Biologically active additive "hepatitis" for prophylaxis and maintenance therapy of liver diseases

 

The invention relates to medicine, namely to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used for the prevention and auxiliary treatment for liver diseases. The proposed dietary Supplement for prevention and maintenance therapy of liver diseases of medicinal plants containing dry water concentrates dandelion root, barberry fruits, herbs chicory, herbs milk Thistle, dry alcohol concentrate grass and flowers of immortelle, pollen, ginger root, citric acid, starch, calcium stearate, sugar, crushed oats and talc at a ratio of components. The invention has a wide range of preventive action, improves functional status in the treatment of chronic liver diseases, it is convenient for oral administration, has a long shelf life. table 1.

The invention relates to medicine, namely to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used for the prevention and auxiliary treatment of diseases of the automatic supplements. Moscow, Kohelet, 2001, S. 291/ that contains immortelle flowers, fennel fruit, rosehips, dandelion root, aloe, marshmallow root, elecampane root, marjoram, an herb St. John's wort, Valerian root, peppermint leaves, plantain leaves, the root of calamus swamp, birch leaves, propolis, leaves of nettle, nutmeg, available in liquid form, packaged in bottles, and used as a tonic in chronic inflammatory liver diseases.

The disadvantage of the drug is observed in individual patients, individual intolerance to some of the components of the drug.

Known biologically active food Supplement "Hepatoma" /Pilate T. L. (editor ). Federal register biologically active additives to food. Moscow, Kohelet, 2001, S. 292/ containing honey, thick extract of corn silk, thick extract immortelle, dense extract of peppermint, dense extract of chamomile flowers, produced in the form of a thick liquid and is used as a tonic for liver and biliary tract.

The disadvantage of the drug is observed in an individual patient ind is for food "Gepatol" /Pilate T. L. (as amended ). Federal register biologically active additives to food. Moscow, Kohelet, 2001, S. 293/ containing nettle, immortelle flowers, leaf birch white, flowers of mullein, St. John's wort herb, buckthorn bark brittle, a grass of a yarrow, dandelion root, corn silk, calamus root, leaf watch three leaf, grass kidney tea. Available in liquid form, packaged in capsules. Used as a tonic for liver and biliary tract, has a mild choleretic and anti-inflammatory effect.

The disadvantage of the drug is observed in individual patients, individual intolerance to some of the components of the drug.

The objective of the invention is the development of a new biologically active additives, with a wide range of preventive actions and improving functional status in the treatment of chronic liver diseases, available in pill form, convenient for use inside, and with a long shelf life.

The invention is aimed at expanding the range of alternative restorative medicines for compensation of individual intolerance is active additive contains dry water concentrates dandelion root, the fruit of the barberry, herbs chicory, herbs milk Thistle, dried alcoholic extract of the herb and flowers of immortelle, pollen, ginger root, citric acid, crushed oats, starch, calcium stearate, talc and sugar in the following ratio of ingredients in the tablet weight of 0.55 g, g: Dry water concentrate, dandelion roots - 0,00001-0,00008 Dry aqueous concentrate of the fruit of barberry 0,00001-0,00008 Dry water concentrate herbs chicory - 0,00001-0,00008 Dry water concentrate herbs milk Thistle - 0,00002-0,00016 Dry alcoholic extract of the herb and flowers of immortelle - 0,0050-0,0400 the Pollen - 0,0050-0,0400 ginger Root - 0,0025-0,0200 citric Acid - 0,0100-0,0800 Oats crushed - 0,0025-0,0200
Starch - 0,0200-0,1000
Calcium stearate - 0,0025-0,0200
Talc - 0,0025-0,0200
Sugar - Rest
A dietary Supplement called "Hepatitis" and can be used as a fortifying agent, improves digestive processes, providing hepatoprotective, hepatotropic action, stabilizing the membranes of liver cells, stimulating the secretory function of the liver, including bile secretion. Also provides antioxidant, antispasmodic, anti-inflammatory effect. Used in treatment of diseases Pescaia and drug liver damage, as health and preventive tools for contacts with hepatotropic poisons.

