Biologically active additive "emotional plus"

 

The invention relates to medicine, namely the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes. The drug contains product processing herbs St. John's wort and magnesium compound - Asparaginate magnesium, dry concentrate of the extract of Rhaponticum, dry concentrate of the extract of Rhodiola rosea, dry concentrate decoction of coffee, pollen, cocoa, citric acid, starch, wheat bran, calcium stearate and sugar. The additive reduces or eliminates mental stress, fear, anxiety. table 1.

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as an auxiliary tonic and mild sedative.

Known biologically active additive to food (BAD) - "Stress Aid" (Pilate T. L. et al. Kazakhstan registry biologically active additives to food. - Almaty: Leovic, 2000, S. 98), which includes vitamins C, B1In2In3In5In6B12, folic acid, Biotin, choline, Inositol, paraminobenzoic acid, flowers osenia. Promotes longer to preserve health, eliminates drowsiness, sharpens vision, increases the body's resistance.

The disadvantage of the drug is observed in individual patients, individual intolerance to some of the components of the drug.

Known biologically active additive to food (BAD) - "St John's Wort" (Pilate T. L. et al. Kazakhstan registry biologically active additives to food. - Almaty: Leovic, 2000, S. 98), which includes St. John's wort, vitamin b6, folic acid, quercetin. Antidepressant, analgesic agent, stimulates the glands of internal secretion. Anti-inflammatory, antimicrobial, hemostatic effect.

The disadvantage of the drug is observed in individual patients, individual intolerance to some of the components of the drug.

Known biologically active additive to food (BAD) - "Hyper" (Pilate T. L. et al. Kazakhstan registry biologically active additives to food. - Almaty: Leovic, 2000, S. 98), which includes St. John's wort, blocadren, hawthorn, vitamins C, B1In6B12magnesium carbonate. Comes in powder form, rastamann is the tool. It is an antidepressant, eliminates the feeling of fear and anxiety.

The disadvantage of the drug is observed in individual patients, individual intolerance to some of the components of the drug.

The objective of the invention is to develop a new affordable drug is a biologically active food supplements in tablet form, suitable for use and having a balanced complex of vitamins and minerals.

The invention is aimed at expanding the range of alternative antidepressant, tonic and sedatives, to compensate for individual intolerance to some of the components of known drugs.

This is achieved by the fact that the proposed drug, possessing tonic and antidepressant containing product processing herbs St. John's wort and magnesium compound. In contrast to the known composition is proposed as product processing herbs St. John's wort contains dry concentrate his tinctures, and as compounds of magnesium - Asparaginate magnesium. In addition, the additive includes dry concentrate of the extract of Rhaponticum, dry concentrate of the extract of Rhodiola rosea, dry concentrate blanch the following ratio of components a tablet weight of 0.36 g, g: Dry concentrate infusions of St. John's wort - 0,00017-0,0014 Dry concentrate of the extract of Rhaponticum - is 0.0002-0,0016 Dry concentrate of the extract of Rhodiola rosea - is 0.0002-0,0016 Dry concentrate decoction of coffee 0,00001-0,00008 pollen - 0,0250-0,1000 Cocoa 0,0050-0,0400 Asparaginate magnesium - 0,0025-0,0200 Citric acid - 0,0025-0,0200 Starch - 0,0200-0,0500
Wheat bran - 0,0100-0,0800
Calcium stearate - 0,0025-0,0200
Sugar - Rest
The drug is called "dietary Supplement "Emotional plus".

BAD "Emotional plus" is recommended for use as an antidepressant, tonic, tonic, sedative, vegetational, sleeping, eliminating Prasangika and intrasonics disorders, inversion of sleep, reduce mental stress tools. Reduces the excitability of the Central nervous system, normalizes the activity of the cardiovascular system, improves sleep quality.

Recommended for the prevention and adjunctive therapy in depression, increased nervous excitability, neurasthenic syndrome, insomnia, headaches due to nervous stress.

The formula is based on the biologically active components, reducing or eliminating not bioelectric activity of the frontal and occipital regions of the cerebral cortex of the brain, that leads to the development of inhibitory processes in the Central nervous system. This effect is particularly pronounced in cases when the Central nervous system is in the excited state.

They affect the Central nervous system by affecting currencybutyl acid in the brain, resulting in lower reflex excitability in the Central nervous system and increase the inhibitory processes in the neurons of cortical and subcortical brain structures.

