A method of combating phytopathogenic diseases of cultivated plants and fungicidal composition

 

Describes a method of combating phytopathogenic diseases of cultivated plants, including processing of cultivated plants or their habitats contaminated by phytopathogenic disease in the form of a mixture or separately synergistic effective amount of the combination of component a) O-methoxymethanol ester 2-[-{[(-methyl)-3-trifloromethyl)amino]oxy}-ortho-tolyl] glyoxalase acid (I) in combination with (b) a second component selected from a range that includes any annelid formula IIB, where R1is fluorine or chlorine, or a carbamate of the formula IIC, where X denotes N or CH and R2denotes 4-CH, 4-Cl or 2,4-dichloro, or the connection IID-methyl-(2)-2-{2-[6-(trifluoromethyl)pyrid-2-intoximeter] phenyl} -3-ethoxyacrylate or connection IIE-(E) -N-methyl-2-[2-(2,5-dimethylphenoxy)-phenyl] -2-methoxykynuramine, or a compound of formula IIF, where R3is methyl or ethyl, or (S)-valinamide formula IIG, where R4is isopropyl, sec-butyl or tert-butyl, R5- 4-chlorophenyl, 4-were, 4-methoxyphenyl or-naphthyl, or (S)-valinamide formula IIH, where R6is isopropyl, sec-butyl or tert-butyl, R7- halogen, methyl, methoxy, n is 0, 1 or 2, or a connection II7-2-methyl-soedinenie formula IIK, where8- halogen, C1-C4-alkyl, or a connection IIZ-N-(3'-(1'-chloro-3-methyl-2'-oxapentane) 3,5-dichloro-4-methylbenzamide or connection IIM-(S)-1-aniline-4-methyl-2-methylthio-4-phenyl imidazolin-5-Oh, or a compound of formula (IIN), or a compound of formula (IIP), or the connection IIQ-O-methyloxime amide N-methyl-2-[{[(-methyl-3-trifloromethyl) imino ] oxy} -ortho-tolyl] glyoxalase acid, as well as fungicidal composition comprising a combination of compounds a) in combination with any compound of formula IIB-IIQ. The technical result is an increase in the efficiency of new combinations. 2 C. and 8 C.p. f-crystals, 6 PL.

The present invention relates to new fungicidal compositions intended for the treatment of phytopathogenic diseases of cultivated plants, in particular of diseases caused by phytopathogenic fungi, and to a method of combating phytopathogenic diseases of cultivated plants.

You know, neprimechatel mushrooms, in this proposal describes their properties and methods of obtaining. On the other hand, as applied to plants, fungicide, intended for processing of various crops of agricultural plants, widely distributed fungicides that are derived anilides, carbamates and amides of amino acids. However, tolerance to them cultivated plants and their activity against phytopathogenic parasitic fungi on plants in many cases, and in various aspects not fully satisfy the needs of agricultural practice.

When creating the present invention found that the application of (a)O-methyloxymorphone-[-{[(-methyl-3-trifloromethyl)imino] oxy} -ortho-tolyl] glyoxalase acid, the compounds of formula I (EP-460575) in combination with
b) or with the compound of the formula IIA

or anilides formula IIB (EP-545099)

where R1denotes fluorine or chlorine;
or carbamate of formula IIC (WO 96/01256 and WO 96/01258)

where X denotes N or CH and R2denotes 4-CH3, 4-CL or 2,4-dichloro;
either with a compound IID (EP-278595)
methyl(2)-2N-methyl-2- [2- (2,5-dimethylphenoxy)phenyl] -2-methoxyamphetamine;
either with a compound of formula IIF (WO 95/21154)

where R3denotes methyl or ethyl;
or (S)-valinamide formula IIG (EP-398072, EP-610764, DE-4321897, WO 96/07638)

where R4denotes isopropyl, sec-butyl or tert-butyl and R5represents 4-chlorophenyl, 4-were, 4-methoxyphenyl or-naphthyl, and where the asymmetric center preferably has the (R) configuration;
or (S)-valinamide formula N (WO 94/25432, WO 96/04252)

where R6denotes isopropyl, sec-butyl or tert-butyl, R7denotes halogen, methyl or methoxy and n is 0, 1 or 2;
either connection IIJ (EP-596254)
N-methyl-2- [2-{-methyl-3-(trifluoromethyl)benzoyloxymethyl} phenyl] -2 - methoxyamphetamine;
either connection C (EP-381330)

