Device for determining the state of the biological object

 

The invention relates to biology and medicine and can be used to determine the status of biological objects. The device contains a microprocessor, a memory unit, a display unit, an alarm unit, a power supply, a start element, digital to analog Converter, analog-to-digital Converter, a current regulator, driver signal, the sensitivity regulator, the regulator resistance and the measuring chamber. The latter consists of the main and compensating sensors and tactile sensors. The measuring chamber in the form of a glass of hydrophobic material with ventilation holes, surrounded by a thermal shunt and mounted on insulating supports, a glass covered with heat shield, on the edge of the glass has a tactile sensor, and installed the main and compensating sensors separated by a heat mirror. The invention provides enhanced functionality studies when determining the condition of a biological object, simplifies them and makes it possible to measure in real-time. 2 C.p. f-crystals, 2 Il.

The invention relates to the field of comparative research biological and j is practical media outside the body of a living organism - from aura to electromagnetic radiation of different ranges. However, more interesting is the study (the journal Science News, 17, 2000, S. 268), according to which the body, as every physical body, creates a concentration of the gas or solution in the boundary layer near the surface of the partition, i.e., the skin, due to adsorption. Therefore, we propose a method of analysis of samples of the gas components of the bio-object (SDO) as a real product of vital activity of living matter. In this case, one of the most important characteristics of the life processes of the bio-object is the dynamics of the allocation of gas components of a biological object or slew rate of PDB, which taking into account the calibration coefficients allows you to monitor the change in the one or the other of the diagnostic parameter of the bio-object. The calibration factor specific parameter of the bio-object is determined by the ratio of the rate of rise CCH and parameter values, measured after a single exposure to certain biological object test a drug that targets the specific parameter of the bio-object, and the level parameter is measured simultaneously with known methods. Measurement of slew rate CCH performed using a specific ISM is Roy and using the established calibration coefficient allows to determine the value of this particular parameter and thus, to monitor the condition of the biological object. This calibration factor can be set for many of the parameters of the bio-object, which has diagnostic value and norms.

Known means of the study of biological objects (see RF patent 2121669, publ. 1998), in which burned a biological sample study and control of biological objects, form the corresponding measurement parameters, compare them and determine the state of the investigated biological object, which uses the measuring chamber, the electrodes of which is connected to the power source.

Known tools do not determine the condition of a biological object by the organic gas component allocated to the skin of the investigated object, but also the dynamics of the allocation of gas components of a biological object, do not allow to monitor certain parameters of the bio-object and difficult to implement.

The present invention is to develop a simple means of determining the state of the biological object on the basis of the analysis of allocated gas components, the dynamics of the allocation of the gas components of the bio-object and use the slew rate of the gas components of the bio-object regional opportunities when determining the condition of a biological object by exploring the parameters of the gas components of a biological object, the dynamics of the allocation of the gas components of the bio-object and use the slew rate of the gas components of the bio-object for monitoring specific parameters of the bio-object, simplify the method of determining the state of the bio-object and monitoring of certain parameters of the bio-object and measuring in real-time.

The result is achieved that the device for determining the condition of a biological object that contains the measuring chamber, the electrodes of which is connected to the power source, the measuring chamber wypolnena the form of a Cup with ventilation holes in the bottom, covered with a heat shield, surrounded by a thermal shunt and mounted on insulating supports, electrodes made in the form of primary and compensatory thermal sensors in the glass and separated by a heat shield on the wall of the Cup has a tactile sensor connected to a microprocessor, connected to a display unit, a memory unit, an alarm unit, a start element and a digital to analog Converter, some conclusions compensatory and basic thermal sensors are connected respectively with the current regulator and control unit soprotivlenie power supply is connected to the current regulator and control unit of resistance, the output of which is connected to the signal shaper connected to the microprocessor and control unit sensitivity, digital to analog Converter connected to the current regulator.

