Benzothiazoline inhibitors proteincontaining

 

The invention relates to new derivatives of benzothiazole General formula (I) or its salt, where p denotes 1; X1and X2together form =O; R1denotes hydrogen, halogen, alkyl, alkoxy; R2denotes hydrogen; R3denotes a-Z4-R6, -Z13-NR7R8; Z4denotes a-Z11-C(O)-Z12-, -Z11-C(O)-O-Z12-; Z11and Z12represent a simple bond or alkylene; Z13denotes a-Z11-C(O)-Z12-; R4denotes hydrogen; R5denotes phenyl, substituted groups Z1, Z2selected from alkyl, halogen, nitro, -HE, hydroxyalkyl, -C(O)Z6, -C(O)OZ6-Z4-NZ7Z8where Z4represents a simple bond; biphenyl, substituted alkyl; naphthalenyl, which optionally can be substituted-HE; chinoline, substituted alkyl; heterocyclics; Z6denotes alkyl which may be optionally substituted by a group-Z4-NZ7Z8, morpholinium; Z7, Z8each independently represents alkyl; R6denotes alkyl optionally substituted by cyano, methoxy, phenyl, -Z4-NZ7Z8and so on; R7denotes hydrogen, alkyl; R8means b>, methoxy, -Z4-NZ7Z8; and so on, the Technical result - obtaining new derivatives of benzothiazole. 2 C. and 8 C.p. f-crystals, 10 PL.

Description text in facsimile form (see graphic part)and

Claims

1. Benzothiazole compound of formula (I) or its saltwhere p denotes 1; X1and X2together form = O; R1denotes hydrogen, halogen, alkyl, alkoxy; R2denotes hydrogen; R3denotes a-Z4-R6, -Z13-NR7R8; Z4denotes a-Z11-C(O)-Z12-, -Z11-C(O)-O-Z12-; Z11and Z12represent a simple bond or alkylene;
Z13denotes a-Z11-C(O)-Z12-;
R4denotes hydrogen;
R5denotes phenyl, substituted groups Z1, Z2selected from alkyl, halogen, nitro, -HE, hydroxyalkyl, -C(O)Z6, -C(O)OZ6heterocyclics-Z4-NZ7Z8where Z4represents a simple bond; biphenyl, substituted alkyl; naphthalenyl, which optionally can be substituted-HE; chinoline, substituted alkyl; heterocyclics;
Z6Z7, Z8each independently represents alkyl;
R6denotes alkyl, optionally substituted by cyano, methoxy, phenyl, -Z4-NZ7Z8, -C(O)Z6; quinil; cycloalkyl, optionally substituted alkyl, -HE, cyano, halogen, methoxy, phenyl which may be substituted by alkyl, halogen or methoxy, Z4-NZ7Z8, alkenyl, benzyl, biphenyl; an unsubstituted cycloalkenyl; cycloalkenyl; phenyl, optionally substituted by alkyl; unsubstituted naphthyl; phenylalkyl optionally substituted by alkyl, halogen, nitro, methoxy; an unsubstituted naphthalenyloxy; heterocycle, including thienyl, tetrahydrofuranyl; heteroseksualci where heterocycle selected from pyrrole, teinila, benzodioxane, imidazole, substituted alkyl or nitro, benzodioxolyl, chinoline, pyridinyl;
R7denotes hydrogen, alkyl;
R8denotes alkyl, optionally substituted by one or more Deputy selected from HE, lower alkyl, quinil, -SZ6, methoxy, -Z4-NZ7Z8; alkenyl; quinil; cycloalkyl, optionally substituted alkyl, quinil, hydroxyalkyl; the unsubstituted cycloalkenyl; phenyl, optionally substituted by one or more, cyano, -SZ6; phenylalkyl, where phenyl may be optionally substituted by one or more Deputy, selected from lower alkyl, methoxy, halogen, -Z4-NZ7Z8, nitro, amino, -HE, the alkyl may be optionally substituted by one or more Deputy, selected from lower alkyl, hydroxyalkyl; the unsubstituted naphthalenyloxy; heterocycle, including 1,3-benzodioxolyl, pyridinyl, optionally substituted lower alkyl, piperidinyl, optionally substituted lower alkyl, pyrrolidinyl, optionally substituted benzyl, pyrimidinyl; heteroseksualci where heterocycle choose from imidazolyl, tetrahydropyranyl, indolyl, substituted methoxy, halogen or lower alkyl, morpholinyl, pyridinyl, teinila, indolyl, optionally substituted lower alkyl, tetrahydrofuranyl, piperidinyl, optionally substituted benzyl or lower alkyl, benzo[b] thiophenyl, pyrrolidinyl, optionally substituted benzyl, lower alkyl or oxo, 2,3-dihydro-1,4-benzodioxane, furanyl, optionally substituted lower alkyl, piperazinil, optionally substituted lower alkyl, azepin.

