A composition for controlling fungal diseases of cultivated plants and the way to deal with them

 

Describes a composition for controlling fungal diseases of cultivated plants, containing (a) compound of imidazole of the formula (I), where R is lower alkyl or alkoxygroup, n is 1, as an active ingredient and (b) one inorganic compound of phosphorus, which is selected from the group comprising phosphoric acid, phosphorous acid and their salts, one or fungicide for phykomycets, which is selected from the group of methyl-(E)-2-{2-[6-(2-cianfrocca)pyrimidine-4-yloxy] phenyl} -3-ethoxyacrylate, methyl-(E)-methoxyimino[-o-tolyloxy)-O-tolyl] acetate, 3-aniline-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidin-2,4-dione, 1-(2-cyano-2-methoxyimino)-3-atilmotin, tetrachloroisophthalonitrile, methyl-N-(2-methoxyacetyl)-N-(2,6-xylyl)-DL-alaninate, (E, Z)-4-[3-(4-chlorophenyl)-3-(3,4-methoxyphenyl)acryloyl]morpholine, inorganic copper fungicide, Tris(ethylphosphonate) aluminum, as an active ingredient, or (C) distributing the agent as an ingredient, increased activity, which is a silicone surfactant or mineral oil, where component (a) and the compound of the phosphorus is in a mass ratio of from 1:50 to 5:1, (a) and the fungicide is the mass ratio is a way of combating fungal diseases of cultivated plants, including the application of the specified composition and method of strengthening the actions of the agent, suppressing fungal diseases of cultivated plants containing the above compounds of formula (I) and distributing agent (C) in relation to the mass/volume (kg/l) from 1:5000 to 1:0.25 in. The technical result consists in increasing therapeutic and/or preventive effects on plants suffering from fungal diseases. 3 S. and 8 C.p. f-crystals, 46 PL.

The technical field to which the invention relates the Invention relates to compositions with significantly enhanced action on harmful all, in particular for therapeutic and/or preventive effect against plant diseases, which are useful in agriculture and horticulture; to a method of suppressing harmful, all with the use of this composition and to a method of enhancing the overwhelming actions on harmful all means to fight against the harmful all.

The prior art with regard to the combination of the active ingredients (a) and (b) used in the present invention (described later), in the European patent EP 298196 reported that the compound of imidazole used in the all, and mentioned the possibility of using compounds optionally in combination with other fungicides. In EP 298196 also reported that the combined use of imidazole compounds structurally similar to the compound of imidazole used in the present invention, as the active ingredient (a), with other fungicides, such as cyanoacetamide (for example, 1-(2-cyano-2-methoxyimino)-3-atilmotin) and chlorinated organic compounds (e.g., tetrachloroisophthalonitrile), leads to increased exposure. In addition, in the European patent EP 337103 describes a means for combating harmful bioorganisms containing at least one compound of imidazole structurally similar to imidazole used in the present invention as an active ingredient, and at least one active ingredient selected from cyanoacetamide, chlorinated organic compounds (including tetrachloroisophthalonitrile), phenylamides (including methyl-N-(2-methoxyacetyl)-N-(2,6-xylyl)-DL-alaninate), derivatives of cinnamic acid, copper compounds and organophosphorus compounds (including postillonne).

Considering these patents from the point of view of the present invention, it should be noted that the x of phosphorus compounds,-ethoxyacrylate or oxazolidinedione. They are not described and not assume explicitly excellent suppressing effect, which may have a composition containing as active ingredient the compound of imidazole and, as an active ingredient, at least one of the compounds selected from the group consisting of cyanoacetamide, organic chlorine compounds, phenylamide, compounds, cinnamic acid, copper compounds and organophosphorus compounds.

With regard to the combination of the active ingredient (a) and amplifying active ingredient (s) (described later), in the European patent EP 298196 describes the usefulness of the imidazole of the present invention as a means for combating harmful all, and specifies that this connection can be enter in the composition of various forms together with adjuvants. In JP-A-Heisei-3-11003 (the term "JP-A" as used here means "not passed examination published patent application of Japan") describes a method of combating harmful, all involving the use of aqueous dispersions containing at least one compound of imidazole of the present invention and surfactant complex is their usual means for combating harmful, all have certain characteristics overwhelming steps. Some of them have insufficient inhibitory effect on some harmful, all or some of the less effective treatment than prevention, or some have a relatively short duration of the residual effect. So sometimes there are cases in which their overwhelming effect on the adverse, all is insufficient when the number of practical uses. In addition, although the connection of the imidazole of formula (I) detects an excellent fungicidal action on phykomycets, he has a tendency to weakening of therapeutic and/or preventive actions depending on the state of development of the disease. From this point of view, the strengthening of actions is also desirable.

On the other hand, in the practical application of tools to combat harmful, all containing the compound of imidazole of the formula (I), it is desirable to minimize the number of used connections for reasons of cost and at the same time to try to deal with many, as far as possible, harmful, all different in appearance, their manifestation time or time of occurrence of the disease. In addition, although the means for combating harmful, all containing as an active requires the strengthening of its therapeutic action.

Description of the invention the present invention have conducted studies to solve the above problems and found that the compound of imidazole of the formula (I) as active ingredient (a) and a specific compound as active ingredient (b) give unexpected results, such that the relative number of connections, you can reduce or augment the vast range of actions than using them separately. The authors also found that the combined use of the active ingredient (a) with increased activity of the ingredient (C) leads to a marked increase of the vast steps, in particular therapeutic action, as compared with the use of one active ingredient (a), thereby it is possible to reduce the amount of active ingredient (a). The present invention is implemented based on the received data.

The present invention relates to compositions for combating harmful, all containing (a) at least one compound of imidazole represented by the formula (I)where R represents a lower alkyl group or lower alkoxygroup and n represents an integer from 1 to 5, as is in fungicide for phykomycets as the active ingredient or
(c) a spreader as increased activity of the ingredient.

The best practical ways of carrying out the invention
In the formula (I) lower alkyl group or the alkyl component of the lower alkoxygroup represented by R, is an alkyl group with 1-6 carbon atoms, such as methyl, ethyl, propyl, butyl, pentyl or hexyl, which may have a linear or branched chain. When n is 2 or more, R may be the same or different.

The imidazole compounds represented by the formula (I) include the following compounds:
4-chloro-2-cyano-1-dimethylsulphamoyl-5-(4-were)imidazole (compound 1);
4-chloro-2-cyano-1-dimethylsulphamoyl-5-(4-methoxyphenyl)imidazole (compound 2);
4-chloro-2-cyano-1-dimethylsulphamoyl-5-(4-ethylphenyl)imidazole (compound 3) and
4-chloro-2-cyano-1-dimethylsulphamoyl-5-(3-methyl-4-methoxyphenyl)imidazole (compound 4).

Imidazole derivatives of the formula (I) can be obtained by known methods described, for example, in European patent EP 298196 or in EP-A-705823.

For inorganic compounds of phosphorus, as active ingredient (b) include phosphoric acid, phosphorous acid, phosphonoacetate acid, condensed phosphoric acid, condensed as alkali metals, alkaline earth metals, aluminum, etc.; heavy metals (with specific gravity of 4 or more), such as zinc, copper, Nickel, manganese, etc., and substituted or unsubstituted ammonium salts.

Salts of phosphoric acid include primary phosphates (e.g. sodium dihydrophosphate, potassium dihydrophosphate, dihydrophosphate aluminum, ammonium dihydrophosphate, dihydrophosphate calcium), secondary phosphates (for example, intrigejosa, declivities, diammoniumphosphate, demagnetised) and tertiary phosphates (e.g., trisodium phosphate, tribalistic, zinc phosphate, aluminum phosphate, ammonium phosphate, ammonium-Magnificat, magnesium phosphate, calcium phosphate).

Salts of phosphorous acid include primary or secondary phosphites (for example, primary or secondary postit sodium, primary or secondary postit potassium, primary or secondary postit calcium).

Salt phosphonoacetic acid include hypophosphite sodium, hypophosphite barium and hypophosphite calcium.

To the condensed phosphoric acids and their salts include polyphosphoric acid (for example, pyrophosphoryl acid) and polyphosphates (for example, sodium pyrophosphate, calcium pyrophosphate, deadlydeliveryreport).

Condensed phosphorous kislota) and polymetaphosphate (for example, trimetaphosphate sodium, tetramethoxy sodium, sodium hexametaphosphate).

To fungicides for phykomycets that can be used as the active ingredient (b) are
-ethoxyacrylate
(for example, methyl-(E)-2-{2-[6-(2-cianfrocca)pyrimidine-4-yloxy]phenyl} -3-ethoxyacrylate,
methyl(E)-methoxyimino[-(o-tolyloxy)-O-tolyl]acetate);
oxazolidinedione
(for example, 3-aniline-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidin-2,4-dione);
cyanoacetamide
(for example, 1-(2-cyano-2-methoxyimino)-3-atilmotin (trivial name of having cymoxanil));
chlorinated organic compounds
(for example, tetrachloroisophthalonitrile (trivial name CHLOROTHALONIL),
pentachloronitrobenzene (trivial name of quintozene));
phenylamide
(for example, methyl-N-(2-methoxyacetyl)-N-(2,6-xylyl)-DL-alaninate (common name metalaxyl),
2-methoxy-N-(2-oxo-1,3-oxazolidin-3-yl)Aceto-2',6'-xylidide (trivial name oxadixyl),
()--2-chloro-N-(2,6-xylylene)--butyrolactone (trivial name of Operas),
methyl-N-phenylacetyl-N-(2,6-xylyl) -DL-alaninate (trivalence name 7.gif">)--[N-(3-chlorophenyl)cyclopropanecarboxamide]--butyrolactone (trivial name zeroforum));
compounds cinnamic acid
(for example, (E,Z)-4-[3-(4-chlorophenyl)-3-(3,4-acid)acryloyl]morpholine (trivial name dimethomorph));
copper compounds
(for example, organic or inorganic copper-containing fungicides) and
organophosphorus compounds
(for example, Tris(ethylphosphonate) aluminum (trivial name postillonne),
O-2,6-dichloro-p-tolyl-O, O-dimethylphosphorodithioate (trivial name cyclophosphates),
(R,S)-S-(R,S)-sec-butyl-O-ethyl-2-oxo-2-thiazolidinethione,
S-benzyl O,O-diisopropylphosphoramidite (trivial name iprobenfos),
O-ethyl-S,S-diphenylphosphinite (trivial name edifenphos),
ethyl-2-deoxyribofuranosyl-5-methylpyrazolo(1,5-a)pyrimidine-6-carboxylate (trivial name pyrazophos)).