Specific, but not limiting the present invention, the exemplary embodiment of the device shown in Fig.1, 2, which depicts the microprocessor 1, the memory unit 2, display unit 3, unit 4 alarm block 5 power element 6 launch, d / a Converter 7, an analog-to-digital Converter 8, the stabilizer 9 current, the signal shaper 10, the controller 11 of the pressure regulator 12 resistance, the measuring chamber 13, the main and compensating thermal sensors 14, 15, tactile sensor 16, the measuring chamber in the form of a Cup 17 of hydrophobic material with ventilation holes 18, 19, surrounded by a thermal shunt 20 and mounted on insulating supports 21, the glass is covered by a heat shield 22, on the edge of the glass is installed tactile sensor 16, the glass set primary and compensating thermal sensors 14, 15 separated by a heat mirror 23, the shutter 24 cups.

The shunt 20 is made of metal with high heat capacity and serves to delay the passage of teplovs eliminate heat transfer between the sensors 14, 15 in the infrared range. The sensor 15 is used to eliminate the influence of temperature gradient and body compensates for temperature drift in the environment of the measuring chamber 13, is not associated with receipt of GKB.

The essence of the invention consists in the burning of gas control components and studied biological objects - the atmosphere and human shaping of measurement parameters - UDutchand the difference of the parameters determine the activity of the zone from the surface which was filmed gas component of the bio-object (CCH). Thus take into account that the signal at burning CCH person is always higher than the signal at burning CCH atmosphere because GKB person contains organic constituents. Conducting a step-by-step study of the skin, establish a distribution zones selection CCH and areas with the highest levels of allocation CCH is the palms of the hands and soles of the feet. In these areas measure the speed of reaching the maximum value of the measurement parameter, register it as the slew rate of the gas components of the bio-object. When conducting tests on various medications and other forms of impact on specific diagnostic parameters of the bio-object simultaneously determine the level of the measured parameter known method is by measuring camera. With respect to the slew rate of the gas components and the measured values of the parameters determine the calibration factor for this characteristic. Subsequent measurement of the slew rate GKB this bioobject the same measuring chamber and using the established calibration coefficient allows to determine the value of the specific characteristics and, thus, to monitor the condition of the biological object. This calibration factor can be set to specific parameters of the bio-object, which has diagnostic value and norms.

The device operates as follows. After power element 6, the microprocessor 1 sets the operating mode "Heating", in which the signal produced by the sensors 14, 15, passes through the imaging unit 10 to the input of analog-to-digital Converter of the microprocessor 1, which converts the signal frequency of 1 kHz in the digital code input to the microprocessor.

The microprocessor 1 through the inverter 7 stabilizer 9 sets the sensors 14, 15 the current required for a mode appropriate to the combustion temperature of the investigated component CCH.

Every second digital code signal shaper 10 is areeda to the value of signal <0.1 mV, that would be consistent with the steady-state thermal regime of the measuring chamber. Then, the microprocessor 1 will give the user through the block 4 sound signal of its willingness to work. Then, the controller 12 of the voltage Converter 8 is installed close to a zero value and is shown in block 3. Starts the Measurement "mode".

The analyzed surface of the body is placed on this signal on the screen 22 of the measuring chamber 13, the signal from the sensor 16 is fixed by the microprocessor 1 as the beginning of tothe measurement recording in arithmetical-logical unit (ALU) of the microprocessor 1, the values of the signal produced by the imaging unit 10. Upon receipt of combustible components of CCH on the sensor 14 due to their combustion occurs at temperatures above the values determined by the current regulator 6, and more (sensor) resistance.

You receive the error signal to the imaging unit 10, which is amplified and fed to the ADC 8. Digital code corresponding to the increased value of the signal is introduced into the ALU of the microprocessor 1, where the values of the ADC counts of 8. Every second ALU of the microprocessor 1 compares the data with the previous value of the ALU, continuing this iterative process until Nalini chamber 13, when the growth temperature due to the combustion gases is compensated by an increasing influence of thermal conductivity of the combustion gases having a lower molecular weight. Fixed peak value of the measurement parameter UDutch. Conducting a step-by-step study of the skin, establish a distribution zones selection CCH and areas with the highest levels of allocation CCH is the palms of the hands and soles of the feet. In these areas measure the speed of reaching the maximum value of the measurement parameter, register it as the slew rate of the gas components of the bio-object. To do this, along with fixing the time t0the time t1also recorded by the microprocessor 1, and is formed with a burning time of CCH (tmountains=t1-t0). At the same time is fixed amplitude value of the parameter UDutch.max=Andmaxand is determined by the slew rate CCH as V=Amax/tmountains.

