Dietary supplement joint grass for prophylaxis and maintenance therapy for inflammatory diseases of the musculoskeletal system

 

The invention relates to medicine, namely to the pharmaceutical industry. Biologically active additive concentrate contains dry extract of burdock roots, dry concentrate of the extract of the herb of knot-grass, dry concentrate of the extract of birch leaves, dry concentrate of the extract of the fruit of the barberry, dry concentrate of the Laurel leaf, dry concentrate propolis tincture, nicotinic, ascorbic acid, starch, oats, calcium stearate and sugar components take in a quantitative content. SUPPLEMENTS reduces the risk of exacerbations of chronic inflammatory diseases of the musculoskeletal system, reduces pain in the joints, stiffness disappears in the morning. table 2.

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as an auxiliary bracing means with hypothermia to reduce the risk of exacerbations of chronic inflammatory diseases of the musculoskeletal system.

Known biologically active food Supplement "Wise dragon" /Pilate T. L. (ed ) Federal register biologically active brucevideos, peony root Molochnikov, the thicket cinnamon bark, Poria, stems Ramazotti, grass azoricum, rhizome ligusticum of Wallich, the root of achyranthes, Ural licorice root, root Grachevka, the root of Chinese Angelica, root of remanei, the root of Campanula. Recommended for use as a General tonic and AIDS in complex therapy of inflammatory diseases of the musculoskeletal system.

Contraindications: individual intolerance to the components of the drug.

Known biologically active food Supplement "Neukom mix) /Pilate T. L. (ed) Federal register of biologically active additives to food), Kohelet, 2000, S. 347/, which consists of the leaves of ash, willow bark, nettle leaves, birch leaves, horsetail herb, bark of harrow, buckthorn bark, rhizomes of couch grass, the fruit of juniper, elderberry flowers, Linden flowers. Recommended for use as a General tonic and AIDS in chronic inflammatory diseases of the musculoskeletal system.

Contraindications: individual intolerance to the components of the drug.

Known biologically active food Supplement "Entertron" /Pilate T. L. (editor ) Federallevel, the roots of chicory, dandelion roots, burdock roots, the fruits of juniper, buckthorn bark, black elderberry flowers, leaves primrose, grass renal tea, herb calendula, birch leaves, the leaves of bearberry, knotweed, fennel fruit, flax seeds. Available in the form of liquid extract of these active substances, put up in capsules. Recommended for use as a General tonic, anti-inflammatory and mild auxiliary medication for diseases of the joints.

A disadvantage of the known drugs is the lack of a balanced complex of vitamins and microelements, as also observed in individual patients, individual intolerance to some of the components of the drug.

The objective of the invention is the development of a new biologically active supplements in pill form, suitable for use and having a balanced complex of vitamins and minerals.

The invention is aimed at expanding the range of alternative bracing means for maintaining the functions of the musculoskeletal system to compensate for individual intolerance to some of the components of known drugs.

This is achieved by h the rat infusion grass knotweed, dry concentrate of the extract of birch leaves, dry concentrate of the extract of the fruit of the barberry, dry concentrate of the extract of the leaf of Laurel, dry concentrate propolis tincture, nicotinic acid, ascorbic acid, starch, oats, calcium stearate and sugar in the following ratio of components a tablet weight of 0.55 g, g: dry concentrate of the extract of burdock roots - 0,0000075-0,000075 dry concentrate of the extract of grass knotweed - 0,0000075-0,000075 dry concentrate of the extract of birch leaves - 0,0000075-0,000075 dry concentrate of the extract of the fruit of barberry 0,0000075-0,000075 dry concentrate of the extract of the leaf of Laurel - 0,0000075-0,000075 dry concentrate propolis tincture - 0,000175-0,00175 nicotinic acid - 0,0010-0,0050 ascorbic acid 0,0050-0,0300 oats - 0,0100-0,0600
starch - 0,0250-0,0750
calcium stearate - 0,0055
sugar - rest
The tool is called - a dietary Supplement Joint grass".

The BAD Joint herb has anti-inflammatory, analgesic, anti-inflammatory effect, improves the metabolism of the cartilage tissue, improves the functional condition of the joints. Recommended for use as a preventive and an adjuvant in the treatment of inflammatory joint diseases and metabolic nature: arthritis, rheumatism, gout/> The invention is illustrated by the following example.

Biologically active food Supplement "Joint grass" in the form of tablets obtained as follows.

The sugar in the number of 84.0 kg weighed, visually check for the presence of mechanical impurities, then in the absence of impurities crushed in the mill. For this sugar out of the bag load portions in the hopper. Powdered sugar through the bottom fitting of the mill gathering into a polyethylene bag, the ends of which are pre-fixed to the fitting. The bag is placed in the receiver.

The output of crushed sugar - 83,0 kg

Oats in the amount of 5.7 kg weighed, visually check for the presence of mechanical impurities, then in the absence of impurities crushed in the mill. For this purpose, oats load portions in the hopper. Crushed oats through the bottom fitting of the mill gathering into a polyethylene bag, the ends of which are pre-fixed to the fitting. The bag is placed in the receiver.