Of these compounds (E)-2-{2-[6-(2-cianfrocca) pyrimidine-4-yloxy]phenyl}-3-ethoxyacrylate (called hereafter "compound (a)"), methyl-(E)-methoxyimino[-(o-tolyloxy)-O-tolyl] acetate (called hereafter "compound (b)) and 3-aniline-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidin is) and ibid, p. 21-26 (1996), respectively.

Of the above organic chlorine-containing compounds is preferred tetrachloroisophthalonitrile. From Veniaminov preferred is methyl-N-(2-methoxyacetyl)-N-(2,6-xylyl)-DL-alaninate. Of organophosphorus compounds preferred is Tris(ethylphosphonate) aluminum. From copper compounds, preferred inorganic copper-containing fungicides.

Inorganic or organic copper-containing fungicides mentioned above, include fungicidal preparations containing, in addition to copper, other than the active ingredients (a) and (b) chemicals (such as fungicides, etc.,).

To inorganic copper-containing fungicides are fungicides containing as the active ingredient oxysulfate copper, such as Sanpun Bordeaux (trade mark, produced Dai-ichi Noyaku K. K., and Hokko Chemical Industry Co., Ltd. and dust DL Sanpun Bordeaux (trade mark, produced Dai-ichi Noyaku K. K., and Hokko Chemical Industry Co., Ltd.); fungicides containing the active ingredient oxychloride copper(I), such as San Bordeaux (trade mark, produced Sankei Chemical Co., Ltd.), Doitsu Borudo And (trademark, manufactured Dai-ichi Noyaku K. K., and Hokko Chemical Industry Co. Co., Ltd.), wettable powder Do-cal (trademark, manufactured Yashima Chemical Industry Co., the edient hydroxide copper, such as Kocide Bordeaux, Kocide DF, Kocide SD (trade names, all manufactured Griffin), etc., and fungicides containing anhydrous copper sulfate(II), such as wettable powder Gandie (trademark, produced Agro-Kanesho Co., Ltd.) etc.

Fungicidal preparations containing inorganic copper fungicide and chemicals such as fungicides, etc.,) other than ingredients (a) and (b) include Bordeaux mixture, containing the main medicaltemplate; fungicides containing copper and sulphur, such as Engei Bordeaux (trade mark, produced Sankei Chemical Co., Ltd.) and so on; fungicides containing copper and validamycin; fungicides containing copper, validamycin and phtalic; fungicides containing copper and pirivenas; fungicides containing copper(I) and vinclozolin; fungicides containing copper and phtalic; fungicides containing copper and procymidon, such as wettable powder Scletane (trademark, manufactured Hokko Chemical Industry Co. Co., Ltd.); wettable powders containing copper(I) and fosetyl; fungicides containing copper and metalaxyl, such as wettable powder Ridomil Copper (trademark, manufactured by Nihon Nohyaku Co., Ltd. ); fungicides containing iprodione and copper(I), such as wettable powder Daisedo (trademark, manufactured Yshima Chemical Industry Co., Ltd.); fungicides containing triacetate go; fungicides containing kasugamycin and copper, such as dust 3DL Kasumin Bordeaux (trade mark, produced Hokko Chemical Industry Co., Ltd.), Kasumin Bordeaux (trade mark, produced Dai-ichi Noyaku K. K., and Hokko Chemical Industry Co., Ltd.) and so on; fungicides containing dithianon and copper(I); fungicides containing streptomycin and copper, such as wettable powder Do-Stomy (trademark, manufactured Ninon Nohyaku Co., Ltd.) and so on; fungicides containing sodium bicarbonate and copper, such as wettable powder G-Fine (trademark, manufactured Yashima Chemical Industry Co., Ltd.), and fungicides containing copper and magyarkanizsa compounds such as Okha Bordeaux (trade mark, produced Sankyo Co., Ltd.), wettable powder Kinset (trademark, produced Agro-Kanesho Co., Ltd), wettable powder Kinset 80 (trademark, produced Agro-Kanesho Co., Ltd), etc.

Of these fungicides containing inorganic copper compounds, particularly preferable to apply fungicides containing one or more active ingredients selected from the group consisting of a hydroxide of copper, oxysulfate copper oxychloride copper, anhydrous copper sulfate(II) and the main medicaltemplate.

Organic copper-containing fungicides include fungicides containing 8-hydroxyquinoline and copper, such as MCA is inhabited by Agro-Kanesho Co., Ltd), flowable wettable powder Quinone-do (trademark, produced Agro-Kanesho Co., Ltd), wettable powder Oxine-copper(I) (trademark, manufactured Tomono Agrica Co., Ltd.), wettable powder Oxine-copper(I) 75 (trademark, manufactured Tomono Agrica Co., Ltd.), wettable powder Oxine-copper(I) 80 (trademark, manufactured Tomono Agrica Co., Ltd., and Nissan Chemical Industries, Ltd. ), flowable wettable powder Oxine-copper(I) (trademark, manufactured Tomono Agrica Co., Ltd., and Nissan Chemical Industries, Ltd. ), wettable powder Dokirin 80 (trademark, manufactured by Nihon Nohyaku Co. Co., Ltd.) and flowable wettable powder Dokirin (trademark, manufactured by Nihon Nohyaku Co., Ltd.) and so on; fungicides based on hydroquinonesulfonic copper, such as Yonepon (trademark, manufactured Yonezawa Depending K. K.), etc.; fungicides on the basis of bis(Ethylenediamine)bis(dodecylbenzenesulfonate) copper(II), such as Sanyol (trademark, manufactured Otsuka Chemical Co., Ltd., and Yonezawa Depending K. K.), etc., and fungicides based on the terephthalate copper.

Fungicidal preparations containing mediolanense fungicide and fungicide other than ingredients (a) and (b) include fungicides containing iprodione(I) and mediolanense connection, fungicides containing oxolinic acid and mediolanense connection, fungicides containing Captan(I), tiara operasie mediolanense connection and dithianon(I), fungicides containing streptomycin and mediolanense connection, fungicides containing thiabendazole(I) and mediolanense connection, fungicides containing fenarimol(I) and mediolanense connection, fungicides containing engine oil and mediolanense connection, and fungicides containing iminoctadine of guazatine(I) and mediolanense connection.

Distributing agent (spreader) is used as the ingredient (C), increased activity. Examples spreader for use in the present invention are surface-active agents (excluding esters sorbitan and higher fatty acids), paraffin oil, animal and/or vegetable oil and mineral oil. In General, the spreaders are not classified with certainty. Some of the animal and/or vegetable oils and mineral oil are used as surface-active substances, and there are a number of spreaders, called a binder, which cannot be clearly classified. Any spreader, which significantly improves the physical properties of the imidazole derivative of the formula (I), such as fixing properties, permeability, the possibility of application and penetration of the stomata, the reinforcing action of the compounds can be used in this is a and to obtain such effect, which is equivalent to an overwhelming effect on all receive with fewer connections. From the above spreaders are preferred surface-active agents (excluding esters sorbitan and higher fatty acids), animal and/or vegetable oil and mineral oil. Preferred non-ionic surface-active agents (excluding esters sorbitan and higher fatty acids), animal and/or vegetable oil and mineral oil.

Suitable nonionic surfactants that can be used as a reinforcing activity of the ingredient (C) include polyoxyethylenesorbitan esters, polyoxyethylenesorbitan esters, polyoxyethylenesorbitan esters, polyoxyethyleneglycol esters, polyoxyethylene esters of fatty acids, polyoxyethylenesorbitan esters of fatty acids, polyoxyethylene amides of fatty acids, amine-N-oxides, such as Aromox C/12W (trademark, manufactured Akzo Chemie), polyoxyalkylene, esters of glycerin and fatty acids, silicon-containing surfactants, surface-active polyoxyethyleneglycol chiefeconomist, such as Reider (Corgi. Among them, preferred are polyoxyethylenated esters, polyoxyethylenesorbitan esters, polyoxyethylene esters of fatty acids, polyoxyethylenated fatty acids, silicon-containing surfactants, esters of higher alcohols and sulfuric acid and diallylmalonate. Preferred silicon-containing surfactants, polyoxyethylenesorbitan esters and polyoxyethylene esters of fatty acids. Especially preferred silicon-containing surfactants, in particular DyneAmic (trademark, manufactured Setre Chemical), KINETIC (trademark, manufactured Setre Chemical), SILWETT L-77 (produced Witco) and SLIPPA (produced Interagro).

Specific examples of preferred nonionic surfactants are shown in table 1. In addition to the applicable non-ionic surface-active substances are policyactioninpolicyrule ether (type silicon-containing surfactants), Renex 36 (trademark, polyoxyethyleneglycol ether produced Voeg AG), Crop Oil Extra (trademark, polyoxyethyleneglycol ether produced Kalo, Inc.), media Ortho X-77 (trade mark, manufactured by Chevron Chemical Company) and SME substances, you can use as a reinforcing activity of the ingredient (C) include surface-active esters of sulfuric acid such as complex alkylsulfonate, or their salts; surfactants based on sulfonic acid, such as naphthylenediisocyanate and ligninsulfonate; salts of fatty acids and fluorine-containing surface-active substances, preferably esters of sulfuric acid and sulfonic acid derivatives. Examples of preferred anionic surfactants are shown in table 2.

Suitable cationic surfactants that can be used as a reinforcing active ingredient (s) are dialkylammonium salts such as NEEDS (trademark, produced by Kao Corporation), and alkylammonium salts such as Arguard T/50 (trademark, manufactured Akzo Chemical), are shown in table 3.

Liquid animal fat and/or vegetable oil that can be used as a reinforcing activity of the ingredient (C) is a vegetable oil, such as corn, soybean oil, linseed oil, sunflower oil, cottonseed oil and rapeseed oil, and liquid animal fat, such as beef W is to SCOIL (produced MVRC). Specific examples of suitable animal fat and/or vegetable oils are given in table 4. Among them, preferably vegetable oil.

To paraffin oil, which can be used as a reinforcing activity of the ingredient (C) include a product obtained from animal fat and/or vegetable oil, a product derived from mineral oils (e.g. oil) and mixtures thereof. Specific examples are given in table 5.

To mineral oil, which can be used as a reinforcing activity of the ingredient (C) include lube oil, fuel oil, and silicone oil. Examples of preferred types of mineral oil are shown in table 6. Of these the most preferred is ISHIOIL (produced Ishihara Sangyo Kaisha, Ltd.).