where R8denotes halogen or1-C4-alkyl, preferably chlorine;
either connection IIL
N-(3'-(1'-chloro-3-methyl-2'-oxapentane))-3,5-dichloro-4-methylbenzamide (EP-600629);
either connection M (EP-551048 and WO 96/03044) (S)-1-aniline-4-methyl-2-methylthio-4-phenylimidazole-5-one;
or with the compound of the formula IIN (WO 98/25465);
-{[(-methyl-3 - trifloromethyl)imino] oxy] -ortho-tolyl]glyoxalase acid (EP-569384) is especially effective for combating or preventing fungal diseases of cultivated plants. These combinations have synergistic fungicidal activity.

The combinations according to the invention can also include more than one active substances constituting the component (b), if you want to expand the range of controlled diseases.

Combinations of active substances are effective against phytopathogenic fungi belonging to the following classes: Ascomycetes (for example Venturia, Podosphaera, Erysiphe, Monilinia, Mycosphaerella, Uncinula); Basidiomycetes (for example, R. Hemileia, Rhizoctonia, Puccinia); imperfect fungi (for example Botrytis, Helminthosporium, Rhynchosporium, Fusarium, Septoria, Cercospora, Alternaria, Pyricularia and Pseudocercosporella herpotrichoides (Tapesia spp. )); Oomycetes (e.g., Phytophthora, Peronospora., Bremia, Pythium, Plasmopara).

Subject to the protection of cultural plants falling under the scope of the present invention include, for example, the following species of plants: cereals (wheat, barley, rye, oats, rice, sorghum and related crops); beet (sugar beet and fodder beet); stone fruit, pome fruit, berry crops (apples, pears, plums, peaches, almonds, cherries, strawberries, podsolnechnikovye, coconut, castor, cocoa beans, groundnuts); cucumber plants (pumpkins, cucumbers, melons); fibre plants (cotton, flax, hemp, jute); citrus crops (oranges, lemons, grapefruit, mandarins); vegetables (spinach, lettuce, asparagus, cabbage, carrots, onions, tomatoes, potatoes, peppers); Laurel crops (avocado, cinnamon tree, camphor tree), or plants such as maize, tobacco, nuts, coffee, sugar cane, tea, vines, hops, bananas and natural rubber plants, as well as ornamentals (flowers, shrubs, deciduous trees and evergreen trees such as conifers). This list does not restrict the scope of the invention.

The combination of the present invention is especially effective against Phytophthora, Peronospora., Bremia, Pythium and Plasmopara, in particular against pathogens monocotyledonous plants such as cereals, including wheat and barley.

The number of combinations according to the invention, which should be applied should depend on various factors, such as the use of connection object processing (plant, soil, seed), the type of processing (for example, spraying, dusting, drazhirovanie seeds), the aim of treatment (prophylactic or therapeutic), the type of fungus, p. the receiving of the formula I are those compounds representing the component (b), as IIB, IIG, IIH, C or IIL.

Other preferred components for mixing with the compound of the formula I are those compounds constituting component (b), as M, IIN, IIP or IIQ.

Another embodiment of the present invention is a combination comprising as component a) a compound of the formula I as component b) a compound of formula IIC, IID, IIE, IIF and IIJ.

Another embodiment of the present invention is a combination comprising as component a) a compound of the formula I as component b) a compound of formula IIA.

With the invention it has been unexpectedly discovered that the use of the compounds of formula I in combination with the compounds of formula II substantially increases the effectiveness of the latter compounds against fungi and Vice versa. Furthermore, the method according to the invention are effective against a broader spectrum of fungi that can be eliminated with the help of active substances according to the invention when they are used.

The mass ratio of components a): b) is chosen so as to obtain a synergistic fungicidal effect. In General, the mass ratio of a):b) is pozicii a) + (b) above, than the sum of the fungicidal action of each of components a) and b) separately.

If component b) is a compound of formula IIA, the mass ratio of a): b) is, for example, in the range from 6:1 to 1:6, preferably from 2:1 to 1:2.

If component b) is a compound of formula IIB, the mass ratio of a):b) is, for example, in the range from 5:1 to 1:20, preferably from 2:1 to 1:20 and most preferably from 1:1 to 1:10.

