Recombinant plasmid dna (options), the method induction of angiogenesis, the method of treating ischemic diseases and composition for treating ischemic diseases

 

The invention relates to biotechnology, genetic engineering, medicine and can be used to treat coronary artery disease. Received three new plasmid DNA: pAng 1 size 6,2, etc., N., pAng 2 size of 6.3 T. p. N. and pAng 3 $ 4.8 T. p. N., capable of expression in mammalian cells. Plasmids contain EcoRI-fragment to human DNA that encodes angiogenin. Introduction in a living organism plasmid DNA provides the induction of angiogenesis. Composition for treating ischemic diseases contains recombinant plasmid DNA pAng 1, or pAng 2, or pAng 3 at a concentration of 45 to 55 mcg per 1 ml of physiological solution. The invention allows the development of methods of treatment of coronary artery disease and to exclude unwanted side effects. 6 C. and 1 C.p. f-crystals, 4 Il., table 1.

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