Biologically active additive "phytoclimate" to reduce the risk of symptoms of menopausal syndrome

 

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as a means to reduce the risk of symptoms of menopausal syndrome. The proposed biologically active additive "Phytoclimate, including dry concentrates infusions of sage leaves, flowers of saffron, marjoram, Royal jelly, crushed ginger root, tocopherol acetate (vitamin E), zinc sulfate, calcium gluconate, starch, sugar, calcium stearate and talc at a ratio of components a tablet weight of 0.55, the Composition helps to overcome stress and fatigue, adjustment, depression, frequency, related climacteric syndrome, improves emotional state. table 2.

The invention relates to medicine, in particular the pharmaceutical industry, which produces drugs therapeutic and prophylactic purposes, and can be used as a means to reduce the risk of symptoms of menopausal syndrome.

Known biologically active additives (BAA) "Artemis" /Pilate T. L. (editor ), Federal ing, vitamin E, vitamin a and used as a tonic for women in the pre - and menopausal periods.

Known biologically active additives (BAA) "Climacteric" /Pilate T. L. (ed ) Federal register of biologically active food additives): Kohelet, 2001, S. 354/, which includes grass renal tea, marigold flowers, grass of a horsetail leaf birch white, URSI, herb, fennel fruit, flax seed, motherwort herb, the flowers of the hawthorn, immortelle flowers, Linden flowers, leaves mother and stepmother, seed dill, herb lemon balm. The BAD is used as a tonic and easing the flow of menopause.

The disadvantage of the drug is observed in individual patients, individual intolerance to some of the components of the drug.

Known biologically active additives (BAA) phytotea "the Secret of youth (for women)"/ Pilate T. L. (editor), Federal register biologically active additives to food, -M: Kohelet, 2001, S. 354, which includes motherwort herb, licorice root, hawthorn fruit, herb oregano, calendula flowers, laminaria thallus. It is used as food SUPPLEMENTS, has a calming effect when pathologically leaky clemencymusic in individual patients, some components of the drug.

The objective of the invention is to develop a new affordable drug is a biologically active food supplements in tablet form, easy to use, featured in menopause, premenstrual syndrome and dysmenorrhea.

This object is achieved in that the proposed dietary Supplement contains dry concentrates infusions of sage leaves, flowers of saffron, marjoram, Royal jelly, zinc, calcium gluconate, starch, sugar, calcium stearate and talc in the following ratio of components a tablet weight of 0.55 g, g: Dry concentrate of the extract of sage leaves - 0,000015-0,00012 Dry concentrate of the extract of the flowers of the saffron - 0,0000004-0,0000015 Dry concentrate of the extract of marjoram - 0,000015-0,00012 Royal jelly - 0,0010-0,0080 ginger Root, chopped - 0,0010-0,0080 tocopherol acetate (vitamin E) - 0,0010-0,0080 zinc Sulfate - 0,0025-0,0100 calcium Gluconate - 0,0250-0,1000 Starch - 0,0200-0,0800
Calcium stearate - 0,0200-0,0800
Talc - 0,0200-0,0800
Sugar - Rest
A dietary Supplement called "Climax".

BAD "Phytoclimate" facilitates the flow of menopause, rejuvenates the female body, stimulates the activity of the female sex glands, normalizes the menstrual cycle, have astronuats by the following example.

Biologically active additive "Phytoclimate" in the form of tablets obtained as follows.

0,573 kg sage leaves, 0,573 kg pre-chopped marjoram, 0,0145 kg of crushed flowers of saffron is poured into an enamel capacity by 15-20 l of water at room temperature of 14 kg Insist on boiling water bath for 25 min with frequent stirring, then cooled to 45 min at room temperature. The infusion is filtered, pressing plant material. If necessary, top up to the required amount of water. Filter 4 layers of gauze.

The output of infusion - 11,6 kg

The sugar in the number of 17.3 kg weighed, visually check for the presence of mechanical impurities, then in the absence of impurities crushed in the mill. For this sugar load portions in the hopper. Powdered sugar through the bottom fitting of the mill gathering into a polyethylene bag, the ends of which are pre-fixed to the fitting. The bag is placed in the receiver.

The output of crushed sugar - 17,1 kg

Ginger root is looking at on the presence of impurities and mechanical impurities, weighed in an amount of 0.6 kg and crushed in the mill.

Yield - 0,573 kg

In malerova in the amount of 0.7 kg and 1.0 kg infusion. Stir the mixture and add in the boiling solution with constant stirring, the paste is brought to a boil.

