The method of obtaining esters of carboxylic acids

 

The invention relates to an improved process for the preparation of esters of carboxylic acids of General formula (I) esterification of the corresponding acids or anhydrides with alcohols in a molar ratio acid:ethanol=1: 0.35 to 2.2 in the presence of hydrocarbons as solvent and aromatic sulfonic acids or acidic sulfate as a catalyst at the boiling temperature of the reaction mixture by distillation of the formed water, followed by washing of the reaction mixture and neutralizing it with an alkaline solution, taken from 5-20 wt. % the excess of the estimated quantity of alkali to neutralize the catalyst, and the reaction mixture is washed at a temperature of 35-50oWith 3-15 wt. % aqueous solution of the chlorides or sulfates of alkaline or alkaline earth metals, and then neutralize it with an alkaline agent, dissolved in a solution of the chlorides or sulfates of alkaline or alkaline earth metals. The invention solves the problem of intensification method of producing esters of carboxylic acids by reducing the time of complete separation of the reaction mixture at the stage of leaching while maintaining the quality and yield of the final product. 1 PL.

wherewhere Y=-OH; m=0, 1, 2; -OC(O)R1; Z=-CH3; -C2H5; -CH2OH;

The present invention relates to the field of synthesis of organic compounds, and in particular to an improved process for the preparation of esters of mono - or of polycarbonic acids with one or polyhydric alcohols of General formula

where


-C2-34H4-66; -CH=CH-; R2=-C3-19H7-39;
when X=H, R1=-C7-25H14-50; R2=-C3-19H7-39; -CH2(OC2H4)1-3Y; -(CH2)1-5Y;


where Y=OH, m=0, 1, 2; -OC(O)R1; Z=-CH3; -C2H5; -CH2OH;

These compounds are used as lubricants, plasticizers in plastics processing, for example, polyvinyl chloride (PVC), used in particular for products in the food and meditsinskaia impurities, such as available strong acids, acid salts, thermally unstable products of the interaction of strong acids with organic compounds that cause degradation of the polymer during processing and operation, and weak staining.

A known method of producing esters of dibasic carboxylic acids With4and alcohol4-C7in the environment of the solvent with sulfoxylate catalyst (French patent 1507372, IPC 08 F, publ.20.11.67). The following technology: the molar ratio of reagents acid (succinic, maleic or fumaric): alcohol (butyl isomers, p) equal to 2.5:5,1, concentration of the solvent 35 wt.% from the reaction mixture, the amount of catalyst (sulfuric acid) - 0.24 wt.% by weight of the reactants; the synthesis is carried out at a temperature of 100-120oWith and end up in 4.5 hours To remove from the reaction mass impurities (catalyst, acid esters, the source of acid), the reaction mass is neutralized double-2-4-fold excess of 6% solution of Na2CO3from the estimated quantity on the content of free acid (or 7-10-fold excess of the calculated amount of sodium carbonate to neutralize the acidity attributable to the catalyst) and washed with water - 1/3 of the mass of the reactions is osvecenie this method to obtain the esters of formula (I) does not allow to obtain products with the same acid number. In addition, the use of the catalyst of sulfuric acid caused a staining product in a dark brown color, and neutralizing the reaction mixture with excess amount of alkaline solution leads to a stable emulsification of the reaction mass and the decrease of yield (up to 65% of rated).