Above the spreaders, i.e., surface-active agents (excluding esters sorbitan and fatty acids), animal fats and/or vegetable oil, paraffin oil, mineral oil, etc. can be appropriately combined for use as a reinforcing active ingredient (s). Combinations of two or more distributing agents include vegetable oil containing a surfactant such as Oleo 11E DP (E. I. du Pont), Fysol 11E (Schering Agrochemicals), Agri Dex (Helena Chemical Co. ), Atplas 411 (ICI Agrochemicals), Herbimax (Love Land Industries, Inc.), concentrate, corn oil Competitor (Red Pancer Chemical), Actipron (Oil Co. ), DASH (BASF AG), Atlas Adherb (Atlas Interlates, Ltd.), Cropspray (Tribart Farm Chemical), Agravia 11TH (Wakker Chemie), Penetrator (Helena Chemical Co.), Atlus Adjuvant Oil (Atlus Intertates, Ltd.) etc. It also includes mixed agents-spreaders listed in table 7.

As described above, in the present invention, in order to increase the connection, you can use any attachment, if it significantly improves the physical properties of the imidazole compounds of formula (I), which would mean it is not treated. Specific examples of the distribution of the agents that cannot be attributed to any of the class described above, are shown in table 8. It is expected that the composition for pest, all containing at least one imidazole of the formula (I) as an active ingredient, and includes a spreader which are useful as reinforcing the active ingredient (s) in the ratio of the present invention, will show a similar effect.

Described above as the active ingredient (b) fungicides for phykomycets have one or more of the following properties: preventive action, remedial action, and permeability. Some of the nycida for phykomycets have one or more such properties, as a preventive action, remedial action, and permeability.

The term "fungicide providing preventive action" means that fungicides have the ability to prevent diseases of plants. Examples of such fungicides are-ethoxyacrylate, oxazolidinedione, cyanoacetamide, organic chlorine compounds, phenylamide, derivatives of cinnamic acid, copper compounds and organophosphorus compounds.

The term "fungicide providing therapeutic effect" means that fungicides can be absorbed by plants to combat established harmful all. Examples of such fungicides are-ethoxyacrylate, cyanoacetamide, phenylamide, derivatives of cinnamic acid and phosphorus compounds.

The term "fungicide with permeability" means that fungicides have the ability to penetrate through the surface of leaves inside. Examples of such fungicides are (-ethoxyacrylate, oxazolidinedione, cyanoacetamide, phenylamide, derivatives of cinnamic acid and phosphorus compounds.

It is expected that in addition to these fungicides, other fungal the first action or permeability, will also produce the same effects as observed in the present invention. For example, fungicides based on dithiocarbamates may be mentioned as examples of fungicides for phykomycets possessing only a preventive effect.

Compositions for pest, all according to the present invention, containing at least one imidazole of the formula (I) as active ingredient (a) and at least one inorganic compound of phosphorus as the active ingredient (b), are particularly suitable for use in agriculture and horticulture. Specifically, they discover a excellent action in the fight against diseases of cultivated plants, such as piricularia rice caused by Pyricularia oryzae, Rhizoctonia rice caused by Rhizoctonia solani, cucumber Anthracnose, caused by Colletotrichum lagenarium, powdery mildew of cucumber caused by Sphaerotheca fuliginea, downy mildew of cucumber caused by Pseudoperonospora cubensis, late blight of tomato caused by Phytophthora infestans, brown spot of tomato, caused lternaria solani, melanosis of citrus, caused by Diaporthe citri, Leena mold of citrus caused by Penicillium digitatum, pear scab caused by Venturia nashicola, Alternaria spotting Apple, caused by Alternaria mali, lagaana Sclerotinia sclerotiorum, the disease, caused by a rust fungus, etc., and diseases transmitted through the soil, caused by phytopathogenic fungi, such as Fusarium, Pythium, Rhizoctonia, Verticillium and Plasmodiophora, etc., In particular, compositions of the present invention find excellent action in the fight against diseases such as late blight of potato, caused by Phytophthora infestans, late blight of pepper caused by Phytophthora capsici, fitoterapia rot of watermelon ordinary, caused by Phytophthora drechsleri, late blight stems of tobacco, caused by Phytophthora nicotianae, var. nicotianae, late blight of tomato caused by Phytophthora infestans, downy mildew of cucumber or watermelon, caused by Pseudoperonospora cubensis, downy mildew of cabbage or Chinese cabbage caused rnospora brassicae, downy mildew of onion caused by Peronospora. destructor, shiroiro-eki-byo onion, caused by Phytophthora porri, and brown rot of watermelon ordinary, caused by Phytophthora capsici, and downy mildew of grape, caused by Plasmopara viticola, and various diseases, transmitted through the soil, caused, for example, Aphanomyces, Pythium. The compositions have a long residual action and find, in particular, excellent therapeutic effect. Therefore, it is possible to fight the disease through treatment Payami stems and leaves through the soil.

Compositions for pest, all according to the present invention, containing at least one compound of imidazole of the formula (I) as active ingredient (a) and fungicide for phykomycets as active ingredient (b), have an excellent fungicidal activity when applied to cultivated plants, such as fruit and vegetable crops (for example, cucumbers, tomatoes, aubergines, etc.); grain cereals (e.g. rice, wheat, etc.); vegetable seed crops; fruits (e.g. apples, pears, grapes, citrus, etc), potatoes, etc. that are contaminated or suspected that they are infected by pathogenic fungi. They discover an excellent suppressing effect in diseases such as powdery mildew, downy mildew, Anthracnose, gray rot, Leena mold, Sclerotinia rot, scab, Alternaria spot, bacterial leaf spot, black spot, melanosis, glomerella rot, late blight, brown spot, pyricularia, Rhizoctonia, blackleg, South Sclerotinia rot, etc. Compositions also exhibit excellent inhibitory effect for diseases that are transmitted through the soil, caused by phykomycets such a long residual action and find in particular, excellent therapeutic effect. Therefore, it is possible to fight the disease through treatment after infection. Furthermore, since the compositions have systemic activity, it is possible to fight the disease stems and leaves through the soil.

In particular, the composition containing at least one compound of imidazole of the formula (I) as active ingredient (a) and a compound of copper and/or organophosphorus compound as a fungicide for phykomycets as active ingredient (b), is particularly useful for agriculture and horticulture. Specifically, the compositions find excellent action in the fight against diseases of cultivated plants, such as piricularia rice caused by Pyricularia oryzae, Rhizoctonia rice caused by Rhizoctonia solani, cucumber Anthracnose, caused by Colletotrichum lagenarium, powdery mildew of cucumber caused by Sphaerotheca fuliginea, downy mildew of cucumber caused by Pseudoperonospora cubensis, late blight of tomato caused by Phytophthora infestans, brown spot of tomato caused by Alternaria solani, melanosis of citrus, caused by Diaporthe citri, Leena mold of citrus caused by Penicillium digitatum, pear scab caused by Venturia nashicola, Alternaria spotting Apple, nerocila rot, caused by Sclerotinia sclerotiorum, rust, blight, etc., and
with diseases transmitted through the soil, caused by phytopathogenic fungi, such as Fusarium, Pythium, Rhizoctonia, Verticillium and Plasmodiophora, etc., In particular, compositions of the present invention find excellent action in the fight against diseases such as late blight of potatoes or tomatoes caused by Phytophthora infestans, downy mildew of cucumber caused by Pseudoperonospora cubensis, downy mildew of grape, caused by Plasmopara viticola, and various diseases, transmitted through the soil, caused by phykomycets, such as Plasmodiophora, Aphanomyces, Pythium, etc.,

Compositions of the present invention have a long residual action, so they find excellent preventive action, as well as find excellent therapeutic effect. Therefore, it is possible to fight the disease through treatment after infection. In addition, because they have a system activity, it is also possible to treat diseases of the stems and leaves through the soil.

In particular, compositions containing a compound of copper as a fungicide for phykomycets, find excellent preventive Gastaut excellent therapeutic effect.

Compositions for pest, all containing at least one compound of imidazole of the formula (I) as active ingredient (a) and the compound of cyanoacetamide, phenylamide or cinnamic acid as a fungicide for phykomycets as active ingredient (b), find an excellent suppressing effect of diseases caused by phykomycets, such as plant diseases, such as downy mildew of cucumbers, watermelons, cabbage, Chinese cabbage, onions, pumpkins and grapes; late blight of potato, red pepper, sweet pepper, watermelon ordinary, pumpkins, tobacco, and tomatoes; shiroiro-eki-byo onions; brown rot of watermelon ordinary; diseases transmitted through the soil, caused by fungi pathogenic to plants, such as Pythium, etc. They also have an excellent action in the fight against disease caused by Plasmodiophora.

Compositions for pest, all containing at least one compound of imidazole of the formula (I) as active ingredient (a) and the compound-ethoxyacrylate, oxazolidinedione or chlorinated organic compound as a fungicide for phykomycets as active ingredient (b), abnaa plants, for example piricularia rice; scurf rice; cucumber Anthracnose; downy mildew of cucumbers, watermelons, cabbage, Chinese cabbage, onions, pumpkins and grapes; powdery mildew of wheat, barley and cucumber; late blight of potato, red pepper, sweet pepper, watermelon ordinary, pumpkins, tobacco, and tomatoes; Septoria diseases of wheat, brown spotting tomatoes; melanosis citrus; Leena mold of citrus fruit; pear scab; Alternaria spotting Apple; shiroiro-eki-byo onions; brown rot of watermelon ordinary; various diseases such as grey mould, Sclerotinia rot, rust and bacterial leaf spot; various diseases that are transmitted through the soil, caused by fungi that are pathogenic for plants, etc., such as Fusarium, Pythium, Rhizoctonia, Verticillium, etc., They also find excellent suppressing effect in diseases caused Plasmodio-phora. Compositions show particularly excellent suppressing effect in diseases such as fitoterapia rot of potato, red pepper, sweet pepper, watermelon ordinary, pumpkins, tobacco, tomatoes, etc. and downy mildew of cucumbers, watermelons, cabbage, Chinese cabbage, onion, pumpkin, grapes, etc.,

In addition, compositions containing actinic, harmful for agriculture and horticulture, such as delphacidae (Delphacidae), cabbage moth (Plutella xylostella), Cicada rice (Nephotettix cincticeps), weevil bean paste (Callosobruchus chinensis), scoop (Spodoptera litura), peach aphid (Myzus persicae), etc.; mites, such as clasic spider bimaculated (Tetranychus uriticae), clasic Carmine spider (Tetranychus cinnabarinus), clasic red citrus (nnychus citri), etc., and nematodes, such as southern root-knot nematode (Meloidogyne incognita) etc.