The output of starch paste - 10,65 kg

In enamel container 5-8 l load 1.6 kg infusion, add 2.1 kg of sugar. Mix, add 0,573 g of Royal jelly, the container was placed into a water bath and incubated for 5 min at a temperature of 95oC.

Yield - kg 4.26 deaths

Powdered sugar and ginger, starch, vitamin E, zinc sulfate, calcium gluconate is sifted through a sieve with the hole diameter of 1 mm, calcium stearate is sifted through a sieve with the hole diameter of 0.5 mm Water solution of Royal jelly in syrup is filtered through 4 layers of gauze.

In a mixer with the cover open load 15 kg powdered sugar, 0,573 kg ginger root, 9.6 kg of starch, 30,52 kg of calcium gluconate, stirred for 5 minutes. Then add 1,43 kg of zinc sulfate and stirred for further 5 minutes Add the remaining calcium gluconate 41 kg), stirred for 5 minutes to Hydrate solution of Royal jelly in syrup 4.26 kg, stirred for 5 min, add starch paste to 10.62 kg, stirred for 10 minutes

Yield - 113,033 kg

Hydrated tablets weight in the number 113,033 kg relativo air distribution device of the drying Cabinet. Set the drying temperature 40-45oWith the increase of which the flow of hot air is automatically disabled. The drying process is carried out for 10 h to a constant weight at periodic stirring (not less than 3 times). The control end of the drying conduct in the laboratory by weighing samples of the product from the trays to a constant weight. The humidity of the product - not more than 2%. Dry tablet weight is directed to a dry granulation.

The output of the dry tablet weight of 101 kg

The dried mixture in an amount of 101 kg load portions in the device for producing granules from dry tablespace. Include a screw device, in which the mixture is forced through the mesh holes with a diameter of 1.5-2.0 mm. To 10 kg of granulate add 0,573 kg of vitamin E. Dry granulate is collected in the receiver. From the receiver the dry granulate load when the cover is open in the mixer. In dry granular pellet mixture in the mixer add 1,03 kg of talc and 1.03 kg of calcium stearate. Include a mixer and stirred for 5 minutes the Finished granulate is passed on tableting.

The output of the finished granulate - 101,0 kg

From the mixer, the dry granulate is directed to tableting in the hopper tablet press mA is well pressing and height of the tablet. When you start the machine turn on a vacuum cleaner.

The diameter of the tablets to 12.00,3 mm

The height of the tablet - 4,00,3 mm

The weight of the tablet is 0.550,03,

During tabletting watching the machine work and quality tablets. Every 30 min check raspadaemost, the strength and the average weight of the tablets. Tablets that do not meet the requirements, rejected and sent for reprocessing. At the end of the process the machine off in the reverse order. Tablets are collected in the receiver and sent to the dust.

Yield - 100,45 kg

The finished tablets are sieved by the vibrating screen through a hole diameter of 8 mm, weighed 8 kg and load in a clean dry plastic bucket. Samples of finished tablets passed into the analytical laboratory for analysis. In accordance tablets norms technical documentation prepared tablets passed the stage of packing.

The output of finished tablets to 99.9 kg

The sequence of operations is the same regardless of the number of prepared composition.

BAD "Phytoclimate" contains the famous authorized for use in medical practice medicines which are in the different States, often associated climacteric syndrome, improves emotional state.

As auxiliary components, ensuring reliability save forms CT in dry form and a short time raspadaemosti them in a humid environment, used starch, bran, sugar, and to improve the fluidity of the granular calcium stearate and talc.

Tablet form is easy to use and has a long shelf life (2 years).

Clinical trials were conducted on volunteers.

BAD "Phytoclimate was appointed as sementelli hormone patients with climacteric syndrome, with a long history from 5 months to 3 years (average of 1.2of 0.7 years) and ineffective therapy for at least 6 months commonly used in this situation means, as well as patients with a diagnosis of uterine fibroids after diagnostic curettage.

Upon initial examination, all patients complained of irritability, estimated to 4-5 points. Complaints expressed sweating showed 40% of women surveyed (more than 4 points), others have noted a moderate sweating (2-3 points). The frequency of inflows amounted to 7-9 in the day that I had and 40-50% of the observed women a pronounced increase in blood pressure - 60-70% of patients.