The patented method of obtaining poliefir (mol. weight 700-5000) for the PVC plasticization, synthesized from aliphatic monocarboxylic acids With7-C18, dicarboxylic acids (adipic, azelaic, phthalic) and neopentyl glycol, or a mixture of neopentyl glycol and ethylene-, propylene - or butyleneglycol (the number of moles of glycol per 1 mol greater than the number of moles of the dicarboxylic acids); as oxide catalyst used dibutyrate (patent of the Netherlands 150486, IPC C 08 L 27/06, publ. 17.01.77). The etherification is carried out at 250oWith, then the pressure was lowered to 2 mm RT.article and distilled off the reaction water and excess glycol in the temperature range 250-260oTo reach an acid number of less than 2.0 mgKOH/g

Videophony way to obtain esters with catalyst - oxide dibutylamine is carried out at a high temperature of 250-260oWith that causes the formation of dark-colored impurities, and removing/p> Reproduction of this method in obtaining esters of the formula (I) did not allow to obtain products with an acid number of less than 7 mgKOH/g

Also known is a method of obtaining esters greases for processing OVH-resins obtained by esterification of aliphatic polyhydric alcohol With2-C25(better With2-C12) a mixture of high molecular weight aliphatic linear monocarboxylic acids. The reaction is carried out by heating at 270oC in nitrogen atmosphere with distillation of water and excess alcohol. Get product having a pH less than 30 mgKOH/g (U.S. patent 4012357, IPC From 08 To 5/09, publ. 15.03.77). The disadvantage of this method is the high energy consumption of the process, a low degree of conversion of the acid, dark colouring products.

As the prototype was taken way to obtain high-molecular esters of carboxylic acids of General formula:

where X=-OC(O)-C12-20H25-41

-C2-8H4-16; -CH=CH-; R2=-C11-19H23-39;
when X=H, R1=-C15-25H30-50;

-CH2-CH2-CH2OH;

Esterification of the corresponding acids or anger the ub>-CH2-CH2-CH2-OH;


when the molar ratio of acid:ethanol=1:1-2,2 in the presence of a hydrocarbon as a solvent and aromatic sulfonic acids or acidic sulfate as a catalyst at the boiling temperature of the reaction mixture by distillation of the water formed, the subsequent washing of the reaction mixture to neutralize it with an alkaline solution, taken from 5-20 wt.% the excess of the estimated quantity of alkali to neutralize the acidity attributable to the catalyst, washing with water and removal of solvent (RF patent 2079481, IPC C 07 C 67/08, publ.20.05.97).

This way we obtain esters with the acidity of 0.6-2.1 mgKOH/g and the output 95-97,5%.

However, the disadvantage of this method of obtaining high-molecular esters of carboxylic acids and the corresponding alcohols is the propensity of the reaction mass to intense emulsification stage leaching from the catalyst. The presence of traces of catalyst in the composition of the lubricant is unacceptable, since the use of such lubricants in the processing of PVC compositions intensive Browning of the final product, which is undesirable.

In connection with significant emulgirovaniu. The time of phase separation at a temperature of 35-50oWith ranges from 300 to 2,800 rpm, depending on the composition of the air.

The increase in time on the stage of leaching and increase operating temperatures leads to significant energy costs, lower productivity and lower quality products.

The invention solves the problem: intensification method of producing esters of carboxylic acids by reducing the time of complete separation of a solution of ester and wash water (reaction mass) at the stage of leaching while maintaining the quality and yield of the final product. This technical result is achieved in that in a method of producing esters of carboxylic acids of General formula:

where


-C2-34H4-66; -CH=CH-;
R2=-C3-19H7-39;
when X=H, R1=-C7-25H14-50;
R2=-C3-19H7-39; -CH2(OC2H4)1-3Y; -(CH2)1-5Y;


where Y=-OH, -OC(O)R1; Z=-CH3; -C2H5; -CH2OH;
oWith 3-15 wt.% aqueous solution of sulphates or chlorides of alkali or alkaline-earth metals, and then neutralize it with an alkaline agent, dissolved in a solution of the chlorides or sulfates of alkaline or alkaline-earth metals.

