Biologically active additive "vascular herbs for prevention and adjuvant therapy conducive to the normalization of cerebral and peripheral blood circulation

 

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as an aid in facilitating the normalization of peripheral (capillary) blood circulation, including the brain. The proposed biologically active additive "Vascular herbs containing dry concentrate decoction of the fruits of Aronia, dry concentrate decoction of leaves, cranberries, dry concentrate of the broth, marjoram, ginger root, rutin, garlic, ascorbic acid, calcium gluconate, starch, calcium stearate, sugar in a ratio of components a tablet weight of 0.55, the Composition promotes normalization of peripheral (capillary) blood circulation, including the brain, to compensate for individual intolerance to some of the components of known drugs. table 1.

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as an aid in facilitating the normalization per is ka to food "Antichain" / Pilate T. L. (ed ) Federal register of biologically active additives to food, -M, Kohelet, 2000, S. 245/, which includes garlic oil, lecithin, vitamin E. Recommended for use as a means of improving cerebral circulation and prevent the development of sclerosis of the blood vessels of the brain.

Known biologically active additive to food (BAD) - "Anti-Stroke" / Pilate T. L. et al. Kazakhstan registry biologically active additives to food, Almaty, Leovic, 2000, S. 142/, which includes pollen, hawthorn, Valerian, cinnamon, cloves, ginger, ascorbic acid, vitamin E, rutin, Asparaginate potassium, Asparaginate magnesium and excipients: starch, oats, calcium stearate, talc, sugar. Recommended for use as a General tonic, angioprotective tool, improves cerebral circulation and oxygen supply of brain tissue. Hypotensive, antiatherosclerotic agent, normalizes the activity of the cardiovascular system. Sedative, antioxidant effect. Comes in pill form and is used as a preventive and as a Supplement in the treatment of disorders of cerebral circulation, in the period of rehabilitation is connected in individual patients with individual intolerance to some of the components of the drug.

The objective of the invention is to develop a new affordable pharmaceuticals are biologically active supplements in pill form, suitable for use, for a compensation of individual intolerance to some of the components of known drugs.

The invention is aimed at expanding the range of alternative means conducive to the normalization of peripheral (capillary) blood circulation, including the brain, to compensate for individual intolerance to some of the components of known drugs.

This is achieved by the fact that the proposed dietary Supplement contains dry concentrate decoction of the fruits of Aronia, dry concentrate decoction of leaves, cranberries, dry concentrate of the broth, marjoram, ginger root, rutin, garlic, ascorbic acid, calcium gluconate, starch, calcium stearate, sugar in the following ratio of components a tablet weight of 0.55 g, g: Dry concentrate decoction of the fruits of Aronia - 0,000015-0,00015 Dry concentrate decoction of leaves of cowberry 0,000015-0,00015 Dry concentrate decoction of herbs oregano 0,0000075-0,000075 Root ginger - 0,0025-0,0100 Rutin - 0,0050-0,0500 Garlic - 0,0100-0,0750 Ascorbic acid 0,0100-0,0750 calcium Gluconate - 0,0100-0,0750 the Collapse of Aditya grass".

BAD "Vascular herbs recommended for use as an anti-inflammatory, Hypo-cholestyramine, angioprotective tool.

BAD strengthens the walls of blood vessels and capillaries, improves elasticity and tone, normalizes vascular permeability, improves metabolic processes in the walls of blood vessels and the microcirculation. Recommended for use as an adjuvant in the treatment of various angiopathies: lesions of the cerebral, coronary vessels, vessels of the lower limbs, rheumatic diseases, atherosclerotic vessels, venous disease congestive and inflammatory nature, trophic ulcers.

The invention is illustrated by the following example.

Biologically active additive "Vascular grass" in the form of tablets obtained as follows.

In the capacity of 10 l, a load of 0.7 kg of fruit Aronia, 12 kg of water at room temperature, insist on a boiling water bath for 45 min, then add pre-chopped marjoram - 0,185 kg and leaves cranberries - 0,37 kg, continue to insist with frequent stirring for 30 minutes, Cooled for 1 h at room temperature. The broth is filtered, pressing plant material. Filter Cerkno check for the presence of mechanical impurities, then, in the absence of impurities crushed in the mill. For this sugar load portions in the hopper. Powdered sugar through the bottom fitting of the mill gathering into a polyethylene bag, the ends of which are pre-fixed to the fitting. The bag is placed in the receiver.