The output of crushed oats - 5,6 kg

The roots of burdock in the number 0,37 kg weighed, visually check for the presence of mechanical impurities. Placed in an enamel container for 15-20 liters. Pre-chopped fruits Barbary is emalirovannoy capacity by 15-20 liters, contains burdock root. Pour 11 kg of water at room temperature, insist on a boiling water bath with frequent stirring for 25 minutes. Then add 0,185 kg of birch leaves, Laurel leaves and grass knotweed and insist for another 20 minutes with frequent stirring. Cool at room temperature for 45 minutes, after which the infusion is filtered, pressing plant material. If necessary, add water to the desired volume. Then filtered through four layers of gauze.

The output of infusion - 9,25 kg

Powdered sugar, oats, starch, ascorbic acid, nicotinic acid powder is sifted to the shaker through a sieve with the hole diameter of 1 mm calcium stearate is sifted through a sieve with the hole diameter of 0.5 mm Tincture of propolis filtered through four layers of gauze.

In an enamelled vessel 10 l weighed on the scales of 8.25 kg of prepared infusion of herbs, bring to a boil. Separate the starch in the amount of 0.7 kg weighed, placed in an enamel capacity of 3 l, add 1.0 kg infusion of herbs. Prepared suspension of starch contribute to the boiling flask with constant stirring, bring to a boil.

The output of starch paste - 9.9 kg
In the mixer when the cover is open propolis in the number of 1.85 kg, stirred for 10 minutes and add the starch paste in the amount of 9.9 kg, stirred for 10 minutes

Yield - 109,85 kg

Hydrated tablets weight in the number 109,85 kg laid out on paper in the trays with a layer thickness of 1,5-2 see Trays install in a drying Cabinet. Include hot air distribution device of the drying Cabinet. Set the drying temperature 40-45oWith the increase of which the flow of hot air is automatically disabled. The drying process is carried out for 10 hours to a constant weight at periodic stirring (not less than 3 times). The control end of the drying conduct in the laboratory by weighing samples of the product from the trays to a constant weight. The humidity of the product - not more than 2%. Dry tablet weight is directed to a dry granulation.

The output of the dry tablet weight - 98,10 kg

The dried mixture in an amount of 98,10 kg load portions in the device for producing granules from dry tablespace. Include a screw device, in which the mixture is forced through the mesh holes with a diameter of 1.5 mm, the Dry granulate is collected in the receiver. From the receiver the dry granulate download scoop when the cover is open in the mixer. To dry the grain is ve 0,37 kg and ascorbic acid in the amount of 1.85 kg, stirred for 10 minutes, then add the sifted calcium stearate in the amount of 1.02 kg Include a mixer and mix for another 5 minutes. The finished granulate is passed on tableting.

The output of the finished granulate - 101,34 kg

From the mixer, the dry granulate is directed to tableting in the hopper tablet press machine. Turn on the engine. Pre-set engine speed in accordance with a bulk weight of the pressing zone and the height of the tablet. When you start the machine turn on a vacuum cleaner.

The diameter of the tablets to 12.00.3 mm;
the height of the tablet 3,80.3 mm;
the average weight of a tablet is 0.55of 0.02,

During tabletting watching the machine work and quality tablets. Every 30 minutes check raspadaemost, the strength and the average weight of the tablets. Tablets that do not meet the requirements, rejected and sent for recycling. At the end of the process the machine off in the reverse order. Tablets are collected in the receiver and sent to the dust.

Yield - 100,33 kg

The finished tablets are sieved by the vibrating screen through a hole diameter of 8 mm, weighed 8 kg and load in a clean dry plastic bag is provided tablets norms technical documentation prepared tablets passed the stage of packing.

The output of finished tablets - 99,32 kg

The sequence of operations is the same regardless of the number of prepared composition.

The BAD Joint grass" contains the famous authorized for use in medical practice medicines which are in the specified combination (see table. 1. Examples 1-4) provide for the reduction or disappearance of symptoms of acute exacerbations of chronic inflammatory diseases of the musculoskeletal system.

As auxiliary components, ensuring reliability maintain the shape of the pressed pellets in a dry form and a short time raspadaemosti them in a humid environment, used starch, oats, sugar, and to improve the fluidity of the granulated calcium stearate and talc.

Tablet form is easy to use and has a long shelf life (2 years).

Clinical trials were conducted on volunteers.

In clinical trials, the BAD Joint grass" was appointed in rheumatoid arthritis.

Greater improvement in clinical parameters were obtained from patients with 1-2 stage, light and medium gravity currents with dysfunction of the joint not less than 2 degree, moderate degree of activity, decreased pain, improving mood, the decrease in frequency of headaches.

It should be noted that the appointment of a BAD led to a more rapid positive dynamics of the main clinical symptoms, starting with a 30-day therapy. Moreover, to the 60-th day of observation reduced severity of clinical and laboratory symptoms 2 times observed in 80% of patients, whereas in the control group at 60%.