Comparison of the proposed method with the prototype shows that it differs from prototype treatment of the reaction mixture by washing at a temperature of 35-50oWith 3-15 wt. % aqueous solution of sulphates or chlorides of alkali or alkaline-earth metals and neutralization of the alkaline agent, dissolved in saline solution. This allows to make a conclusion on the conformity of the proposed method the criterion of "novelty". The inventive treatment of the reaction mass: its sequence and conditions of implementation are not described in literature, therefore, the inventive method corresponds criteri sulfates or chlorides of alkali or alkaline-earth metals, followed by neutralization of its alkaline agent, dissolved in saline solution, in combination with other essential features of the process allows significantly intensify the method of obtaining esters, reducing the time separation at the stage of washing the reaction mass from 300-2800 min 5-15 min while maintaining a high yield of the final product (96-97,5%) and a low acid number of 0.6 to 1.5 mgKOH/g

Nike following examples illustrate the invention.

The acid number of the catalyst is determined by the amount of catalyst (aromatic sulfonic acids and acidic sulfate) contained in the reaction mass before and after washing. Quantitative determination of the catalyst is carried out according to method MA 6-01-2-302-87, Institute of polymers, Dzerzhinsk, allowing separately to determine the content in the reaction mixture of strong acids (e.g., BSC, TJC, H2SO4, HCl, etc.,) and a relatively weak organic acids (such as adipic, phthalic, stearic, etc.,).

Example 1. Synthesis of esters is carried out in a reactor with mechanical agitation of the reaction mixture, the temperature sensor, the system Dean-stark for the Department released the reaction of water and the continuous boiling of the solvent.

Charged to the reactor 98 g (1 mol) of maleic anhydride and 2.2 moles), 311 g of cyclohexane (35%), 8.7 g of benzosulfimide (BSC) - 1.5 wt.% from the mass of reagents and heated 6 hours at a temperature 82-96oWhen the boiling reaction mixture. After 6 h of synthesis is separated 18 g of N2About the acidity of the reaction mixture is set to 3.9 g mgKOH/g, and the acidity of the catalyst - 3.2 mgKOH/g, the Reaction mass at a temperature of 35oWith washed with 70 ml of a 3.0% solution of NaCl. A clear separation of organic and aqueous phases after 15 minutes, the Acidity of the catalyst, the reaction mass is reduced to 0.3 mgKOH/g, the acidity of the organic portion was 0.8 mgKOH/g, the Catalyst is neutralized 0,22 g Paon (the excess of estimated 20%), dissolved in 50 ml of 3% NaCl solution, intensive mixing of solutions within 5 min. Separation of the organic phase and washing solution is done for 15 minutes the Organic layer is filtered and out under vacuum 30-150 mm RT.article and a temperature of 60-80oWith Argonauts solvent. The finished product is obtained with an acid number of 1.5 mgKOH/g, the output 542 g (97% of the settlement), light yellow color.

Example 2. The method of synthesis in example 1, but changing the machining conditions of the reaction mass, as reflected in the table.

Example 3. Synthesis is carried out as in example 1, but was charged to the reactor 146 g (1 mol) adipinate the reagents), heated for 7 hours at a temperature 84-95oWith boiling of the reaction mixture. After 7 h of synthesis of the acidity of the reaction mixture decreases to 3.1 mgKOH/g, the Reaction mass is washed at a temperature of 50oWith 100 ml of 4% solution MgS4intensive stirring 3 min, the separation of organic and aqueous phases after 7 minutes, the Acidity of the reaction mass becomes 0,95 mgKOH/g, and the acidity of the catalyst of 0.5 mgKOH/g Neutralize residual catalyst conduct 0.6 g Paon (the excess of estimated 20%) dissolved in 100 ml of 4% solution gS4. Intensive mixing of 4 min, a clear separation of the phases after 8 minutes the Solvent is removed from the product by vacuum distillation. Receive 676 g of finished product (96,5% of rated) with an acid number of 1.2 mgKOH/g of light-yellow color.