2. Connection on p. 1, characterized in that R denotes 1, and each R12denotes hydrogen.

4. Connection on p. 1, wherein R4denotes hydrogen.

5. Connection on p. 1, wherein R5denotes a substituted phenyl with the substituents Z1and Z2.

6. Connection on p. 1, characterized in that X1and X2together form = o

7. Connection on p. 1, characterized in that Z13denotes a-Z11-C(O)-Z12-.

8. Benzothiazole compound of formula (I) or its salt

where p denotes 1;
X1and X2together form = O;
R1denotes hydrogen, halogen, alkyl, alkoxy;
R2denotes hydrogen;
R3denotes a-Z4-R6, -Z13-NR7R8;
Z4denotes a-Z11-C(O)-Z12-, -Z11-C(O)-O-Z12-;
Z11and Z12represent a simple bond or alkylene;
Z13denotes a-Z11-C(O)-Z12-;
R4denotes hydrogen;
R5denotes phenyl, substituted groups Z1, Z2selected from alkyl, halogen, nitro, -HE, hydroxyalkyl, -C(O)Z6-C(O)OZ6, Z4-NZ7Z8heterocyclics, where Z4represents a simple bond; biphenyl, substituted alkyl; naftel the sludge, which may be optionally substituted by a group-Z4-NZ7Z8, morpholinium;
Z7, Z8each independently represents alkyl;
R6denotes alkyl, optionally substituted by cyano, methoxy, phenyl, -Z4-NZ7Z8, -C(O)Z6; quinil; cycloalkyl, optionally substituted alkyl, -HE, cyano, halogen, methoxy, phenyl which may be substituted by alkyl, halogen or methoxy, Z4-NZ7Z8, alkenyl, benzyl, biphenyl; an unsubstituted cycloalkenyl; cycloalkenyl; phenyl, optionally substituted by alkyl; unsubstituted naphthyl; phenylalkyl, optionally substituted by alkyl, halogen, nitro, methoxy; an unsubstituted naphthalenyloxy; heterocycle, including thienyl, tetrahydrofuranyl; heteroseksualci where heterocycle selected from pyrrole, teinila, benzodioxane, imidazole, substituted alkyl or nitro, benzodioxolyl, chinoline, pyridinyl;
R7denotes hydrogen, alkyl;
R8denotes alkyl, optionally substituted by one or more Deputy selected from HE, lower alkyl, quinil, -SZ6, methoxy, -Z4-NZ7Z8; alkenyl; quinil; cycloalkyl, optionally substituted alkyl, quinil, Giverny from alkyl, halogen, methoxy, phenyl, benzoyl, cycloalkyl, morpholinyl, 1,3,4-oxadiazole, cyano, -SZ6; phenylalkyl, where phenyl may be optionally substituted by one or more Deputy, selected from lower alkyl, methoxy, halogen, -Z4-NZ7Z8, nitro, amino, -HE, the alkyl may be optionally substituted by one or more Deputy, selected from lower alkyl, hydroxyalkyl; the unsubstituted naphthalenyloxy; heterocycle, including 1,3-benzodioxolyl, pyridinyl, optionally substituted lower alkyl, piperidinyl, optionally substituted lower alkyl, pyrrolidinyl, optionally substituted benzyl, pyrimidinyl; heteroseksualci where heterocycle choose from imidazolyl, tetrahydropyranyl, indolyl, substituted methoxy, halogen or lower alkyl, morpholinyl, pyridinyl, teinila, indolyl, optionally substituted lower alkyl, tetrahydrofuranyl, piperidinyl, optionally substituted benzyl or lower alkyl, benzo[b] thiophenyl, pyrrolidinyl, optionally substituted benzyl, lower alkyl or oxo, 2,3-dihydro-1,4-benzodioxane, furanyl, optionally substituted lower alkyl, piperazinil, optionally substituted lower alkyl, azepin.< /> 1,1-dimethylethylene ether[6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
2-amino-N-(2,4,6-trimetilfenil)-6-benzothiazolinone, triptorelin (1: 1);
2-(acetylamino)-N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-(benzoylamine)-N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(1-oxopropyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(1-oxobutyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(1,1-dimethylethyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[bis(1-methylethyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
1,1-dimethylethylene ether [6-bromo-4-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ester [4-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-bromo-7-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [7-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-bromo-5-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid,
1,1-dimethylethylene amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(phenylmethyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[ethylamino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(butylamino)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(cyclopropylamino)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
(R)-2-[[[[(3,3-dimethylcyclohexyl)methyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2(R)-2-[[[[(3,3-dimethylcyclohexyl)methyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(cyclohexylmethyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2,3-dihydro-1H-inden-1-yl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(1-naphthaleneacetic)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[[2-(1-H-imidazol-4-yl)ethyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[(tetrahydro-2-furanyl)methyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[[2-(5-methoxy-1H-indol-3-yl)ethyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[[2-(4-morpholinyl)ethyl] amino] carbonyl] Amin is ylphenyl)-6-benzothiazolinone;
2-[[[(1,1,3,3-TETRAMETHYLBUTYL)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(1,1-dimethyl-propyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(1,5-dimethylpentyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(cyclopentylamine)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[1[(1,1-dimethyl-2-hydroxyethyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[(3-methoxyphenyl)methyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[(3-were)methyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[(4-chlorophenyl)methyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[[2-(4-methoxyphenyl)ethyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(2-propylamino)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(2-propylamino)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(3-phenylpropyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[ 1-(hydroxymethyl)cyclopentyl] amino] carbonyl] amino] -N-(2,4,6-timetype is)-6-benzothiazolinone;
2-[[[(1-propinball)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(1,3-dimethylpentyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[ 3-(methylthio)propyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[ 1-(methoxymethyl)propyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[[2-(2-thienyl)ethyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[(2,6-acid)methyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
(R)-2-[[[[1-(hydroxymethyl)-2-phenylethyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
(R)-2-[[[(1-phenylethyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(1-adamantylamine)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[[2-(4-forfinal)-1,1-dimethylethyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[[2-(2-predinisone)ethyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(1-methyl-1-phenylethyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
(R)-2-[[[[1-(4-were)ethyl] amino] carbonylmethyl)-6-benzothiazolinone;
2 -[[[[(4-methoxyphenyl)methyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(4-cyclohexylphenol)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(5,6,7,8-tetrahydro-1-naphthalenyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2,3-dihydro-1H-inden-5-yl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(1,3-benzodioxol-Ilmenau)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(2-pyridinylamino)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(3-methyl-2-pyridinyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(4-methyl-2-pyridinyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2-chloro-5-were)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2,6-dichlorophenyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2-methoxyphenyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[([(1,1'-the biphenyl] -2-ylamino)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2-benzoylphenyl)amino] carbonyl] amino] -N-(2,4,6-trimethylhexane;
N-(2,4,6-trimetilfenil)-2-[[[(2,4,6-trimetilfenil)amino] carbonyl] amino] -6-benzothiazolinone;
2 -[[[[ 2-methyl-6-(1-methylethyl)phenyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(3,5-differenl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(3-methoxyphenyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(3-were)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(4-cyanophenyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(4-forfinal)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(4-chlorophenyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
ethyl ester 4-[[[[6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] amino] carbonyl] amino] benzoic acid;
2-[[[(3,4,5-trimethoxyphenyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(3,4-acid)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[ 2,6-bis-(1-methylethyl)phenyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2-propylphenyl)amino] carbonyl] amino] -N-(2,4,6-trimethylphenyl thiazolecarboxamide;
