The method of treatment of degenerative diseases of the retina

 

(57) Abstract:

The invention relates to medicine, namely to ophthalmology, and for the treatment of degenerative diseases of the retina. To do this, along with vasodilators and metabolic drugs as a means of improving hemorheological properties of blood, use ASColor, assigning prolonged use of plates of askolong 1 time per day on the gums. The method allows to avoid retro-bulbar injection, which improves blood flow to the retina.

The invention relates to medicine, namely to ophthalmology vascular.

A significant place in ophthalmology is age-related macular degeneration and inherited retinal disease characterized by bilateral lesions and progressive visual impairment. These diseases cause disability of working age, and the development of macular degeneration is one of the main causes significant vision loss until the occurrence of blindness in the second half of life of the patient.

Currently there is no common point of view on the pathogenesis of these diseases. However, we know that in all cases of these diseases should include the use of means improves blood supply to the retina, microcirculation and indicators of hemorheology, in particular, should be used drugs, reducing platelet aggregation (antiplatelet agents).

Known means for reducing platelet aggregation in the blood, including acetylsalicylic acid (ASA), immobilized in a polymeric matrix carrier (RF patent 2095064, class a 61 K 31/60, 47/48, 1995) tool is a plate having adhesive properties, which contains a low dose of ASA is 12.5 mg. It aplitsiruetsya on the mucous membrane of the gums. This ensures the receipt of the ASC in systemic circulation without direct irritating effect of aspirin on the mucosa of the gastrointestinal tract.

Closest to the invention is a method of treatment of degenerative diseases of the retina through the use of the drug trental, improve its blood supply. It is used in addition to vasodilator and metabolic drugs. Trental, according to experimental and clinical studies conducted at the research Institute of eye diseases. Helmholtz has angioprotective properties, improves microcirculation and hemorheological properties of blood (Keko practice has significant restrictions associated with the pain and trauma of invasive retro-bulbar how the introduction of this drug.

The aim of the invention is to increase the efficiency of the treatment method.

This objective is achieved in that in the method of treatment of degenerative diseases of the retina, which contains the application along with vasodilators and metabolic drugs drugs that improve blood flow to the retina, as the last use of ASColor. It is prescribed long-term for 1 plate per day in the form of application to the gums.

Preparation of ASColor used as a means of improving hemorheological properties of blood. In it a small amount of the ASC and has antiplatelet effect.

This drug is possible on an outpatient basis, does not require special medical manipulations, is not associated with significant trauma periorbital tissues and stressful situations that occur when applying trental.

The proposed method of treatment is that all patients who have retinal dystrophy in need of treatment, instead of episodic injections trental appointed laparatomy (complain), drugs metabolic stimulants (taufon, pikamilon).

Examined 30 patients with hereditary degeneration and age-related macular degeneration of the retina. The study was conducted double-blind, randomized, crossover, placebo-controlled manner.

All patients within 2 months daily 1 time per day was held applications: within 30 days, patients received placebo and during the same time period were treated by askolong dose of 1 record per day.

The source and end of each treatment period the patients were examined using the following methods: examination of front section, biomicroscopy, ophthalmoscopy, fluorescent angiography fundus perimetry, electroretinography.

The results of clinical and instrumental examination of the patients revealed a positive influence of askolong on the functional state of the retina in different electrophysiological parameters at 40-55% of patients.

Along with improved data electroretinography there was an increase of visual acuity of 0.1 to 0.15 47% and 54% of patients, respectively, with the retinal abiotrophy and age-related macular degeneration.

Analysis of the s and the condition of the retina.

Thus, the drug ASColor has a positive effect on visual function and condition of the retina. Noninvasive and availability of this treatment on an outpatient basis, which determines the possibility of long-term repeated use of the drug, make feasible its use for the treatment of malnutrition and promising in the treatment of vascular disease of the retina.