Example 4. Synthesis is carried out as in example 1. Synthesis take 55 g (0.5 mol) of diethylene glycol, 256 g (1 mol) of palmitic acid, 170 g of cyclohexane (35 wt. %), 1.8 g of acid potassium sulfate (0.6% of the mass of the reactants) and carry out the synthesis in a period of 7 hours at a temperature of 85-95oC and the boiling of the reaction mixture until the acid number of 2.6 mgKOH/g, and the acidity of the catalyst accounted for 1.7 mgKOH/g Rinse hold 100 ml of 12% solution such as NaCl. Intensive mixing 3 5 mgKOH/g Neutralization of the catalyst is carried out by treatment of the reaction mixture of 30 ml of 12% solution Nl with dissolved in it 0,150 g of KOH (excess of 6% of the settlement). Time bundle 8 minutes After separation of the wash water, filtration and distillation under vacuum of the solvent receive 284 g of finished product (97% of rated) light brown color with an acid number of 2.1 mgKOH/g

Example 5. Synthesis is carried out as in example 1. Charged to the reactor of 45.3 g (0,35 mol) of pentaerythritol, 286 g (1 mol) of stearic acid, 220 g of toluene (40 wt. %) and 10 g (3 wt.%) BSC. Synthesis is carried out for 9 hours at a temperature of 106-117oC and the boiling of the reaction mixture until the pH of the reaction mixture of 7.6 mgKOH/g, and the acidity of the catalyst falls to 5.5 mgKOH/g catalyst Separation is carried out at a temperature of 45oDouble rinse water 5% KCl solution in 70 ml per operation, while stirring 5 min, the time separation of the reaction mass from the leaching solution 6 minutes Acidity of the reaction mass was 2.5 mgKOH/g, and the catalyst is 0.3 mgKOH/g To neutralize this amount of catalyst is treated with the reaction mass 50 ml of 5% KCl solution with dissolved 0.1 g of NaOH (excess estimated number of 15%). Mixing concrete is accurate vacuum 130-30 mm RT.article and get 300 grams of the finished product (96,5% of rated) with an acid number of 1.7 mgKOH/g light brown color.

Example 6. Synthesis is carried out as in example 1. Charged to the reactor 84 grams (0.7 moles) of trimethyloctane, 570 g (2 mol) of synthetic fatty acid fraction17-C21, 650 g (50%) of heptane, 16.5 g (1.5 wt.%) toluenesulfonic acid and carry out the synthesis in a period of 10 hours at a temperature 100-108oC and the boiling of the reaction mixture to pH 6.3 mgKOH/g, and the acidity of the catalyst has a 4.7 mgKOH/g is given by 3 times washing with 8% aqueous solution of sodium sulfate in 50 ml of solution for operation at 50oWith intensive stirring for 4 min, bundle 4 minutes Acidity of the reaction mass after leaching 1.9 mgKOH/g and an acidity corresponding to the catalyst - 0.2 mgKOH/g To neutralize the catalyst is treated with the reaction mass 50 ml of 8% sodium sulfate with dissolved in it 0,250 g of KOH (14 wt.%, exceeds the calculated amount). Intensive stirring 5 min, the bundle 10 minutes After filtration and removal of the solvent receive 595 g of product with an acid number of 2.1 mgKOH/g, yield 97%, light brown color.

Example 7. Synthesis is carried out as in example 1. Charged to the reactor 280 g of dimeric fatty acid is the temperature of 100-110oC for 10 h acidity of the reaction mass 5.8 mgKOH/g, and the acidity of the catalyst is 4.8 mgKOH/g

Leaching is carried out at 40oWith 150 g of 6% aqueous solution of CaCl2intensive stirring for 3 min, a clear separation of phases after 5 minutes the Residual content of the catalyst 0.45 mgKOH/g, which is neutralized 0.25 g of KOH dissolved in 70 ml of 6% solution of CaCl2(the excess of estimated 6%) at the temperature of the reaction mass 40oWith intensive mixing 5 minutes a Clear separation of the phases after 7 minutes After vacuum distillation of the solvent to obtain 330 g of finished product (96% of the settlement) with an acid number of 2.1 mgKOH/g, light brown color.