At the signal, the block 4 is given command of withdrawal of body surface with the screen measuring chamber 13.

After the opening of the measuring chamber 13, the gas component goes out of its scope, the signal at the input of the shaper 10 begins to fall. The microprocessor detects the lower the minimum value of UDutch. the slew rate CCH V microprocessor 1 amends, associated with a low rate of change of the signal near the point of thermal equilibrium. Data on the value of the slew rate GKB are displayed in the unit 3 and stored in block 2 as the data of the current value of the velocity.

In the "Analysis" microprocessor 1 provides a comparison of the current speed values with the average values accumulated in block 2 for specific patient for a specific period of research. After analyzing these data, the program of the microprocessor 1 performs the refinement of these data.

To be able to monitor various characteristics of the homeostasis of a biological object using slew rate CCH, it is necessary to form the calibration coefficients. For example, when conducting a test on the impact of glucose determining the sugar content in the blood simultaneously determine the level of sugar with glucometer "ONE NOUCH" and simultaneously register the slew rate of the gas components of the bio-object, using the measuring chamber 13. With respect to the slew rate of the gas components and the measured values of the parameters determine the calibration factor For this parameter. Subsequent measurement of the slew rate GKB this bio-object and use usanewlineamazon, to monitor the status of the bio-object and non-invasive method. This calibration factor can be set for any particular setting of the bio-object, which has diagnostic value and norms, such as cholesterol, adrenaline, insulin, etc., the Limiting values of the parameters are entered in the memory unit 2, and when exceeding their values, the microprocessor 1 outputs to the user through the block 4, the audio signal of the critical parameter value.

The amount of memory unit 2 allows you to collect data on many patients in a single instrument.

Thus, advantages of the invention consist in the extension of functionality when determining the condition of a biological object by exploring the parameters of the gas components of a biological object, the dynamics of the allocation of the gas components of the bio-object and use the slew rate of the gas components of the bio-object for monitoring certain parameters of the bio-object the facilitation of the means to determine the condition of the biological object and monitoring of certain parameters of the bio-object and measuring in real time, which allows to significantly improve the diagnostic value of research settings CCH and ispolneniya condition of a biological object, containing the measuring chamber, the electrodes and the power source, characterized in that the measuring chamber in the form of a glass of hydrophobic material with ventilation holes in the bottom, covered with a heat shield, surrounded by a thermal shunt and mounted on insulating supports, electrodes made in the form of the main and compensating sensors mounted in a glass and split heat shield-mirror, on the wall of the Cup has a tactile sensor connected to the microprocessor, which is connected to the display unit, the memory unit, the alarm unit and the digital-to-analogue Converter, some conclusions compensatory and basic sensors are connected respectively with the current regulator and the regulator resistance, and other findings of the joint and connected to the driver signal and the sensitivity regulator, a power source connected to the current regulator and the regulator resistance, the output of which is connected to the signal shaper connected to the microprocessor and controller sensitivity, digital to analog Converter connected to the current regulator.

2. The device under item 1, characterized in that as the main and compensating Dutch mirror made of metallized plastic.

 

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SUBSTANCE: method involves carrying out urological examination for determining hydrodynamic resistance of ureter calculated from formula Z=8Lμ/(πR4), where Z is the hydrodynamic resistance of ureter, L is the ureter length, R is the ureter radius, μ is the urine viscosity. Angle α at which the ureter enters the urinary bladder is determined from formula cosα = 8l1μ/(ZπR4), where l1 is the perpendicular drawn from the upper edge of the ureter to the its exit projection line, μ is the urine viscosity, Z is the hydrodynamic resistance of ureter, R is the ureter radius. Vesicoureteral reflux recidivation is predicted when the angle of α+90° is less than 120°.

EFFECT: enhanced effectiveness in reducing the number of recidivation cases.

2 dwg, 1 tbl

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