2-[[[[2-(4-morpholinyl)phenyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(3-bromo-2-were)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2,6-acid)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2-bromo-5-methoxyphenyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2-methoxy-6-were)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2,3-dimethyl-1H-indol-5-yl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[[3-(1,3,4-oxidiazol-2-yl)phenyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2-chloro-6-were)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[ 3-(methylthio)phenyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(4-methoxy-2-were)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(4-methoxycyclohexyl)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(2,2-dimethyl-1-oxopropyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(2-titilate)amino] -N-(2,4,6-trimetilfenil)-6-Benz is clebuterol)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(cyclopentanecarbonyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(3-cyclopentyl-1-oxopropyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(cyclopenten-1-ylcarbonyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(cyclopentylacetyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(1-oxo-2-phenylpropyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(2-methyl-1-oxopropyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(1-oxo-3-phenoxypropan)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(1-oxo-3-phenylpropyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[3-(2-methoxyphenyl)-1-oxopropyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[3-(2,3,4-trimethoxyphenyl)-1-oxopropyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(1,4-dioxaphetyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(2-naphthaleneacetic)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(2-chloro-6-forfinal)acetyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(2-were)acetyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(3-methoxyphenyl)acetyl] amino] -N-(2,4,6-timetype
2-[(1-oxo-4-pentenyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
methyl ester 5-oxo-5[[6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] Amin] pentanol acid;
2-[(1-oxohexyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(1-oxoethyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(1-oxo-4-(2-thienyl)butyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(3-thienylboronic)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(4-nitrophenyl)acetyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[3,5-bis(trifluoromethyl)phenyl] acetyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[2-[4-(2-methylpropyl " phenyl] -1-oxopropyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(3-cyclohexen-1-yl)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[3-(3-methoxyphenyl)-1-oxopropyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(2,3,6-trichlorophenyl)acetyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(1,3-benzodioxol-5-yl)acetyl] amines-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[2-(phenylmethoxy)phenyl] acetyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(3,5-diaopi] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(tetrahydro-2-furanyl)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[2-(acetylamino)-1-oxopropyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[2-(acetylamino)-1-oxohexyl] amino] -N-(2,4,6-trimethylphenyl)-6-benzothiazolinone;
2-[(cyclopropylmethyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
N, N-dimethyl-N'-[6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] butandione;
2-[(1-adamantylamine)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(4-methylcyclohexyl)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(3-methoxy-1-oxopropyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
1,1-dimethylethylene ether [6-[[(2,3-dihydro-1H-inden-5-yl)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[(2-naphthalenamine)carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(3-hydroxy-2-naphthalenyl)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(2-fluoro-5-were)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(2-chloro-6-were)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1 letilly ether [6-[[(4-bromo-2-were)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(3-bromo-2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[[2,6-dimethyl-3-(1-methylethyl)phenyl)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(2-bromo-4,6-dimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(2-methyl-6-chinoline)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(4-methoxy-2-naphthalenyl)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(6-methyl-5-chinoline)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-ether dimethylethylene[6-[[[2-(2-hydroxyethyl)-6-were] amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether[6-[[(2,6-dimethyl-3-nitrophenyl)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether[6-[[(2-bromo-3,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(2-acetyl-6-hydroxyphenyl)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-ether dimethylethylene[6-[[[4-[[(1,1-dimethylmethoxy)carbonyl] amino] -2,3,5,6-tetramethylene] amino] carbon is l] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[[3-acetylamino] -4,6-dimetilfenil] amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(2,6-acid)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(2-methyl-1-naphthalenyl)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
methyl ester 3-[[[2-[[(1,1-dimethylmethoxy)carbonyl] amino] -6-benzothiazolyl] carbonyl] amino] -4-methyl-2-thiophencarboxylic acid;
methyl ether [6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
2-[[(acetylamino)acetyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[(1,1-dimethylethyl)amino] carbonyl] amino] -6-benzothiazolinone;
N-(2,6-dichlorophenyl)-2-[[[(1,1-dimethylethyl)amino] carbonyl] amino] -6-benzothiazolinone;
N-(4-bromo-2,6-dimetilfenil)-2-[[[(1,1-dimethylethyl)amino] carbonyl] amino] -6-benzothiazolinone;
N-(4-carbomethoxy-2,6-dimetilfenil)-2-[[[(1,1-dimethylethyl)amino] carbonyl] amino] -6-benzothiazolinone;
N-(4-hydroxymethyl-2,6-dimetilfenil)-2-[[[(1,1-dimethylethyl)amino] carbonyl] amino] -6-benzothiazolinone;
1,1-dimethylethylene ester [4-methyl-6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] cardiotherapy ether 4-methoxy-[6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
triptorelin (1: 1) 2-amino-4-methoxy-N-(2,4,6-trimetilfenil)-6-benzothiazolesulfonamide;
2-[[(methylamino)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[methylamino] carbonyl] amino] -4-methoxy-N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
1,1-dimethylethylene ester of 5-methoxy-[6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
triptorelin (1: 1) 2-amino-N-(4-N, N-dimethylamino-2,3,5,6-TETRAMETHYLBUTYL)-6-benzothiazolesulfonamide;
1,1-dimethylethylene ester 5-chloro-[6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ester of 7-chloro-[6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
2-amino-5-hydroxy-N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
1,1-dimethylethylene ester 5-tert. -butoxycarbonyl-[6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
2-[[[(1,1-dimethylethyl)amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[(cyclopropylamino)carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[(cyclopentylamine)carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[[1-(ethinyl)cyclohexyl] amino] carbonyl] amino] -N-(2,-6-benzothiazolinone;
2-[[[(2,3-dihydro-1H-inden-1-yl)amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2 -[[[[ 2-(1H-imidazol-4-yl)ethyl] amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2 -[[[[(tetrahydro-2-furanyl)methyl] amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[[[2-(5-methoxy-1H-indol-3-yl)ethyl] amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[[(1,1-dimethyl-2-hydroxyethyl)amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[[(1,1-dimethyl-propyl)amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2 -[[[[(3-methoxyphenyl)methyl] amino)carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2 -[[[[(4-methoxyphenyl)methyl] amino)carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[(2-propylamino)carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[(2-propylamino)carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[[(3-phenylpropyl)amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2 -[[[[ 1-(hydroxymethyl)cyclopentyl] amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2 -[[[[ 1-(methoxymethyl)propyl] amino] carbonyl] amino] -N-(2,6-diazocarbonyl;
2-[[[(3,4,5-trimethoxyphenyl)amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[(1,3-benzodioxol-5-ylamino)carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[[(4-forfinal)amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[(cyclopropylamino)carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[(cyclopentylamine)carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2 -[[[[ 1-(ethinyl)cyclohexyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[(4-methyl-cyclohexyl)amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[(2,3-dihydro-1H-inden-1-yl)amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2 -[[[[ 2-(1H-imidazol-4-yl)ethyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2 -[[[[(tetrahydro-2-furanyl)methyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[[2-(5-methoxy-1H-indol-3-yl)ethyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[(1,1-dimethyl-2-hydroxyethyl)amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[(1,1-dimethyl-propyl)amino] carbonyl] am the R-6-were)-6-benzothiazolinone;
2 -[[[[(4-methoxyphenyl)methyl] amino)carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[(2-propylamino)carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[(2-propylamino)carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[(3-phenylpropyl)amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2 -[[[[ 1-(hydroxymethyl)cyclopentyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2 -[[[[ 1-(methoxymethyl)propyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
(R)-2-[[[(1-phenylethyl)amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[(2,3-dimethyl-1H-indol-5-yl)ethyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[(3,4,5-trimethoxyphenyl)amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[(1,3-benzodioxol-5-ylamino)carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[(4-forfinal)amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2 -[[[[(1-methoxycarbonyl)cyclopropyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