Example 8. Synthesis is carried out as in example 1, but was charged to the reactor 74 g (0.5 mole) of phthalic anhydride, 248,5 g (of 1.05 mol) of cetyl alcohol, 215 g of petroleum ether fraction with a boiling point of 70-100o(40 wt%), 5.5 g of benzosulfimide (1,7% by weight of reactants), heat 9 hours at a temperature 82-96oWhen boiling the reaction mixture and achieve reduction of acid number to 4.9 mgKOH/g, and the acidity of the catalyst falls 3.6 mgKOH/g, the Reaction mass is washed at a temperature of 40oWith twice 50 ml of 9% rest respectively. Acidity washed out of the reaction mass 1.5 mgKOH/g, and the acidity of the catalyst falls of 0.2 mgKOH/g To neutralize the residual catalyst in 30 ml of 9% solution of KCl is dissolved 0.18 g Panso3(the excess of estimated at 10%) and injected into the washed reaction mass under vigorous stirring. After 3 minutes, stirring after 10 minutes the organic and the aqueous layer was separated, separated the organic layer. After filtration from it Argonauts under vacuum (30-100 mm RT.CT.) the solvent and is a ready-made product weight 301,5 g (96,5%) light yellow color, an acid number of 1.3 mgKOH/g

Example 9. Synthesis is carried out as in example 1. Loaded into the reactor 141 g of oleic acid (0,5 mol), 49 g of glycerin (or 0.57 mole), 3.2 g of BSC (1,7% by weight of reactants), 120 g of toluene (39%) and carry out the synthesis at a temperature of 106-117oWith 6 h with removal of 8.5 ml of the reaction water. The acidity of the reaction mixture 4.9 mgKOH/g, and 4.1 mgKOH/g belong to the acidity of the catalyst. Washed twice with 30 g of a 5% solution Nl at a temperature of 40oWith stirring the solution for 2 min and the clear separation of aqueous and organic phases 6 minutes Acidity of the catalyst is 0.3 mgKOH/g, organic acid - 0.9 mgKOH/g Neutralize residual try to clear boundaries 10 minutes The finished product after distillation of the solvent - 176 g (96,5% of rated) with an acid number of 2.6 mgKOH/g, color - light brown.

Example. 10. Synthesis is carried out as in example 1, but was charged to the reactor 59 g (0.5 mol) of succinic acid, 298 g (1.1 mol) of synthetic alcohol fraction16-C20(content of Oh groups corresponds to the alcohol With18H37IT), 192 g (35% by weight of the reaction mixture) cyclohexane, 5.5 g of acidic sodium sulfate (1.5% of the weight of the reactants), heated 6 hours at a temperature 84-92oWhen boiling the reaction mixture and get the reaction mass with an acid number 5,2 mgKOH/g, and the acidity of the catalyst produces 4.6 mgKOH/g Washed reaction mass of 100 ml of 3% solution of CaCl2mixed for 4 min, sucks to have a clear separation of phases 7 minimum Acidity of residual catalyst 0.45 mgKOH/g, which neutralize 0.25 g of KOH dissolved in 50 ml of 3% solution of CaCl2(excess CON from the calculated 5%) under stirring for 3 minutes a Clear separation of the aqueous and organic phases is achieved after 14 minutes the Organic layer is filtered and, after removal of the solvent receive the finished product is a light yellow color with an acid value of 1.0 mgKOH/g Yield 328 g (97% of rated).

