Derivatives dihydronaphthalene

 

The invention relates to the derivatives of dihydronaphthalene formula I, where R1represents hydrogen, hydroxyl or alkyloxy, R2represents hydrogen, lower alkyl, aralkyl or phenyl, and R3represents pyridyl or imidazolyl. The compounds have activity of inhibiting 17-hydroxylase and/or C17-20-LiAZ, the activity of inhibiting the synthesis of thromboxane A2 and/or activity of inhibiting aromatase. The technical result obtained new compounds possess valuable biological properties. 3 S. p. f-crystals, 5 PL.

Description text in facsimile form (see graphic part). Tn

Claims

1. Derivatives dihydronaphthalene formula Iwhere R1represents hydrogen, hydroxyl or alkyloxy; R2represents lower alkyl, aralkyl or phenyl; R3represents pyridyl or imidazolyl.

2. Derivatives dihydronaphthalene formulawhere R1represents hydrogen, hydroxyl or alkyloxy straight or branched chain C1alkyl; R3represents pyridyl or imidazolyl.

3. Derivatives dihydronaphthalene formula

where R1represents hydrogen, hydroxyl or alkyloxy straight or branched chain C1-C6;
R2represents hydrogen, alkyl straight or branched chain C1-C6, phenyl or aralkyl;
R3represents pyridyl or imidazolyl,
moreover, these derivatives have activity of inhibiting 17-hydroxylase and/or C17-20-LiAZ, the activity of inhibiting the synthesis of thromboxane A2 and/or activity of inhibiting aromatase.

 

Same patents:

The invention relates to new compounds having formula I or formula II:

< / BR>
< / BR>
where R1represents H, lower alkylthio or R1together with R2form a-CH2-; each of R2and R3independently represents H or lower alkyl; R4represents Oh or H2; R5is H, unsubstituted lower alkyl, cyclohexyl - lower alkyl; each of R6and R7independently represents hydrogen, phenyl, naphthyl, -C(O)-NHCHR13CO2R14or substituted phenyl, where the Deputy represents halogen, lower alkyl, lower alkoxy, hydroxy, or phenyl - lower alkoxy; R8represents H or lower alkyl; R9represents H or lower alkyl; R12is NR9or S; R13is lower alkylthio; R14represents H or lower alkyl; or their pharmaceutically acceptable salts, with the exception of 4,5-bis(4-methoxyphenyl)-2-(4-thiazolidinediones)thiazole and its hydrochloride

The invention relates to new amide derivatives of General formula (I) or their salts, where a means thiazolidin, imidazoline, triazoline, benzimidazolyl, benzothiazolyl, thiadiazolyl, imidazopyridine or imidazothiazole; X is a bond, -NR5-, -NR5CO-, -NR5CONH-, NR5SO2-, -NR5C(= NH)NH-; R1means H, lower alkyl, aryl, pyridyl, thienyl, furyl, thiazolyl, benzimidazolyl, imidazopyridine, triazolyl, thiadiazolyl, imidazolyl, imidazothiazoles, benzothiazolyl, cyclohexyl, which may be optionally substituted with halogen, lower alkyl, -OH, -CN, -NO2, -CF3, -NH2, -O-lower alkyl, and the Deputy of the lower alkyl may be substituted by phenyl, naphthyl, fullam, tanila or pyridium;2a, R2bmean H or lower alkyl; R3means hydrogen or lower alkyl; R4a, R4bmean H or HE, or taken together form a group =O or =N-O-lower alkyl; R5means H or lower alkyl

The invention relates to a method for producing esters of L-carnosine and their salts, including the interaction of L-carnosine with the lower alcohol in an anhydrous environment of the corresponding alcohol by cooling, in the presence of an acid catalyst, followed by the selection of the target product and its purification

The invention relates to derivatives of N-sulfanilimide formula I, where R1and R2denote hydrogen, halogen, C1-4alkyl, C1-4alkoxycarbonyl or phenyl which can be substituted one to three times, equal or different residues from the group comprising halogen, C1-4alkyl, trifluoromethyl; R3- halogen, cyano, trifluoromethyl; R4- 4-isoxazolyl, pyrazolyl, which may be substituted with halogen, C1-4the alkyl, amino group, cycloalkyl, as well as their acid-salt additive

The invention relates to new substituted 4-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazoles and 4-(2,3-dihydro-1H-inden-1-yl)-1H-imidazoles and their additive salts, to processes for their preparation and to pharmaceutical compositions based on them

The invention relates to the field of organic chemistry and relates to a method of obtaining new derivatives of imidazole

The invention relates to methods of producing substituted imidazole derivatives and their non-toxic pharmaceutically acceptable acid additive salts

The invention relates to the field of organic chemistry, namely to a new method of obtaining 4-arylpyrimidines General formula I

< / BR>
where R1, R2- H or lower alkyl, which can be used in organic synthesis, including the synthesis of biologically active compounds

The invention relates to new biologically active compound derived isonicotinic acid of General formula I,

with antimycobacterial and immunotropic activity, which can find application in medicine

The invention relates to an improved process for the preparation of CIS-1-{2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl] ethyl} pyrrolidine, which is a substance to obtain the (-)CIS-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)phenyl-5,6,7,8-tetrahydronaphthalen-2-ol, which is used in the treatment of osteoporosis, as well as to intermediate compounds for this method

The invention relates to new derivatives of naphthalene or dihydronaphthalene formula I, where R1means-HE or-O(C1-C4-alkyl), R2- C1-C6-alkyl or C5-C7-cycloalkyl, X represents-CH(OH)-, or-CH2-, M represents-CH2-CH2- or-CH=CH-, n is 2 or 3, R3denotes 1-piperidinyl or 1-pyrrolidinyl, or their pharmaceutically acceptable salts

The invention relates to stabilizers for organic materials against oxidative, thermal or light degradation

The invention relates to the field of petrochemicals, more specifically to methods for stabilizers for rubbers, thermoplastic elastomers and rubbers

The invention relates to a previously undescribed perchlorates of diphenylethylenediamine General formula (I)

< / BR>
where n= 0,1; R1, R6the atom of hydrogen or halogen, C1-C6alkyl, C1-C6alkoxy or di(C1-C6)alkylamino; R2, R5= a hydrogen atom or halogen, C1-C6- alkoxy - or actigraphy; R3, R4the atom of hydrogen or C1-C6alkoxygroup; R7=R8=R9a hydrogen atom, or R7+R9=(CH2)1-3and R8=H; if n=0 have the General formula (Ia-C):

< / BR>
(perchlorate 1,5-diphenyl-3-ethoxymethyleneamino), and when n=1 have the General formula (I-R):

< / BR>
(perchlorate 1,7-diphenyl-3,5-diethoxymethylsilane) and which can be used as a promising synthons in organic synthesis, and in particular in the synthesis of fluorescent dyes (Durder J. A

The invention relates to new derivatives of cyclohexane and tetrahydropyrane, the way they are received, fungicidal compositions on their basis and use of this composition for combating fungi

The invention relates to the field of organic chemistry

The invention relates to the field of reception of dimethylmethylene (DMT) of 5 - (o -, m - or p-tolyl)-Penta-1 - or-2-ene or 5-phenyl-Gex-1 - or-2-ene used as an intermediate for obtaining naphthalenesulphonic acids
Up!