Use the specified purpose combination previously used substances has become possible as a result of established authors more pronounced qualities, providing cholagogue, diaphoretic, diuretic, spasmolytic effect, leading to increased secretion of bile, promotes the discharge of small stones from the gall bladder.

Optimally determined number of components obtained experimentally.

And while the impact of these substances on the human body are known, but their use in the new composition and in small doses gives a new effect, allowing the use of biologically active additives as new pharmacological tools.

The invention is illustrated by the following example.

In enamel container 15 l load pre-chopped dandelion roots 0,19 kg, pour 11,4 kg of water at room temperature, insist on a boiling water bath for 25 min, then add the fruit of Berberis 0,19 kg, fruits, milk Thistle 0.38 kg and herb chicory 0,19 kg and continue to insist on a boiling water bath for 25 min with frequent agitation. Remove from water bath and allow the ez 4 layers of gauze.

The output of 9.5 kg

The sugar in the number 67,9 kg weigh the bag on the scale, visually check for the presence of mechanical impurities, then, in the absence of impurities, crushed in the mill. For this sugar load portions in the hopper. Powdered sugar through the bottom fitting of the mill gathering into a polyethylene bag, the ends of which are pre-fixed to the fitting. The bag is placed in the receiver.

The output of crushed sugar - 67,3 kg

Oats in the amount of 10.4 kg weigh the bag on the scale, visually check for the presence of mechanical impurities, then, in the absence of impurities, crushed in the mill. For this purpose, the oats out of the bag load portions in the hopper. Crushed oats through the bottom fitting of the mill gathering into a polyethylene bag, the ends of which are pre-fixed to the fitting. The bag is placed in the receiver.

The output of crushed oats and 10.3 kg

Ginger root in the amount of 0.95 kg weigh the bag on the scale, visually check for the presence of mechanical impurities, then, in the absence of impurities, crushed in the mill. For this purpose, the ginger out of the bag load portions in the hopper. Crushed ginger root through the bottom fitting of the mill is collected in bold chopped ginger - 0,94 kg

The pollen in the amount of 1.9 kg weigh the bag on the scale, visually check for the presence of mechanical impurities, then, in the absence of impurities, crushed in the mill. The pollen out of the bag load portions using a shovel into the hopper. Crushed pollen through the bottom fitting of the mill gathering into a polyethylene bag, the ends of which are pre-fixed to the fitting. The bag is placed in the receiver.

The output of crushed pollen - 1,88 kg

In enamel container 10 l weighed on the scales of 6.5 kg of broth and bring to a boil. Separately prepare a suspension, for this mix 0.525 kg of starch and 1 kg of broth, mix thoroughly and add to the boiling broth with constant stirring. The solution is brought to a boil.

The output of starch paste to 8.0 kg

In enamel container for 7-10 l weighed 2 kg of broth, add 3.5 kg of sugar, bring to boil with constant stirring. Boil 5 minutes, then add 3.75 kg of citric acid. The mixture was thoroughly stirred until complete dissolution of the acid and filtered through 4 layers of gauze.

Output - 9,25 kg

In the mixer load 63,8 kg powdered sugar, add 0,94 kg ginger root, 1, ablaut 14,475 kg of starch and powdered oats 10,3 kg and everything is stirred for 10 minutes. Moisturize with a solution of citric acid in the amount of the 9.25 kg, the mixture is stirred 5 min, then moisturize starch paste in the amount of 8.0 kg Stirred for 10 minutes

Yield - 110,545 kg

The wet mass in the number 110,545 kg load portions in the device for producing granules from wet tablespace. Include a screw device, in which the mixture is forced through the mesh holes with a diameter of 4-5 mm Wet granules are collected in the receiver. From the receiver the wet granulate is passed for drying.