Example 11. Sinteso acidity corresponds to 1 pray acid8), 260 g (2,2 mole) of hexamethylenimine, 420 g of cyclohexane (50 wt. %), 7.6 g of benzosulfimide (1.8% of the mass of the reactants). For 8 h synthesis at 82-88oWith the acidity of the reaction mixture is set to 4.8 mgKOH/g, and the acidity of the catalyst 3.2 mgKOH/g, the Reaction mass is washed twice with 80 ml of 5% aqueous solution of sodium sulfate mixing for 3 min, settling to a clear separation of phases in the first operation 5 minutes, the second 12 minutes Acidity of the reaction mixture after washing 1.7 mgKOH/g and the acidity of the catalyst is 0.3 mgKOH/g, which is neutralized 0,186 g Paon (8% of the excess over estimated), dissolved in 60 ml of 5% aqueous solution of PA2SO4.

After filtration and distillation of cyclohexane get the finished product is a light brown color with acidity 2.6 mgKOH/g Yield 370 g ( 96,3% of rated).

Example 12. Synthesis is carried out as in example 1, but was charged to the reactor 382 g of synthetic fatty acid fraction21-C26(on the acidity of 1.0 corresponds pray organic acids With24), 96 g of tetraethyleneglycol (0,49 mol), 320 g of benzene (40 wt. %) and 10 g benzosulfimide (2.0 wt.% from the sum of the masses of the reactants). The reaction mixture is heated to boiling and carry out the synthesis of temperate on the acidity of the catalyst. Reaction mass at 45oWith washed with 120 ml of a 13% aqueous solution of NaCl. Stirring 3 minutes, 10 minutes defending the Acid number is 1.7 mgKOH/g, and the acidity of the catalyst is 0.5 mgKOH/g Residual catalyst is neutralized 0.33 g Paon (the excess of estimated 20%), dissolved in 70 ml of a 13% solution Nl. Mixing 4 min, defending 15 minutes From the organic layer Argonauts solvent and receive 443 g of finished product with a yield of 96.5%. The product is a light brown color, an acid number of 1.9 mgKOH/g

From the table it follows that the use in a method of producing esters of leaching the reaction mass with 35-50oWith water 3-15 wt. % solution of chlorides or sulfates of alkaline or alkaline-earth metals, followed by neutralization with an alkaline agent, dissolved in saline solution, can significantly intensify the process of obtaining esters for reducing the time of the separation of the reaction mixture at the stage of leaching from 300-2800 min (prototype) 4-15 min while maintaining the quality and yield of the final product. Acid number of the ester is 0.8-2.6 mgKOH/g, output 96-97,5%. But the prototype of 0.6-2.1 mgKOH/g and 95-97,5%, respectively.

Leaching the reaction mass in the 35o(For example, 30oC) increases the separation of the reaction mixture and at a temperature above the 50o(For example, 60oC) leads to the hydrolysis of the ether.

The decrease in the concentration of saline Eyewash solution for at least 3 wt.% increases the separation of the reaction mass, and more than 15 wt.% affects the extractibility of the catalyst.


Claims

The method of obtaining esters of carboxylic acids of General formula

where


-C2-34H4-66; -CH=CH-
R2=-C3-19H7-39;
when X=H, R1=-C7-25H14-50; R2=-C3-19H7-39; -CH2(OC2H4)1-3Y; -(CH2)1-5Y;


where Y=-OH; m=0, 1, 2; -OC(O)R1; Z=-CH3; -C2H5; -CH2OH;

esterification of the corresponding acids or anhydrides with alcohols in a molar ratio acid:ethanol=1:0.35 to 2.2 in the presence of hydrocarbons as solvent and aromatic sulfonic acids or acidic sulfate as catalyst at a temperature instrumentation is her alkaline solution, taken from 5-20 wt.% the excess of the estimated quantity of alkali to neutralize the catalyst, wherein the reaction mixture is washed at a temperature of 35-50oWith 3-15 wt.% an aqueous solution of chlorides or sulfates of alkaline or alkaline earth metals, and then neutralize it with an alkaline agent, dissolved in a solution of the chlorides or sulfates of alkaline or alkaline earth metals.