Compositions for pest, all containing the active ingredient (a) and amplifying active ingredient (s) of the present invention, particularly suitable for use in agriculture and horticulture. To bad all that can be treated with these compositions, which are pathogenic for plants fungi that cause diseases of plants, such as piricularia rice, Rhizoctonia rice; cucumber Anthracnose; powdery mildew of cucumbers; downy mildew of cucumber, watermelon, cabbage, Chinese cabbage, onions and grapes; late blight of potato, red pepper, sweet pepper, watermelon ordinary, pumpkins, tobacco; fitoterapia rotten tomatoes; brown spotting tomatoes; melanosis citrus; Leena mold of citrus; the scab g is, rust, etc.; soil containing pathogenic fungi that cause various plant diseases such as Fusarium, Pytchium, Rhizoctonia, Verticillium, Plasmodiophora, etc. ; insects, such as delacey, cabbage moth, Cicada rice, bean weevil, bollworm, aphids, peach, etc.; ticks, such as clasic spider bimaculated, clasic Carmine spider, clasic red citrus, etc. ; and nematodes, such as southern root-knot nematode, etc., more Specifically, they are effective when ficitional rot of potato, red pepper, sweet pepper, the ordinary watermelon, pumpkins, tobacco, and tomatoes, and downy mildew of cucumbers, watermelons, cabbage, Chinese cabbage, onions, pumpkins and grapes. Compositions containing the active ingredient (a) and amplifying active ingredient (s), have a long residual effect and find not only an excellent preventive effect, but also an excellent therapeutic effect. Therefore, it is possible to fight the disease through treatment after infection.

Active ingredients, including other described later pesticides and active ingredients (a) and (b) and increases the activity of the ingredient (s) included in the compositions for pest, all of this image is key, aqueous solutions, granules, concentrated suspensions, etc., together with various adjuvants common to agricultural products. Active ingredient (a) (the compound of imidazole of the formula (I)), the active ingredient (b) and other specific compounds can be mixed to form the composition, or each of them can be prepared separately and then mixed together. When applying the drug can be used as such or diluted to a certain concentration of an appropriate diluent, for example water.

Examples of adjuvants that can be used are carriers, emulsifiers, suspendresume agents, thickeners, stabilizers, dispersing agents, wetting agents, except those used as a reinforcing active ingredient (s), surfactant, wetting, penetrators, antifreeze agents, antifoams, etc., These adjuvants add accordingly if necessary.

The media are divided solid carriers and liquid carriers. For solid media include powders of animal and vegetable origin (e.g., starch, sugar, powdered cellulose, cyclodextrin, activated carbon, crushed soy beans, PSH is to, kaolin, bentonite, botanicalgarden complexes, calcium carbonate, calcium sulfate, sodium bicarbonate, zeolite, diatomaceous earth, white carbon, clay, alumina, silica, sulfur powder, slaked lime, etc). Examples of liquid carriers are water, vegetable oils (e.g. soybean oil, cottonseed oil), liquid animal fats (e.g., beef tallow, whale oil, etc.,), alcohols (for example ethyl alcohol, ethylene glycol, etc.,), ketones (e.g. acetone, methyl ethyl ketone, isobutylketone, isophorone, etc.,), ethers (e.g. dioxane, tetrahydrofuran, etc.,), aliphatic hydrocarbons (e.g. kerosene, light oil, liquid paraffin, etc.,), aromatic hydrocarbons (e.g. toluene, xylene, trimethylbenzene, tetramethylbenzene, cyclohexane, solvent-naphtha, etc.,), halogenated hydrocarbons (e.g. chloroform, chlorobenzene, etc.,), acid amides (e.g. dimethylformamide, etc.,), esters (e.g. ethyl acetate, complex glycerol esters of fatty acids and etc.), NITRILES (e.g. acetonitrile, etc.,), sulfur-containing compounds (e.g. dimethyl sulfoxide, etc.,), N-methyl-2-pyrrolidone, N,N-dimethylformamide and so on. Wetting agents (except used as a reinforcing esters of fatty acids.

In compositions containing at least one compound of imidazole of the formula (I) as the active compounds (a) and at least one inorganic compound of phosphorus as the active ingredient (b), the mass ratio (a) and (b) is usually from 1:300 to 300:1, preferably from 1: 100 to 100:1, preferably from 1:50 to 5:1 and most preferably from 1:50 to 1:10.

In compositions containing at least one compound of imidazole of the formula (I) as the active compounds (a) and at least one fungicide for phykomycets as active ingredient (b), the mass ratio (a) and (b) is usually from 1:10000 to 10000:1, preferably from 1: 1000 to 10000:1, preferably from 1:100 to 1000:1. In particular, compositions containing at least one compound of imidazole of the formula (I) as the active compounds (a) and at least one connection of cyanoacetamide as active ingredient (b) (fungicide for phykomycets), the mass ratio (a) and (b) is preferably from 1:300 to 5:1. When, in particular, compounds of copper and/or organophosphorus compounds are used as active ingredient (b) (fungicide for phykomycets), the mass ratio of (a) the NGOs preferably from 1:50 to 5:1.

In the compositions containing the active ingredient (a) and amplifying active ingredient (s) mass ratio (a) and (C) is usually from 1: 5000 to 2000: 1, preferably from 0.05:99,95 to 90:10, preferably from 0.2:99,8 to 80:20.

A method of combating harmful, all using the compositions for pest, all of the present invention is also in the scope of the present invention.

When applying the compositions to combat harmful, all containing at least one compound of imidazole of the formula (I) as active ingredient (a) and at least one inorganic compound of phosphorus as the active ingredient (b), you cannot install certain total concentration for application of the active ingredients (a) and (b), because they change depending on, for example, from being cultivated plants, processing method, form of the drug and quantity of drug used. For example, the connection of the imidazole of formula (I) and the inorganic compound of phosphorus are used at concentrations from 1 to 1000 ppm and from 1 to 5000 ppm, respectively, during the processing of the leaves, and from 10 to 10,000 g/ha, and from 10 to 50000 g/ha, respectively during cultivation.

When priola formula (I) as active ingredient (a) and at least one fungicide for phykomycets selected from the group consisting of compounds-ethoxyacrylate, connection oxazolidinedione, connection cyanoacetamide, organic chlorine compounds, compounds phenylamide, a derivative of cinnamic acid, as the active ingredient (b), you cannot install certain total concentration for the application of active ingredients, because they vary depending on the type of fungicide, the treated cultivated plants, processing method, form of the drug and the number of used drug, graphics processing and malicious fungus, which are struggling. In the case of processing the leaves, for example, the connection of the imidazole of formula (I) and the fungicide used at concentrations of from 0.01 to 1000 ppm, and from 0.01 to 1000 ppm, respectively, preferably from 0.1 to 500 ppm and 0.1 to 500 ppm, respectively.

When applying the compositions to combat harmful, all containing at least one compound of imidazole of the formula (I) as active ingredient (a) and a compound of copper and/or organophosphorus compound as active ingredient (b), it is impossible to establish certain General compositeimage fungicide, cultivated cultivated plants, processing method, form of drug, amount of drug used, graphics processing and malicious fungus, which are struggling. For example, the connection of the imidazole of formula (I) and the fungicide used at concentrations of from 0.01 to 1000 ppm and from 1 to 5000 ppm, respectively, during the processing of the leaves, and from 10 to 10,000 g/ha, and from 10 to 50000 g/ha, respectively during cultivation.

When applying the compositions to combat harmful, all containing the active ingredient (a) and amplifying active ingredient (s), you cannot install certain total concentration to use these ingredients because they vary, for example, from being cultivated plants, processing method, form of the drug and quantity of drug used. For example, the active ingredient (a) and amplifying active ingredient (s) are used at concentrations from 0.1 to 10000 ppm and from 0.01 to 50 ppm, respectively, during the processing of the leaves, and from 0.01 to 100 kg/ha and from 0.1 to 0.5 kg/ha, respectively during cultivation.

Compositions containing the active ingredients (a) and (b), can be used in a mixture or in combination, e.g., with other pesticides, fertilizers and IDA, except for use as active ingredients (a) and (b), fungicides, insecticides, acaricides, nematicides, antiviral agents, attractants, herbicides and plant growth regulators. In particular, a mixture or combination of compositions for pest, all of the present invention and one or more active ingredients of fungicides other than to be used as active ingredients (a) and (b) may have improved properties, in the sense of the range of measurable destruction of harmful of all, the graphics processing and suppressive activity against harmful of all. The connection of the imidazole of formula (I) as active ingredient (a), the inorganic compound of phosphorus and/or fungicide for phykomycets as active ingredient (b) and active(s) ingredient(s) from among fungicides, other than the active ingredients (a) and (b) can be entered in separate formulations and mixing when using either one or at least two of them to mix and enter in one of the drug.

When at least one connection imidazole of the formula (I) as active ingredient (s) comprise at least one inorganic compound of phosphorus and/or at least about before applying, exhibits much enhanced the inhibitory effect compared with the previously prepared composition. Therefore, a suitable option is, when the composition containing the active ingredient (a) and, if necessary, various adjuvants, and the composition containing the active ingredient (b) and, if necessary, various adjuvants, are packaged separately and shipped in the form of the drug in two packages. For example, the active ingredient (s) and active ingredient (b) can be dissolved in appropriate liquid media and packaging individually or active ingredient (a) and a mixture of the active ingredient (b) and other fungicides are dissolved in appropriate liquid media and packaged individually.

In the method of combating harmful, all with the use of compositions containing the active ingredient (a) and amplifying the activity of the ingredient (C), the composition can be applied in the form of a mixture with the above-described other pesticides, which can cause enhanced activity. Typical examples of other useful pesticides are compounds of asola, such as triflumizole (trivial name), etc.; compounds finokalia, such as chinomethionat (trivial name), etc.; is connected to the m (trivial name), etc.; derivatives sultanovoy acid, such as dichlofluanid (trivial name), etc.; compounds isoxazol such as hydroxyethoxy (trivial name), etc.; compounds dicarboximide, such as procymidone (trivial name), etc.; compounds benzanilide, such as flutolanil (trivial name), etc., and benzamide compounds such as (R,S)-4-chloro-N-[cyano(ethoxymethyl)]benzamid etc.

Preferred variants of compositions for pest, all in accordance with the present invention containing the active ingredients (a) and (b) below only for purposes of explanation, but not limitation.

(1) Composition for pest all, where at least one inorganic compound of phosphorus and/or at least one fungicide for phykomycets have a preventive effect.

(2) Composition for pest all, where at least one inorganic compound of phosphorus and/or at least one fungicide for phykomycets have a therapeutic effect.