The calming effect of these substances is manifested slowly but steadily. Gone is the feeling of tension, irritability, anxiety.

Sedative effects of the drug contributes to subjective improvement of sleep and sleep latency (time required to fall asleep), thus leaving no morning residual effects.

Components of the drug impact, calming and improving the cardiovascular system. At heart they act indirectly through the Central nervous system and directly on the heart muscle.

Neuroregulatory influence on the activity of the heart muscle is directly related to the sedative effect of the drug. Along with this, the components of the preparation is the giving of the heart muscle, preventing her fatigue.

The invention is illustrated by the following example.

Ground coffee in the amount of 0.29 kg load in a container and pour the purified water at room temperature of 4 kg and insist on a boiling water bath with frequent stirring for 35 minutes, then cooled to 45 min at room temperature. The broth is filtered, pressing plant material. If necessary, top up to the required amount of water. Filtered through 4 layers of gauze.

The output of broth (2% dry) 2,9 kg

The sugar in the number 66,70 kg weigh the bag on the scale, visually check for the presence of mineral and organic impurities, then in the absence of impurities crushed in the mill. For this sugar out of the bag load portions in the hopper. Powdered sugar through the bottom fitting of the mill gathering into a polyethylene bag, the ends of which are pre-fixed to the fitting. The bag is placed in the receiver.

The output of crushed sugar 65,9 kg

Wheat bran in the amount of 5.8 kg weigh the bag on the scale, visually check for the presence of mineral and organic impurities, then in the absence of impurities crushed in the mill. For this bran out of the bag load portions in the boot Bunkyo the positive fix on the fitting. The bag is placed in the receiver.

The output of crushed bran 5,72 kg

Cocoa beans in the amount of 2.9 kg weigh the bag on the scale, visually check for the presence of mineral and organic impurities, then in the absence of impurities crushed in the mill. To do this, cocoa beans out of the bag load portions in the hopper. Powdered cocoa through the bottom fitting of the mill gathering into a polyethylene bag, the ends of which are pre-fixed to the fitting. The bag is placed in the receiver.

The output of crushed cocoa 2,861 kg

Later in enameled capacity 5 l weighed 2.5 kg decoction of coffee, bring to a boil, stirring with a wooden spatula. Separately weigh the starch in the amount of 0.29 kg, placed in an enamel capacity of 3 l, add 0.4 kg decoction of coffee. Prepared suspension of starch contribute to the boiling flask with constant stirring, bring to a boil.

The output of starch paste 3,15 kg

In the enameled capacity 5 l bring to a boil 2 kg of water, add 1,43 kg citric acid, stirred until complete dissolution of the acid.

The output of 3.42.

Powdered sugar, bran, cocoa, pollen, starch, magnesium Asparaginate sift on the shaker through a sieve by tincture of St. John's wort, the extract of Rhodiola rosea extract of Rhaponticum, as well as the citric acid solution is filtered through four layers of gauze.

In a mixer with the cover open load 16,0 kg powdered sugar, add 1,43 kg Asparaginate magnesium. The mixture is stirred for 10 minutes. Then add 2,861 kg powdered cocoa, 5.72 kg bran and 10,01 kg of starch. Stirred for 10 minutes. Then add 14,3 kg pollen and remaining sugar 50 kg and stirred again for 10 minutes. Moisturize farmakopejnymi extract (4% dry) Rhaponticum carthamoides 2.9 kg, the extract (4% dry) Rhodiola rosea 2.9 kg and infusion (3,5% of dry) Hypericum 2.9 kg, stirred for 10 minutes, add the citric acid solution of 3.42 kg, stirred for 5 minutes. Then add the starch paste 3.15 kg and again stirred for 10 minutes.

The product yield 115,62 kg

The wet mass in the number 115,62 kg load portions in the device for producing granules from wet tablespace. Include a screw device, in which the mixture is forced through the mesh holes with a diameter of 4-5 mm

Hydrated tablets weight in the number 115,62 kg laid out on paper in the trays with a layer thickness of 1,5-2 see Trays install in a drying Cabinet. Include hot air in rasprodazha hot air is automatically disabled. The drying process is carried out for 8-10 hours until a constant weight at periodic stirring (not less than 3 times). The control end of the drying conduct in the laboratory by weighing samples of the product from the trays to a constant weight. The humidity of the product is not more than 2%. Dry tablet weight is directed to a dry granulation.