If component b) is a compound of formula IIC, the mass ratio of a): b) is, for example, in the range from 5:1 to 1:5, preferably from 3:1 to 1:3 and most preferably from 2:1 to 1:2.

If component b) is a compound of formula (IID), the mass ratio of a): b) is, for example, in the range from 5:1 to 1:5, preferably from 3:1 to 1:3 and most preferably from 2:1 to 1:2.

If component b) is a compound of formula IIE, the mass ratio of a): b) is, for example, in the range from 5:1 to 1:5, preferably from 3:1 to 1:3 and most preferably from 2:1 to 1:2.

If component b) is a compound of formula IIF, the mass ratio of a): b) is, for example, in the range from 5:1 to 1:5, prefer the mules IIG, the mass ratio of a): b) is, for example, in the range from 5:1 to 1:5, preferably from 3:1 to 1:3 and most preferably from 2:1 to 1:2.

If component b) is a compound of formula IIH, the mass ratio of a): b) is, for example, in the range from 5:1 to 1:5, preferably from 3:1 to 1:3 and most preferably from 2:1 to 1:2.

If component b) is a compound of formula IIJ, the mass ratio of a): b) is, for example, in the range from 5:1 to 1:5, preferably from 3:1 to 1:3 and most preferably from 2:1 to 1:2.

If component b) is a compound of formula C, the mass ratio of a):b) is, for example, in the range from 5:1 to 1:20, preferably from 3:1 to 1:10 and most preferably from 2:1 to 1:5.

If component b) is a compound of formula IIL, the mass ratio of a): b) is, for example, in the range from 5:1 to 1:5, preferably from 2:1 to 1:2 and most preferably from 1.5:1 to 1:1,5.

If component b) is a compound of formula M, the mass ratio of a): b) is, for example, in the range from 5:1 to 1:5, preferably from 2:1 to 1:2.

If component b) is a compound of formula IIN, mass sootnosheniem a compound of formula IIP, the mass ratio of a): b) is, for example, in the range from 6:1 to 1:6, preferably from 2:1 to 1:2.

If component b) is a compound of formula IIQ, the mass ratio of a): b) is, for example, in the range from 6:1 to 1:6, preferably from 2:1 to 1:2.

The method according to the invention includes the treatment of the plants or their habitat an effective fungicide total, in a mixture or separately, the compounds of formula I and the compounds constituting component (b).

The concept of "habitat" in the context of this description refers to fields that are cultivated cultivated cultivated plants or who sowed seeds of cultivated plants, or to the place where you planted seed. The concept of "seed material" means material for propagation, such as cuttings, seedlings, seeds, sprouted or soaked seeds.

New combinations are highly effective against a broad spectrum of phytopathogenic fungi, in particular from the classes of imperfect fungi and Oomycetes. Some of them have a systemic effect and can be used as fungicides for treatment of leaves and soil fungicides.

Fungicidal combined their seeds, especially on such crops as wheat, rye, barley, oats, rice, maize, lawns, cotton, soybeans, coffee, sugarcane, fruit and ornamental crops in the horticulture and viticulture, and in vegetables such as cucumbers, beans and pumpkins.

Combinations used by processing directly mushrooms or seed, plant or materials, which threatens to defeat mushrooms, or soil effective as a fungicide number of active substances.

Agents can be introduced before or after infection of the materials, plants or seeds by the fungi.

New combinations are especially useful for combating plant diseases caused by the following pathogens:
Erysiphe graminis on cereals,
Erysiphe cichoracerum and Sphaerotheca fuliginea on the pumpkins
Podosphaera leucotricha on Apple trees,
Uncinula necator on grapes,
Puccinia spp. on grain,
Rhizoctonia spp. on cotton, rice and lawn grasses,
Ustilago spp. on cereals and sugar cane,
Venturia inaequalis (scab pathogen) on Apple trees,
Helminthosporium spp. on grain,
Septoria nodorum on wheat,
Septoria tritici on wheat soft white-grained,
Rhynchosporium secalis on barley,
Botrytis cinereae (the causative agent of grey mold) on strawberries, tomatoes and grapes,
Cercospora arachidicola the rpotrichoides (Tapesia spp.) on wheat and barley,
Pyrenophera teres on barley,
Pyricularia oryza rice,
Phytophthora infestans on potatoes and tomatoes,
Fusarium spp. and Verticillium spp. on various plants
Plasmopara viticola on grapes,
Alternaria spp. on fruits and vegetables.