Hydrated tablets weight in the number 110,545 kg laid out on paper in the trays with a layer thickness of 1,5-2 see Trays install in a drying Cabinet. Include hot air distribution device of the drying Cabinet. Set the drying temperature 40-45oWith the increase of which the flow of hot air is automatically disabled. The drying process is carried out for 10 hours to a constant weight at periodic stirring. The control end of the drying conduct in the laboratory by weighing samples of the product from the trays to a constant weight. The humidity of the product - not more than 4%. Dry tablet weight is directed to a dry granulation.

Output dry toluene granulate from dry tablespace. Include a screw device, in which the mixture is forced through a mesh with holes of diameter 1.5 to 2.0 mm, the Dry granulate is collected in the receiver. From the receiver the dry granulate download scoop when the cover is open in the mixer, add 1,03 kg sieved calcium stearate and 1.03 kg of talc. Include a stirrer and stirred for 10 minutes. The finished granulate is directed to tableting.

The yield of dry granulate - 102 kg

From the mixer, the dry granulate is directed to tableting in the hopper tablet press machine. Turn on the engine. Pre-set engine speed in accordance with a bulk weight of the pressing zone and the height of the tablet. When you start the machine turn on a vacuum cleaner.

The diameter of the tablets to 12.00.2 mm,
The height of the tablet - 3,90.2 mm,
The average weight of a tablet - 0.55 g0,03
During tabletting watching the machine work and quality tablets. Every 30 minutes check raspadaemost, the strength and the average weight of the tablets. Tablets that do not meet the requirements, rejected and sent for reprocessing. At the end of the process the machine off in the reverse order. Tablets are collected in price through a hole diameter of 10 mm, weighed in 8-12 kg and load in a clean dry plastic bucket. Samples of finished tablets passed into the analytical laboratory for analysis. In accordance tablets norms technical documentation prepared tablets passed the stage of packing.

The output of finished tablets - 101 kg

The sequence of operations is the same regardless of the number of prepared composition.

Biologically active additive "Hepatitis" includes known authorized for use in medical practice of medicinal substances in the specified combination (see table, examples 1-4) provide for the reduction or disappearance of symptoms of biliary tract and liver.

As auxiliary components, ensuring reliability maintain the shape of the pressed pellets in a dry form and a short time raspadaemosti them in a humid environment, used starch, oats, sugar, and to improve the flowability of the granules and increase the strength of the pressing - calcium stearate and talc. Available in tablet form, which is convenient to use, has a long shelf life (2 years).

Clinical trials of herbal remedies was conducted in an urban Advisory-territorial th composition.

Thus, the proposed biologically active additive "Hepatitis" is a newly available drug with a wide range of preventive actions and improving functional status in the treatment of chronic liver diseases, convenient for use inside and with a long shelf life.


Claims

Dietary Supplement for the prevention and maintenance therapy of liver diseases on the basis of medicinal plants, characterized in that it contains dry water concentrates dandelion root, barberry fruits, herbs chicory, herbs milk Thistle, dry alcohol concentrate grass and flowers of immortelle, pollen, ginger root, citric acid, crushed oats, starch, calcium stearate, talc and sugar in the following ratio of ingredients in the tablet weight of 0.55 g, g:
Dry water concentrate, dandelion roots - 0,00001 - 0,00008
Dry aqueous concentrate of the fruit of barberry 0,00001 - 0,00008
Dry water concentrate herbs chicory - 0,00001 - 0,00008
Dry water concentrate herbs milk Thistle - 0,00002 - 0,00016
Dry alcoholic extract of the herb and flowers of immortelle - 0,0050 - 0,0400
The pollen is 0,0050 - 0,00 - 0,1000
Calcium stearate - 0,0025 - 0,0200
Talc - 0,0025 - 0,0200
Sugar - Rest

 

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