In the course of treatment using SUPPLEMENTS "Phytoclimate" noted a pronounced positive dynamics of clinical signs. The most marked changes were noted in patients with climacteric syndrome, due to age-related changes. Almost full clinical effect was achieved in all patients of this group. Stopped the rise in blood pressure, normalized sleep and psycho-emotional state of patients. The tides were observed only in 20% of patients with a frequency of not more than 1 times a day.

Dynamics of total and autonomic symptoms in patients with climacteric syndrome when using BAA "Phytoclimate" (conditional average scores on a five-point scale) are given in table.2.

After the treatment the patient noted significant improvement of psycho-emotional state, improve sleep quality.


Claims

Biologically active additive to reduce the risk of manifestations of the climacteric syndrome on the basis of vegetative raw material, characterized in that it contains dry concentrates infusions of sage leaves, flowers of saffron, marjoram, Maton is calcium stearate, talc and sugar in the following ratio of components a tablet weight of 0.55 g, g:
Dry concentrate of the extract of sage leaves - 0,000015-0,00012
Dry concentrate of the extract of the flowers of the saffron - 0,0000004-0,0000015
Dry concentrate of the extract of marjoram - 0,000015-0,00012
Royal jelly - 0,0010-0,0080
Ginger root, chopped - 0,0010-0,0080
Tocopherol acetate (vitamin E) - 0,0010-0,0080
Zinc sulfate - 0,0025-0,0100
Calcium gluconate - 0,0250-0,1000
Starch - 0,0200-0,0800
Calcium stearate - 0,0200-0,0800
Talc - 0,0200-0,0800
Sugar - Else-

 

Same patents:
The invention relates to medicine and for new ways of correction of oestrogen deficiency in natural or artificial menopause
The invention relates to medicine, gynecology, and can be used for the treatment of menopausal syndrome

The invention relates to new naphtylpropionate F.-ly (I), where R1and R2- N, -HE or-O(C1-C4-alkyl); R3- 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholinyl, dialkylamino - or 1-hexamethylen-aminogroup; n = 2 or 3, or pharmaceutically acceptable salts

The invention relates to new niftystories compounds of formula I, where R1and R2- H, -OH, -O(C1-C4alkyl), -OCOC6H5, -OCO(C1-C6alkyl), -OSO2(C4-C6alkyl); R3- 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, 1 hexamethyleneimino; intermediate compounds, which are suitable for easing symptoms of postmenopausal syndrome, including osteoporosis, hyperlipemia and estrogenzawisimy cancer, and inhibition of uterine fibroids, endometriosis and proliferation of aortic smooth muscle cells

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as an aid in facilitating the regulation of the respiratory system
The invention relates to the field of medicine and relates to means neuroleptic action on the basis of haloperidol

The invention relates to a pharmaceutical composition comprising: 1) an antifungal agent, which is (-)-(2R-CIS-)-4-[4-[4-[4-[[5-(2,4-differenl)tetrahydro-5-(1H-1,2,4-triazole-1-ylmethyl)furan-3-yl] methoxy] phenyl] -1-piperazinil] phenyl] -2,4-dihydro-2-[(S)-hydroxypropyl]-3H-1,2,4-triazole-3-one, 2) at least one nonionic surfactant and (3) diluent

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used for the prevention and adjuvant therapy of hypotension and vascular dystonia

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as an auxiliary tonic and mild sedative

The invention relates to medicine, in particular to the drug based on an extract of motherwort, intended for the treatment of functional disorders of the Central nervous system

The invention relates to medicine

The invention relates to pharmaceutical compositions containing the inhibitor nm g COA reductase (E.)-7-[4-(4-forfinal)-6-isopropyl-2-[methyl(methylsulphonyl)amino] pyrimidine-5-yl]-(3R, 5S)-3,5-dihydroxide-6-envoy acid or its pharmaceutically acceptable salt as an active ingredient
The invention relates to medicine, in particular to pharmaceutical drugs used in cardiovascular diseases

The invention relates to medicine, namely to the pharmaceutical industry

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as an aid in facilitating the regulation of the respiratory system
The invention relates to medicine, in particular to balms to treat impotence, prostatitis and benign prostatic hyperplasia
The invention relates to the field of pharmacology, and relates to biologically active compounds from plant material, which, on the one hand, can be used as biologically active food supplements as a nonspecific measure to increase the body's resistance to adverse influences, prevention of morbidity and normalize the functioning of the body, and on the other hand, can be used as the basis for medicines, in particular for the treatment of cancer
Up!