 

Same patents:

The invention relates to the synthesis of biologically active chemical compounds and can be implemented in pharmacology, medicine and agriculture

The invention relates to synthetic organic chemistry, namely to a process for the preparation of esters of carboxylic acids of General formula:

< / BR>
where R is alkyl, aryl, substituted aryl, furyl, substituted furyl

R' is alkyl WITH1-C4

The invention relates to methods of producing optically active cyclobutanone the compounds of formula 1, where R3is a protective group

The invention relates to a method for obtaining compounds of formula I, where X denotes the radical, inert under the conditions of the reaction; m is 0; R3denote hydrogen, CH3CH2F or CHF2Y denotes a group OR4N(R5)2or N(CH3)OCH3; R4and R5each independently of one another denotes hydrogen or C1-C8alkyl or (R5)2together with the nitrogen atom to which they are bound, form a 5 - or 6-membered unsubstituted or substituted ring, according to which (a) conduct the interaction of the compounds of formula II, where X and m have the above for formula I, values and R1and R2each independently of one another denote WITH1-C6alkyl, C1-C6alkenyl, C1-C6alkoxyalkyl or3-C6cycloalkyl or R1and R2together with the nitrogen atom form an unsubstituted or substituted 6 - or 7-membered ring which in addition to the nitrogen atom may contain an additional nitrogen atom, in an aprotic solvent with an organolithium compound of formula III, where R7denotes an organic anionic radical; b) carry out the interaction of the obtained lithium complex with the compound of the formula IV, where)2or N(CH3)OCH3; R4stands WITH1-C8alkyl; R6represents C1-C8alkyl; or R6)2together with the nitrogen atom to which they are bound, form a 5 - or 6-membered unsubstituted or substituted ring with obtaining the compounds of formula V; C) is connected in any order in 1) is subjected to occimiano 0-methylhydroxylamine or are occimiano hydroxylamine, and then methylated, formatierung or diftormetilirovaniya; 2) enter into interaction with the ether of Harborview acid

-methoxykynuramine acids" target="_blank">

The invention relates to a method of producing methylamino- methoxykynuramine acids of the formula I, where Y represents a C-organic radical through reaction of Pinner interaction achilleid formula II with an alcohol and subsequent interaction of the formed in the Pinner reaction of ester of the formula (IV) with hydroxylamine to obtain the oxime of the formula V by methylation of the oxime of the formula V to oximoula ether of the formula VI or b) somethingitaliano obtaining oximoula ester of formula VI, followed by interaction oximoula ester of formula VI with methylamine, characterized in that in the reaction of Pinner used alcohol of the formula III R-OH, boiling point above 75C

The invention relates to ester compounds, method of their production and their use as a means for spooling the fiber

The invention relates to organic chemistry, namely the method of obtaining the ethyl ester of 10-(2,3,4-trimetoksi-6-were) decanoas acid - intermediate, suitable for the synthesis of idebenone - drug nootropic action

The invention relates to compounds of the formula

< / BR>
in which R1and R2each independently represents CNS group containing 1 to 4 carbon atoms, R3- H or acylcarnitine group containing 2 to 5 carbon atoms, R4- CNS group containing 1 to 4 carbon atoms, in free form and also, if such exist, in the form of salt

The invention relates to derivatives of 2,4-dichlorophenoxyacetic (2,4-D) and 4-chlorophenoxyacetic (4-chlorthal) acids, in particular fatty esters and alkoxy-substituted alcohols, as herbicides and plant growth regulators

The invention relates to new (+) or (-)-8-halogen-6-hydroxyoctanoic acids of the formula I, where X denotes Cl, Br, I, alkyl esters of formula II and their salts with-methylbenzylamino formula III

The invention relates to a method for producing esters of fatty acids and sorbitan and/or their alkoxysilane derivatives by reacting fatty acids directly with sorbitol in the presence of catalytic systems
Up!