Antivirus derivative of pyrimidinedione, the method of production thereof and pharmaceutical composition based on them

 

The invention relates to a new group of individual compounds of General formula Iwhere R denotes cyclopropyl, cyclobutyl, cyclohexyl, phenyl, unsubstituted or mono -, di - or tizamidine group selected from hydroxy, C1-C4of alkyl, C1-C4alkoxy, halogen, trifloromethyl, ceanography and amino groups; 1-or 2-naphthyl, 9-anthracene; 2-anthrachinone, Persil, unsubstituted or substituted group selected from1-C4of alkyl, C1-C4alkoxy, ceanography and halogen; 2-, 3 - or 4-chinoline, oxiranyl, 1-benzotriazolyl, 2-benzoxazolyl, furanyl, substituted C1-C4alkoxycarbonyl; C1-C4alkylsulphonyl or benzoyl; R1denotes halogen or1-C4alkyl, R2and R3independently represent hydrogen or C1-C4alkyl; X denotes an oxygen atom and Y represents an oxygen atom, a sulfur atom or a carbonyl, or their pharmaceutically acceptable salts, method of production thereof and pharmaceutical composition having antiviral activity, containing antiviruse-effective amount of compounds of General formula I. 3 S. and 1 C.p. f-crystals, 2 tab.

Text opisannaya General formula Iwhere R denotes cyclopropyl; cyclobutyl; cyclohexyl; phenyl, unsubstituted or mono-, di - or tizamidine group selected from hydroxy, C1-C4of alkyl, C1-C4alkoxy, halogen, trifloromethyl, ceanography and amino groups; 1 - or 2-naphthyl; 9-anthracene; 2-anthrachinone; pyridyl, unsubstituted or substituted group selected from1-C4of alkyl, C1-C4alkoxy, ceanography and halogen; 2-, 3 - or 4-chinoline; oxiranyl; 1-benzotriazolyl; 2-benzoxazolyl; furanyl, substituted C1-C4alkoxycarbonyl; C1-C4alkylsulphonyl or benzoyl; R1denotes halogen or1-C4alkyl; R2and R3independently represent hydrogen or C1-C4alkyl; X denotes an oxygen atom; Y represents an oxygen atom, a sulfur atom or a carbonyl,
or its pharmaceutically acceptable salt.

2. The compound of General formula I on p. 1, where R1represents ethyl or isopropyl, and R2and R3represent methyl.

3. The method of obtaining compounds of General formula I by the interaction of the compounds of formula II with the compound of the formula III


4. Pharmaceutical composition having antiviral activity, containing antiviruse-effective amount of compounds of General formula I on PP. 1 and 2, or its pharmaceutically acceptable salt and pharmaceutically acceptable carriers.

 

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