The output of crushed sugar - 75,1 kg

The garlic in the amount of 3.8 kg weighed, visually check for the presence of mechanical impurities, then in the absence of impurities crushed in the mill. For this garlic load portions in the hopper. Chopped garlic through the bottom fitting of the mill gathering into a polyethylene bag, the ends of which are pre-fixed to the fitting. The bag is placed in the receiver.

The output of crushed garlic - 3,7 kg

The roots of the ginger in the number of 0.95 kg weighed, visually check for the presence of mechanical impurities, then in the absence of impurities crushed in the mill. To do this, the roots of the ginger out of the bag load portions in the hopper. Chopped ginger roots through the bottom fitting of the mill gathering into a polyethylene bag, the ends of which are pre-fixed to the fitting. The bag is placed in the receiver.

The output of crushed ginger - 0,93 kg

In Amelia this take 0.5 kg of starch and 0.8 kg of broth, mix and add to the boiling solution, bring to boil with constant stirring.

The product yield is 10 kg.

Crushed sugar, ginger, garlic, rutin, ascorbic acid, calcium gluconate, starch is sifted through a sieve with the hole diameter of 1 mm calcium stearate is sifted through a sieve with the hole diameter of 0.5 mm Water filtered through 4 layers of gauze.

In a mixer with the cover open load 30 kg powdered sugar, 3.7 kg of garlic and 4.65 kg of calcium gluconate, thoroughly stirred for 10 min, then add 9,4 kg of starch and 60 kg of sugar and stirred for 10 minutes the resulting mixture is moistened starch paste in the broth of 10 kg and a further stirred for 10 minutes

Yield - 93,7 8 kg.

The wet mass in the number 103,78 kg load portions in the device for producing granules from wet tablespace. Include a screw device, in which the mixture is forced through the mesh holes with a diameter of 4-5 mm Wet granules are collected in the receiver. From the receiver the wet granulate is passed for drying.

Yield - 103,28 kg
Hydrated tablets weight in the number 103,28 kg laid out on paper in the trays, with a layer thickness of 1.5-2 cm Trays installed in the drying slivaut temperature drying 40-50oWith the increase of which the flow of hot air is automatically disabled. The drying process is carried out for 10 h to a constant weight, with occasional stirring (not less than 3 times). The control end of the drying conduct in the laboratory by weighing samples of the product from the trays to a constant weight. The humidity of the product - not more than 2%. Dry tablet weight is directed to a dry granulation.

The output of the dry tablet weight - 94,6 kg

The dried mixture in an amount of 94.6 kg load portions in the device for producing granules from dry tablespace. Include a screw device, in which the mixture is forced through a mesh with holes of diameter 1.5 to 2.0 mm, the Dry granulate is collected in the receiver. From the receiver the dry granulate load when the cover is open in the mixer, add a mixture consisting of 4,65 kg of ascorbic acid, 1,85 kg rutin. Include a stirrer and stirred for 10 minutes Then upload 1.02 kg of calcium stearate. Stirred for further 10 minutes, the Dry granulate is directed to tableting.

The yield of dry granulate - 102,07 kg

From the mixer the dry granulate in the number 102,07 kg sent to tableting in the hopper tablet press machine.

Include the main results weight a compaction zone and the height of the tablet. When you start the machine turn on a vacuum cleaner.

The diameter of the tablets to 12.00.3 mm;
the height of the tablet is 3.80.3 mm;
the average weight of a tablet - 0.55 g0,02.

During tabletting watching the machine work and quality tablets. Every 30 min check raspadaemost, the strength and the average weight of the tablets. Tablets that do not meet the requirements, rejected and sent for reprocessing. At the end of the process the machine off in the reverse order. Tablets are collected in the receiver and sent to the dust.

Yield - 101,535 kg

The finished tablets in the number 100,5 kg sieved by the vibrating screen through a hole diameter of 8 mm, weighed 8 kg and load in a clean dry plastic bucket. Samples of finished tablets passed into the analytical laboratory for analysis. In accordance tablets norms technical documentation, prepared tablets passed the stage of packing.

The output of finished tablets - 101 kg

The sequence of operations is the same, regardless of the number of prepared composition.