The output of the dry tablet weight 102,08 kg

The dried mixture in an amount of 100,941 kg load portions in the device for producing granules from dry tablespace. Include a screw device, in which the mixture is forced through the mesh holes with a diameter of 1.5 mm, the Dry granulate is collected in the receiver. From the receiver the dry granulate load when the cover is open in the mixer.

The yield of dry granulate 99,94 kg

To the dry granulated pellet mixture in a mixer add the sifted calcium stearate in an amount of 1.03 kg Include a stirrer and stirred for 10 minutes. The finished granulate is passed on tableting.

The output of the finished granulate 102 kg

13. From the mixer, the dry granulate is directed to tableting in the hopper tablet press machine. Turn on the engine. Pre-set engine speed in accordance with a bulk weight, �hr/177.gif">0.3 mm;
the height of the tablet 3,20.3 mm;
the average weight of the tablets 0.36g0,03.

During tabletting watching the machine work and quality tablets. Every 30 minutes check raspadaemost, the strength and the average weight of the tablets. Tablets that do not meet the requirements, rejected and sent for recycling. At the end of the process the machine off in the reverse order. Tablets are collected in the receiver and sent to the dust.

The product yield 101,50 kg

The finished tablets are sieved by the vibrating screen through a hole diameter of 8 mm, weighed 8 kg and load in a clean dry plastic bucket and pack up.

The output of finished tablets 101 kg

The sequence of operations is the same regardless of the number of prepared composition.

BAD "Emotional plus" contains the famous permitted for use in medical practice medicines which are in the specified combination (see table, examples 1-4) provide for the reduction or disappearance of symptoms.

As auxiliary components, ensuring reliability maintain the shape of the pressed pellets in a dry form and a short time raspadaemosti their Messiah. >Available in tablet form, which is convenient to use, has a long shelf life (2 years).

Clinical trials were conducted in the Department of neurology, Military hospital of the border troops of the national security Committee. For the past two months have been effectively applied BAD "Emotional plus in combination with tranquilizers and antidepressants (increases the effect) in the dose of 1 so x 3 times per day with a further increase of the dose up to 2 tons x 3 times a day to get a distinct therapeutic effect. BAD "Emotional plus appointed for emotional disorders (anxiety and hypochondria, depressive syndromes), psychosomatic reactions. In the subsequent abolition of the basic therapy recommended the continuation of the SBC "Emotional plus to avoid the syndrome. Bioactive additives require long-term use with repeated courses of treatment, preferably with basic therapy. The maximum effect of the drug observed in functional palindromic States. The drug enhances therapeutic activity of basic drugs, does not lead to drug resistance, does not cause adverse allergic reactions.

Clinical testing BAD "Emotional plus provoder "Mental Health Center" of Ministry of health of the Republic of Kazakhstan with 24.07.2000 on 25.09.2000. BAD "Emotional plus was administered in patients with primary unexpressed mental disorders. Register of clinical manifestations of the disease in these patients: different manifestations of sleep disorders, neurotic disorders, vascular depression mild and moderate. In children the participants were selected on neurotic manifestations and mental retardation. The drug was administered with parental consent. The results of testing the drug in 47% had a good result, 53% of the ulterior effect, no adverse events were noted, the deterioration was not observed. In General, the testing showed that BAD "Emotional plus effective for children, the elderly, with neurotic disorders.


Claims

The drug, possessing tonic and antidepressant action, including product processing herbs St. John's wort and magnesium compound, characterized in that the quality of the product processing herbs St. John's wort product contains dry concentrate its tincture, as compounds of magnesium - Asparaginate magnesium and additionally includes dry concentrate of the extract of Rhaponticum, dry concentrate of the extract of Rhodiola rosea, dry concentrate decoction of coffee, floral pilnie components on the tablet weight 0.36 g, g:
Dry concentrate infusions of St. John's wort - 0,00017-0,0014
Dry concentrate of the extract of Rhaponticum - is 0.0002-0,0016
Dry concentrate of the extract of Rhodiola rosea - is 0.0002-0,0016
Dry concentrate decoction of coffee 0,00001-0,00008
Pollen - 0,0250-0,1000
Cocoa 0,0050-0,0400
Asparaginate magnesium - 0,0025-0,0200
Citric acid - 0,0025-0,0200
Starch - 0,0200-0,0500
Wheat bran - 0,0100-0,0800
Calcium stearate - 0,0025-0,0200
Sugar - Ostalnoe

 

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