The remedy for the prevention and treatment of mycotoxicosis in poultry

 

(57) Abstract:

The tool includes active carbon, additionally contains sodium Selenite, copper sulphate and magnesium, cobalt chloride and sodium bicarbonate in the following ratio, wt.%: active carbon 30,0-34,0, sodium Selenite 0,2-0,27, copper sulfate 1,0-1,3, cobalt chloride 0,7-1,3, magnesium sulfate 32,0-37,0, sodium bicarbonate rest. The tool has an extended range of therapeutic effects due to the combined effect of its components and is effective for the prevention and treatment of mycotoxicosis.

The invention relates to veterinary medicine, namely, veterinary pharmacy, in particular to methods for veterinary drugs for the prevention and treatment of mycotoxicosis in poultry.

There are literary information on the protective effect of cobalt chloride in experimental acute T-2 toxicosis in laboratory animals (tutelian C. A. , Kravchenko, L. C. Mycotoxins. - M.: Medicine, 1985. - S. 159), copper sulfate at birds when aflatoxicoses (Kachanov S. N. Mycotoxins and mycotoxicoses in farm animals. - M. , 1989. - S. 42) and of sodium Selenite when exposed to T-2 toxin in pigs.

The disadvantage of these drugs in the Paseo is a wide spread practice.

It is known the use of activated carbon for poisoning birds alkaloids and toxins of fungi (taken by the author for the prototype: see I. Petrukhin Century, feeds and Feed additives. The Handbook. - M.: Rosagropromizdat, 1989. - S. 465).

Lack of preparation is the narrow focus of the mechanism of action (absorption), and with prolonged use at high doses the drug can bind some vitamins (Artemyev M. A. Prescription Handbook of poultry diseases. - M.: Kolos, 1972. - S. 42). In addition, the formed complexes are short, and to prevent resorption of toxins, it is necessary to prescribe laxatives for rapid excretion from the intestine absorbed poisons (Most honey. the encyclopedia. Ed. 2-E. - M., 1956. - T. 1. - S. 512).

The technical solution of the invention is to improve the prevention and treatment of mycotoxicosis poultry by expanding the range of therapeutic action of the product is due to the combined effect of its components and their various etiotropic-pathogenetic orientation.

The solution of this problem is achieved in that the means for prevention and treatment ecotoxity magnesium and copper, the cobalt chloride and sodium bicarbonate in the following ratio, wt.%:

Active coal - 30,0-34,0

Sodium Selenite - 0,2-0,27

The copper sulfate - 1,0-1,3

Magnesium sulfate - 32,0-37,0

The cobalt chloride - 0,7-1,3

Sodium bicarbonate - Rest

The novelty of the claimed technical solution due to the fact that the agent is effective when combined mycotoxicosis, has in addition to absorbent, antioxidant, antitoxic, immuno - and growth-promoting properties and provides comprehensive etiotropic-pathogenic action. Selected in the formulation of macro - and micronutrients are not chemically antagonists, and the combination included in the drug component is justified by the synergistic positive effect on the body.

In particular, the carbon sorbent, blended, has an adsorption capacity for alkaloids, glucosides, some organic compounds and practically does not adsorb inorganic substances. Absorbs carbon dioxide, ammonia, hydrogen sulfide, bacterial toxins and other Included tools sodium Selenite is a strong hepatoprotector, antioxidant, containing processes pereokislenie lipid biologists who, however, what selenium slows down the growth of malignant tumors, has radioprotective properties (Tyurin H. Selenium fosters the cell. - Knowledge is power. - 1976. - 3. - S. 24 and 25), stimulates the formation of hemoglobin, the erythropoiesis in the blood of chickens, regulates the absorption and consumption of vitamins a, D, E and K in the body, has protective properties for poisoning birds toxins of fungi of the genus Aspergillyus. Cobalt as biotic exogenous origin that can be included in the biochemical structure of the system, stimulates the body's defenses by enhancing the activity of complement serum, antibody production, increase falifornia activity pseudosinella. Cobalt promotes better digestibility of feed nutrients. Traditionally, the cobalt in the diet of poultry injected in the form of chlorides. Once in the body of broilers, it has a marked effect on the deposition of vitamins a and b12in liver. Given the decline in recent years in the diets of poultry standards of feeds of animal origin, which are a source of vitamin b12this physiological role of cobalt is very important. Moreover, the low commercial value of cobalt salts in the case of inclusion in the diet of N. the setting and the permeability of cell membranes to toxins) and the growth-promoting effect on the bird. Set of copper for hematopoiesis, tissue respiration and use of iron in the body. In the form of salts of the copper itself serves as an oxidizing catalyst and promotes the use of glucose and glycogen deposits in the liver, stimulates egg production. In addition, the copper sulfate used in food poisoning (Subbotin C. M. and other Modern medicines in veterinary medicine. - Rostov-on-don, 2000. - S. 34). Magnesium sulfate helps eliminate toxins from the body due to the dissociation of the latter on calcium ions and the remainder of the sulfuric acid, thereby increasing the secretory and motor function. It is used as antidote for poisoning by alkaloids, cyanide, heavy metals. The mechanism of the protective action of sodium bicarbonate during mycotoxicoses is, apparently, that in the body he dissociates to sodium ion and ion balance coal islote, and in the dissociation of strong acids with acidic residues form non-toxic salts. As the connection to slightly alkaline reaction of sodium bicarbonate has not pronounced anti-inflammatory action, and so better use it with absorbent substances.

According to research the provision of the task, that allows to judge about inventive step of the claimed technical solution.