(3) the Composition for pest all, where at least one inorganic compound of phosphorus and/or at least one fungicide for phycomycete inorganic compound of phosphorus and/or, at least one fungicide for phykomycets have a preventive effect and therapeutic effect.

(5) the Composition for pest all, where at least one inorganic compound of phosphorus and/or at least one fungicide for phykomycets have a preventive effect and permeability.

(6) the Composition for pest all, where at least one inorganic compound of phosphorus and/or at least one fungicide for phykomycets have medicinal action and permeability.

(7) the Composition for pest all, where at least one inorganic compound of phosphorus and/or at least one fungicide for phykomycets have a preventive effect, therapeutic action, and permeability.

(8) the Composition for pest all, where the active ingredient (b) is at least one organophosphorus compound.

(9) the Composition for pest all, where the active ingredient (b) is at least one fungicide for phykomycets.

(10) the Composition for pest, all under item (9), where the fungicide for phykomycets p is relata, connection oxazolidinedione, connection cyanoacetamide, organic chlorine compounds, compounds phenylamide, compounds cinnamic acid, copper compounds and organophosphorus compounds.

(11) a Composition for combating harmful, all under item (9), where the fungicide for phykomycets represents a connection-ethoxyacrylate and/or connection of oxazolidinedione.

(12) the Composition for pest, all under item (9), where the fungicide for phykomycets is a compound selected from the group consisting of compounds cyanoacetamide, organic chlorine compounds, compounds phenylamide, compounds cinnamic acid, copper compounds and organophosphorus compounds.

(13) the Composition for pest, all on the PP. (9), (10) or (11), where the fungicide for phykomycets represents a connection-ethoxyacrylate.

(14) the Composition for pest, all under item (13), where the connection-ethoxyacrylate represents methyl(E)-2-{2-[6-(2-cianfrocca)pyrimidine-4-yloxy] phenyl} -3-ethoxyacrylate or methyl(E)-methoxyimino[-(o-tolyloxy)-O-toleto represents a connection of oxazolidinedione.

(16) the Composition for pest, all under item (15), where the fungicide for phykomycets is a 3-aniline-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidin-2,4-dione.

(17) the Composition for pest, all on the PP. (9), (10) or (12), where the fungicide for phykomycets represents a connection of cyanoacetamide.

(18) a Composition for combating harmful, all under item (17), where the connection cyanoacetamide represents a 1-(2-cyano-2-methoxyimino)-3-utilmately.

(19) the Composition for pest, all on the PP. (9), (10) or (12), where the fungicide for phykomycets is a chlorinated organic compound.

(20) the Composition for pest, all under item (19), where the chlorinated organic compound is tetrachloroisophthalonitrile or pentachloronitrobenzene.

(21) a Composition for combating harmful, all under item (19), where the chlorinated organic compound is tetrachloroisophthalonitrile.

(22) the Composition for pest, all on the PP. (9), (10) or (12), where the fungicide for phykomycets represents a connection of phenylamide.

(23) the Composition for pest, all under item (22), gdis methyl-N-(2-methoxyacetyl)-N-(2,6-xylyl)-DL-alaninate, 2-methoxy-N-(2-oxo-1,3-oxazolidin-3-yl)Aceto-2', 6'-xylidide, ()--2-chloro-N-(2,6-xylylene)--butyrolactone, methyl-N-phenylacetyl-N-(2,6-xylyl)-DL-alaninate, methyl-N-(2-furoyl)-N-(2,6-xylyl)-DL-alaninate and ()--[N-(3-chlorophenyl)cyclopropanecarboxamide]--butyrolactone.

(24) the Composition for pest, all under item (22), where the connection phenylamide represents methyl-N-(2-methoxyacetyl)-N-(2,6-xylyl)-DL-alaninate.

(25) the Composition for pest, all on the PP. (9), (10) or (12), where the fungicide for phykomycets is a combination of cinnamic acid.

(26) the Composition for pest, all under item (25), where the connection cinnamic acid is an (E,Z)-4-[3-(4-chlorophenyl)-3-(3,4-acid)acryloyl]morpholine.

(27) the Composition for pest, all on the PP. (9), (10) or (12), where the fungicide for phykomycets is a combination of copper and/or organophosphorus compound.

(28) the Composition for pest, all under item (27), where copper is an inorganic copper fungicide and/s active ingredient of inorganic copper fungicide is at least one compound selected from the group consisting of a hydroxide of copper, oxysulfate copper oxychloride copper, anhydrous copper sulfate(II) and the main copper-callywhite.

(30) the Composition for pest, all under item(27), where the organophosphorus compound is at least one compound selected from the group consisting of Tris(ethylphosphonate) aluminum, O-2,6-dichloro-p-tolyl-O, O-dimethylphosphorodithioate, (R,S)-S-(R,S)-sec-butyl-O-ethyl-2-oxo-2-thiazolidinethione, S-benzoildiizopropilfosforamidata, O-ethyldiphenylphosphine and ethyl-2-deoxyribofuranosyl-5-methylpyrazolo(1,5-a)pyrimidine-6-carboxylate.

(31) the Composition for pest, all under item(27), where the organophosphorus compound is a Tris(ethylphosphonate) aluminum.

(32) the Composition for pest, all under item (27), where the mass ratio of at least one imidazole compounds of formula (I) and compounds of copper and/or organophosphorus compounds is from 1: 2000 to 2000:1.

Preferred variants of application of the composition containing the active ingredient (a) and amplifying active ingredient (s), to the bad, all described below only in teeth ingredient (s), you can apply to bad, all in the form of aqueous dispersions. In this way, the water dispersion of spray over the places where there are harmful, all waiting for their appearance, such as foliage useful plants or soil. Aqueous dispersion is particularly effective for application to foliage. The aqueous dispersion receive, for example, through:
(i) dispersion of the drug active ingredient in water and adding to the resulting dispersion increased activity of the ingredient; (ii) dispersion of the drug containing the active ingredient and increases the activity of the ingredient in water or by a method similar to (i) or (ii). The aqueous dispersion for use is obtained using 1 liter of water is 0.1-10000 mg compositions for pest all, so as to obtain a concentration of active ingredient 0.1 to 10000 h/million Water spray dispersion in an amount of from 100 to 10,000 l/ha

(2) the Composition containing the active ingredient (a) and amplifying active ingredient (s) can be applied in the form of a water suspension in the same manner as in the case of aqueous dispersions. The concentration of active ingredient in the aqueous suspension is from 0.1 to 10000 h/million Aqueous suspension ragbrai for pest, all of the present invention when applied as a fungicide for agriculture or horticulture.

Example test 1
Validation of therapeutic action when downy mildew of cucumbers
Composition for combating harmful, all containing compound 1 and the inorganic compound of phosphorus, indicated in table 9, at a concentration of 100 ppm and 2000 ppm, respectively, obtained by mixing the aqueous suspension concentrate compound 1 and 20% wettable powder of inorganic phosphorus compounds. Wettable 20% of the powder of inorganic phosphorus compounds obtained in accordance with a reference example of the composition below.

Cucumber (variety Suyo) were grown in plastic pots (diameter 7.5 cm). When the plant has reached a phase of the second sheet, it was inoculable by spraying a suspension of spores of the fungus that causes downy mildew (Pseudoperonospora cubensis). After 24 hours the plants using the device for spraying were sprayed vysheperechislennoe composition (10 ml per pot). For comparison conducted the same test with 10 ml of a composition containing 2000 ppm of inorganic phosphorus compounds not containing compound 1, or 10 ml of a composition containing 100 ppm of compound 1 and not containing inorganic phosphorus compounds. The plants were kept in chambers at the UNT incidence (%) according to the following formula. The results are shown in table 9.

The incidence rate (%)=(a/b) x 100 where: a is the area of damage to the treated plants and the b - area damage control (untreated plants).

theoretical incidence rate (%) can be calculated by the following formula Colby. In cases where the incidence of the test compositions lower than theoretical ratio, the test composition may produce a synergistic effect. In these cases, theoretical incidence rate (%) is given in table 9 in parentheses. theoretical incidence rate (%)=(X1x Y1)/100, where X1is the incidence (%) of a plant treated with only compound 1, and Y1is the incidence (%) of a plant treated with only inorganic compound of phosphorus.

Sample test 2
Validation of therapeutic action when downy mildew of cucumbers
Composition for combating harmful, all containing compound 1 in the above mentioned concentrations and inorganic compound of phosphorus, indicated in table 10, at a concentration of 250 ppm, were prepared by mixing the concentrate with water suspen the content of inorganic fillers phosphorus compounds prepared in accordance with a reference example of the composition, below.

Cucumber (variety Suyo) were grown in plastic pots (diameter 7.5 cm). When the plant has reached a phase of the second sheet, it was inoculable by spraying a suspension of spores of the fungus that causes downy mildew (Pseudoperonospora cubensis). After 24 hours the plants using the device for spraying were sprayed prepared with the above composition (10 ml per pot). For comparison, performed the same test using 10 ml per pot of a composition containing 250 ppm of inorganic phosphorus compounds not containing compound 1, or 10 ml per pot of a composition containing compound 1 in a certain concentration and containing no inorganic phosphorus compounds. The plants were kept in chambers at 22-24oC for 4 days and measured the damaged area of the first sheet, the results were calculated the incidence rate (%) according to the following formula. The results are shown in table 10.

The incidence rate (%)=(a/b) x 100 where: a is the area of damage to the treated plants and the b - area damage control (untreated plants).

theoretical incidence rate (%) can be calculated by the following formula Colby. When coefficient to produce a synergistic effect. In these cases, theoretical incidence rate (%) is given in table 10 in parentheses. theoretical incidence rate (%)=(X2x Y2)/100, where X2is the incidence (%) of a plant treated with only compound 1, and Y2is the incidence (%) of a plant treated with only inorganic compound of phosphorus.

Example test 3
Field test influence in downy mildew of cucumbers
Five pieces of cucumber seedlings (variety Tokiwa kohai on Hikari, 3, type, P) in phase two leaves were planted in plots (3 m2each) in the field, located in Kusatsu City, Shiqa, Japan, may 10, 1997. Composition containing 50 ppm of compound 1 and 1500 ppm of inorganic phosphorus compounds shown in table 11, was sprayed using a small sprayer in an amount of 500 ml per plot 10 and 17 June. For comparison conducted the same field test using a composition containing 1500 ppm of inorganic phosphorus compounds, or compositions containing only 50 ppm of compound 1. June 23, examined all the leaves to get the index of suppression in accordance with the following rating system. The results privedeniem. table A).