Applique of askolong gum 1 time per day is necessary and sufficient, as it provides a significant improvement of visual functions. This is confirmed by the results of the above objective methods of examination of patients.

The method of treatment of degenerative diseases of the retina by using along with vasodilators and metabolic drugs drug that improves blood circulation, characterized in that as a drug that improves blood flow to the retina, use ASColor, and prescribe long-term use of plates of askolong 1 time per day on the gums.

 

Same patents:
The invention relates to medicine, namely to ophthalmology, and for the correction of functional disorders of the visual analyzer

The invention relates to medicine, in particular to ophthalmology, and is intended to improve the treatment results of patients with blunt trauma of the eyeball, complicated intraocular hemorrhage

-converting enzyme)" target="_blank">

The invention relates to novel ortho-sulfonamidophenylhydrazine heteroaryl hydroxamic acids of the formula

< / BR>
where W and X are both carbon, T is nitrogen, U represents CR1where R1represents hydrogen, or alkyl containing 1-8 carbon atoms, R represents-N(CH2R5)-SO2Z, Q represents -(C=O)-NHOH, with

< / BR>
is a benzene ring, or is a heteroaryl ring of 5 to 6 atoms in the cycle, which may contain 0-2 heteroatoms selected from nitrogen, oxygen and sulfur, in addition to the heteroatom of nitrogen, denoted as W, where benzene or heteroaryl ring may optionally contain one or two substituent R1where permissible; Z is phenyl, which is optionally substituted by phenyl, alkyl with 1-8 carbon atoms, or a group OR2; R1represents halogen, alkyl with 1-8 carbon atoms, alkenyl with 2-6 carbon atoms, perfluoroalkyl from 1 to 4 carbon atoms, phenyl, optionally substituted by 1-2 groups OR2group-NO2group -(CH2)nZ, where Z is a phenyl which allows an alkyl with 1-8 carbon atoms, phenyl, optionally substituted with halogen, or heteroaryl radical containing 5 to 6 atoms in the cycle, including 1-2 heteroatoms selected from nitrogen, oxygen and sulfur; R5represents hydrogen, alkyl with 1-8 carbon atoms, phenyl, or heteroaryl containing 5 to 6 atoms in the cycle, including 1-2 heteroatoms selected from nitrogen, oxygen and sulfur; or their pharmaceutically acceptable salts
The invention relates to medicine, namely to ophthalmology, and for the treatment of diabetic retinopathy
The invention relates to the field of medicine

The invention relates to medicine, namely to ophthalmology, and for the prevention of recurrence of erosion and ulceration of the cornea on the eye ended with the healing of burn wounds with bilateral burns after keratoplasty about ulceration of the cornea of one eye

The invention relates to medicine, namely to ophthalmology, and for the treatment of serotonin deficiency in patients with diabetic retinopathy
The invention relates to medicine, namely to ophthalmology, and for the treatment of bullous keratopathy
The invention relates to medicine, namely to ophthalmology and for the treatment of herpetic eye lesions

The invention relates to medicine, namely to ophthalmology

The invention relates to medicine and relates to the application of sodium nukleospermata as a drug for the treatment of HIV infection
The invention relates to medicine, namely to urology, and for prophylaxis and complex treatment of urolithiasis

The invention relates to a group of compounds of General formula (I) high degree of purification

The invention relates to medicine and provides substances that are effective against tumors and viruses, for which conventional anti-tumor agents and antiviral agents exhibit only insufficient effects, and have cancerostatic action and antiviral effects on different tumor immune

The invention relates to medicine, in particular a drug containing COA-thioesters arylpropionic acids, alloxanic acids or acetylsalicylate, R-ibuprofen or ibuprofen racemate containing up to 49% of S-ibuprofen or derivatives of these compounds which are metabolized in the body in a similar way
The invention relates to the field of veterinary medicine

The invention relates to medical equipment, namely to devices used in surgical ophthalmology
Up!