For processing plants compound of formula I is used at a rate of from 50 to 200 g/ha, preferably from 75 to 150 g/ha, for example 75, 100 or 125 g/ha, in combination with a compound selected from components b), which is used at a rate of from 50 to 1500 g/ha, preferably from 60 to 1000 g/ha, for example 75, 80, 100, 125, 150, 175, 200, 300, 500 or 1000 g/ha, depending on the class of chemicals used as component b). If component b) is a compound of formula IIA, then it is used in combination with the compound of the formula I in the normal flow, for example, from 50 to 400 g D. C./ha If the component b) is a compound of formula IIB, it is used in combination with the compound of the formula I in the normal flow, for example, from 50 to 1500 g D. C./ha If the component b) is a compound of formula IIC, it is used in combination with the compound of the formula I in the normal flow, for example, from 50 to 300 g D. C./ha If the component b) is a compound of formula IID, then it is used in combination with the compound of the formula I in the normal flow, for example and with the compound of the formula I in the normal flow, for example, from 50 to 300 g D. C./ha If the component b) is a compound of formula IIF, it is used in combination with the compound of the formula I in the normal flow, for example, from 50 to 300 g D. C./ha If the component b) is a compound of formula IIG, it is used in combination with the compound of the formula I in the normal flow, for example, from 50 to 400 g D. C./ha If the component b) is a compound of formula IIH, it is used in combination with the compound of the formula I in the normal flow, for example, from 50 to 400 g D. C./ha If the component b) is a compound of formula IIJ, it is used in combination with the compound of the formula I in the normal flow, for example, from 50 to 300 g D. C./ha If the component b) is a compound of formula C, it is used in combination with the compound of the formula I in the normal flow, for example, from 20 to 2000 D. C./ha If the component b) is a compound of formula IIL, then it is used in combination with the compound of the formula I in the normal flow, for example, from 50 to 200 g D. C./ha If the component b) is a compound of formula M, it is used in combination with the compound of the formula I in the normal flow, for example, from 50 to 200 g D. C./ha If the component b) is a compound of formula IIN, it is used in a compound of formula IIP, it is used in combination with the compound of the formula I in the normal flow, for example, from 50 to 400 g D. C./ha If the component b) is a compound of formula IIQ, it is used in combination with the compound of the formula I in the normal flow, for example, from 50 to 400 g of nutrient content/ha.

In agricultural practice, norms of consumption depend on the type of exposure and range from 0.02 to 3 kg of active substance per hectare.

If the active substances used for seed treatment, is usually sufficient to use the consumption rate of from 0.001 to 50, and preferably from 0.01 to 10 g/kg seed.

The invention also relates to fungicidal compositions comprising a compound of formula I and the compound constituting the component (b).

The composition according to the invention can be applied in any conventional form, for example in the form of double packaging, soluble granules, flowable or wettable powder, in combination with an acceptable agricultural adjuvants. Such compositions can be obtained in the usual way, for example by mixing the active ingredients with appropriate adjuvants (diluents or solvents, and optionally with other members of the preparative form ingredients, which are compounds, which are usually used for the manufacture of preparative forms, such as, for example, natural or regenerated mineral substances, solvents, dispersing agents, wetting agents, adhesives, thickeners, binders or fertilizers. Such carriers are described, for example, in WO 96/22690.

The specific composition to be applied in the form of spraying, such as dispersible in water concentrates or wettable powders, may contain surfactants such as wetting and dispersing agents, for example condensation products of formaldehyde and naphthalenesulfonate, alkylarylsulfonate, ligninsulfonate, aliphatic alkylsulfate and ethoxylated alkylphenol and an ethoxylated aliphatic alcohol.

Composition intended for drazhirovanija seeds, causing the seeds are well known manner, using a combination according to the invention and a diluent acceptable for drazhirovanija seeds preparative form, for example in the form of aqueous suspensions or in the form of a dry powder having good adhesive properties in relation to seeds. Such compositions intended for drazhirovanija seeds, well known in this region is of active substances in capsulated form, for example in the form of capsules with a slow release of the active substances or in the form of microcapsules.