1,1-dimethylethylene ether [6-[[[(2,6-dimethyl-4-FeNi is N-dimethylmethoxy)phenyl] amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[[(2,6-dimethyl-(2-morpholinoethoxy) phenyl] amino] carbonyl] -2-benzothiazolyl] carbamino acid;
2-[(cyclopropanecarbonyl)amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[(2-methyl-cyclopropanecarbonyl)amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[(2,2-dichloro-1-methyl-cyclopropanecarbonyl)amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[(1-hydroxy-cyclopropanecarbonyl)amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
N-(2-chloro-6-were)-2-[(cyclobutanecarbonyl)amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[(cyclopentanecarbonyl)amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[(cyclopentylacetyl)amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[(methoxyacetyl)amino] -6 - benzothiazolinone;
N-(2-chloro-6-were)-2-[(1-oxo-2-phenylpropyl)amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[(1-oxo-2-methylpropyl)amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[(1-oxo-3-phenylpropyl)amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[3-(2-methoxyphenyl)-1-oxopropyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[1-oxo-3-(2,3,4-trimethoxyphenyl) propyl] amino] -6-benzothiazolinone; 2-[[(2-chloro-6-forfinal)acetyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[(2-were)acetyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[(3-methoxyphenyl)acetyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[(4-chlorophenyl)acetyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[(l-oxo-4-pentenyl)amino] -6-benzothiazolinone;
methyl ester 5-[[6-[[(2-chloro-6-were)amino] carbonyl] -2-benzothiazolyl] amino] -5-oxopentanoic acid;
N-(2-chloro-6-were)-2-[(1-oxohexyl)amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[3-(3-methoxyphenyl)-l-oxopropyl] amino] -6-benzothiazolinone;
2-[[(1,3-benzodioxol-5-yl)acetyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[3-(1,3-benzodioxol-5-yl)-1-oxopropyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[(3,5-acid)acetyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[(cyclopentylacetyl)amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[(1-methylcyclopropyl)carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[2-(trimethylsilyl)cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[1-(4-methoxyphenyl is)carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[1-(4-were)cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[1-(4-chlorophenyl)cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
1,1-ether dimethylethylene[1-[[[6-[[(2-chloro-6-were)amino] carbonyl] -2-benzothiazolyl] amino] carbonyl] cyclopropyl] carbamino acid;
(1S-TRANS)-N-(2-chloro-6-were)-2-[[[2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
(1S-CIS)-N-(2-chloro-6-were)-2-[[[2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[(1-vinylcyclopropyl)carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[(2-formilliar)carbonyl] amino] -6-benzothiazolinone;
ethyl ester 2-[[[6-[[(2-chloro-6-were)amino] carbonyl] -2-benzothiazolyl] amino] carbonyl] cyclopropanecarboxylic acid;
methyl ester 2-[[[6-[[(2-chloro-6-were)amino] carbonyl] -2-benzothiazolyl] amino] carbonyl] -1-methylcyclopropene acid;
N-(2-chloro-6-were)-2-[[[2-(phenylmethyl)cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
N-[6-[[(2-chloro-6-were)amino] carbonyl] -2-benzothiazolyl] -2-chinainternational;
N-(2-chloro-6-were the o] -6-benzothiazolesulfonamide;
TRANS-N-(2-chloro-6-were)-2-[[[2-[(dimethylamino)methyl] cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[(1-methyl-1H-pyrrol-2-yl)acetyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[5-(dimethylamino)-1-oxobutyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[4-(dimethylamino)-1-oxobutyl] amino] -6-benzothiazolinone;
TRANS-N-(2-chloro-6-were)-2-[[[2-(1-pyrrolidinyl)cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
TRANS-N-(2-chloro-6-were)-2-[[[2-(1-piperidinylmethyl)cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[(dimethylamino)acetyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[3-(2-methyl-4-nitro-1H-imidazol-1-yl)-1-oxopropyl] amino] -6-benzothiazolinone;
2-[(cyclobutanecarbonyl)amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[(cyclopentanecarbonyl)amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[(cyclopentylacetyl)amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
N-(2,6-dimetilfenil)-2-[(1-oxo-2-phenylpropyl)amino] -6-benzothiazolinone;
N-(2,6-dimetilfenil)-2-[(2-methyl-1-oxopropyl)amino] -6-benzothiazolinone;
N-(2,6-dimetilfenil)-2-[(1-oxo-3-phenylpropyl)amino] -6-benzothiazolylthio)-2-[[3-(2,3,4-trimethoxyphenyl)-1-oxopropyl] amino] -6-benzothiazolinone;
N-(2,6-dimetilfenil)-2-[(1,4-dioxaphetyl)amino] -6-benzothiazolinone;
2-[(2,2-dimethyl-1-oxobutyl)amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
N-(2,6-dimetilfenil)-2-[(methoxyacetyl)amino] -6-benzothiazolinone;
N, N-dimethyl-N'-[6-[[(2,6-dimethylphenyl)amino] carbonyl] -2-benzothiazolyl] butandione;
N-(2,6-dimetilfenil)-2-[[(1-methylcyclopropyl] carbonyl] amino] -6-benzothiazolinone;
2-[[(2-chloro-6-forfinal)acetyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
N-(2,6-dimetilfenil)-2-[[(2-were)acetyl] amino] -6-benzothiazolinone;
N-(2,6-dimetilfenil)-2-[[(3-methoxyphenyl)acetyl] amino] -6-benzothiazolinone;
2-[[(4-chlorophenyl)acetyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
N-(2,6-dimetilfenil)-2-[(l-oxo-4-pentenyl)amino] -6-benzothiazolinone;
N-(2,6-dimetilfenil)-2-[(1-oxohexyl)amino] -6-benzothiazolinone;
N-(2,6-dimetilfenil)-2-[[3-(3-methoxyphenyl)-1-oxopropyl] amino] -6-benzothiazolinone;
2-[[3-(1,3-benzodioxol-5-yl)-1-oxopropyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[(1,3-benzodioxol-5-yl)acetyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[(3,5-acid)acetyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[(cyclopropylmethyl)amino] -N-(2,6-diltiazemcream;
N-(2,6-dimetilfenil)-2-[[[2-(trimethylsilyl)cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
2-[(cyclopropanecarbonyl)amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
N-(2,6-dimetilfenil)-2-[[(2-methylcyclopropyl)carbonyl] amino] -6-benzothiazolinone;
TRANS-N-(2,6-dimetilfenil)-2-[[(2-vinylcyclopropyl)carbonyl] amino] -6-benzothiazolinone;
N-(2,6-dimetilfenil)-2-[[[1-(4-were)cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
2-[[[1-(4-chlorophenyl)cyclopropyl] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
1,1-ether dimethylethylene[1-[[[6-[[(2,6-dimetilfenil)amino] carbonyl] -2-benzothiazolyl] amino] carbonyl] cyclopropyl] carbamino acid;
(1S-CIS)-2-[[[2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropyl] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
N-(2,6-dimetilfenil)-2-[[[1-(4-methoxyphenyl)cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
N-(2,6-dimetilfenil)-2-[[(1-vinylcyclopropyl)carbonyl] amino] -6-benzothiazolinone;
N-(2,6-dimetilfenil)-2-[[(2-formilliar)carbonyl] amino] -6-benzothiazolinone;
ethyl ester 2-[[[6-[[(2,6-dimetilfenil)amino] carbonyl] -2-benzothiazolyl] amino] carbonyl] cyclopropanecarboxylic acid;
2-[[(2-councilapproved] -2-benzothiazolyl] amino] carbonyl] -1-methylcyclopropene acid;
(1S-TRANS)-2-[[[2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropyl] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
N-(2,4,6-trimetilfenil)-2-[[[2-(trimethylsilyl)cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
2-[[(2-methylcyclopropyl)carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
TRANS-2-[[(2-vinylcyclopropyl)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
ethyl ester 2-[[[6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] amino] carbonyl] cyclopropanecarboxylic acid;
1,1-ether dimethylethylene[1-[[[6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] amino] carbonyl] cyclopropyl] carbamino acid;
(1S-TRANS)-2-[[[2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropyl] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
(1S-CIS)-2-[[[2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropyl] carbonyl] amino] -N-(2,4,6-dimetilfenil)-6-benzothiazolinone;
2-[[(1-vinylcyclopropyl)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(2-formilliar)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(2-cancelerror)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
methyl ester 2-[[[6-[[(2,4,6-trimethyl the Teal)cyclopropyl] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[1-(4-were)cyclopropyl] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[1-(4-chlorophenyl)cyclopropyl] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[1-(4-methoxyphenyl)cyclopropyl] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[2-(1-piperidinyl)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(2-chlorophenyl)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(2-forfinal)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[(2-phenoxyethyl)amino] carbonyl] amino] -6-benzothiazolinone;
2-[[[(benzo[b] thiophene-3-ylmethyl)amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
(R)-N-(2-chloro-6-were)-2-[[[(2-hydroxy-1-phenylethyl)amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[[4-(dimethylamino)phenyl] methyl] amino] carbonyl] amino] -6-benzothiazolinone;
(S)-N-(2-chloro-6-were)-2-[[[(2-hydroxy-1-phenylethyl)amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(4-nitrophenyl)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[2-(1-pyrrolidin the methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[2-(2-pyridinyl)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[(3-pyrrolidinyl)amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[(4-pyrrolidinyl)amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(3-chlorophenyl)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(2,3-dichlorophenyl)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(3,4-differenl)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(2,6-acid)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(2-ethoxyphenyl)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[2-(3-methoxyphenyl)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[2-(4-methoxyphenyl)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(2-were)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(3-were) arbonyl] amino] -6-benzothiazolinone;
