Dietary supplement stress minus" for the prevention and adjunctive therapy in levels of stress, mental and physical stress

 

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as a preventive and auxiliary means when levels of stress, mental and physical stress. The proposed dietary Supplement Stress minus", including dry concentrate of the extract of the herb lemon balm, dry concentrate of the extract of marjoram, dry concentrate of the extract of Rhodiola rosea, pollen, crushed ginger root, succinic acid, ascorbic acid, vitamin E, calcium gluconate, and starch, wheat bran, talc, calcium stearate and sugar in a mixing ratio in g a tablet weight of 0.55, the Use of this composition is firming and soothing means of compensating individual intolerance to some of the components of known drugs. table 2.

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as a preventive and support the Eski active food additive (BAA) - "Proteostasis" (Federal register biologically active additives to food./ Edited by Pilate T. L. - M. : Kohelet, 2001, S. 69), which includes flowers, rose hips, Linden flowers, fruits and leaves of raspberries, the fruit of fennel, buckthorn bark, grass water pepper, plantain leaves, grass, lemon balm, immortelle flowers, grass horsetail.

Recommended for use as a mild sedative and a tonic.

Known biologically active food Supplement - tea "Ivan Kuzmich 2" (Federal register biologically active additives to food./ Edited by Pilate T. L. - M.: Kohelet, 2000, S. 65), which consists of Valerian, hawthorn, lemon balm, hops, peppermint, chamomile. Recommended for use as a General tonic and mild sedatives.

Known biologically active food Supplement "pax" (Pilate T. L. et al. Kazakhstan registry biologically active additives to food. - Almaty: Leovic, 2000, S. 94), which includes lemon balm, lavender, vitamins of group b, N, PP, compounds of magnesium, calcium and excipients. Has a calming effect in stressful situations, protects against nervousness, excitement, a feeling of peace of mind without compromising performance, without pretee tool for toxicity during pregnancy, coughing, headaches.

A disadvantage of the known drugs is observed in individual patients, individual intolerance to some of the components of the drug.

The objective of the invention is to develop a new alternative available drug is a biologically active food supplements in tablet form, suitable for use and having a balanced complex of vitamins and minerals.

The invention is aimed at expanding the range of alternative restorative and sedatives, to compensate for individual intolerance to some of the components of known drugs.

The problem is solved in that the proposed dietary Supplement for the prevention and adjunctive therapy in levels of stress, mental and physical stress, including dry concentrate of the extract of the herb lemon balm, dry concentrate of the extract of marjoram, dry concentrate of the extract of Rhodiola rosea, pollen, crushed ginger root, succinic acid, ascorbic acid, vitamin E, calcium gluconate, and starch, wheat bran, talc, calcium stearate and sugar with the following ratio of components, g ) - 0,000015-0,00015 Dry concentrate of the extract of Rhodiola rosea - 0,00004-0,00040 pollen - 0,0010-0,010 Chopped ginger - 0,0010-0,010 Succinic acid - 0,0010-0,010 Ascorbic acid 0,0010-0,010 Vitamin E - 0,0010-0,010 calcium Gluconate - 0,0010-0,010
Starch - being 0.036
Wheat bran - 0.020
Talc - being 0.036
Calcium stearate - being 0.036
Sugar - Rest
A dietary Supplement called "Stress minus".

BAD Stress minus" is recommended for use as a General tonic, tonic, sedative, vegetational, sleeping, eliminating Prasangika and intrasonics disorders, inversion of sleep, reduce mental stress tools. Reduces the excitability of the Central nervous system, normalizes the activity of the cardiovascular system, improves sleep quality.

Recommended as a preventive and adjuvant levels of stress, mental and physical stress.

Biologically active additive "Stress minus" in the form of tablets obtained as follows.

In enamel container 15 l weighed shredded 0,572 kg herb balm and 0,572 kg marjoram, pour 12.6 kg of water at room temperature and insist on kitasaiwai, pressing plant material. If necessary, top up to the required amount of water. Filtered through 4 layers of gauze.

