A family of peptides with neurotropic properties

 

The invention relates to peptides of General formula a-B-C-D-Pro-Gly-Pro-X, where A - O-Met(O), -Met, -Thr, -Ala, -Lys-Gly, -Glu, -Arg, -His, -Phe -,- Tyr, -Trp, B - O, -Glu, -Lys, -Tyr, -Gly, -Arg-Val-Pro; - O, -His, -Pro-Asp-Gly, -Arg, -Tyr, -Val-Phe; D - O-Phe, -His, -Arg, -Lys, -Ala, -Tyr, -Thr, -Pro-Ile; X - O-Il, highly neurotropic activity (refers to the lack of amino acids), provided that excluded peptides: Glu-His-Phe-Pro-Gly-Pro, Thr-Lys-Pro-Arg-Pro-Gly-Pro, Tyr-Pro-Phe-Pro-Gly-Pro-Ile and Met-Glu-His-Phe-Pro-Gly-Pro. Compounds useful as neurotropic preparations for correction of nervous and mental fatigue, to increase the adaptive capacities of the human body in extreme situations and in different pathologies of the Central nervous system, including mental illness. 2 C.p. f-crystals, 12 tab., 2 Il.

Description text in facsimile form.

Claims

1. The peptides of General formula a-B-C-D-Pro-Gly-Pro-X, where A - O-Met(O), -Met, -Thr, -Ala, -Lys-Gly, -Glu, -Arg, -His, -Phe -,- Tyr, -Trp, B-O, -Glu, -Lys, -Tyr, -Gly, -Arg-Val-Pro;-O, -His, -Pro, -Asp-Gly, -Arg, -Tyr, -Val-Phe; D-O-Phe, -His, -Arg, -Lys, -Ala, -Tyr, -Thr, -Pro-Ile; X-O-Ile with neurotropic activity (refers to the lack of amino acids), provided that excluded peptides: Glu-His-Phe-Pro-Gly-Pro, Thr-Lys-Pro-Arg-Pro-Gly-Pro, Tyr-Pro-Phe-Pro-Gly-Pro-Ile and Met-Glu-His-Phe-Pro-Gly-Pro.

elusivemuse the peptide with the N-terminal seven amino acids A.

3. The peptide according to PP.1 and 2, obtained by synthesis heptapeptide a-B-C-D-Pro-Gly-Pro and, if necessary, attach with the end of the molecules of the eighth amino acid X.

 

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