(S)-N-(2-chloro-6-were)-2-[[[[1-(hydroxymethyl)-2-phenylethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[2-(phenylamino)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[(2-thienylmethyl)amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[2-(1H-indol-3-yl)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
2 -[[[[(4-AMINOPHENYL)methyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[(diphenylmethyl)amino] carbonyl] amino] -6-benzothiazolinone;
(1R-Exo)-2-[[(bicyclo[2.2.1] heptane-2-ylamino)carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(4-chlorophenyl)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2 -[[[[ l-(4-chlorophenyl)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
(R)-N-(2-chloro-6-were)-2-[[[[1-(4-were)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
(S)-N-(2-chloro-6-were)-2-[[[[1-(4-were)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(4-forfinal)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[1-(4-forfinal) the Nile] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[1-(4-methoxyphenyl)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
(S)-N-(2-chloro-6-were)-2-[[[1-(phenylethyl)amino] carbonyl] amino] -6-benzothiazolinone;
ethyl ester and-[[[[6-[[(2-chloro-6-were)amino] carbonyl] -2-benzothiazolyl] amino] carbonyl] amino] benzyloxy acid;
N-(2-chloro-6-were)-2-[[[[2-(4-were)-1-phenylethyl] amino] carbonyl] amino] -6-benzothiazolinone;
(R)-N-(2-chloro-6-were)-2-[[[(1-phenylpropyl)amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(4-were)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
(R)-N-(2-chloro-6-were)-2-[[[[1-(4-nitrophenyl)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2 -[[[[ l-(4-chlorophenyl)phenylmethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[2-(phenylthio)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
2 -[[[[(2-bromophenyl)methyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[2-(3-forfinal)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2[[[[[4-(trifluoromethyl)phenyl] methyl] amino] carbonyl] amino] -6-benzothiazolinone;
2 -[[[[(3-bromophenyl)IU is but] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[(2-amino-2-oxo-1-phenylethyl)amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[3-(1H-imidazol-1-yl)propyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(2,4-acid)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(3-chloro-4-were)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
2 -[[[[(3-chloro-4-forfinal)methyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2 -[[[[(2-chloro-6-forfinal)methyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2 -[[[[(2-chloro-4-forfinal)methyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(3,5-differenl)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(2,5-acid)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(3,5-dimetilfenil)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(3,4-acid)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(3,5-acid)methyl] amino] carbonyl] amino] -6-benzothiazol said;
N-(2-chloro-6-were)-2-[[[[[4-(1,2,3-the thiadiazole-4-yl)phenyl] methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[2-(2-chlorophenyl)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[(1-methyl-phenylethyl)amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(2,5-dichlorophenyl)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(2,4-dimetilfenil)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[1-(1-naphthalenyl)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(3,4,5-trimethoxyphenyl)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(3,4,6-trimethoxyphenyl)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
2 -[[[[(4-bromophenyl)methyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
ethyl ester of [1R(endo, endo)] -3-[[[[6-[[(2-chloro-6-were)amino] carbonyl] -2-benzothiazolyl] amino] carbonyl] amino] bicyclo[2.2.1] hept-5-ene-2-carboxylic acid;
ethyl ester of [1S(Exo, Exo)] -3-[[[[6-[[(2-chloro-6-were)amino] carbonyl] -2-benzothiazolyl] amino] carbonyl] amino] bicyclo [2.2.1] hept-5-ene-2-carboxylic acid;
] bicyclo[2.2.1] hept-5-ene-2-carboxylic acid;
[1R(endo, endo)] -N-(2-chloro-6-were)-2-[[[[3-(hydroxymethyl) bicyclo [2.2.1] hept-5-EN-2-yl] amino] carbonyl] amino] -6-benzothiazolinone;
[1S(endo, endo)] -N-(2-chloro-6-were)-2-[[[[3-(hydroxymethyl) bicyclo[2.2.1] heptane-2-yl] amino] carbonyl] amino] -6-benzothiazolinone;
[1R(Exo, Exo)] -N-(2-chloro-6-were)-2-[[[[3-(hydroxymethyl) bicyclo[2.2.1] heptane-2-yl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(3-forfinal)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(2-methoxyphenyl)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
(Exo, Exo)-2-[[[[3-(aminocarbonyl)bicyclo[2.2.1] hept-5-EN-2-yl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
(S)-N-(2-chloro-6-were)-2-[[[[1-(1-naphthalenyl)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[[3-(trifluoromethyl)phenyl] methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[(phenylmethyl)amino] carbonyl] amino] -6-benzothiazolinone;
(endo, endo)-2-[[[[3-(aminocarbonyl)bicyclo[2.2.1] hept-5-EN-2-yl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[1-(4-hydroxyphenyl)ethyl] amino] keno] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[(2,3-dimetilfenil)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
(R)-N-(2-chloro-6-were)-2-[[[[1-(1-naphthalenyl)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[2-(dimethylamino)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[1,1-dimethyl-2-(dimethylamino)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[1-(phenylmethyl)-4-piperidinyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[3-(2-methyl-1-piperidinyl)propyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[2-(1-methyl-2-pyrrolidinyl)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[3-(4-morpholinyl)propyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[1-(phenylmethyl)-3-pyrrolidinyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[3-(diethylamino)propyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[3-(4-methyl-1-piperazinil)propyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[2-(l-piperazinil)ethyl] amino] carbonyl] amino] -6-br /> N-(2-chloro-6-were)-2-[[[(2,2,6,6-tetramethyl-4-piperidinyl)amino] carbonyl] amino] -6-benzothiazolinone;
(R)-N-(2-chloro-6-were)-2-[[[[1-(phenylmethyl)-3-pyrrolidinyl] amino] carbonyl] amino] -6-benzothiazolinone;
(S)-N-(2-chloro-6-were)-2-[[[[1-(phenylmethyl)-3-pyrrolidinyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[3-(1-piperidinyl)propyl] amino] carbonyl] amino] -6-benzothiazolinone
N-(2-chloro-6-were)-2-[[[[3-(1-piperidinyl)propyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2 -[[[[ l-(2-pyridinyl)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2 -[[[[ l-(3-pyridinyl)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[3-(2-oxo-l-pyrrolidinyl)propyl] amino] carbonyl] amino] -6-benzothiazolinone;
ethyl ester 4-[[[[6-[[(2-chloro-6-were)amino] carbonyl] -2-benzothiazolyl] amino] carbonyl] amino] -1-piperidinecarboxylic acid;
(S)-2-[[[[1-(4-bromophenyl)ethyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
(1S-CIS)-2-[[[[2-(aminocarbonyl)cyclohexyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[[3-(1-azepin-1-yl)propyl] amino] carbonyl] amino] -N-(2-what about] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[(3-pyrrolidinyl)carbonyl] amino] -6-benzothiazolinone;
4-[[[[[6-[[(2-chloro-6-were)amino] carbonyl] -2-benzothiazolyl] amino] carbonyl] amino] methyl] benzoic acid;
N-(2-chloro-6-were)-2-[[(3-pyridinylamino)carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[(4-pyridinylamino)carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[2-(1H-pyrrol-3-yl)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[(2-pyridinylamino)carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[(2-pyrimidinamine)carbonyl] amino] -6-benzothiazolinone;
methyl ester 4-[[[[[6-[[(2-chloro-6-were)amino] carbonyl] -2-benzothiazolyl] amino] carbonyl] amino] methyl] benzoic acid;
N-(2-chloro-6-were)-2-[[[[(1-ethyl-2-pyrrolidinyl)methyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[2-[(5-the nitro-2-pyridinyl)amino] ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[(1-ethyl-3-piperidinyl)amino] carbonyl] amino] -6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[[2-(6-fluoro-1H-indol-2-yl)ethyl] amino] carbonyl] amino] -6-benzothiazolinone;
TRANS-N-(2-chloro-6-ENT-6-were)-2-[[[2-(4-ethoxyphenyl)cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
TRANS-N-(2-chloro-6-were)-2-[[[2-(4-forfinal)cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
TRANS-N-(2-chloro-6-were)-2-[[[2-[4-(1-methylethyl)phenyl] cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
TRANS-N-(2-chloro-6-were)-2-[[[2-[4-(trifluoromethyl)phenyl] cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
TRANS-N-(2-chloro-6-were)-2-[[[2-(4-nitrophenyl)cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
TRANS-N-(2-chloro-6-were)-2-[[[2-(4-tianfeng)cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
TRANS-2-[[(2-[1,1'-the biphenyl] -4-enciclopedie] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
TRANS-2-[[[2-(1,3-benzodioxol-4-yl)cyclopropyl] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
TRANS-N-(2-chloro-6-were)-2-[[[2-(3-chlorophenyl)cyclopropyl] carbonyl] amino] -6-benzothiazolinone;
TRANS-N-(2-chloro-6-were)-2-[[[2-(3-tianfeng)cyclopropyl] carbonyl] amino] -6-benzothiazolinone; and
TRANS-N-(2-chloro-6-were)-2-[[[2-(3-nitrophenyl)cyclopropyl] carbonyl] amino] -6-benzothiazolinone.