The yield of extract (1.5% of dry) 11 kg

The sugar in the number 67,9 kg weigh the bag on the scale, visually check for the presence of mechanical impurities, then in the absence of impurities crushed in the mill. For this sugar out of the bag load portions in the hopper. Powdered sugar through the bottom fitting of the mill gathering into a polyethylene bag, the ends of which are pre-fixed to the fitting. The bag is placed in the receiver.

The output of crushed sugar and 67.2 kg

Wheat bran in the amount of 5.9 kg weigh the bag on the scale, visually check for the presence of mechanical impurities, then, in the absence of impurities, crushed in the mill. This wheat bran out of the bag load portions in the hopper. Shredded wheat bran through the bottom fitting of the mill gathering into a polyethylene bag, the ends of which are pre-fixed to the fitting. The bag is placed in the receiver.

Output of wheat bran 5,8 kg

Ginger root in the amount of 1.5 kg is weighed in the bag on the scale, visually check for the presence of mechanical impurities, then when tststr. Crushed ginger root through the bottom fitting of the mill gathering into a polyethylene bag, the ends of which are pre-fixed to the fitting. The bag is placed in the receiver.

The output of crushed ginger root 1,43 kg

The pollen in the amount of 5.8 kg weigh the bag on the scale, visually check for the presence of mineral and organic impurities, then in the absence of impurities crushed in the mill. The pollen load portions in the hopper. Crushed pollen through the bottom fitting of the mill gathering into a polyethylene bag, the ends of which are pre-fixed to the fitting. The bag is placed in the receiver.

Output pollen 5,7 kg

In the enameled capacity 15 l bring to a boil 10 kg infusion of herbs lemon balm and oregano. Separately mix 0.8 kg of starch and 1 kg of the extract, the mixture is stirred and added to the boiling solution with constant stirring, bring to a boil.

The output of starch paste 11,7 kg

Powdered sugar, bran, ginger root, pollen, as well as calcium gluconate, succinic acid and ascorbic, vitamin E, starch is sifted through a sieve with the hole diameter of 1 mm, calcium stearate, talc sift through katodrytis cover load 10 kg of powdered sugar, add 0,572 kg of succinic acid, ginger root 1,43 kg, calcium gluconate 2.9 kg, stirred for 10 minutes, then add crushed bran 5.8 kg, pollen 5.7 kg, starch 9,5 kg (in terms of 100% of the drug), stirred for 10 minutes, then add to 57.2 kg of sugar and mix for another 10 minutes. Moisturize the extract of Rhodiola rosea (4% dry) 2.9 kg, stirred 5 minutes, and moisturize starch paste 11.7 kg, stirred for 10 minutes.

Yield 107,702 kg

The wet mass in the number 107,702 kg push through the unit to get wet granule with a hole in the mesh with a diameter of 4-5 mm

Hydrated tablets weight in the number 107,702 kg laid out on paper in the trays with a layer thickness of 1,5-2 see Trays install in a drying Cabinet. Include hot air distribution device of the drying Cabinet. Set the drying temperature 40-45oWith the increase of which the flow of hot air is automatically disabled. The drying process is carried out for 10 hours to a constant weight at periodic stirring (at least 3 times). The control end of the drying conduct in the laboratory by weighing samples of the product from the trays to a constant weight. Humidity product,902 kg

The dried mixture in an amount of 93,902 kg load portions in the device for producing granules from dry tablespace. Include a screw device, in which the mixture is forced through a mesh with holes of diameter 1.5 to 2.0 mm, the Dry granulate is collected in the receiver. From the receiver the dry granulate load when the cover is open in the mixer. To the dry granulated pellet mixture in the mixer and add the pre-mixed vitamin E 1,43 kg and ascorbic acid 5.8 kg, stirred for 10 minutes, then optivault of 1.03 kg of talc and 1.03 kg of calcium stearate. Include a mixer and stirred for 5 minutes. The finished granulate is passed on tableting.