In General, the compositions include from 0.01 to 90 wt.% active ingredient, from 0 to 20% of the accepted agricultural surfactant and 10 to 99.99% solid(s) or liquid (s), adjuvant(s), active ingredient includes at least a compound of formula I with a compound selected from components b) and optionally other active substances, in particular guazatine and fenpiclonil. Concentrated forms of the compositions generally contain from about 2 to 80%, preferably from about 5 to 70 wt.% the active substance. Used for the processing composition may, for example, contain from 0.01 to 20 wt.%, preferably from 0.01 to 5 wt.% the active substance.

Examples of specific compositions in the form of these combinations are described, for example, in WO 96/22690, and represents, for example, wettable powders, emulsion concentrate, dusty, extruded pellets, granules, coated, suspension concentrate.

Suspension capsules slow release
28 parts of a combination of compounds of formula I and compounds selected from components b), or each of these with the ia-NAT/mixture polietilen-polyphenylisocyanate. This mixture emuleret in a mixture, containing 1.2 parts of polyvinyl alcohol, 0.05 part of antifoam and 51.6 parts of water, to obtain particles of the desired size. To this emulsion is added a mixture containing 2.8 parts of 1,6-diaminohexane 5.3 parts of water. The mixture is stirred until completion of the polymerization reaction.

The resulting suspension capsules stabilized by adding a 0.25 parts of a thickening agent, and 3 parts of dispersing agent. The composition is in the form of a suspension of capsules contains 28% of active substances. The average diameter of the capsules is 8-15 microns.

The resulting composition is applied to seeds in the form of a water suspension using a device suitable for this purpose.

At that time, as concentrated compositions are more preferred as marketed products, direct consumer typically uses dilute compositions.

Biological examples
It is believed that there is a synergistic effect, if the activity of the combination of active substances is higher than the sum of the activities of the individual components.

The value of E, i.e., the activity expected for a given combination of active substances, are estimated using the so-called Colby formula as follows (Colby, S. R. "Calculati the existing substances (D. C.) per liter of mixture for spraying;
X means the activity (in %) of the active substance I using p ppm million active substance;
Y means the activity (in %) of the active substance II when using q frequent./million active substance.

According to the Colby formula the expected (additive) activity of the active ingredients I+II using p+q ppm million active substance is:
,
if you have received actually is (On) is higher than the expected value (E), the activity of the combination is vergadain, i.e., has a synergistic effect.

In another embodiment, a synergistic effect can be determined from the curves of dependence of activity on the dose according to the so-called method of Wadley. According to this method, the efficiency of nutrient content is determined by comparison of the extent of damage by the fungus treated plants and untreated, similarly infected and grown in the same conditions, the control plants. Every nutrient content test in 4-5 concentrations. The curves of dependence of activity on the dose used to determine the values of the EU90(i.e., the concentration of nutrient content, providing 90% eradication of the disease) of individual compounds as well as combinations of the compound compared with the values which could be obtained if there were only an additive effect of the components of the EU90(A+B)projection. Is EU90(A+B)projectioncounting method Wadley (Levi and others, EPPO-Bulletin 16, 1986, 651-657):
,
where a and b denote the mass ratio of the compounds a and B in the mixture and indexes (A), (B) and (A+B) are obtained in reality the values of the EU90compounds a, B or the combination of A+B. the Ratio EU90(A+B)projection/EU90(A+B)recipis coeeficient interaction (F). In the case of synergism F>1.

Example-1: Residual protective action against Venturia inaequalis on Apple trees
Cuttings of Apple with fresh shoots length of 10-20 cm are sprayed until drops of water mix to spray obtained from the preparative form of a mixture of active substances in the form of wettable powder, and after 24 h infect suspension of conidia of the fungus. The plants are incubated for 5 days at a relative humidity of 90-100% and then kept in a greenhouse for a further 10 days at 20-24oC. Assess the defeat of the fungus through 12 days after infection.

Example b-2 (a): Activity against Botrytis cinerea on apples
Artificially p is operativnoy form of a mixture of active substances. The treated fruits are then inoculant spore suspension of the fungus and incubated for 1 week at high humidity and a temperature of about 20oC. the Fungicidal activity of the tested mixture of compounds is determined by the number of damaged places that have started to rot.

