Biologically active additive "phytoprostanes" for prophylaxis and maintenance therapy for diseases of the prostate and urinary tract

 

The invention relates to medicine, namely the pharmaceutical industry. Dietary Supplement contains dry concentrates, broth pumpkin seeds, propolis tincture, tincture of walnut and decoction of leaves of bearberry, pollen, cinnamon, vitamin E, zinc sulfate, starch, calcium stearate and sugar. Biologically active additive has a tonic, tonic effect, contributes to the prolongation of active longevity. table 1.

The invention relates to medicine, in particular to the pharmaceutical industry for the production of drugs therapeutic and prophylactic purposes, and can be used as a means of contributing to the treatment of diseases of the prostate and urinary tract.

Known biologically active additive to food (BAD) "Aurita" (Federal register biologically active additives to food./ Edited by Pilate T. L. - M.: Kohelet, 2001, S. 336) containing pumpkin seeds and vitamin E. it is Used as a means to normalize the function of the bladder and prostate.

The disadvantage of the drug is observed in individual patients, individual ate Plus" (Federal register biologically active additives to food./ Ed. Pilate T. L. - M. : Kohelet, 2001, S. 336), which consists of the fruit of the palm tree Saw Pallmetto, the bark of the African plum, pumpkin seeds, vitamin E, zinc gluconate. Comes in powder form in capsules. Used as an aid in the treatment of diseases of the prostate.

The disadvantage of the drug is observed in individual patients, individual intolerance to some of the components of the drug.

The objective of the invention is the development of a new biologically active supplements in pill form, easy to use, recommended as a restorative tonic for persons with chronic prostatitis, contributing to the prolongation of active longevity.

The invention is aimed at expanding Arsenal of drugs in the treatment of prostate diseases, contributing to the prolongation of active longevity, as well as alternative means for cases of individual intolerance of the individual ingredients.

This is achieved by the fact that the proposed dietary Supplement contains dry concentrates, broth pumpkin seeds, propolis tincture, tincture of walnut and decoction of the leaf is the total proportion of components a tablet weight of 0.55 g, g: Dry concentrate of the broth, pumpkin seeds and 0.0001-0,0008 Dry concentrate propolis tincture - 0,00035-0,0014 Dry concentrate infusions walnut - 0,000175-0,0014 Dry concentrate decoction of leaves of a bearberry - 0,00001-0,00008 pollen - 0,0100-0,0400 Cinnamon - 0,0010-0,0040 Vitamin E - 0,0010-0,0040 zinc Sulfate - 0,0025-0,0100 Starch - 0,0200-0,0500
Calcium stearate - 0,0200-0,0500
Sugar - Rest
Dietary Supplement named "Phytoprostanes".

BAD "Phytoprostanes" has a tonic, tonic, antimicrobial, anti-inflammatory, diuretic, absorbing effects and, in addition, has a positive influence on the condition and function of the prostate gland, facilitates urination, pain syndrome and manifests immunostimulating effect.

The invention is illustrated by the following example.

Biologically active additive "Phytoprostanes" in the form of tablets obtained as follows.

The sugar in the number 80,80 kg weighed, visually check for the presence of mechanical impurities, then in the absence of impurities crushed in the mill. For this sugar load portions in the hopper. Powdered sugar through the bottom fitting of the mill is collected in polite elchinova sugar 80 kg.

Pollen in the amount of 9.4 kg weighed, visually check for the presence of mechanical impurities, then in the absence of impurities crushed in the mill. The pollen load portions in the hopper. Crushed pollen through the bottom fitting of the mill gathering into a polyethylene bag, the ends of which are pre-fixed to the fitting. The bag is placed in the receiver.

The output of crushed pollen 9,3 kg

In enamel container load of 1.85 kg of pumpkin seeds, pre-breaking of the integrity of the skin, fill in 10 kg of water at room temperature, incubated in a boiling water bath for 30 minutes, then add the leaves of the bearberry 0,185 kg and kept in a boiling water bath with frequent stirring for another 30 minutes, then the broth is filtered hot through 4 layers of gauze. If necessary, add up to the required number.

The output of the finished broth 8 kg.

In an enamelled vessel is brought to a boil 7 kg of broth. Separately mixed with 0.6 kg of starch and 1 kg of broth from pumpkin seeds and leaves of bearberry. Stir the mixture and add in the boiling solution with constant stirring, bring to a boil.

The output of starch paste 8,55 kg

ISM the holes 1 mm, calcium stearate is sifted through a sieve with the hole diameter of 0.5 mm, pharmacopeial tincture (3,5% of dry) propolis, pharmacopeial tincture (3,5% of dry) walnut, water is filtered through 4 layers of gauze.

