearinovokisly - 10
Example 3. Prevention of infectious-inflammatory diseases of the oropharynx was performed in 90 patients aged 15 to 65 years. The control group consisted of 30 patients who received local treatment by lubricating mucous membranes pharynx Lugol solution with glycerin 2 times a day. Patients of the main group took 7 days Pharyngal 1 tablet 4 times a day after meals, not swallowing, not grinding. Within one minute the tablet Pharyngula tightly sticks to the palate and remains in the mouth to complete resorption within 1-2 caslevania oropharynx for 3-3,5 years.

Example 4. The treatment was conducted in an Urban teaching hospital, Saransk.

Patient K. , 29 years. The diagnosis of pharyngitis. Complaint: pain in the fauces, headache, weakness.

When the examination is marked hyperemia and infiltration palate and Palatine arches.

The patient before the appointment of Pharyngula received standard (antibacterial, desensitized, symptomatic) therapy.

Pharyngal used 1 tablet 6 times a day for 7 days. Each tablet firmly fixed on the sky and disappeared within 1.5 hours.

After the end of treatment was subjectively noted the rapid disappearance of unpleasant sensations in the oropharynx in the form of pain, burning and sore after an average of 2 days. Disappeared hoarseness, at the same time noted improvement in General condition disappeared weakness, headache, appetite improved.

Objectively (pharyngoscope) noted the disappearance of hyperemia and infiltration of the Palatine arches (average 2 days) and the disappearance of purulent follicles and caseous plugs in the gaps (average 2 days). Disappeared hyperemia and granularity of the mucosa of the posterior pharyngeal wall, infiltrative changes and swelling of the granules. Positive dynamics from podcast the>/p>Example 5. The treatment was carried out in the ENT clinic of the Russian University of peoples ' friendship, Moscow.

Patient S., aged 15. Diagnosis: chronic atrophic pharyngitis.

Treatment: Pharyngal 0.65 g 1 tablet 4 times a day.

Tablet pharyngula within minutes tightly adheres to the sky and remains in the mouth to complete resorption within 2 hours.

Analysis of sensory-analogue scale showed that on day 5 after the treatment the patient With. noted clinical improvement, which was manifested by a decrease pain in the throat, soreness, sore, cough and sticky mucus. Within 5 days of treatment dynamics of average values of severity of symptoms showed a decrease in mean score from 15.3 to 4.1. To 7 days of treatment, these symptoms disappeared completely.

From the 3rd day of treatment decreased edema and hyperemia of the mucous membrane of the pharynx. The marked increase in S-IgA in oropharyngeal secret 6.5 times its level returned to near normal. IgG increased significantly after treatment in 3.8 times. This indicates the increase of local immunity in the treatment pharyngula. After treatment disappeared pathogens in crops from the mucous membranes of the oropharynx. (Data taken from thesis Lebedeva N. A. "Hranice the e), Moscow, 2000).

Multicomponent antimicrobial, anti-inflammatory, wound healing and pain-relieving tool pharyngal providing a comprehensive therapeutic effect and intended for the prevention and treatment of infectious-inflammatory diseases of the oropharynx, is a slow-release cheek tablet, existing active substance which is a dry water-soluble extract is widely known medicinal plant Hypericum, calendula, yarrow, licorice root, rosehips, and is included in the tools beet pectin, food agar, ascorbic acid, sugar, sodium carboxymethylcellulose, calcium stearinovokisly. The selection of the ingredients of the extract was carried out on the basis of the known properties of these plants so that along with mestnik antimicrobial and anti-inflammatory action of pharyngula to achieve adaptogenic and anti-allergic effect. The tool can be used on treatment with antibiotics or sulfonamides. Slow resorption of tablets in the oral cavity, as well as 4-6 times the receiving means allows to ensure a lasting impact of the medicinal components of the oral mucosa is a new acid, vitamins P, PP, flavonoids, carotenoids, organic acids, trace elements (rose, St. John's wort, calendula), and connections with glucocorticoid activity (licorice), which have the effect of detoxification and contributes to the overall resistance of the body to infectious, as well as reducing the allergic component of inflammation.

Included in the means of bitterness (yarrow) increased salivation, improve the activity of the gastrointestinal tract and increase appetite. Thus, the proposed combination of herbal ingredients allows you to complement and enhance the action of each component and to achieve local - antimicrobial, anti-inflammatory and wound-healing action and thereby to achieve obscherezorbtivnymi, adaptogenic and anti-allergic effect.

therapeutic efficacy of Pharyngula along with direct effects on the microflora in the mucosa of the oropharynx includes the normalization of the intestinal microflora, resulting in improved immunological reactivity and non-specific resistance of the organism of patients.


Claims

1. Means for profilaktike substances, characterized in that, as an active ingredient it contains a dry water-soluble extract of medicinal plants, further comprises ascorbic acid, and as excipients contains beet pectin, agar food, sodium carboxymethylcellulose, sugar, calcium stearinovokisly in the following ratio, wt. %:
The beet pectin - 7-23
Sodium carboxymethylcellulose - 8 -25
Agar food - 3-12
Sugar - 3-12
Ascorbic acid - 3-12
Calcium stearinovokisly - 1-1,2
Extract of medicinal plants - Rest
this active component is obtained by extraction of medicinal plants herbs St. John's wort, marigold, yarrow, licorice root and rosehips 25% ethyl alcohol, taken in the ratio, by weight. %:
St. John's wort herb - 15-35
Calendula flowers - 15-35
Yarrow herb - 7-20
Licorice root - 5-15
Rosehips - 15-25
2. Means under item 1, characterized in that it is intended to palatal or cheek introduction.

3. Tool for PP. 1 and 2, characterized in that it possesses a snap-in system.

4. Tool for PP. 1-3, characterized in that it is intended for the prevention and Leche is essich tonsillectomy, adenotomy.

5. Tool for PP. 1-4, characterized in that the dose for adults and children over 12 years of age is 4-6 tablets per day, 1 tablet 4-6 times a day.

6. Tool for PP. 1-5, characterized in that the dose for children aged 7 to 12 years is 2/3 dose adults and children aged 5 to 7 years 1/2 of the adult dose.

 

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