Method for the treatment of psoriatic arthritis

 

(57) Abstract:

The invention relates to medicine, physiotherapy and can be used for the treatment of psoriatic arthritis. Twice a day on the affected joints affected by a magnetic field with induction on the surface of the body 80-100 MT. The first exposure is carried out with 9 to 11 h, and the second from 13 to 15 o'clock Magnetic system moved over the affected joints in a circular motion clockwise with a speed of 3-4 cm/s In the region of small joints exposed for 0.5 to 1.5 minutes On the area of the large joints exposed for 3-4 min rate of 7-9 days. The method allows to increase the effectiveness of the treatment of psoriatic arthritis.

The invention relates to medicine, namely to physical therapy and dermatology, and relates to methods of treatment of psoriatic arthritis.

There is a method of treatment of psoriatic arthritis, including the effects of anti-inflammatory, antihistamine, giposensibiliziruyuschey, sedatives, adaptogenes, vitamins, bio-stimulants, local therapy and betatron [1,2].

The disadvantage of this method is the duration of treatment more than 16-18 days and the presence in some cases the unwanted side reactions is surrounding the appointment of anti-inflammatory, antihistamines, giposensibiliziruyuschey, sedatives, adaptogenes, vitamins, bio-stimulants, local therapy and directional effects of magnetic therapy [3] . Magnetic therapy is magnetic system "Igla", consisting of two permanent magnets plate shape, arranged in one plane at the junction interface and facing each other and the irradiated surface opposite poles.

However, the effectiveness of this method of treatment is insufficient, because in some cases after therapy remains moderate pain symptoms.

The problem solved by this invention is the reduction of treatment time and achieve a more pronounced therapeutic effect.

The problem is solved by assigning medical therapy with simultaneous impact on the affected joint twice a day with an interval of 4-5 hours a magnetic field with induction 80-100 MT, the field formed by the magnetic system consisting of two magnets plate form, located at the junction interface in the same plane and facing each other and the workpiece surface opposite poles. During the procedure the system moves in a circular motion on h is t when the action on the area of the large joints, the course 14-18 procedures (7-9 days).

The authors analyzed the literature was not found signs identical to the distinctive features of the proposed method, and they are not explicitly derived from the prior art for a specialist. This method is passed clinical trials in the Siberian state medical University and showed high efficiency of recovery with psoriatic arthritis, which was reflected in the reduction of terms of disease progression compared with traditional therapy for 5-7 days. Thus, this solution meets the criteria of the invention of "novelty", "inventive step" and "industrial applicability".

The rationale. In the present method used magnetic system formed by connection to a common ground at the junction interface of the two permanent magnets facing to the body and to each other opposite poles. This design creates in the patient's body is inhomogeneous in the direction and the magnetic field, which increases the efficiency of magnetised and increases reserve capacity of the organism.

Induction of permanent magnets on the body surface 80-100 MT selected takakai the magnetic field showed a high effectiveness of the treatment of some diseases, not including psoriatic arthritis. In the present method used twice during the day the influence of a magnetic field. This improves the efficiency effects due to the summation in time orientation, and hence the structure of the magnetic field on the damaged pathological process of the fabric. The first exposure in the morning from 9 to 11 o'clock, the second from 13 to 15 hours selected based on biorhythms of the human body and the duration of effect saving procedures magnetised conducted in the morning (9 to 11 hours). The magnetization that is performed by moving the system over the affected joints in a circular motion clockwise with a speed of 3-4 cm per second. This allows healing effect on damaged tissue is not constant, and low-frequency magnetic field, which increases the effectiveness of the treatment. The exposure duration for 0.5-1.5 minutes when the action on the area of the small joints and 3-4 minutes when the action on the area of the large joints are considering the volume and area of the body that need Magnificat, at the same time impact on the damaged areas is minimal.

Use the increase of treatment time is not feasible by reason of what is needed is a stable therapeutic effect is achieved at specified duration of the course.

Example.

Patient S. , 38 years old, was treated at the clinic of skin diseases of the Siberian medical University. The diagnosis at admission to the hospital: psoriasis vulgaris, numular-patchy form, progressive stage, the autumn-winter type. Psoriatic arthritis, synovial-bone shape, a high degree of activity. Complaints received at a scaly rash bright red color on the skin of the scalp, trunk and extremities. In addition, bothered by pain in the interphalangeal and metatarsophalangeal joints III-V toes of his left foot, resulting in movement and physical activity, swelling and redness of the periarticular tissues. From the anamnesis: the first appearance of skin rash began to disturb the patient since 1992, when the skin of the scalp and arms after nervous strain appeared scaly bright red rash. When viewed from the dermatologist and was diagnosed with Psoriasis. A year later similar lesions appeared on the skin of the trunk and lower extremities. Since 1995, in addition to the skin rash, the patient began to disturb pains in the joints III-V the author and the articular process in the autumn-winter period of time.