Example b-2 (b): Activity against Botrytis cinerea on tomatoes
4-week-old plants of tomato varieties "Roter Gnom" process preparative form of test compounds in the chamber for spraying. 2 days after treatment the plants tomatoes inoculant by spraying pilot plants suspensory dispute. Assess the symptoms of the disease after incubation in a growth chamber for 4 days at 20oC and a relative humidity of 95%.

Example b-2(in): Activity against Botrytis cinerea on grapes
5-week-long shank grapes "Gutedel" process preparative form of test compounds in the chamber for spraying. 2 days after treatment the plants grapes inoculant by spraying pilot plants suspensory dispute. Assess the symptoms of the disease after incubation in the greenhouse for 4 days at 21oC and a relative humidity of 95%.

Example b-3: Activity against Podosphaera leucotriha on the stalk of the Apple
the Noi form of a mixture of active substances. Treated plants after 24 h infect suspension of conidia of the fungus and placed in the artificial climate chamber at a relative humidity of 70% and a temperature of 20oC. Assess the defeat of the fungus through 12 days after infection.

Example b-4: Activity against Cereals teres on barley
10-day plants of barley cultivar Golden Promise" spray mixture for spraying, obtained from the preparative form of a mixture of active substances. Treated plants after 24 h infect suspension of conidia of the fungus and incubated in the artificial climate chamber at a relative humidity of 70% and a temperature of 20-22oC. Assess the defeat of the fungus through 5 days after infection.

Example B-5: Efficacy against Erysiphe graminis f. sp. tritici on wheat
5-10 seeds of wheat cultivar Arina" sown in plastic pots with a diameter of 7 cm and grown for 7-12 days at 20oC and relative humidity of 50-70%. When the primary leaves are fully opened, the plants are treated by spraying with aqueous solutions for spraying containing individual compounds or mixtures thereof (hereinafter called forth century). All of the connections are in the form of experimental or marketed preparative forms, combination the nodding leaves almost to the dripping (for each treatment using three flower pot). At 24 h after treatment or for 24 h before processing plants inoculant in the chamber for insemination of fresh spores Erysiphe graminis f. sp. tritici. Then the plants are incubated in growth chamber at 20oC and relative humidity of 60%. 7 days after inoculation to determine the lesion (in percent) primary leaves. The efficiency of nutrient content is determined by comparison of the extent of damage by the fungus treated plants and untreated, similarly infected and grown in the same conditions, the control plants. Every nutrient content test in 4-5 concentrations. The coefficient of synergy calculated according to Colby.

Example B-6: Activity against Uncinula necator
4-week-old plants of grapes (4-5 leaves) sprayed almost to the dripping of a suspension containing 250 mg/l of active ingredient. Then caused to the suspension allowed to dry. After 1 day of treated plants inoculant by pollination of the test plants freshly harvested codename; then plants incubated in growth chamber for 10-14 days at 22oC and relative humidity of 70%. The effectiveness of the test compounds is determined by comparing the extent of damage by the fungus treated plants and untreated,these examples showed high activity.

Example B-7: Activity against Plasmopara viticola on grapes
The shank of the grapes at the stage of 4-5 leaves sprayed until dripping water mixture for spraying (0.02% of active substance) prepared from wettable powder of the mixture of active substances, and after 24 h infect suspension of sporangia of the fungus. Defeat the fungus is evaluated after incubation for 6 days at a relative humidity of 95-100% and at a temperature of 20oC.

Example B-8: Activity against Phytophthora infestans on tomato plants
(a) Medical action
Plants of tomato varieties "Roter Gnom" grown for 3 weeks and then sprayed with a suspension of zoospores of the fungus and incubated in a chamber at 18-20oWith and saturated atmospheric humidity. Hydration stopped after 24 hours After the plants had dried, they are sprayed with mixture resulting from the wetting of the powder of active substances in a concentration of 200 ppm million After received in the spray coating had dried, the plants are returned to a hydrating chamber for 4 days. The number and size of the typical damage of leaves that emerged after this period of time, used as a criterion in assessing the effectiveness of the test compounds.

b) a Protective system de frequent./million (relative to the volume of soil) to the soil surface 3-week-old tomato plants of the variety "Roter Gnom", grown in pots. After 3 days the underside of leaves are sprayed with a suspension of zoospores of Phytophthora infestans. then the plants are incubated for 5 days in the chamber for spraying at 18-20oWith and saturated atmospheric humidity. After this time period appear typical damage, the size and number of which are used to evaluate the effectiveness of the tested substances.

