Gel "sobi", which has antiviral activity and transdermal properties for the treatment of hiv-infected patients

 

The invention relates to pharmacology and medicine. Gel "SOBI", which has antiviral activity and transdermal properties for the treatment of HIV-infected patients, contains silver sulfadiazine, dimethylsulfoxide and alcohol tincture of propolis, and as the basis of a polyethylene oxide gel PEG-1500, in the following ratio of components per 100 ml volume: sulfadiazine 1-1,5 g; dimethylsulfoxide 10-15 ml; 10% alcohol tincture of propolis prepared in 80% alcohol 10-15 ml; polyethylene oxide gel PEG-1500 - rest, and the particle size of silver sulfadiazine does not exceed 5-10 μm. The drug improves the efficiency of treatment. table 1.

The invention relates to pharmacology and medicine and can be used to treat patients infected with HIV (human immunodeficiency virus), at any stage of the disease, including AIDS patients, as well as other viruses, including the attendant.

It is known that medicines on the basis of "silver sulfadiazine have antiseptic and antiviral activity.

So cream "Dermazin containing 1% silver sulfadiazine in hydrophilic basis [1], prevents and suppresses infections is m, what it is designed to fight infection only on the surface of the tissue, i.e., open wounds, burns, but may not affect viruses and microorganisms inside the tissues and cells of the body.

Closest to the claimed is considered drug drug Sulfadiazine for inhibition of AIDS virus during sexual contact" [2] the prototype. The drug is intended for the treatment of HIV infection on the surface of the mucous membranes of the genital organs. That is known as an antiseptic and may not be effective in the treatment of already infected with HIV and patients with AIDS patients, the infection has spread to the blood and lymphatic systems, organs, tissues, cells of the patient.

The purpose of the proposed solutions - improving the efficiency of outdoor therapeutic agents against HIV. The practice of treating AIDS patients and HIV-infected shows that the disease is almost always accompanied by enlarged lymph nodes. They increase several times, malevolently or painless on palpation. This points to the fact that in the lymph nodes accumulates a large number of viral particles in infected cells and blood leukocytes, the time, if you do not use additional means of combating HIV infection, acting locally, i.e. directly in areas where there is active viral replication.

The task of creating a transdermal drug that can penetrate deep into the tissues of the body and into the cells for direct contact with the virus, i.e., capable enough to easily penetrate the skin and mucous membranes of the organs of the patient when the outer surface of the contact.

Applying the gel contains: the active anti-virus component "Sulfadiazine", dimethylsulfoxide (DMSO) as a carrier of silver ions inside affected by HIV cells, for direct contact with the virus, alcohol tincture of PROPOLIS and based gel of polyethylene oxide (PEG-1500). Gel (PEG-1500) take a ready made technology approved in THE 9154-004-1182-1987-93. The specified gel of polyethylene oxide (PEG-1500) obtained by the method of radiation crosslinking under the influence of ionizing radiation at a dose of 40 - 420 GSR. The resulting gel contains the actual polyethylene oxide only 4-6%, remainder water, and therefore he has good ability procel small molecules). To increase the penetrating ability in the tissue of the main medicinal component of silver sulfadiazine used in gel, powder "silver sulfadiazine" pre-processed by grinding it on a special roll mill to obtain a particle size of not more than 5-10 microns.

This particle size corresponds to the size of the pores of the skin, hair tubules, lymph vessels, blood capillaries, which promotes the free penetration of particles in the tissues, particularly in the lymph nodes. In the tissues of the affected body "sulfadiazine" moderately dissociates. Silver ions are released evenly and slowly enough and therefore not bound to quickly and widely with chlorine ions, proteins and other components of body fluids. Present sulfa component "silver sulfadiazine", suppresses the lymph nodes associated bacterial infection. Contained in the gel DMSO performs a special function, i.e., specifically solatium silver ions and performs transmembrane migration of silver ions inside viral particles and infected cells that contributes to their further inactivation of competent cells of the immune system. Prov.ICO-chemical properties, probably increases their internal energy intensity, which makes them more active.

The presence of gel propolis increases the efficiency of the gel as a drug due to the unique properties of propolis, which is a natural bio-component, has anesthetic, antitoxic, antiviral, antifungal, antioxidant, antitumor properties, enhances immune resistance of the organism of the patient. He also serves as perfumes, softening and masking the smell of organic matter (DMSO), due to the high content in the structure of natural essential oils.

EXAMPLE 1.

The inventive gel is prepared by mixing at a volume of 100 ml: 1 g "silver sulfadiazine with particle sizes not more than 5-10 ám, 10 ml of DMSO and 10 ml of 10% alcohol tincture of propolis prepared in 80% ethyl alcohol. Add to 100 ml gel of polyethylene oxide (PEG-1500) and carefully mix all ingredients until a homogeneous consistency. Get a homogeneous gel with a pleasant smell, which is important for the patient, white, leaves no traces on the skin and clothing. Received the drug is Packed in glass containers and store in a dark, cool onanti the following number: "Sulfadiazine" - 1.5 g DMSO - 15 ml Alcohol 10% tincture of propolis prepared 80% ethanol and 15 ml Gel of polyethylene oxide (PEG 1500) - the Rest.

The effectiveness of the gel was tested in Novosibirsk oblast AIDS centre (Novosibirsk region p. Koltsovo) to HIV-infected patients simultaneously carried out by treatment with micro preparations containing silver. Treatment of the gel was carried out in the case of patients increased painless or slightly painful lymph nodes in the neck, armpits, groin. This fact indicated the presence of active viral replication of HIV in the lymph nodes. The gel was applied 2 times a day directly on the area of the enlarged lymph nodes with a layer of 1-2 mm with its subsequent rubbing of the skin with light movements of the fingers. Treatment of HIV-infected patients during therapy preparations containing silver, with parallel rubbing of the skin the inventive gel in the area of enlarged lymph nodes were more efficient and gave good therapeutic result in a shorter treatment time. The treatment time was reduced by 15-20%.

The table below shows the results of a clinically Prov.) with the participation of five patients from different regions of the Russian Federation. The results of the treatment were evaluated by us on the physiological condition of patients at the end of the planned treatment duration of 20 days. During the course of treatment we recorded the dynamics of change in time of the state (the size in diameter, consistency) of lymph nodes of patients.

Sources of information 1. Cream "Germain". Abstract of the firm Lek Pharmaceutical and Chemical Company d.d.

2. Patent EP 287204 CL, A 61 K 31/635. Publication 19.10.88, prototype.

Claims

The gel, which has antiviral activity and transdermal properties for the treatment of HIV-infected patients, containing silver sulfadiazine and a base, characterized in that it further comprises dimethyl sulfoxide and alcohol tincture of propolis, and as the basis of a polyethylene oxide gel PEG-1500, in the following ratio of components per 100 ml volume: Sulfadiazine, g - 1 - 1,5 dimethyl Sulfoxide, ml - 10 - 15 10% alcohol tincture of propolis prepared in 80% alcohol, ml - 10 - 15
The polyethylene oxide gel PEG-1500 - Rest
moreover, the particle size of silver sulfadiazine does not exceed 5-10 μm.

 

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