Method of treating psoriasis in combination with chronic opisthorchiasis

 

(57) Abstract:

The method relates to medicine, dermatology, and can be used for the treatment of patients with psoriasis in combination with chronic opisthorchiasis. Before deworming take vicodin 0.5 g 3 times a day before meals for 14 days, and deworming spend biologically active additive to food "Acoral" 1 dessert spoon 2 times a day 40 minutes after a meal for 7 days, then take cholagogue 1 capsule 3 times a day for 7 days. This invention will reduce the number of complications and high efficiency deworming.

The invention relates to the field of medicine, dermatology and relates to methods of treating psoriasis in combination with chronic opisthorchiasis.

There is a method of treatment of patients with combined pathology using praziquantel, appointed in the usual dose of 60 mg/kg of body weight on the night circuit 3 times with an interval of 4 hours. De-worming was 100%. However, for patients with psoriasis this treatment causes the complication of skin lesions in the form of appearance of new lesions, especially in the first days after deworming, followed sudi. , "Features of psoriasis, stomach and biliary system when combined with chronic opisthorchiasis". The dissertation on competition of a scientific degree of candidate of medical Sciences. Tomsk, 1999).

A new technical result is a decrease in the number of complications and high efficiency deworming achieve application of a new method of treating psoriasis in combination with chronic opisthorchiasis, consisting of deworming during the stationary phase of the process, and before deworming appointed nicodin 0.5 g 3 times a day before meals for 14 days, and deworming spend biologically active additive to food "Acoral" 1 dessert spoon 2 times a day after 40 minutes after a meal for 7 days, after which assign cholagogue 1 capsule 3 times a day for 7 days.

The method is as follows.

Before beginning treatment for translation an advanced stage of psoriasis in inpatient ambulatory patient receives the following treatment: detoxification therapy (solution of sodium thiosulfate and 30% at 10 ml/10), antihistamines (kestin 1 tablet a day for 10 days), vitamins (vitamins C is m Unna.

Also the patient is undergoing physical examination (complete blood count, urinalysis, biochemical analysis of blood), liver ultrasound, duodenal intubation or enzyme-linked immunosorbent assay for opisthorchiasis to IgG.

When in duodenal bile eggs opistorhisov or higher titer by ELISA, the patient receives outpatient treatment for nicotine 0.5 g 3 times a day before meals for 14 days, then spend deworming biologically active additive to food "Acoral" 1 dessert spoon 2 times a day for 7 days, after which assign cholagogue 1 capsule 3 times a day for 7 days.

Biologically active food Supplement "Acoral" represents granules from light brown to dark brown, bitter taste, with low specific smell.

Composition: complex of biologically active substances of aspen bark and grass Russian Thistle:phenolic glycosides (salicin, salikortin, tremuloides, tremulatsin and others), tannins, organic acids, triterpenoid, bitterness, pectin, carbohydrates, glycinebetaine, flavonoids, ketodienes acids, sterols, carotenoids. As the filler used glucose.

In one package of the product (42 g) At anti opisthorchosis, choleretic, anti-inflammatory, hepatoprotective effect.

Unlike hoksila and biltricide "Acoral non-toxic, deprived allergenic, embryotoxic and mutagenic properties.

Indications for use: complex treatment of acute and chronic opisthorchiasis, especially when there are contraindications to the appointment hloksila and biltricide for repeated courses deworming, and also as a means of normalizing the function of the biliary system in opisthorchiasis and improves digestive processes.

The method of application.

It is recommended to use "Acoral" in conjunction with Lahaina and Florenti.

In the complex therapy of chronic opisthorchiasis: 1. Hepatoprotector Lohein and gastroprotective tool Ahilan take 1 teaspoon 3 times a day for 30-40 minutes before meals for one month before deworming during treatment corsola and not less than 1 month after the course of deworming.

2. Florence concentrate adaptogenic agent) diluted in 10 times and take 3 times a day before meals for the first three days of treatment corsola 1 tablespoon, then 2 tablespoons until the end of the course.

"Ek what it does not possess, contraindications to the use of is intolerance of the individual components of the drug. Form release: plastic packing 42,

"Acoral" produced according to TU 9365-018-20680882-2000.

Registration certificate 002016. R. 643.09.2000. Biolit, Russia, Tomsk, Prospekt Academic, 3.

This food additive of plant origin, which is favourable for the treatment of opisthorchiasis in patients with psoriasis. Dose and sequence of use of the drug selected on the basis of clinical observations. After treatment conducted duodenal intubation, according to which determined the efficacy of deworming. The rate of reception of biologically active food supplements "Acoral" necessary and sufficient, which is confirmed by clinical observations for this category of patients. When deworming during the period of less than 7 days reduces the effectiveness of deworming, and lengthening the period of more than 7 days, resulting in additional side effects that are undesirable to patients with psoriasis. In the day time the drug is given for the convenience of observation of patients in 2 hours to increase the concentration of the herbal drug to more effect sufficient for the clinical observations for effective deworming in this category of patients. Purpose before deworming nicotine, has choleretic and bactericidal action, you can copy the inflammation in the biliary tract and be treated in a more favourable environment. The use of cholagogue, not bactericidal, establishes a positive effect on the state of the biliary system, as by this time copied the signs of acute inflammation in the biliary tract, but remains hypotension gallbladder.