Example B-9: Activity against Phytophthora on potato plants
a) Residual protective action
2-3-week-old potato plants (cultivar Bintje) grown for 3 weeks and then sprayed with a mixture for spraying (0.02% of active substance) prepared from formulations of the test compounds in the form of wetting of the powder. After 24 hours the treated plants are infected by a suspension of sporangia of the fungus. Defeat the fungus evaluated after incubation of the infected plants for 5 days at a relative humidity of 90-100% and 20oC.

b) System action
2-3-week-old potato plants (cultivar Bintje) were grown for 3 weeks, pour mixture for spraying (0.02% of active substance relative to the volume of soil) prepared from formulations of the test compounds in the form of wetting I plants. After 48 hours the treated plants are infected by a suspension of sporangia of the fungus. Defeat the fungus evaluated after incubation of the infected plants for 5 days at a relative humidity of 90-100% and 20oC.

The effectiveness of testing combinations and individual active substances in the above experiments is determined by comparison of the extent of damage the fungus with the degree of the damage untreated, similarly inoculated control plants.

The invention is illustrated by the following examples.

Example 1
Test for protection against Sphaerotheca fuliginea
(on the culture of cucumbers)
Solvent: 49 parts by weight of acetone
Emulsifier; 1 part by weight alkylarylsulphonates ether
To prepare a suitable preparation of 1 part by weight of active compound is mixed with the specified amount of solvent and emulsifier, and the resulting concentrate is diluted with water to the desired concentration or experimental or sales composition is diluted with water to the desired concentration.

For testing protective activity, young plants are sprayed with a preparation of active compound at the specified coverage rate. After drying infect plants with an aqueous suspension of the atmospheric humidity of approximately 70%.

Testing is carried out after 7 days after infection. 0% means an efficacy in the control, 100% means no signs of illness.

The data table. 1A and b clearly show that the observed activity of the combinations of active compounds according to the invention is higher than the calculated activity, i.e. there is a synergistic effect.

Example 2.

Test for protection against Sphaerotheca fuliginea (culture cucumbers)
Solvents: 24.5 parts by weight of acetone
24.5 parts by weight of dimethylacetamide
Emulsifier: 1 part by weight alkylarylsulphonates ether
To prepare a suitable preparation of 1 part by weight of active compound is mixed with the specified amount of solvent and emulsifier, and the resulting concentrate is diluted with water to the desired concentration or experimental or sales composition is diluted with water to the desired concentration.

For testing protective activity, young plants are sprayed with a preparation of active compound at the specified coverage rate. After drying plants infect aqueous spore suspension Sphaerotheca fuliginea. Then the plants are placed in a greenhouse with a temperature of approximately 23oC and a relative atmospheric humidity priblizitel the lack of signs of illness.

The data table. 2A-2d show clearly that the observed activity of the combinations of active compounds according to the invention is higher than the calculated activity, i.e. there is a synergistic effect.


Claims

1. A method of combating phytopathogenic diseases of cultivated plants, including processing of cultivated plants or their habitats infected with a pathogenic disease, in the form of a mixture or separately, a synergistic effective amount of a combination of the first component representing a)O-methyloxymorphone-[-{[(-methyl-3-trifloromethyl)imino]oxy}-ortho-tolyl]glyoxalase acid (I) in combination with (b) a second component selected from a range that includes
or anilide formula IIB

where R1denotes fluorine or chlorine;
or a carbamate of the formula IIC

where X denotes N or CH and R2denotes 4-CH3, 4-CL or 2,4-dichloro;
or the connection IID
methyl(2)-2- { 2- [6-(trifluoromethyl)pyrid-2-intoximeter]phenyl}-3-ethoxyacrylate
or the connection IIE
(E)-N-methyl-2-[2- (2,5-dimethylphenoxy)phenyl] -2-methoxyimino-mi is br /> or (S)-valinamide formula IIG

where R4denotes isopropyl, sec-butyl or tert-butyl and
R5represents 4-chlorophenyl, 4-were, 4-methoxyphenyl or-naphthyl,
and where the asymmetric center preferably has the (R) configuration; or (S)-valinamide formula IIH

