Biologically active additive "bronchoactive" for prophylaxis and maintenance therapy of asthma and inflammatory diseases of the respiratory system

 

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as an aid in facilitating the regulation of the respiratory system. The proposed biologically active additive based on medicinal plants containing dry extract of licorice root dry aqueous concentrates of Valerian root, herb, sage, herb, hyssop, dry concentrate infusions peppermint, crushed ginger root, zinc sulfate, calcium gluconate, starch, calcium stearate and sugar at a certain ratio of ingredients. The invention expands the range of medicines for the treatment of acute and chronic respiratory diseases, alternative for cases of individual intolerance of the individual ingredients. table 2.

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as an auxiliary means used to prevent the exacerbation of asthma and inflammatory diseases the Cesky supplements./ Ed. Pilate T. L. - M: Kohelet, 2001, S. 249), containing corn silk, hops, St. John's wort herb, dandelion root, calamus root, leaf watch three leaf, yarrow herb, the herb centaury, tormentil root, fennel fruit, herb, peppermint leaf, buckthorn bark cracking. Provides tonic, mild expectorant action, is used as anti-inflammatory agents. Comes in powder form, packaged in capsules.

The disadvantage of this drug is an individual intolerance to the components.

Known biologically active food Supplement "Milo" (Federal register biologically active additives to food./ Edited by Pilate T. L. - M: Kohelet, 2001, S. 248) containing leaf plantain, grass of dodici, rhizomes and roots of elecampane, licorice root, thyme herb, the herb St. John's wort, a grass of a yarrow, Acorus calamus rhizome, flax seeds, chamomile flowers and excipients - formers and fillers. Available in tablet form.

Has a restorative effect, including for persons who are predisposed to diseases of the respiratory system.

The disadvantage of this drug is an individual intolerance to the components.

The invention is aimed at expanding the range of drugs for the treatment of acute and chronic respiratory diseases, alternative for cases of individual intolerance of the individual ingredients.

The problem is solved in that the proposed dietary Supplement contains dry extract of licorice root dry aqueous concentrates of Valerian root, herb, sage, herb, hyssop, dry concentrate infusions peppermint, crushed ginger root, zinc sulfate, calcium gluconate, starch, calcium stearate and sugar in the following ratio of ingredients in the tablet weight of 0.55 g, g: Dry extract of licorice root - 0,0075-0,0600 Dry water concentrate roots of elecampane - 0,00002-0,00016 Dry water concentrate grass sage - 0,00001-0,00008 Dry water concentrate herb hyssop - 0,00002-0,000060 Dry concentrate infusions peppermint - 0,000175-0,0014 Chopped ginger - 0,0040-0,0500 zinc Sulfate - 0,0025-0,0200 calcium Gluconate - 0,0100-0,0600 Starch - 0,0250-0,1000
Calcium stearate - 0,0025-0,0100
Sugar - Rest
Dietary Supplement named "Bronchos the relieving muscle of bronchi, to help reduce the swelling and inflammation in the lungs. Used for the prevention of acute bronchial asthma and inflammatory diseases of the respiratory system.

It is recommended as an adjuvant in acute and chronic diseases of the respiratory tract, accompanied by severe cough syndrome: acute respiratory infections, the common cold, pharyngolaryngeal, bronchitis, tracheitis, traheobronhity, pneumonia; difficulty phlegm.

The invention is illustrated by the following example.

In enamel container 15 l weighed 0,37 kg pre-ground roots of elecampane, pour 12.0 kg of water at room temperature, insist on a boiling water bath with frequent stirring for 35 minutes, then add 0,37 kg pre-powdered herb hyssop and 0.18 kg of grass and sage and continue to insist on a boiling water bath for 25 minutes, Cooled at room temperature for 60 minutes, the Broth is filtered, pressing plant material. If necessary, add water to the desired volume. Filtered through 4 layers of gauze.

The output of broth (2% dry) 9,25 kg

Sugar is looking at on the presence of impurities and mechanical impurities, weighed 83,2 kg and crushed imesa and mechanical impurities weighed 3.7 kg and crushed in the mill. The output of crushed calcium gluconate to 3.67 kg

Ginger root is looking at on the presence of impurities and mechanical impurities, weighed 0.2 kg and crushed in the mill. The output of crushed ginger root 0,18 kg

Crushed sugar, ginger, starch, calcium gluconate and zinc sulfate is sieved through a sieve with the hole diameter of 1.0 mm, calcium stearate is sifted through a sieve with the hole diameter of 0.5 mm Tincture of peppermint filtered through a funnel and 4 layers of gauze.

In the enameled capacity 15 l bring to a boil 6.25 kg of broth. Separately mix 0.5 kg of starch and 1.0 kg of water, mix thoroughly and add to the boiling broth with constant stirring. The solution is brought to a boil.

The output of 7.7 kg

On the scales weighed 3,65 kg of dry extract of licorice and transferred to enamel container 15 l add 2.0 kg of broth and mix. If necessary, heated. Filtered through the funnel and 4 layers of gauze.