BAD "Vascular grass" contains the famous permitted for skin is t be used as an adjuvant in the treatment of various angiopathies: cerebral lesions, the coronary arteries, the vessels of the lower limbs, rheumatic diseases, atherosclerotic vessels, venous disease congestive and inflammatory nature, trophic ulcers.

As auxiliary components, ensuring reliability maintain the shape of the pressed pellets in a dry form and a short time raspadaemosti them in a humid environment, used starch and sugar, and to improve the fluidity of the granulated calcium stearate.

Tablet form is easy to use and has a long shelf life (2 years).

Clinical trials were conducted on volunteers.

In clinical trials of dietary SUPPLEMENTS, "Vascular grass" was assigned patients with atherosclerotic vascular lesions of the lower extremities (Leriche's syndrome).

When admitted to hospital, the presence of pain at rest was said 10% of patients, moderate trophic disorders - 40% of patients. Distance walk up to the moment of occurrence of intermittent claudication in 70% of cases ranged from 20-30 to 100 m At ultrasonic dopplerography (USDG) in all patients of both groups noted the collateral nature of blood flow below the femoral artery (in the popliteal arteries and the arteries of the foot and lower indices lodygensky intensive conservative therapy in all patients reported a moderate improvement in clinical symptoms and the absence of pronounced trends in the incidence of blood circulation in the lower extremities according to the USDG (as it is usually observed).

After discharge from the hospital patients within 60 days were treated BAD "Vascular grass". Assessment of symptoms at 30 and 60 day outpatient period showed that the use of dietary SUPPLEMENTS "Vascular" at the outpatient stage in monotherapy provided good (50%) and satisfactory (50%) the results on the dynamics of the main clinical symptoms and data USDG. Eliminated pain at rest and trophic disorders. On 50-400% increase in the distance of painless walking, with an average of 40% (even with severe distal shape of the lesion). There was a trend to an increase of indexes ankle pressure on the arteries of the foot (25-30%).

A similar positive trend was noted in patients treated with Trental and Vitamin E, i.e., funds with documented effectiveness, included in the official record of outpatient treatment in these patients (B. M. cat. "Guidelines for the management of patients with atherosclerosis of the lower extremities", Moscow, 1998, S. 28).

Next BAD "Vascular grass" was assigned patients suffering from diabetes and tuberculosis, with the aim of improving the microcirculation of the internal organs.

Long-term monitoring (2 months) for patients treated with ven and long. Their evidence to a greater extent depends on the duration of the disease: the longer the patients were diabetics, the more often met among them vascular disorders. Accession TB infection would increase the weight for diabetes. Therefore, use of the drug "Vascular grass showed different results in the observed patients. The best results were observed in patients with infiltrative tuberculosis and duration of diabetes are not more than 2 years. In these patients by the end of the first month has seen the disappearance of tingling and burning in the feet, hands and feet became warm, the pain along the nerves. In the remaining patients, similar changes occurred only at the end of the second month of treatment. The worst results - the lack of clinical dynamics was noted in 3 patients with fibrous-cavelossim tuberculosis of the lungs. Apparently, the combination of two severe illnesses such as tuberculosis and diabetes mellitus had a double negative effect on the microcirculation. This hindered the development of recovery processes and greatly complicated the treatment of both TB and diabetes.


Claims

Biologists peripheral blood based on vegetable raw materials, characterized in that it contains a dry concentrate decoction of the fruits of Aronia, dry concentrate decoction of leaves, cranberries, dry concentrate of the broth, marjoram, ginger root, rutin, garlic, ascorbic acid, calcium gluconate, starch, calcium stearate, sugar in the following ratio of components a tablet weight of 0.55 g, g:
Dry concentrate decoction of the fruits of Aronia - 0,000015-0,00015
Dry concentrate decoction of leaves of cowberry 0,000015-0,00015
Dry concentrate decoction of herbs oregano 0,0000075-0,000075
Ginger root - 0,0025-0,0100
Rutin - 0,0050-0,0500
Garlic - 0,0100-0,0750
Ascorbic acid - 0,0100-0,0750
Calcium gluconate - 0,0100-0,0750
Starch - 0,0200-0,1000
Calcium stearate - 0,0020-0,0100
Sugar - Ostalnoe

 

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