where R6denotes isopropyl, sec-butyl or tert-butyl;
R7denotes halogen, methyl or methoxy;
n is 0, 1 or 2;
or the connection IIJ
N-methyl-2- [2- {-methyl-3-(trifluoromethyl)benzoyloxymethyl} phenyl]-2 - methoxykynuramine;
or a compound of the formula C

where R8denotes halogen or1-C4alkyl, preferably chlorine;
or the connection IIL
N- (3' - (1' -chloro-3-methyl-2' -oxapentane)) -3,5-dichloro-4-methylbenzamide;
or the connection M
(S)-1-aniline-4-methyl-2-methylthio-4-phenylimidazole-5-he;
or a compound of the formula IIN

either the compound of formula IIP;

or the connection IIQ
O-methyloxime amide N-methyl-2-[-{[(-methyl-3-triptoreline the formula IIB, IIG, N, K and IIL.

3. The method according to p. 1, where component b) is chosen from the group comprising compounds of formula IIC, IID, IIE, IIF and IIJ.

4. The method according to p. 1, where component b) is chosen from the group comprising compounds of formula M, IIN, IIP or IIQ.

5. The method according to any of paragraphs.1-4, where the components a) and b) is applied in an amount to provide a synergistic effect against disease, particularly a synergistic fungicidal activity.

6. Fungicidal composition comprising effective as a fungicide combination of (a) compounds of formula I on p. 1 in combination b) or with the compound of the formula IIB or a compound of formula IIC, or with the compound (IID), or a compound IIE, or with a compound of formula IIF, or with the compound of the formula IIG, or with a compound of formula IIH, or connection IIJ, or with the compound of the formula C or connection IIL, or with the compound of the formula M, or with the compound of the formula IIN, or with a compound of formula IIP, or connection IIQ, as defined in paragraph 1.

7. The composition according to p. 6, in which the mass ratio of a):b) ranges from 10:1 to 1:20.

8. The composition according to p. 6, where component b) is chosen from the group comprising compounds of formula IIB, IIG, IIH, C and IIL.

9. The composition according to p. 6, where component b) is chosen by yuppy, including compounds of formulas M, IIN, IIP and IIQ.

Priority points and features:
08.06.1998 - PP.1-10, including mixtures containing components II B,C,D,E,F,G,H,J,K,Z,M;
17.02.1999 - PP.1-10, including mixtures containing components II N,P,Q.

 

Same patents:

The invention relates to the field of pest control, in particular fungicidal tool and method of combating fungi

The invention relates to the field of pest control, in particular fungicidal tool and method of combating fungi

The invention relates to the field of pest control, in particular fungicidal tool and method of combating fungi

The invention relates to a new compound exhibiting fungicidal activity

The invention relates to cosmetic and concerns preservative containing iodopropynyl and Phenoxyethanol in a mass ratio of 1:90 to 1: 400

The invention relates to a means to control weeds, in particular to the herbicide agent containing as an active ingredient (A) nitrile 1-(3-chloro-4,5,6,7-tetrahydropyrazolo-[1,5-a]-pyridine-2-yl)-5-(methylpropylamine)-4-pyrazolecarboxylate acid, and optionally, as an active ingredient (B) a substance selected from the group comprising bentazon, molinet, Diuron, thiobencarb, butachlor, pretilachlor, timepart, fenoxaprop-ethyl, clomipram, cinmetacin, bromobutyl, chinkara, mefenacet, pyrazosulfuron-ethyl, asbroker, chinaculture, tanishlar, cumyluron, MK 243, nitroanilide, anilofos, belforest, bifenox, SN-900, MSRA, nitrofen, oxadiazon, pendimethalin, simetryn, sulcotrione (SA), trifluralin, piperophos, perimutter, ethoxysulfuron, benzylbromide, pyrazolate, paradoxien, benzefoam, cycloaliphatic, cyhalofop, NBA-061 and azimsulfuron

The invention relates to biocidal compositions and, in particular, synergistic mixtures or combinations galanopoulou connection and serosoderjaschei s-triazine

The invention relates to herbicide compositions containing herbicide derived sulfonylureas and at least one serviced, choose from a wide range of serviceof

The invention relates to derivatives of heterocyclic compounds, as well as agricultural and horticultural fungicides containing these compounds as active ingredients

The invention relates to substances which are able to suppress the vital activity of bacteria, and can be used to prevent the growth of sulfate reducing bacteria in different technological environments, particularly in the oil industry
Up!