The output of the finished granulate 102,0 kg

From the mixer, the dry granulate is directed to tableting in the hopper tablet press machine.

The tablet diameter 12,00.2 mm;
the height of the tablet 3,80.2 mm;
the average weight of the tablets 0.55 g0,03.

Every 30 minutes check raspadaemost, the strength and the average weight of the tablets. Tablets are collected in the receiver and sent to the dust.

The yield of 101.5 kg

The finished tablets are sieved by the vibrating screen through a hole diameter of 8 bleak 101 kg

The sequence of operations is the same regardless of the number of prepared composition.

BAD Stress minus" contains the famous permitted for use in medical practice medicines which are in the specified combination (table. 1, examples 1-4) ensures reduction of the excitability of the Central nervous system, normalizes the activity of the cardiovascular system, improves sleep quality.

As auxiliary components, ensuring reliability maintain the shape of the pressed pellets in a dry form and a short time raspadaemosti them in a humid environment, used starch, bran, sugar, and to improve the fluidity of the granulated calcium stearate and talc.

Available in tablet form, which is convenient to use, has a long shelf life (2 years). Tablets have good raspadaemost.

Clinical trials were conducted psycho-neurological dispensary 12, , Moscow (patients with stressinducing adjustment disorder).

During clinical trials was observed in patients with phobia exams, disorders of adaptive reactions, post-traumatic stress.

On initial examination in all patients otechnyh manifestations.

Patients who took SUPPLEMENTS of Stress minus", to 10 days of therapy noted the distinct dynamics of such symptoms as fatigue; weakness was observed only in 10% of patients, somatovegetative disorders (tremor, sweating, tachycardia) in 50% of cases. All patients who took SUPPLEMENTS of Stress minus" improved quality of sleep, diminished mood. A full course of clinical observations showed that 20 days of treatment BAD "Stress minus" well leveled mood even in elderly patients, where its effectiveness in relation to symptoms such as weakness, fatigue, anxiety, were insufficient.

BAD Stress minus most effective in patients with phobias exams and disorders of adaptive reactions, especially pronounced in young patients. The effect of the drug was significantly less pronounced in post-traumatic stress disorder in the elderly with a vascular pathology.

The efficiency of use of DIETARY Stress minus" in the treatment of stress conditions are shown in table 2, where the given values are the average of the conditional score, which was measured by the symptom and the symptom prevalence in the group of interest.

During use of SUPPLEMENTS was not observed n what are psychotherapy, lagged significantly behind in terms of intensity and pace compared to the main group. Especially slowly succumbed to regress asthenia, sleep disorders and somatovegetative disorders.

Thus, the BAD Stress minus sedative, vegetotherapy and hypnotic effects. May be recommended in the treatment of phobias exams, disorders of adaptive reactions and anxiolytic disorders, psycho-emotional overload.


Claims

Dietary Supplement for the prevention and adjunctive therapy in levels of stress, mental and physical strain, characterized in that it includes dry concentrate of the extract of the herb lemon balm, dry concentrate of the extract of marjoram, dry concentrate of the extract of Rhodiola rosea, pollen, crushed ginger root, succinic acid, ascorbic acid, vitamin E, calcium gluconate, and starch, wheat bran, talc, calcium stearate and sugar with the following ratio of components, g a tablet weight of 0.55 g:
Dry concentrate of the extract of the herb Melissa 0,000015-0,00015
Dry concentrate of the extract of marjoram - 0,000015-0,00015
Dry concentrate of the extract of Rhodiola rosea - 0,00 Ascorbic acid 0,0010-0,010
Vitamin E - 0,0010-0,010
Calcium gluconate - 0,0010-0,010
Starch - being 0.036
Wheat bran - 0.020
Talc - being 0.036
Calcium stearate - being 0.036
Sugar - Else-

 