10. Connection on p. 9, this compound of formula I or its salt is chosen from the group which includes:
1,1-dimethylethylene ether [6-[[(2,thiazolecarboxamide, triptorelin (1: 1);
2-(acetylamino)-N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-(benzoylamine)-N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(1-oxopropyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(1-oxobutyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(1,1-dimethylethyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[bis(1-methylethyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
1,1-dimethylethylene ether [6-bromo-4-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ester [4-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-bromo-7-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [7-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-bromo-5-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ester [5-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
2-[[[phenylamino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(butylamino)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(cyclopropylamino)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
(R)-2-[[[[(3,3-dimethylcyclohexyl)methyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(4-methylcyclohexyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(cyclohexylmethyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2,3-dihydro-1H-inden-1-yl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(1-naphthaleneacetic)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[[2-(1-H-imidazol-4-yl)ethyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[(tetrahydro-2-furanyl)methyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[[2-(5-methoxy-1H-indol-3-yl)ethyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[[2-(4-morpholinyl)ethyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[[2-(2-pyridinyl)ethyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(1,1,3,3-TETRAMETHYLBUTYL)amino] carb,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(1,5-dimethylpentyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(cyclopentylamine)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(1,1-dimethyl-2-hydroxyethyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[(3-methoxyphenyl)methyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[(3-were)methyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[(4-chlorophenyl)methyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[[2-(4-methoxyphenyl)ethyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(2-propylamino)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(2-propylamino)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(3-phenylpropyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[ 1-(hydroxymethyl)cyclopentyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[[4-(1,1-dimethylethyl)cyclohexyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(1-propinball)amino] carbonyl] amino] -N-(2,4,6-trimethanolamine;
2 -[[[[ 3-(methylthio)propyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[ 1-(methoxymethyl)propyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[[2-(2-thienyl)ethyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[(2,6-acid)methyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
(R)-2-[[[[1-(hydroxymethyl)-2-phenylethyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
(R)-2-[[[(1-phenylethyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(1-adamantylamine)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[[2-(4-forfinal)-1,1-dimethylethyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[[2-(2-predinisone)ethyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(1-methyl-1-phenylethyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
(R)-2-[[[[1-(4-were)ethyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(1-methylheptan)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[(4-methoxyphenyl)methyl] amino] CT is N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(5,6,7,8-tetrahydro-1-naphthalenyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2,3-dihydro-1H-inden-5-yl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(1,3-benzodioxol-Ilmenau)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(2-pyridinylamino)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(3-methyl-2-pyridinyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(4-methyl-2-pyridinyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2-chloro-5-were)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2,6-dichlorophenyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2-methoxyphenyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(1,1'-biphenyl)-2-ylamino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2-benzoylphenyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2-were)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
N-(2,4,6-trimetilfenil)-2-[[[(2,4,6-trimetilfenil)amino] carbonyl] amino] -6-benzothiazoline;
2-[[[(3,5-differenl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(3-methoxyphenyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(3-were)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(4-cyanophenyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(4-forfinal)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(4-chlorophenyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
ethyl ester 4-[[[[6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] amino] carbonyl] amino] benzoic acid;
2-[[[(3,4,5-trimethoxyphenyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(3,4-acid)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[ 2,6-bis-(1-methylethyl)phenyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2-propylphenyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(3-bromo-2,4,6-trimetilfenil)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[[2-(4-morpholinyl)phenyl] amino] carbonyl] amino] -N-(2,4,6-trim societybased;
2-[[[(2,6-acid)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2-bromo-5-methoxyphenyl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2-methoxy-6-were)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2,3-dimethyl-1H-indol-5-yl)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[[3-(1,3,4-oxidiazol-2-yl)phenyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(2-chloro-6-were)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2 -[[[[ 3-(methylthio)phenyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[(4-methoxy-2-were)amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(4-methoxycyclohexyl)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(2,2-dimethyl-1-oxopropyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(2-titilate)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(cyclopropanecarbonyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(cyclobutanecarbonyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(cyclop,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(cyclopenten-1-ylcarbonyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(cyclopentylacetyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(1-oxo-2-phenylpropyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(2-methyl-1-oxopropyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(1-oxo-3-phenoxypropan)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(1-oxo-3-phenylpropyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[3-(2-sexiphenyl)-1-oxopropyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[3-(2,3,4-trimethoxyphenyl)-1-oxopropyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(1,4-dioxaphetyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(2-naphthaleneacetic)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(2-chloro-6-forfinal)acetyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(2-were)acetyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(3-methoxyphenyl)acetyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(4-chlorophenyl)acetyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(1-oxo-4-pentenyl)amino] -N-(2,4,6-trimetilfenil)-6-benzoate the new acid;
2-[(1-oxohexyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(1-oxoethyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(1-oxo-4-(2-thienyl)butyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(3-thienylboronic)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2[[(4-nitrophenyl)acetyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[3,5-bis(trifluoromethyl)phenyl] acetyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[2-[4-(2-methylpropyl " phenyl] -1-oxopropyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[3-(3-methoxyphenyl)-1-oxopropyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(2,3,6-trichlorophenyl)acetyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(1,3-benzodioxol-5-yl)acetyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[[2-(phenylmethoxy)phenyl] acetyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(3,5-acid)acetyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[3-(1,3-benzodioxol-5-yl)-1-oxopropyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(tetrahydro-2-furanyl)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[2-(AC] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(cyclopropylmethyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
N, N-dimethyl-N'-[6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] butandione;
2-[(1-adamantylamine)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[[(4-methylcyclohexyl)carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
2-[(3-methoxy-1-oxopropyl)amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
1,1-dimethylethylene ether[6-[[(2,3-dihydro-1H-inden-5-yl)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[(2-naphthalenamine)carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(3-hydroxy-2-naphthalenyl)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(2-fluoro-5-were)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(2-chloro-6-were)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(2,6-dimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(4-bromo-2-were)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(3-bromo-2,4,6-trimetilfenil)aenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(2-bromo-4,6-dimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(2-methyl-6-chinoline)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(4-methoxy-2-naphthalenyl)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(6-methyl-5-chinoline)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-ether dimethylethyl[6-[[[2-(2-hydroxyethyl)-6-were] amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(2,6-dimethyl-3-nitrophenyl)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(2-bromo-3,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(2-acetyl-6-hydroxyphenyl)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-ether dimethylethylene[6-[[[4-[[(1,1-dimethylmethoxy)carbonyl] amino] -2,3,5,6-tetramethylene] amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(4-bromo-2,6-dimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[[3-acetylamino] -4,6-dimetilfenil] amino] Carbo-2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[(2-methyl-1-naphthalenyl)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
methyl ester 3-[[[2-[[(1,1-dimethylmethoxy)carbonyl] amino] -6-benzothiazolyl] carbonyl] amino] -4-methyl-2-thiophencarboxylic acid;
methyl ether [6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
2-[[(acetylamino)acetyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
N-(2-chloro-6-were)-2-[[[(1,1-dimethylethyl)amino] carbonyl] amino] -6-benzothiazolinone;
N-(2,6-dichlorophenyl)-2-[[[(1,1-dimethylethyl)amino] carbonyl] amino] -6-benzothiazolinone;
N-(4-bromo-2,6-dimetilfenil)-2-[[[(1,1-dimethylethyl)amino] carbonyl] amino] -6-benzothiazolinone;
N-(4-carbomethoxy-2,6-dimetilfenil)-2-[[[(1,1-dimethylethyl)amino] carbonyl] amino] -6-benzothiazolinone;
N-(4-hydroxymethyl-2,6-dimetilfenil)-2-[[[(1,1-dimethylethyl)amino] carbonyl] amino] -6-benzothiazolinone;
1,1-dimethylethylene ester [4-methyl-6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
triptorelin(1: 1)2-amino-4-methyl-N-(2,4,6-trimetilfenil)-6-benzothiazolesulfonamide;
1,1-dimethylethylene ether 4-methoxy-[6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid; 2-[[[methylamino] carbonyl] amino] -4-methoxy-N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
1,1-dimethylethylene ester of 5-methoxy-[6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
triptorelin (1: 1) 2-amino-N-(4-N, N-dimethylamino-2,3,5,6-TETRAMETHYLBUTYL)-6-benzothiazolesulfonamide;
1,1-dimethylethylene ester 5-chloro-[6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ester of 7-chloro-[6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
2-amino-5-hydroxy-N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
1,1-dimethylethyl ester 5-tert. -butoxycarbonyl-[6-[[(2,4,6-trimetilfenil)amino] carbonyl] -2-benzothiazolyl] carbamino acid;
2-[[[(1,1-dimethylethyl)amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[(cyclopropylamino)carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[(cyclopentylamine)carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2 -[[[[ 1-(ethinyl)cyclohexyl] amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[[(4-methyl-cyclohexyl)amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[[(2,3-dihydro-1H-inden-1-yl)ail] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2 -[[[[(tetrahydro-2-furanyl)methyl] amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[[[2-(5-methoxy-1H-indol-3-yl)ethyl] amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[[(1,1-dimethyl-2-hydroxyethyl)amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[[(1,1-dimethyl-propyl)amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2 -[[[[(3-methoxyphenyl)methyl] amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2 -[[[[(4-methoxyphenyl)methyl] amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[(2-propylamino)carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[(2-propylamino)carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[[(3-phenylpropyl)amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2 -[[[[ 1-(hydroxymethyl)cyclopentyl] amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2 -[[[[ 1-(methoxymethyl)propyl] amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
(R)-2-[[[(1-phenylethyl)amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[[(3,4,5-trimethoxyphenyl)amino] carbonyl] amino] -N-(2,6-dimethylferrocene;
2-[[[(4-forfinal)amino] carbonyl] amino] -N-(2,6-dimetilfenil)-6-benzothiazolinone;
2-[[(cyclopropylamino)carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[(cyclopentylamine)carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2 -[[[[ 1-(ethinyl)cyclohexyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[(4-methyl-cyclohexyl)amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[(2,3-dihydro-1H-inden-1-yl)amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2 -[[[[ 2-(1H-imidazol-4-yl)ethyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2 -[[[[(tetrahydro-2-furanyl)methyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[[2-(5-methoxy-1H-indol-3-yl)ethyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[(1,1-dimethyl-2-hydroxyethyl)amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[(1,1-dimethyl-propyl)amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2 -[[[[(3-methoxyphenyl)methyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2 -[[[[(4-methoxyphenyl)methyl] amino]-6-were)-6-benzothiazolinone;
2-[[(2-propylamino)carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[(3-phenylpropyl)amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2 -[[[[ 1-(hydroxymethyl)cyclopentyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2 -[[[[ 1-(methoxymethyl)propyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
(R)-2-[[[(1-phenylethyl)amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[(2,3-dimethyl-1H-indol-5-yl)ethyl] amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[(3,4,5-trimethoxyphenyl)amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[(1,3-benzodioxol-5-ylamino)carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[[[(4-forfinal)amino] carbonyl] amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2 -[[[[(1-methoxycarbonyl)cyclopropyl] amino] carbonyl] amino] -N-(2,4,6-trimetilfenil)-6-benzothiazolinone;
1,1-dimethylethylene ether [6-[[[(2,6-dimethyl-4-phenyl)phenyl] amino] carbonyl] -2-benzothiazolyl] carbamino acid;
1,1-dimethylethylene ether [6-[[[(2,6-dimethyl-4-(2-N, N-dimethylmethoxy)fennel] amino] carbonyl] -2-benzothiazolyl] carbamino Kalinovo acid;
2-[(cyclopropanecarbonyl)amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[(2-methyl-cyclopropanecarbonyl)amino] -N-(2-chloro-6-were)-6-benzothiazolinone;
2-[(2,2-dichloro-1-methyl-cyclopropanecarbonyl)amino] -N-(2-chloro-6-were)-6-benzothiazolinone; and
2-[(1-hydroxy-cyclopropanecarbonyl)amino] -N-(2-chloro-6-were)-6-benzothiazolinone.