In a mixer with the cover open load 80,0 kg powdered sugar, 9.6 kg of starch, 9.3 kg of pollen and stirred for 5 minutes. Separately in an enamelled vessel is stirred 0,37 kg vitamin e, and 7 kg of the mixture from the mixer, and a separate mix of 0.93 kg of zinc sulfate and 10 kg of the mixture from the mixer includes a mixer of the mixer and add the cooked mixture with vitamin E and zinc sulfate, stirred for 10 min, then add the cinnamon powder 0,37 kg, stirred for 5 minutes. The resulting mixture is moistened when the stirrer tincture of propolis in the amount of 3.7 kg and infusion of walnut 1,85 kg Stirred for 5 min, add starch paste in the broth 8,55 kg Stirred for 10 minutes

Hydrated tablets weight in the number 114,67 kg laid out on paper in the trays with a layer thickness of 1,5-2 see Trays install in a drying Cabinet. Include hot air distribution device of the drying Cabinet. Set the drying temperature 40-45oWith the increase which is hot in the sky stirring (at least 3 times). The control end of the drying conduct in the laboratory by weighing samples of the product from the trays to a constant weight. The humidity of the product is not more than 2%. Dry tablet weight is directed to a dry granulation.

The output of the dry tablet weight 102,98 kg

The dried mixture in an amount of 102,98 kg load portions in the device for producing granules from dry tablespace. Include a screw device, in which the mixture is forced through a mesh with holes of diameter 1.5 to 2.0 mm, the Dry granulate is collected in the receiver. From the receiver the dry granulate download scoop when the cover is open in the mixer. To the dry granulated pellet mixture in the mixer and add the sifted calcium stearate in the amount of 1.02 kg Include a mixer and stirred for 5 minutes. The finished granulate is passed on tableting.

The output of the finished granulate 101,78 kg

From the mixer, the dry granulate is directed to tableting in the hopper tablet press machine. Turn on the engine. Pre-set engine speed in accordance with a bulk weight of the pressing zone and the height of the tablet. When you start the machine turn on a vacuum cleaner.

The tablet diameter 12,00.2 mm;
the height of the tabla is tiravanija watching the machine work and quality tablets. Every 30 minutes check raspadaemost, the strength and the average weight of the tablets. Tablets that do not meet the requirements, rejected and sent for reprocessing. At the end of the process the machine off in the reverse order. Tablets are collected in the receiver and sent to the dust.

The product yield 100,84 kg

The finished tablets are sieved by the vibrating screen through a hole diameter of 8 mm, weighed 8 kg and load in a clean dry plastic bucket. Samples of finished tablets passed into the analytical laboratory for analysis. In accordance tablets norms technical documentation prepared tablets passed the stage of packing.

The output of finished tablets 100 kg.

The sequence of operations is the same regardless of the number of prepared composition.

BAD "Phytoprostanes" contains the famous authorized for use in medical practice medicines which are in the specified combination (see table, examples 1-4) provides a reduction or disappearance of symptoms of the prostate and urinary tract.

As auxiliary components, ensuring reliability maintain the shape of the pressed pellets in dry is the input of a granulate calcium stearate.

Tablet form is easy to use and has a long shelf life (2 years).

Clinical trial were given to the volunteers.

When assessing the clinical efficacy of dietary SUPPLEMENTS "Phytoprostanes was appointed in complex therapy of patients with chronic prostatitis, hospitalized in the surgical hospital on various occasion. The source of the most frequent complaints were dysuria and a nagging pain in the perineum and suprapubic region (100-70% of patients), often met leukocyturia (in the 3rd portion of urine after massage of the prostate gland) and bacteria. In 20% of patients reported a significant reduction in potency. By rectal examination was most frequently encountered pain and tightness of individual sections of the prostate gland (in 70-90% of cases).

On the background of the treatment with the inclusion of the BAD "Prostatic" noted a pronounced positive dynamics. Greater improvement on all indicators of clinical and laboratory parameters were obtained in patients with moderate dysuria and leukocyturia and moderately severe induration and tenderness of the prostate by rectal examination.

Earlier purpose BAD "Phytoprostanes" when is FDI. Moreover, the 21 day follow-up decrease in the severity of clinical and laboratory symptoms 2 times observed in 80% of patients.


Claims

Dietary Supplement for the prevention and maintenance therapy for diseases of the prostate and urinary tract based on vegetable raw materials, characterized in that it contains dry concentrates broth pumpkin seeds, propolis tincture, tincture of walnut and decoction of leaves of bearberry, pollen, cinnamon, vitamin E, zinc sulfate, starch, calcium stearate and sugar in the following ratio of components a tablet weight of 0.55 g, g:
Dry concentrate of the broth, pumpkin seeds and 0.0001-0,0008
Dry concentrate propolis tincture - 0,00035-0,0014
Dry concentrate infusions walnut - 0,000175-0,0014
Dry concentrate decoction of leaves of a bearberry - 0,00001-0,00008
Pollen - 0,0100-0,0400
Cinnamon - 0,0010-0,0040
Vitamin E - 0,0010-0,0040
Zinc sulfate - 0,0025-0,0100
Starch - 0,0200-0,0500
Calcium stearate - 0,0200-0,0500
Sugar Ostalnoe

 

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