Side effects of taking SUPPLEMENTS in patients of all groups were observed.

Patients with "mild" form of the disease treated with the drug on an outpatient basis, 100% of the observations noted a reduction in pain and the elimination of morning stiffness.

On the background of monotherapy BAA reported a positive trend in all patients of this group. Received clinical improvement in patients with stage 1, mild severity, impaired joint function of 1 degree, moderate degree of activity. It was noted a marked decrease in joint pain, no stiffness in the morning.

Positive dynamics was noted in the assessment of quality of life: improved mood, decreased the frequency of occurrence of headaches disappeared weakness, patients have better tolerate domestic and industrial load (PL. 2).

These dynamometry in" patients, taking a specific drug, was the appointment of pyrazinamide, which causes pain in patients in large and small joints, causing considerable inconvenience to the patient and requires the use of analgesics. In the observed patients during the inspection objective criteria lesions of bone and joints were found. The skin over the joints was not hyperemic, the form remained the same. Limitations in movement was not observed, however, almost always in small joints of the hands, knees and hip joints felt aching pain, worse at night.

Observations showed that by the end of the month the results of treatment were similar in both groups. Patients of the first group joint pain disappeared as a result of cancellation pyrazinamide, and in patients of the second group - the impact of the drug "Joint grass". This gives grounds to recommend the drug, "Joint grass to eliminate adverse effects from the use of specific anti-TB therapy.


Claims

Dietary Supplement for the prevention and adjuvant therapy for inflammatory diseases of Degutiene burdock, dry concentrate of the extract of the herb of knot-grass, dry concentrate of the extract of birch leaves, dry concentrate of the extract of the fruit of the barberry, dry concentrate of the extract of the leaf of Laurel, dry concentrate propolis tincture, nicotinic acid, ascorbic acid, starch, oats, calcium stearate and sugar in the following ratio of components a tablet weight of 0.55 g, g:
Dry concentrate of the extract of burdock roots - 0,0000075-0,000075
Dry concentrate of the extract of grass knotweed - 0,0000075-0,000075
Dry concentrate of the extract of birch leaves - 0,0000075-0,000075
Dry concentrate of the extract of the fruit of barberry 0,0000075-0,000075
Dry concentrate of the extract of the leaf of Laurel - 0,0000075-0,000075
Dry concentrate propolis tincture - 0,000175-0,00175
Nicotinic acid - 0,0010-0,0050
Ascorbic acid - 0,0050-0,0300
Starch - 0,0250-0,0750
Oats - 0,0100-0,0600
Calcium stearate - 0,0055
Sugar - Ostalnoe

 

Same patents:

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as an aid in facilitating the regulation of the respiratory system
The invention relates to medicine, in particular to balms to treat impotence, prostatitis and benign prostatic hyperplasia
The invention relates to the field of pharmacology, and relates to biologically active compounds from plant material, which, on the one hand, can be used as biologically active food supplements as a nonspecific measure to increase the body's resistance to adverse influences, prevention of morbidity and normalize the functioning of the body, and on the other hand, can be used as the basis for medicines, in particular for the treatment of cancer

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used for the prevention and adjuvant therapy of hypotension and vascular dystonia

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as an auxiliary tonic and mild sedative

The invention relates to medicine, in particular to the drug based on an extract of motherwort, intended for the treatment of functional disorders of the Central nervous system
The invention relates to medicine, namely, cosmetic products for skin care to rejuvenate, prevent and eliminate wrinkles

The invention relates to pharmacy
The invention relates to medicine, pulmonology and can be used for the treatment of chronic bronchitis
The invention relates to medicine, namely relates to a method of obtaining vitamin complex pills

The invention relates to medicine, namely to methods for healing the human body
The invention relates to medicine, in particular to obstetrics and Perinatology, and for the prevention of perinatal pathology after infection in women during pregnancy

The invention relates to the field of medicine

The invention relates to pharmaceutical industry and relates to the development of new drugs for medicine and veterinary medicine

The invention relates to medicine and can be used in Oncology for chemotherapy of malignant tumors
The invention relates to medicine, namely to ophthalmology, and is intended for the treatment of inflammatory diseases of the iris and ciliary body, accompanied fibrinous exudation

FIELD: medicine.

SUBSTANCE: before applying substitute hormonal therapy (SHT) on should evaluate antithrombogenic activity of vascular wall in women. For this purpose one should determine quantitative values of ADP-induced aggregation of thrombocytes, activity of antithrombin III in blood and fibrinolytic blood activity both before and after "cuff"-test. Then one should detect the indices calculated as the ratio of mentioned values both before and after carrying out the mentioned test. If mentioned indices are decreased against the norm by 20-40% women should be prescribed to undergo SHT at additional introduction of aspirin and supradin. The method provides prophylaxis of cardio-vascular diseases in this category of female patients due to correcting affected functional activity of vascular endothelium.

EFFECT: higher efficiency of prophylaxis.

1 cl, 1 ex, 4 tbl

Up!