Same patents:
The invention relates to medicine, in particular to pharmaceutical drugs used in the treatment of insomnia (difficulty falling asleep, night waking, early waking, secondary sleep disorders in mental disorders)
Medical center // 2195954
The invention relates to medicine and refers to compositions that have anti-stress effect, relieving emotional stress and normalizing sleep
The invention relates to medicine, namely to dentistry, and for sedation in dental surgeries

The invention relates to a new 2-{4-[4-(4,5-dichloro-2-Mei-1-yl)butyl]-1-piperazinil}-5-torpedinidae formula I (see

The invention relates to new derivatives of benzodioxole, benzofuran, dihydrobenzofuran and benzodioxane or their pharmaceutically acceptable solvate of General formula I

< / BR>
where Q1and Q2every means independently hydrogen or halogen;

X is CH2CH or oxygen;

Y represents CR3, CR3R4or (CH2)nwith n = 1-4;

Z denotes CH2CH or oxygen;

R means hydrogen, halogen or alkyl WITH1-4in both cases;

m denotes 1 or 2;

R1means1-6-alkyl, C3-6-cycloalkyl,1-3-haloalkyl,1-6-alkylamino,2-6alkenyl,1-4-alkoxy(C1-4)alkyl, C1-C4-alkylthio(C1-4)alkyl or triptorelin-C1-4;

R2means hydrogen, halogen or C1-4-alkyl; and

R3and R4each independently mean hydrogen or C1-4-alkyl,

containing pharmaceutical compositions for the treatment of sleep disorders, and disorders associated with disturbance of circadian rhythms

The invention relates to new arylpyrimidines compounds of formula I having the effect of antagonist 5HT2B-receptor, and pharmaceutical compositions

The invention relates to a new vysokomernoa tritium N-[3-(3-cyanopyridyl [1,5-a] pyrimidin-yl-)phenyl] -N-ethylacetamide formula I, which has a sedative effect and is agonist benzodiazepinovyh recipes
The invention relates to chemical-pharmaceutical industry, namely, creating a potent tranquilizer
The invention relates to medicine, and pharmacy, and can be used to obtain relief funds

The invention relates to analogs of 2-aminoindane General formula I, where R1and R2independently represent hydrogen, C1-C8alkyl; X is CH2R3or NHSO2R4; Y represents hydrogen, NHSO2R4, SO2(Ph); R3is NHSO2R4,

SO2R4, CONR1R2; R4represents C1-C8alkyl, phenyl or phenyl, substituted by-CN or-CF3; and their pharmaceutically acceptable salts, active receptor Dopamine D3

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as a means to reduce the risk of symptoms of menopausal syndrome

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as an aid in facilitating the regulation of the respiratory system
The invention relates to the field of medicine and relates to means neuroleptic action on the basis of haloperidol

The invention relates to a pharmaceutical composition comprising: 1) an antifungal agent, which is (-)-(2R-CIS-)-4-[4-[4-[4-[[5-(2,4-differenl)tetrahydro-5-(1H-1,2,4-triazole-1-ylmethyl)furan-3-yl] methoxy] phenyl] -1-piperazinil] phenyl] -2,4-dihydro-2-[(S)-hydroxypropyl]-3H-1,2,4-triazole-3-one, 2) at least one nonionic surfactant and (3) diluent

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used for the prevention and adjuvant therapy of hypotension and vascular dystonia

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as an auxiliary tonic and mild sedative

The invention relates to medicine, in particular to the drug based on an extract of motherwort, intended for the treatment of functional disorders of the Central nervous system

The invention relates to medicine

The invention relates to pharmaceutical compositions containing the inhibitor nm g COA reductase (E.)-7-[4-(4-forfinal)-6-isopropyl-2-[methyl(methylsulphonyl)amino] pyrimidine-5-yl]-(3R, 5S)-3,5-dihydroxide-6-envoy acid or its pharmaceutically acceptable salt as an active ingredient

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as an aid in facilitating the normalization of peripheral (capillary) blood circulation, including brain
Up!