Output 5,62 kg

In the mixer load of 9.6 kg of starch, 3,67 kg calcium gluconate, 0,92 kg zinc sulphate and 0.18 kg of ginger, mix 10 min, then add powdered sugar to 82.4 kg three portions (two licorice root extract 5,62 kg, stirred for 5 min, add 1,84 kg pharmacopeias tinctures (3,5% of dry) peppermint, stirred for 5 min and add 7,7 kg of starch paste, stirred for 10 minutes

The product yield 111,93 kg

The wet mass in the number 111,93 load portions in the unit to get wet granules from wet tablespace. Include a screw device, in which the mixture is forced through the mesh holes with a diameter of 4-5 mm Wet granules are collected in the receiver. From the receiver the wet granulate is passed for drying.

The product yield byr111.4 kg

Hydrated tablets weight in the number byr111.4 kg laid out on paper in the trays with a layer thickness of 1,5-2 see Trays install in a drying Cabinet. Include hot air distribution device of the drying Cabinet. Set the drying temperature 40-45oWith the increase of which the flow of hot air is automatically disabled. The drying process is carried out for 10 hours to a constant weight at periodic stirring (at least 3 times). The control end of the drying conduct in the laboratory by weighing samples of the product from the trays to a constant weight. The humidity of the product is not more than 2%. Dry tablet weight is directed to the dry growcom portions in the device for producing granules from dry tablespace. Include a screw device, in which the mixture is forced through the mesh holes with a diameter of 1.5-2.0 mm. To the obtained pellet mass in the mixer add 1,01 kg sieved calcium stearate, include a stirrer and stirred for 10 minutes. The finished granulate is passed on tableting.

The output of the finished granulate 101,0 kg

From the mixer, the dry granulate is directed to tableting in the hopper tablet press machine. Pre-set engine speed in accordance with a bulk weight of the pressing zone and the height of the tablet. When you start the machine turn on a vacuum cleaner.

The tablet diameter 12,00.3 mm;
the height of the tablet 3,80.3 mm;
the average weight of the tablets 0,55by 0.055 mm

During tabletting watching the machine work and quality tablets. Every 30 minutes check raspadaemost, the strength and the average weight of the tablets. Tablets that do not meet the requirements, rejected and sent for reprocessing. At the end of the process the machine off in the reverse order. Tablets are collected in the receiver and sent to the dust.

The product yield 100,5 kg

The finished tablets sift through si buckets. Samples of finished tablets passed into the analytical laboratory for analysis. In accordance tablets norms technical documentation prepared tablets passed the stage of packing.

The output of finished tablets 100,0 kg

The sequence of operations is the same regardless of the number of prepared composition.

BAD "Bronchoactive" contains the famous permitted for use in medical practice medicines which are in the specified combination (table. 1, examples 1-4) provide for the reduction or disappearance of symptoms of the respiratory system.

As auxiliary components, ensuring reliability maintain the shape of the pressed pellets in a dry form and a short time raspadaemosti them in a humid environment, used starch, sugar, and to improve the fluidity of the granular calcium stearate.

Available in tablet form, which is convenient to use, has a long shelf life (2 years).

In clinical studies of dietary SUPPLEMENTS, "Bronchoactive" assigned patients at the age from 2 to 70 years with ENT pathology and nonspecific inflammatory diseases of the lung. According to nosological forms has identified the following diseases: acute common cold, sharp parentof with ENT pathology with disease duration from 2 to 12 days on the background add to the standard therapy of the drug "Bronchoactive" stuffy nose stoped to 5-8 day. All patients in this group when you study marked improvement in nasal mucociliary clearance in an average of 4.8 minutes.

In patients with bronchopulmonary pathology were noted pronounced positive dynamics of the drainage function of bronchi, helped by liquefaction and mitigation secret. In this regard, changed the structure of the cough. For 3 days the cough becomes wet, with heavy expectoration. From that moment marked reduction in the incidence of cough with a full withdrawal to 10 days. Against this background, in patients with breathing difficulties or shortness of breath noted marked improvements. For 4 days the breath of patients treated BAD, becomes calm, deep. Normalization auscultatory data for 10-14 days (table.2).

Improvement of respiratory tract contributed to the improvement of the General condition of the patients. When subjective assessment of the feelings of exhaustion, weakness, General malaise patients were noted to 4-7 days.


Claims

Dietary Supplement for the prevention and maintenance therapy of asthma and inflammatory diseases of the respiratory system on the basis of medicinal plant the herb sage, herb hyssop, dry concentrate infusions peppermint, crushed ginger root, zinc sulfate, calcium gluconate, starch, calcium stearate and sugar in the following ratio of ingredients in the tablet weight of 0.55 g, g:
Dry extract of licorice root - 0,0075-0,0600
Dry water concentrate roots of elecampane - 0,00002-0,00016
Dry water concentrate grass sage - 0,00001-0,00008
Dry water concentrate herb hyssop - 0,00002-0,000060
Dry concentrate infusions peppermint - 0,000175-0,0014
Chopped ginger - 0,0040-0,0500
Zinc sulfate - 0,0025-0,0200
Calcium gluconate - 0,0100-0,0600
Starch - 0,0250-0,1000
Calcium stearate - 0,0025-0,0100
Sugar - Ostalnoe

 

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