As for the criterion "industrial applicability", then all of the included tools components made by Hasformula (GCF) for use in medical and veterinary practice, it is not toxic at recommended doses, which ensures the safety of the proposed tools.

The proposed tool is a complete organic-mineral therapeutic drug, a powder gray-black odourless.

The drug is well combined with other methods and means of treatment. Has anti-toxic, anti-inflammatory, immuno - and growth-promoting action. In recommended doses is not toxic.

The determinant of a drug given property, is the percentage ratio between components included in the product, and the consistency of its preparation.

Since the main components of the product are active coal, copper sulphate and cobalt chloride, in the following examples, the activated carbon is taken in quantities 30,0; 32,0; 34,0; 36,0; 38,0 and 40.0 g of copper sulphate in quantities 0,8; 1,0; EP 1. Connect 0.27 g of sodium Selenite, 0.8 g of copper sulfate, 0.7 g of cobalt chloride and 15 g of active charcoal and grind to a powder. Separately grind the remaining number of active charcoal (15 g). Connect the milled samples, add 33 g of magnesium sulfate and missing to 100 g quantity of sodium bicarbonate and thoroughly mix.

Get the product of the following composition, wt.%:

Active coal - 30,0

Sodium Selenite is 0.27

The copper sulfate - 0,80

Magnesium sulfate - 33,0

The cobalt chloride - 0,7

Sodium bicarbonate - Rest

In the recipe data of the number of active coal, copper sulphate and cobalt chloride do not provide the necessary protection of the body from the action of mycotoxins.

Example 2. Unite for milling 0.27 g of sodium Selenite, 1.0 g of copper sulfate, 1.0 g of cobalt chloride and 15 g of active charcoal. Then grind the remaining 17 g of active charcoal. To the United grinded powder type of 33.0 g of magnesium sulfate and missing to 100 g quantity of sodium bicarbonate and mix thoroughly.

Get the product of the following composition, wt.%:

Active coal - 32,0

Sodium Selenite is 0.27

The copper sulfate - 1,0

Sulfate m is employed in a sufficient degree of its fungicidal and growth-promoting properties, and the cobalt chloride - immunostimulatory properties.

Example 3. Take the following amounts of components: sodium Selenite 0.27 g, sulphate of copper of 1.3 g of cobalt chloride 1.3 g, activated carbon 15 g and grind. Then separately grind 19 g of active charcoal. Combine the crushed samples, add 33 g of magnesium sulfate and the required amount of sodium bicarbonate and thoroughly mix.

Get the finished product of the following composition, wt.%:

Active carbon is 34.0

Sodium Selenite is 0.27

The copper sulfate - 1,3

Magnesium sulfate - 33,0

The cobalt chloride - 1,3

Sodium bicarbonate - Rest

This ratio of components has allowed to solve the problem on the prevention and reduction of toxic effects of mycotoxins on the body of the bird.

Example 4. Connect 0.27 g of sodium Selenite, 1.4 g of copper sulphate and cobalt chloride and grind to a powder. Separately grind the remaining number of active coal (21 g). Connect the milled samples, add 33 g of magnesium sulfate and missing to 100 g quantity of sodium bicarbonate and thoroughly mix.

Get the finished product of the following composition, wt.%:

Active coal - 36,0

The village is s - Else

Example 5. Combine and grind 0.27 g of sodium Selenite, 1.5 g of copper sulphate and cobalt chloride and 15 g of active charcoal. Then grind the remaining 23 g of active charcoal. To the United grinded powder add to 33.9 g of magnesium sulfate and the missing amount of sodium bicarbonate and mix thoroughly.

Get the finished product of the following composition, wt.%:

Active coal - 38,0

Sodium Selenite is 0.27

The copper sulfate - 1,5

Magnesium sulfate - 33,0

The cobalt chloride and 1.5

Sodium bicarbonate - Rest

Example 6. Take the following amounts of components: sodium Selenite 0.27 g, copper sulphate and cobalt chloride 1.6 g of active charcoal 15 g and grind to a powder. Then separately grind 25 grams of activated carbon. Combine the crushed samples, add 33 g of magnesium sulfate and missing to 100 g quantity of sodium bicarbonate and thoroughly mix.

Get the finished product of the following composition, wt.%:

Active coal - 40,0

Sodium Selenite is 0.27

The copper sulfate - 1,6

Magnesium sulfate - 33,0

The cobalt chloride - 1,3

Sodium bicarbonate - Rest

Based on the above examples, the best option E. the number of active coal significantly below the recommended minimum doses for short-term use in food poisoning, it can be used long-term in preventive purposes. Adsorption capacity of coal on the background of the binding effect of copper sulfate and laxative properties of magnesium sulfate increases. A higher concentration of active coal impractical because it leads to the rise of the drug and increases the probability of binding is useful for the body of organic substances. These amounts of cobalt chloride and copper sulfate increase of protective forces of an organism, decrease sensitivity and permeability to toxins epithelial cells of the gastrointestinal tract and do not exceed the recommended rates of entry in the feed.

The tool set of agricultural bird in a mixture with the feed in the amount of 0,15%.

Negative side effects in the use of funds is not marked.

The remedy for the prevention and treatment of mycotoxicosis in poultry, including activated carbon, characterized in that it further contains sodium Selenite, copper sulphate and magnesium, cobalt chloride and sodium bicarbonate in the following ratio, wt.%:

Active coal - 30,0-34,0

Sodium Selenite - 0,2-0,27

The copper sulfate - 1,0-1,3

Magnesium sulfate - 32,0-

 

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1 dwg

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