Example test 4
Validation of therapeutic action when downy mildew of cucumbers
Cucumber (variety Suyo) were grown in plastic pots (diameter 7.5 cm). When the plant has reached a phase of the second sheet, it was inoculable by spraying a suspension of spores of the fungus that causes downy mildew (Pseudrnsr ubnsis). After 24 hours the plants using the device for spraying were sprayed with a composition containing the compounds listed in tables 12-19, in the relevant specified concentrations. The plants were kept in chambers at 22-24oC for 6 days and measured the damaged area of the first sheet, the results were calculated the incidence rate (%) according to the following formula. The results are shown in tables 12-19.

The incidence rate (%)=(a/b) x 100 where: a is the area of damage to the treated plants and the b - area damage control (untreated plants).

theoretical incidence rate (%) can be calculated by the following formula Colby. In cases where the incidence of the test compositions lower than theoretical ratio, the test composition may produce a synergistic effect. In these cases, theorem is barb (%)=(X3x Y3)/100, where X2is the incidence (%) of a plant treated with only compound 1, 2 or 3, and Y3is the incidence (%) of a plant treated with only compound (a), i.e., methyl-(E)-2-{2-[6-(2-cianfrocca)pyrimidine-4-yloxy] phenyl} -3-ethoxyacrylate, compound (b) (i.e., methyl-(E)-methoxyimino[-(o-tolyloxy)-O-tolyl] acetate), cymoxanil, metalaxyl or dimethomorph.

Example test 5
Validation of therapeutic action when downy mildew of cucumbers
Cucumber (variety Suyo) were grown in plastic pots (diameter 7.5 cm). When the plant has reached a phase of the second sheet, it was inoculable by spraying a suspension of spores of the fungus that causes powdery mildew (Pseudoperonospora cubensis). After 18 hours the two plants using the device for spraying were sprayed with 20 ml of a composition containing compound 1 and compound (C) (3-aniline-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidin-2,4-dione) in the respective concentrations shown in table 20. The plants were kept in chambers at 22-24oC for 5 days and measured the average area of damage on two plants, the results were calculated the incidence rate (%) tactician incidence (%) can be calculated by the following formula Colby. In cases where the incidence of the test compositions lower than theoretical ratio, the test composition may produce a synergistic effect. In these cases, theoretical incidence rate (%) is given in table 20 in parentheses. theoretical incidence rate (%)=(X4x Y4)/100, where X4is the incidence (%) of a plant treated with only compound 1, and Y4is the incidence (%) of a plant treated with only compound (C).

Example test 6
Validation of therapeutic action when late blight of tomatoes
Tomatoes (variety Ponderosa) were grown in plastic pots (diameter 7.5 cm). When the plant has reached a phase of the fourth sheet, it was inoculable by spraying a suspension of the zoosporangium inside host fungus that causes late blight (Phytophthora infestans). After 6 hours the plants using the device for spraying were sprayed composition (10 ml per pot) containing compound 1 and having cymoxanil, metalaxyl or dimethomorph in the relevant concentration specified in tables 21-23. The plants were kept in chambers at 22-24oC for 3-5 days and measured the area of damage, the results were calculated coefficient is izah 21-23.

theoretical incidence rate (%) can be calculated by the following formula Colby. In cases where the incidence of the test compositions lower than theoretical ratio, the test composition may produce a synergistic effect. In these cases, theoretical incidence rate (%) specified in tables 21-23 in brackets.

theoretical incidence rate (%)= (X5x Y5)/100, where X5is the incidence (%) of a plant treated with only compound 1, and Y5is the incidence (%) of a plant treated with only cymoxanil, metalaxyl or dimethomorph.

Example test 7
Field trials with downy mildew of cucumbers
Seven seedlings of cucumber (variety Tokiwa kohai on Hikari, 3, R type) were planted in plots (5 m2each) in the field, located in Kusatsu City, Shiga, Japan, may 9, 1995. A composition comprising compound 1 and CHLOROTHALONIL in the respective concentrations shown in table 24, using a small sprayer was sprayed over the plants in the amount of 500-750 ml per plot 30 may and 6 June. June 14, examined all the leaves to get the index of suppression according to their pathogenic fungi were not, so the disease was spontaneous (see table B).

Example test 8
Check preventive actions on downy mildew of cucumbers
Cucumber (variety Suyo) were grown in plastic pots (diameter 7.5 cm). When the plant has reached a phase of the second sheet, with a device for spraying were sprayed with 10 ml of a composition containing compound 1 and Doitsu Borudo A (trademark wettable powder based oxychloride of copper, is Hokko Chemical Industry Co., Ltd.) in the respective concentrations shown in table 25. After 24 hours the plant was inoculable suspension of spores of the fungus that causes downy mildew (Pseudoperonospora cubensis). The plants were kept in chambers at 22-24oC for 6 days and measured the damaged area of the first sheet, the results were calculated the incidence rate (%) according to the following formula. The results are shown in table 25.

The incidence rate (%)=(a/b) x 100 where: a is the area of damage to the treated plants and the b - area damage control (untreated plants).

theoretical incidence rate (%) can be calculated by the following formula Colby. In cases where the incidence of the tested korroloka theoretical incidence rate (%) is given in table 25 in parentheses. theoretical incidence rate (%)=(X6x Y6)/100, where X6is the incidence (%) of a plant treated with only compound 1, and Y6is the incidence (%) of a plant treated with only Doitsu Borudo A.

Example test 9
Check preventive actions when late blight of tomatoes
Tomatoes (variety Ponderosa) were grown in plastic pots (diameter 7.5 cm). When the plant has reached a phase of the fourth leaf, seedlings using the device for spraying were sprayed with 10 ml of a composition containing compound 1 and Kcide Bordeaux (trade mark wettable powder on the basis of the hydroxide of copper, is Griffin) or Doitsu Borudo A (trademark wettable powder based oxychloride of copper, is Hokko Chemical Industry Co. Co., Ltd.), in appropriate concentrations listed in tables 26 and 27. After 24 hours the plants were inoculable by spraying a suspension of the zoosporangium inside host fungus that causes late blight (Phytophthora infestans). The plants were kept in chambers at 22-24oC for 3 days and measured the area of damage, the results were calculated the incidence rate (%) in the same manner as in the example test 1. The obtained results of the alley to the Colby formula. In cases where the incidence of the test compositions lower than theoretical ratio, the test composition may produce a synergistic effect. In these cases, theoretical incidence rate (%) specified in tables 26 and 27 in parentheses. theoretical incidence rate (%)=(X7x Y7)/100, where X7is the incidence (%) of a plant treated with only compound 1, and Y7is the incidence (%) of a plant treated with only Kocide Bordeaux or Doitsu Borudo A.

Example test 10
Validation of therapeutic action when downy mildew of cucumbers
Cucumber (variety Suyo) were grown in plastic pots (diameter 7.5 cm). When the plant has reached a phase of the second sheet, it was inoculable by spraying a suspension of spores of the fungus that causes downy mildew (Pseudoperonospora cubensis). After 24 hours the plants using the device for spraying were sprayed with 10 ml of a composition containing compound 1 and Tris(ethylphosphonate) aluminum (postillonne) in the respective concentrations shown in table 28. The plants were kept in chambers at 22-24oC for 6 days and measured the area of damage, the results wyczesany in table 28.

theoretical incidence rate (%) can be calculated by the following formula Colby. In cases where the incidence of the test compositions lower than theoretical ratio, the test composition may produce a synergistic effect. In these cases, theoretical incidence rate (%) specified in table 28 in parentheses. theoretical incidence rate (%)=(X8x Y8)/100, where X8is the incidence (%) of a plant treated with only compound 1, and Y8is the incidence (%) of a plant treated with only testimonium.

The example tests 11
Validation of therapeutic action when downy mildew of cucumbers
Obtaining a water dispersion
Distributing agent (spreader - amplifying active ingredient) specified in table 29, was diluted with water to 500 or 1000 times, was added compound 1 at a concentration of 100 ppm or 12.5 ppm and obtained water dispersion. For comparison, in the same way prepared aqueous dispersion containing 100 ppm or 12.5 ppm of compounds 1 and not containing reinforcing active ingredient.

Test method and results
Cucumber (variety Suyo) is ovali by spraying a suspension of spores of the fungus, causing downy mildew (Pseudoperonospora cubensis). After 15-24 hours over the plants with a device for spraying were sprayed water dispersion in 20 ml of 0.25 m2. The plants were kept in chambers at 22-24oC for 4-6 days and measured the damaged area of the first sheet to get the index of suppression in accordance with the following grading system (see table). The results are shown in table 29.

The example tests 12
Validation of therapeutic action when late blight of tomatoes
Obtaining a water dispersion
The spreader (increased activity ingredient) specified in table 30, diluted with water to 500 times, was added compound 1 at a concentration of 400 ppm or 12.5 ppm and obtained water dispersion.

For comparison, the same method of preparing the aqueous dispersion, excluding use as a distributing agent surface-active esters sorbitan and fatty acids listed in table 30 (agents-spreaders for comparison a, b and C), and adding the compound 1 at a concentration of 400 h/million For another comparison was prepared in the same way water suspension containing 400 ppm or 12.5 ppm of compounds 1 and not containing reinforcing activity ingredi the R-7.5 cm). When the plant has reached a phase of the fourth sheet, it was inoculable by spraying a suspension of the zoosporangium inside host fungus that causes late blight (Phytophtora infestans). After 4 hours over the plant with a device for spraying were sprayed prepared above suspension in 20 ml of 0.25 m2. After exposure of the plants in chambers at 22-24oC for 3 days measured the area of damage and the results were calculated the suppression index in accordance with the same rating system as in the example test 11. The results are shown in table 31.

The example tests 13
Validation of therapeutic action when late blight of tomatoes
Obtaining a water dispersion
Agent-spreader (increased activity ingredient) specified in table 32, was diluted with water in 2000 was added compound 1 at a concentration of 100 ppm, was obtained aqueous dispersion. For comparison, in the same way prepared aqueous dispersion containing 100 ppm of compound 1 and not containing reinforcing active ingredient.

Test methodology and results
Tomatoes (variety Ponderosa) were grown in plastic pots (diameter 7.5 cm). When the plant has reached a phase of the fourth sheet, it was inoculable by spraying VSUES is to spray was sprayed prepared above suspension in 20 ml of 0.25 m2. After exposure of the plants in chambers at 22-24oC for 3 days measured the area of damage and the results were calculated the suppression index in accordance with the same rating system as in the example test 11. The results are shown in table 32.