 

Same patents:

The invention relates to new derivatives of aminothiazole formula I and their pharmaceutically acceptable salts, where R1and R2independently of one another denote hydrogen, fluorine or lower alkyl; R3denotes heteroaryl selected from oxazolyl, which is substituted by one or more substituents selected from lower alkyl, halogen, carbamoyl, allyloxycarbonyl, alkylcarboxylic; or benzoxazole; R4denotes hydrogen;-alkyl which can be optionally substituted with halogen, alkoxy, hydroxy, allyloxycarbonyl, alkylcarboxylic, amino, carbamoyl; CO-cycloalkyl; CO-aryl, where aryl represents phenyl which may be optionally substituted with halogen, lower alkyl, alkoxy, amino, cyano or naphthyl, and so on; or COO-alkyl; COO-cycloalkyl; soo-phenyl; COO-alkyl-phenyl; SO2-alkyl; SO2-phenyl, C(NCN)NH-phenyl, where phenyl may be optionally substituted with halogen; R5denotes hydrogen; m is an integer from 0 to 2; n is 0

The invention relates to amino acid derivatives of the formula I

< / BR>
or its non-toxic salt or its hydrate, the pharmaceutical composition having inhibitory effect on calcium channel iv-type; the inhibitor calcium channel N-type; a pharmaceutical composition for prevention and/or treatment of cerebral infarction and pharmaceutical compositions for the treatment of pain

The invention relates to a derivative of sulfoaluminate and sulphoniumhydroxide acid of formula I, its pharmaceutically acceptable salts, where W is-HE-or-NHOH; X denotes (a) a heterocyclic radical selected from the group comprising imidazolines, dihydrobenzofuranyl and so on, b) -NR1SO2R2where R1denotes a hydrogen atom, R2denotes an unsubstituted phenylalkyl and so on; Y represents carbon or sulfur, with the proviso that when Y represents carbon, n is equal to 2; Z represents phenyl, optionally substituted with halogen, unsubstituted alkoxy, phenyloxy, optionally substituted with halogen, phenylacetonitrile, 4-methylpiperazine, 4-phenylpiperidine, pyridyloxy, -NR'1COR'2, -SO2R'2where R'1denotes a hydrogen atom, R'2denotes phenyl, optionally substituted by hydroxy or phenyl, pyridinyl, substituted-CF3; m denotes an integer from 1 to 4, n represents an integer of 1 or 2

The invention relates to new cyclic diamine compounds of the formula I, where

< / BR>
represents an optionally substituted divalent residue of benzene, where the substituents are selected from unsubstituted lower alkyl groups, unsubstituted lower alkoxygroup, unsubstituted lower acyl group, a lower allylthiourea, lower alkylsulfonyl group, halogen atom, etc. or unsubstituted pyridine; Ar represents a phenyl group which may be substituted by one to four groups selected from unsubstituted lower alkyl group, the unsubstituted alkoxygroup, low allylthiourea, lower alkylsulfonyl group, and so on, optional substituted amino group, alkylenedioxy; X is-NH-, oxygen atom or sulfur atom; Y is a sulfur atom, sulfoxide or sulfon; Z represents a single bond or-NR2-; R2- the atom of hydrogen or unsubstituted lower alkyl group; l = 2 or 3; m = 2 or 3; n = 1, 2, or 3, or their salts, or their solvate

The invention relates to new derivatives isothiazolinones acid of the formula I, where R stands for a group-OR1or-SR2in which R1means alkyl with 1-6 carbon atoms, a substituted once residues selected from the group comprising halogenoalkanes with 1-6 carbon atoms and 1 to 5 halogen atoms, dialkylamino with 1-6 carbon atoms in each alkyl part, phenylalkyl with 1-4 carbon atoms in the CNS parts and pyrrolidinyloxyl with 1-4 carbon atoms in the CNS part, and twice by hydroxyl, or so, m and n is 2, R3means phenyl, R4means alkyl with 1-4 carbon atoms, R2means alkyl with 1-6 carbon atoms, or R2means phenylalkyl with 1-2 carbon atoms in the alkyl part, with the phenyl portion may be substituted with halogen

The invention relates to a new derivative of solidilin formula (I) where one of X, Y and Z represents C=O or C=S, and one of the remaining X, Y and Z denotes a group With=, and the other group C=S; R1, R2and R3are Deputy or X, Y and Z, or nitrogen atom and may be the same or different and denote hydrogen, halogen, hydroxy, nitro, etc., the group -(CH2)n-O - and may be joined through the nitrogen atom, or X, Y, Z, n is 1-4, Ar denotes a phenylene or naftilan, R4denotes hydrogen or forms a bond with group a, And denotes nitrogen or CR5, R5denotes hydrogen, halogen or forms a bond with R4In means O or S, when a is CR5and means that, when a is N, its tautomeric forms, stereoisomers, polymorphic forms, pharmaceutically acceptable salt and solvate

The invention relates to the derivatives of propanolamine formula (I) and their pharmaceutically acceptable salts, where R1and R2means phenyl, naphthyl, pyridyl, thienyl, pyrimidyl, thiazolyl, hinely, piperazinil, oxazolyl, which may be substituted with halogen, HE, NO2, NH2, COOH, etc., R3-R8mean hydrogen, hydroxyl, (C1-C8-alkoxy, NH2-THE OTHER9, -N(R9R10, R9-R10mean hydrogen or (C1-C8)alkyl, X is CH or N, Y represents CH or N, provided that the residues R1, R2X and Y are not simultaneously mean R1- phenyl, R2is phenyl, X is CH, Y is CH