An example of the method for the patient:

Patient Konovalov, A. A., 42, has applied to the Regional clinical hospital, Tomsk, diagnosed with Chronic opisthorchiasis. Chronic acalculous cholecystitis under mild exacerbation. Biliary dyskinesia on hyponatremia type. Concomitant diagnosis: Psoriasis, guttate-plaque, progressive stage, common, autumn and winter.

Upon receipt complained of heaviness in the right hypochondrium, a constant bitter taste in the mouth, nausea, decreased appetite.

From history revealed that the patient suffers from psoriasis for about 20 years. Last worsening appeared a month ago. the t 30% 10 ml/10), antihistamines (kestin 1 tablet 1 time a day for 10 days), vitamins ("Centrum" 1 tablet 1 time a day a month), sedatives (novopassit 1 tablespoon 3 times daily for 30 days). Outer: cream Unna.

The last 4 years have trouble heaviness in the right hypochondrium, periodic pain in this area, fatty food intolerance, nausea.

Performed outpatient physical examination, ultrasound, duodenal intubation, ELISA opisthorchiasis to IgG.

In General, the analysis of blood eosinophilia of up to 5%. In General urine analysis showed no pathological changes. Biochemical analysis of blood within normal limits.

According to chromatic miotroponogo duodenal intubation revealed dyskinesia of the gallbladder on hyponatremia type: gallbladder bile flowed in a large volume of 110 ml (normal 60 ml) and time to expiration was extended to 46 minutes (at a rate of 21 min). Revealed hypotonia of the sphincter of Oddi.

Microscopy bile discovered eggs opistorhisov (5-6 in the field of view). The higher titer by ELISA on opisthorchiasis to IgG 0,36 (at a rate of 0.29).

By ultrasound gallbladder volume was considerably is opened stage patients received treatment of chronic opisthorchiasis.

Objective: Normastenicheskom physique. On the skin of the scalp, torso, elbows, and knees papules pink-brown coalescing into plaques covered with silvery-white scales, which are easily removed by poskablivanii. Psoriatic triad positive (the phenomenon of stearic spots, the phenomenon of psoriasis of the film, the phenomenon of the point of bleeding). Tongue coated white bloom. In the lungs, the heart and without pathology. The abdomen is soft, with tenderness in the right hypochondrium moderately painful. Positive symptoms and Kera Murphy.

For the treatment of chronic opisthorchiasis and Hyper motility gallbladder dyskinesia was assigned to the following treatment: preparing for deworming nicotine 0.5 g 3 times a day before meals for 14 days, then were treated biologically active additive to food "Acoral" 1 dessert spoon 2 times a day after 40 minutes after a meal for 7 days, after which the patient received cholagogue 1 capsule 3 times a day for 7 days.

Treatment the patient has suffered well. After deworming biologically active additive to food "Acoral" side effects were noted. The appearance of lesions on the skin, itching was not observed the Oia was not feeling nausea, improved appetite. After treatment of chronic opisthorchiasis held control duodenal intubation, ultrasound. According to the fractional duodenal volume of the gallbladder bile and the time to expiration is normalized and 62 ml (normal 60 ml) and 23 min (at a rate of 21 min). Microscopy revealed bile single egg opistorhisov. By ultrasound gallbladder volume was 54 cm3that is the norm. Within a week after treatment was achieved regression of psoriasis. One month after the treatment, the patient noted improvement in health complaints from the digestive tract is not present, nausea disappeared and normal appetite. A repeated duodenal intubation. Microscopy bile eggs opistorhisov not identified. The skin was at the stage regression.

In this way treated 15 patients with psoriasis in combination with chronic opisthorchiasis. Side effects of the skin, the gastrointestinal tract in the treatment of this method was not. The effectiveness of deworming amounted to 86.7%.

Thus, the proposed method allows to treat bolaria. This gave the opportunity to use highly toxic drug praziquantel and more gently with a high efficiency (86,7%) to treat patients suffering from psoriasis.

Method of treating psoriasis in combination with chronic opisthorchiasis, consisting of deworming during the stationary phase of the process, characterized in that before deworming take vicodin 0.5 g 3 times a day before meals for 14 days, and deworming spend biologically active additive to food "Acoral" 1 dessert spoon 2 times a day 40 minutes after a meal for 7 days, then take cholagogue 1 capsule 3 times a day for 7 days.

 

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