The example tests 14
Check preventive actions when late blight of tomatoes
Obtaining a water dispersion
Agent-spreader 58 or 91 (increased activity ingredient) was diluted with water to 500 times and was added compound 1 in the above mentioned concentrations, obtained water dispersion. For comparison, the same method of preparing the aqueous dispersion containing the same number of compounds 1 and not containing reinforcing active ingredient.

Test methodology and results
Tomatoes (variety Ponderosa) were grown in plastic pots (diameter 7.5 cm). When the plant has reached a phase of the fourth sheet over him with a device for spraying were sprayed prepared above suspension in 20 ml of 0.25 m2. 24 hours after spraying plants for inoculation were sprayed with a suspension of zoosporangium inside host fungus that causes late blight (Phytophthora infestans), and the plants were kept in chambers at 22-24oC for 3 days. ISM is OK as in the example test 11. The results are shown in table 33.

Example test 15
Validation of therapeutic action when downy mildew of cucumbers
Obtaining a water dispersion
Distributing agent (increased activity ingredient) specified in table 34, was diluted with water to 500 or 2000 times, was added compound 1 at a concentration of 12.5 ppm and obtained water dispersion. For comparison, in the same way prepared aqueous dispersion containing 12,5 ppm of compounds 1 and not containing reinforcing active ingredient.

Test method and results
Cucumber (variety Suyo) were grown in plastic pots (diameter 7.5 cm). When the plant has reached a phase of the second sheet, it was inoculable by spraying a suspension of spores of the fungus that causes downy mildew (Pseudoperonospora cubensis). After 15-24 hours over the plants with a device for spraying were sprayed water dispersion in 20 ml of 0.25 m2. The plants were kept in chambers at 22-24oC for 5 days and measured the damaged area of the first sheet to obtain the ratio of damaged leaf area to intact (%). The results are shown in table 34.

Note: all parts in prepositio 1, wt.h.:
(1) the Connection 1 - 5
(2) Declivities - 7
(3) Diatomaceous earth - 82
(4) Dialkilsuljfoksidih - 2
(5) Sulfate polyoxyethyleneglycol ether - 4
The above components are mixed to a homogeneous state and get a wettable powder.

Example composition 2, wt.h.:
(1) the Connection 1 - 5
(2) Dodecahydrate tertiary phosphate - 16
(3) Diatomaceous earth - 73
(4) Dialkilsuljfoksidih - 2
(5) Sulfate polyoxyethyleneglycol ether - 4
The above components are mixed to a homogeneous state and get a wettable powder.

Example of composition 3, wt.h.

(1) the Connection 1 - 5
(2) Declivities - 18
(3) Kerosene - 63
(4) Dialkilsuljfoksidih - 2
(5) a Mixture derived polyoxyethyleneglycol and polyoxyethylenesorbitan - 12
The above components are mixed until smooth and finely milled, get a suspension concentrate.

Example of composition 4, wt.h.:
(1) Kaolin - 78
(2) the Condensate-naphthalenesulfonate sodium and formaldehyde - 2
(3) Polyoxyethyleneglycol - 5
(4) Hydrated amorphous silica - 15
A mixture of the above components, dialight is notizie 5, wt.h.:
(1) Kaolin - 78
(2) the Condensate-naphthalenesulfonate sodium and formaldehyde - 2
(3) Polyoxyethyleneglycol - 5
(4) Hydrated amorphous silica - 15
A mixture of the above components, the connection 1 and metalaxyl mixed at a mass ratio of 8:1:1 and get a wettable powder.

An example of a composition of 6 wt.h.:
(1) Connection 2, wt.h.: - 0,5
(2) Metalaxyl - 0,5
(3) Bentonite - 20
(4) Kaolin - 74
(5) Ligninsulfonate sodium - 5
The above components are mixed with a quantity of water sufficient for granulation, then granularit and receive granules.

Example compositions 7, wt.h.:
(1) Connection 3 - 0,25
(2) Metalaxyl - 0,25
(3) calcium Carbonate - 99,0
(4) Phosphate lowest alcohol - 0,5
The above components are mixed until smooth and get the dust.

An example of the composition 8, wt.h.:
(1) Kaolin - 78
(2) the Condensate-naphthalenesulfonate sodium and formaldehyde - 2
(3) Polyoxyethyleneglycol - 5
(4) Hydrated amorphous silica - 15
A mixture of the above components, compounds 1, Kocide Bordeaux (trade mark), mixed at a mass ratio of 0.8:76,8:22,4 and get socialdiligence sodium and formaldehyde - 2
(3) Polyoxyethyleneglycol - 5
(4) Hydrated amorphous silica - 15
A mixture of the above components, connections 1 and Duitch Bordeaux And (trademark) is mixed at a mass ratio of 5:67,2:27,8 and get a wettable powder.

An example of a composition of 10 wt.h.:
(1) the Connection 1 - 0,25
(2) dust DL Sanpun Bordeaux (trade mark, produced Dai-ichi Noyaku K. K., and Hokko Chemical Industry Co., Ltd.) - 0,25
(3) sodium Carbonate - 99,0
(4) Phosphate lowest alcohol - 0,5
The above components are mixed until smooth and get the dust.

An example of the composition 11, wt.h.:
(1) the Connection 1 - 0,5
(2) dust DL Sanpun Bordeaux (trade mark, produced Dai-ichi Noyaku K. K., and Hokko Chemical Industry Co., Ltd.) - 0,5
(3) Bentonite - 20
(4) Kaolin - 74
(5) Ligninsulfonate sodium - 5
The above components are mixed together with a quantity of water sufficient for granulation, then granularit and receive granules.

An example of the composition 12, wt.h.:
(1) the Connection 1 - 5
(2) Tris(ethylphosphonate) aluminum (postillonne) - 5
(3) Diatomaceous earth - 84
(4) Ligninsulfonate calcium - 2
(5) Dialkilsuljfoksidih - 4
The above components are mixed to a homogeneous state and get a wettable powder.

An example of the composition 13, �tp://img.russianpatents.com/img_data/59/590213.gif">POULENC) - 1,1
(3) a Dispersant and wetting Supragil MNS/90 (trademark) - 1,1
(4) a Dispersant and suspendisse agent Vegum - 1,7
(5) Urea (acts as antifreeze) - 11.1V
(6) Protivovospalitel SM5572F (trademark) - 0,1
(7) Distilled water - 73,8
The above components (1) to(7) are mixed and wet grinding as long as the average particle size of the active ingredient reaches 2 μm, and get a suspension. To 90 hours resulting suspension, add 10 including increased activity of the ingredient, then mixed by shaking and get the concentrate water suspension.

An example of the composition 14, wt.h.:
(1) Compound 1 (active ingredient) - 10,0
(2) a Dispersant SOPROPHOR FLK (trademark, producedPOULENC) - 1,0
(3) a Dispersant and wetting Supragil MNS/90 (trademark) - 1,0
(4) a Dispersant and suspendisse agent Vegum - 1,5
(5) Urea (acts as antifreeze) - 10,0
(6) Protivovospalitel SM5572F (trademark) - 0,1
(7) Distilled water - 66,4
(8) Enhance the activity of the ingredient - 10,0
The above components (1) to(8) are mixed and wet grinding as long as the average particle size of the active ingredient reaches 2 μm, inset-naphthalenesulfonate sodium and formaldehyde - 2
(3) Polyoxyethyleneglycol - 5
(4) Hydrated amorphous silica - 15
The above components and the inorganic compound of phosphorus mixed at a mass ratio of 4:1 and receive a 20% wettable powder on the basis of inorganic phosphorus compounds.

The example tests 16
(1) test Methods and test results
Evaluation of therapeutic effect in diseases of tomatoes
The preparation of an aqueous dispersion
Each of the distributing agent: 2-3, polyoxyethyleneglycol ether, 4-9, polyoxyethyleneglycol ether, 22, silicone surfactant, 67, mineral oil and Tween 20, was dispersed in water to obtain a concentration of 2000 ppm and then add 4-chloro-2-cyano-1-dimethylsulphamoyl-5-(4-were)imidazole (compound 1) with a concentration of 400 ppm, getting in the water dispersion. As a control sample in the same way as described above dispersion, prepare a water dispersion which does not contain the ingredient, increased activity, and contains compound 1 at a concentration of 400 h/million

Biological method of testing and results
Tomatoes (variety Ponderosa) is grown in asiania suspension of zoosporangium inside host fungi Phytophtora infestans. After 4 hours, the plants are sprayed using a spray gun described above aqueous dispersion at a rate of 10 ml/pot. Control the water dispersion containing the compound 1, also sprinkle in a similar way. The plant is kept in a chamber at a temperature of 22-24oWith in 3 days and determine the area of damage. Calculate the ratio of the area of the lesion sprayed sample to the area of destruction of the sample with a water control as the rate of prevalence of disease (%). The results are presented in table 35.

The test example 17
Evaluation of preventive actions for diseases of tomatoes
The preparation of an aqueous suspension
Each of the distributing agent: 4-5, polyoxyethyleneglycol ether, and 23, silicone surfactant, dispersed in water to obtain a concentration of 1000 ppm and then add 4-chloro-2-cyano-1-dimethylsulphamoyl-5-(4-were)imidazole (compound 1) to obtain the concentration 267 ppm, getting in the water dispersion. As a control sample in the same way as described above dispersion, prepare a water dispersion which does not contain the ingredient, increased activity, and contains compound 1 at a concentration of 267 h/million< (diameter 7.5 cm). When reaching the phase of the fourth leaf of the plant is sprayed using a spray gun described above aqueous dispersion, which is brought to a predetermined concentration, the rate of 300 l/ha

Control the water dispersion containing the compound 1, is sprayed in the same way. 24 hours after spraying infect the plant by spraying a suspension of the zoosporangium inside host fungi Phytophtora infestans. The plant is kept in a chamber at a temperature of 22-24oWith in 3 days and determine the area of damage. Calculate the ratio of the area of the lesion treated sample to the area of destruction of the sample with a water control incidence (%). The results are presented in table 37.

The test example 18
Evaluation of preventive actions when late blight of tomatoes
Tomatoes (variety Ponderosa) grown in plastic pots (diameter 7.5 cm). When reaching the phase of the fourth leaf seedlings sprayed with spray 10 ml of a composition containing the compound of imidazole (compound 1 of this patent application or compound A-1b EP 337103) and one fungicide for phykomycets in the respective concentrations indicated in the tables 35-40. After 24 hours infect the plant by spraying a suspension of the EPA is CA 35) or 4 days (other table) and determine the area of damage from which calculate the incidence rate in accordance with the following formula. The results are shown in tables 35-40.