The invention relates to the derivatives of pyrrolidine formula I

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where R1- H, C1-C6alkyl; phenyl, possibly substituted; biphenyl, possibly substituted; 1H, 5H - pyrido [3,2,1-ij] chinolin; phenyl WITH1-C6alkyl, optionally substituted; biphenyl WITH1-C6alkyl, optionally substituted; biphenylcarboxylic; terphenyl; naphthyl, optionally substituted; Z denotes-S-, -O-, -och2-, -N(R16), where R16- H, C1-C6alkyl, C3-C8cycloalkyl1-C6alkyl, panels1-C6alkyl, a chemical bond; X1means-CO-, -(CH2)r-CO-N(R17), where R17means H, C1-C6alkyl (where r = 0 or 1), -CH2NHSO2-, -(CH2)s-N (R18)-CO- (where R18- N, s=1-3), - CH2NHCОСН2O-, -CH2N (R19Of PINES = CH- (where R19- H, -CH2OCH2-, -CH2-N (R20)-CH2- (where R20- H, C1-C6alkyl, C1-C6alkylsulphonyl, phenylcarbinol)1-C5alkylen,2-C4albaniles, a chemical bond; X2- phenylene, optionally substituted hydroxy, theoffender, purandar, piperidinyl,< / BR>
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R2and R3each - H; and R4- phenyl, possibly substituted with halogen; R5- phenyl, possibly substituted; a cycle of G is phenyl,3-C7cycloalkyl, pyridyl, thienyl; loop J is phenyl; L is phenyl; p=0-2;----- means the presence or absence of chemical bonding;displays a CIS - or TRANS-configuration D relative to E; provided that X1means-CH2NHCО-, X2means 1,4-phenylene and X3means a chemical bond or a C1-C5alkylen, when the carbon atom bound CD and adjacent carbon atom in the cycle are connected by a simple relation and V1does not mean a chemical bond, when X1means-CH2O-; and pharmaceutically acceptable salt or hydrate of the compound

The invention relates to new heterocyclic compounds of the formula (I), where R1represents a group of formula (II), R is 2,4-dioxothiazolidine-5-ylmethylene group and others, And represents C1-6alkylenes group, A represents an oxygen atom, R4represents a substituted phenyl or pyridyl which may have a Deputy, R6represents a hydrogen atom or a C1-6alkyl group, D represents an oxygen atom or sulfur, E is a CH group or a nitrogen atom, or their pharmacologically acceptable salts

The invention relates to the production of derivatives of 3-amino-2-mercaptobenzoic acid of the formula I, in which X represents fluorine, n = 0 or 1, Z represents CO-a or CS-A1A represents hydrogen, halogen, OR1or SR2, A1denotes hydrogen or or1, R1and R2denote hydrogen, substituted or unsubstituted, saturated or unsaturated hydrocarbon radical with an open chain, containing not more than 8 carbon atoms; the interaction of the compounds of formula II in which T represents hydrogen, C1-C6alkyl, C3-C6alkenyl,3-C6quinil,3-C6cycloalkyl or substituted or unsubstituted phenyl, benzyl or phenethyl; with aqueous strong base

The invention relates to new chemical substances, which have valuable pharmacological properties, more particularly to a nitrogen-containing heterocyclic compounds of General formula I

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where X is oxygen or sulfur;

Y is carbon or nitrogen;

Z is carbon or nitrogen, and Y and Z are not simultaneously mean nitrogen;

R1and R2independent from each other and denote hydrogen, alkyl with 1 to 6 carbon atoms, halogen, trifluoromethyl, nitrile, alkoxy with 1 to 6 carbon atoms, a group of CO2R7where R7means hydrogen or alkyl with 1 to 6 carbon atoms, group-C(O)NR8R9where R8and R9not dependent from each other and denote hydrogen, alkyl with 1 to 3 carbon atoms, methoxy or together with the nitrogen form a morpholine, pyrrolidine or piperidine-NR10R11where R10and R11denote hydrogen or alkyl with 1 to 6 carbon atoms, group-C(O)R12where R12means alkyl with 1 to 6 carbon atoms, group-SO2R12where R12has the specified value, -NHC(O)R12where R12has the specified value, -NHSO2R12where R12has a specified value, and-SO2NR13R14where R13and R142R12where R12has the specified value, -NHC(O)R12where R12has the specified value, -NHSO2R12where R12has the specified value, -SO2NR13R14where R13and R14have a specified value, a nitrogroup, 1-piperidinyl, 2-, 3 - or 4-pyridine, morpholine, thiomorpholine, pyrrolidine, imidazole, unsubstituted or substituted at the nitrogen by alkyl with 1 to 4 carbon atoms, 2-thiazole, 2-methyl-4-thiazole, dialkylamino with 1 to 4 carbon atoms in each alkyl group, or alkilany ether with 1 to 4 carbon atoms;

R4an ester of formula-CO2R16where R16means alkyl with 1 to 4 carbon atoms, the amide of formula C(O)NR17R18where R17and R18independent from each other and denote hydrogen, alkyl with 1 to 2 carbon atoms, methoxy or together with the nitrogen form a morpholine, piperidine or pyrrolidine, phenyl, unsubstituted or substituted by residues from the group comprising halogen, alkyl with 1 to 4 carbon atoms, alkoxy with 1 to 4 carbon atoms, 3-methyl-1,2,4-oxadiazol-5-yl, 2 - or 3-thienyl, 2-, 3 - or 4-pyridyl, 4-pyrazolylborate 4 stands, the ketone of the formula C(O)R19'where R19means alkyl with 1 to 3 carbon atoms, phenyl or 1-Mei-2-yl, a simple ester of the formula-CH2OR20where R20means alkyl with 1 to 3 carbon atoms, thioether formula-CH2SR20where R20has the specified value, the group CH2SO2CH3amines of the formula-CH2N(R20)2where R20has the specified value, the remainder of the formula-CH2NHC(O)R21where R21means methyl, amino or methylamino - group-CH2NHSO2Me2where Me denotes methyl carbamate of the formula CH2OC(O)NHCH3;

R5and R6independent from each other and denote hydrogen or methyl;

n is 0,1 or 2,

Provided that the substituents are not simultaneously have the following meanings: Y and Z is carbon, R1or R2hydrogen, halogen, alkyl with 1 to 4 carbon atoms, alkoxy with 1 to 4 carbon atoms, cyano, nitro, trifluoromethyl, R3unsubstituted phenyl and R4group-C(O)OR16'where R16'means hydrogen, alkyl, alkenyl or quinil, group-C(O)N(R18')(R19'), where R18'and R19'denote hydrogen, alkyl with 1 to 6 carbon atoms, phenyl, alkoxy or together with the nitrogen form pyrrolidine, piperidine or morpholine, cyanotic, unsubstituted phenyl and 4-imidazole,

in the form of a racemate or an individual enantiomers and their salts, are inhibitors of leukotriene biosynthesis

The invention relates to organic chemistry, in particular to the synthesis of substituted 6-hydroxybenzothiazole containing labile fragments

The invention relates to benzothiazole derivative that is highly effective as a medicinal product, namely, benzothiazole derivative, useful as a preventive and therapeutic agent for diseases in which the function of suppressing the production of leukotrienes and thromboxanes are effective

The invention relates to new derivatives of 2-aminobenzothiazole, and to their use in pharmaceutical compositions having activity against convulsions induced by glutamate

The invention relates to medicine, in particular to immunology, and the development of ways immunomodulation using nucleotides

The invention relates to the field of medicine, veterinary and food industry and can be widely used as the treatment of deficiency States of the human or animal, and, in particular, in the manufacture of various food products used for the prevention of iodine deficiency

The invention relates to medicine, namely to drugs with immunomodulatory, anti-inflammatory, antitumor and antioxidant effect

The invention relates to medicine, in particular to new biologically active substances
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