The incidence rate (%)= (a/b) x 100, where a represents the size of the lesions treated plants, and b represents the area of damage control (untreated plants).

theoretical incidence rate (%) can be calculated from the following formula Colby. In cases where the incidence of the tested composition is lower than theoretical incidence rate, the test composition may produce a synergistic effect. In these cases, theoretical incidence rate (%) are presented in tables 35-42.

theoretical incidence rate (%)= (X1x Y1)/100, where X1is the incidence (%) of a plant treated with only compound of imidazole and Y1is the incidence (%) of a plant treated with only fungicide for phykomycets.

The test example 19
Evaluation of preventive actions when downy mildew of cucumbers
Cucumber (variety Suyo) grown in plastic pots (diameter 7.5 cm). When the plant rassoedinenie 1 of this patent application or the compound A-1b EP337103) in appropriate concentrations, shown in tables 5 and 6. After 24 hours infect the plant by spraying the spore suspension of fungi downy mildew (Pseudoperonospora cubensis). The plant is kept in a chamber at a temperature of 22-24oC for 5 days (table 42) or 6 days (table 41), and determine the size of the lesion, from which calculate the incidence rate in accordance with the following formula. The results are shown in tables 41 and 42.

The incidence rate (%)= (a/b) x 100, where a represents the size of the lesions treated plants, and b represents the area of damage control (untreated plants).

theoretical incidence rate (%) can be calculated from the following formula Colby. In cases where the incidence of the tested composition is lower than theoretical incidence rate, the test composition may produce a synergistic effect. In these cases, theoretical rate of prevalence of disease (%) are presented in tables 41 and 42 in parentheses. theoretical incidence rate (%)= (X2x Y2)/100, where X2is the incidence (%) of a plant treated with only compound imidazolinones.

Example test 20
(1) test Methods and test results
Evaluation
therapeutic effect in diseases of tomatoes
The preparation of an aqueous dispersion
Distributing agent 23 on the basis of silicone surfactant, SILWET L-77 (see table 2), reinforcing the action of the active ingredient is dispersed in water to obtain a given concentration, and then add 4-chloro-2-cyano-1-dimethylsulphamoyl-5-(4-were)imidazole (compound 1) to obtain the aqueous dispersion.

As a control sample in the same way as described above dispersion, prepare a water dispersion which does not contain the ingredient, increased activity, and contains compound 1 at a given concentration.

Biological method of testing and results
Tomatoes (variety Ponderosa) grown in plastic pots (diameter 7.5 cm). When a plant of the fourth phase of its leaves are sprayed with the above-described aqueous dispersion of 7.5 ml 0.25 m2. Control the water dispersion containing the compound 1, also via atomizer spray in the same way. After 24 hours infect plants by spraying a suspension of the zoosporangium inside host fungi Phytophtora infestans. The plant is kept in a chamber at a temperature of 20 the processed sample to the area of the lesion sample from the control of both the rate of prevalence of disease (%). The results are presented in table 43.

Grading scale:
0: no damage
1: damage less than 10%
2: damage 10% or more but less than 25%
3: damage 25% or more but less than 50%
4: damage 50% or more
The incidence rate (IR)=(rate of damage 1 sheet)+(rate of damage 1 sheet)+(rate of damage 2 sheets)+(rate of damage 3 sheets)+(rate of damage 4 sheets): h.

Industrial applicability
Compositions for pest, all corresponding to the present invention, have a strong therapeutic and/or preventive effect on plants suffering from diseases caused by harmful all, and allow you to fight harmful all. In particular, compositions containing reinforcing the active ingredient exhibit enhanced therapeutic effect, which reduces the amount of active ingredient.

Although the invention is described in detail and with reference to the characteristic variations of its embodiment, for professionals in this area of technology will be obvious that it is possible to make various changes and modifications without departing from the essence and scope of the invention. cultivated plants, containing (a) compound of imidazole of the formula

where R represents a lower alkyl group or lower alkoxygroup;
n is 1,
as the active ingredient, and (b) one inorganic compound of phosphorus, which is selected from the group comprising phosphoric acid, phosphorous acid and their salts, one or fungicide for phykomycets, which is selected from the group comprising methyl-(E)-2-{ 2-[6-(2-cianfrocca)pyrimidine-4-yloxy] phenyl} -3-ethoxyacrylate, methyl-(E)-methoxyimino[-(o-tolyloxy)-o-tolyl] acetate, 3-aniline-5-methyl-5-(4-phenoxyphenyl)-1, C-oxazolidin-2,4-dione, 1-(2-cyano-2-methoxyimino)-3-utilmately, tetrachloroisophthalonitrile, methyl-N-(2-methoxyacetyl)-N-(2,6-xylyl)-DL-alaninate, (E, Z)-4-[3-(4-chlorophenyl)-3-(3,4-methoxyphenyl)acryloyl] -morpholine, inorganic copper fungicide and Tris(ethylphosphonate) aluminum, as an active ingredient, or (C) distributing the agent as an ingredient, increased activity, which is a silicone surfactant or mineral oil, where component (a) and the compound of phosphorus are in a mass ratio of from 1: 50 to 5: 1, (a) and the fungicide are in a mass ratio is, the de composition comprises (a) compound of imidazole represented by the formula (I)

where R represents a lower alkyl group or lower alkoxygroup;
n is 1,
as the active ingredient, and (b) one inorganic compound of phosphorus, which is selected from the group comprising phosphoric acid, phosphorous acid and their salts, one or fungicide for phykomycets, which is selected from the group comprising methyl-(E)-2-{ 2-[6-(2-cianfrocca)pyrimidine-4-yloxy] phenyl} -3-ethoxyacrylate, methyl-(E)-methoxyimino[-(o-tolyloxy)-o-tolyl] acetate, 3-aniline-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidin-2,4-dione, 1-(2-cyano-2-methoxyimino)-3-utilmately, tetrachloroisophthalonitrile, methyl-N-(2-methoxyacetyl)-N-(2,6-xylyl)-DL-alaninate, (E, Z)-4-[3-(4-chlorophenyl)-3-(3,4-methoxyphenyl)acryloyl] -morpholine, inorganic copper fungicide and Tris(ethylphosphonate) aluminum as an active ingredient.

3. The composition according to p. 2, where the active ingredient (b) is an inorganic compound of phosphorus, which is selected from the group comprising phosphoric acid, phosphorous acid and their salts.

4. The composition according to p. 2, where the active ingredient (b) is a hydroxy] phenyl} -3-ethoxyacrylate, methyl(E)-methoxyimino[-(o-tolyloxy)-o-tolyl] acetate, 3-aniline-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidin-2,4-dione, 1-(2-cyano-2-methoxyimino)-3-utilmately, tetrachloroisophthalonitrile, methyl-N-(2-methoxyacetyl)-N-(2,6-xylyl)-DL-alaninate, (E, Z)-4-[3-(4-chlorophenyl)-3-(3,4-methoxyphenyl)acryloyl] -morpholine, inorganic copper fungicide and Tris(ethylphosphonate) aluminum.

5. The composition according to p. 4, where the compound of imidazole and fungicide are in a mass ratio of from 1: 300 to 300: 1.

6. Composition under item 1, which contains (a) compound of imidazole represented by the formula (I)

where R represents a lower alkyl group or lower alkoxygroup;
n is 1,
as the active ingredient, and (C) distributing the agent as an ingredient, increased activity, which is a silicone surfactant or mineral oil.

7. A method for controlling fungal diseases of cultivated plants, comprising applying a composition for controlling fungal diseases of cultivated plants which comprises (a) compound of imidazole represented by the formula (I)

where R pint, and
(b) one inorganic compound of phosphorus, which is selected from the group comprising phosphoric acid, phosphorous acid and their salts, one or fungicide for phykomycets, which is selected from the group comprising methyl-(E)-2-{ 2-[6-(2-cianfrocca)pyrimidine-4-yloxy] phenyl } -3-ethoxyacrylate, methyl-(E)-methoxyimino[-(o-tolyloxy)-o-tolyl] acetate, 3-aniline-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidin-2,4-dione, 1-(2-cyano-2-methoxyimino)-3-utilmately, tetrachloroisophthalonitrile, methyl-N-(2-methoxyacetyl)-N-(2,6-xylyl)-DL-alaninate, (E, Z)-4-[3-(4-chlorophenyl)-3-(3,4-methoxyphenyl)acryloyl] -morpholine, inorganic copper fungicide and Tris(ethylphosphonate) aluminum or (C) distributing the agent as an ingredient, increased activity, which is a silicone surfactant or mineral oil, where component (a) and the compound of phosphorus are in a mass ratio of from 1: 5 to 1: 30, (a) and the fungicide are in a mass ratio of from 1: 2000 to 1000: 1, or (a) and (C) are in relation mass/volume (kg/l) from 1: 5000 to 1: 0.25 in.

8. The method according to p. 7, where the composition comprises (a) compound of imidazole represented by the formula (I)

where R represents (C) one inorganic compound of phosphorus, which is selected from the group comprising phosphoric acid, phosphorous acid and their salts, one or fungicide for phykomycets, which is selected from the group comprising methyl-(E)-2-{ 2-[6-(2-cianfrocca)pyrimidine-4-yloxy] phenyl} -3-ethoxyacrylate, methyl-(E)-methoxyimino[-(o-tolyloxy)-o-tolyl] acetate, 3-aniline-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidin-2,4-dione, 1-(2-cyano-2-methoxyimino)-3-utilmately, tetrachloroisophthalonitrile, methyl-N-(2-methoxyacetyl)-N-[2,6-xylyl)-DL-alaninate, (E, Z)-4-[3-(4-chlorophenyl)-3-(3,4-methoxyphenyl)acryloyl] -morpholine, inorganic copper fungicide and Tris(ethylphosphonate) aluminum as an active ingredient.

9. The method according to p. 1, where the composition comprises (a) compound of imidazole represented by the formula (I)

where R represents a lower alkyl group or lower alkoxygroup;
n is 1,
as the active ingredient, and (C) distributing the agent as an ingredient, increased activity, which is a silicone surfactant or mineral oil.

10. The method according to p. 9, where the composition is in the form of aqueous dispersions.

11. Method of strengthening the actions of the agent, podavlyauschaya, represented by formula (I)

where R represents a lower alkyl group or lower alkoxygroup;
n is 1,
which includes the application along with the active ingredient, the distribution agent (s) as an ingredient, increased activity, representing a silicone surfactant or mineral oil, and the compound of imidazole and (C) are in the ratio of mass/volume (kg/l) from 1: 5000 to 1: 0.25 in.

Priority points
25.04.1997 on PP. 6,9,10,11;
11.07.1997 on p. 3;
19.08.1997 on PP. 1,2,4,5,7,8.

 

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