Admission: General condition is satisfactory, mucous membranes clean, damp. Heart sounds are clear, rhythmic, pulse 78 beats/min, blood pressure of 120/80 mm RT.article.

Status localis: on the scalp, chest, abdomen, back, upper and lower extremities revealed a bright red papules and plaques, sharply infiltrated. On the surface of psoriatic efflorescence noted melkopuzyrchatoy peeling with silvery-white color, located in the center of the elements, the periphery of the lesions in the form of narrow bezel red free from peeling. Detected positive psoriatic triad. During the inspection of the joints revealed a sharp hyperemia, edema interphalangeal and metatarsophalangeal joints III-V toes of his left foot. During passive and active movements, as well as palpation in these joints have seen a sharp pain.

Was conducted the following tests: ultrasound of abdominal organs. Conclusion: Signs of chronic cholecystitis. Diffuse changes of the liver tissue. Esophagogastroduodenoscopy. Conclusion: Focal granular gastritis. Complete blood count: HB - 140 g/l, ESR - 12 mm/h, WBC - 5.7 g/l, erythrocytes - 4,6, eosinophils - 2%, lymphocytes - SLO -++++, urea - 7.2 mmol/l, amylase - 26 g/h l, thymol test - 1,6%, seromukoidy - 0,28%

The treatment was carried out in accordance with the claimed method, namely: was assigned to drug therapy: diasorin 1 tablet 2 times a day for 15 days, pills Valerian 2 units 3 times a day - 15 days, capsules aevit 2 units 2 times a day - in the course of 1 month, vitamin B1 at 1 ml/m 10, vitamin B6 at 1 ml/m 10, the ascorbic acid solution 5% at 1 ml/m 10, a solution of nicotinic acid 1% at 1ml/m 10, a solution of aloe extract in/m in 1 ml of 10 local - 2% papaverina ointment.

Magnet held on the first day of treatment, daily, 2 times a day, patient is in sitting position. The first procedure was administered in 9 hours, the second in 13 hours. Magnetic system with induction on the surface of the body 100 MT, formed by connection to a common ground at the junction interface of permanent magnets facing to each other and to the body opposite poles, moved in a circular motion clockwise with a speed of 3 cm per second for 3 minutes Total dose rate was 9 session two treatments a day.

Reducing the soreness of the joints was noted after running 2 sessions, on the 6th day of pain in the joints fully ol the century Periarticular swelling of the tissues began to decrease after 2 days from start physiotherapy and completely disappeared after 7 sessions.

After a full course of magnetotherapy assigned to the background of the traditional medical treatment, subjective complaints of the patient is not present, the objective changes in the affected joints also were not found.

At discharge: cutaneous manifestations of psoriasis corresponded to the regressive stage of the disease, subjective complaints of the patient and any objective data for the defeat of joints have been identified.

The proposed method for the treatment of psoriatic arthritis is as follows. The patient is prescribed medical therapy, including the use of antihistamines, giposensibiliziruyuschey, sedatives, adaptogenes, vitamins, bio-stimulants, local therapy with simultaneous conduction of magnetic therapy.

Magnetic therapy is used from the first day of treatment and carry out as follows: the patient is sitting or lying down. Procedures carried out daily, 2 times a day. The first procedure is carried out in the morning during the time period from 9 to 11, and the second after 4-5 hours after the first, in prolintane plate shape, located at the junction interface in the same plane and facing each other and the workpiece surface opposite poles that move in a circular motion clockwise with a speed of 3-4 cm per second for 0.5-1.5 minutes on the area of the small joints and 3-4 minutes on the area of the large joints. Course 14-18 procedures (7-9 days) for two treatments a day.

The advantages of the proposed method consist in the reduction of treatment time, more efficient use of therapeutic action of the magnetic field at all stages of treatment without side effects and remote adverse effects, it is non-invasive, simple, does not cause adverse reactions, can be used in inpatient and outpatient settings. For its implementation does not require special conditions, expensive equipment.

It should be noted that the effect of magnetic field on the affected joints in patients with psoriatic arthritis allows to exclude from complex medical treatment anti-inflammatory drugs (non-steroidal anti-inflammatory drugs, glucocorticoid hormones), which reduces the likelihood of undesirable side reactions observed in some cases when use in the treatment of patients with psoriatic arthritis // Act. the matters. sovr. medicine, So 2: MES. Dokl. VII scientific and practical. conference of physicians. - Novosibirsk. - 1997. - S. 336-337.

2. Zuev A. C. "the Results of betacarotene in the complex treatment of patients with psoriatic arthritis // Act. the matters. a resort. and physiotherap.: Matera, ubil. scientific-practical. conference Netif. - Tomsk. - 1997. - S. 204-205.

3. Kiselev, S., A. Zuev Century a New method of complex treatment of psoriatic arthritis. // V Midilli. Symposium "New in dermatology, andrology, obstetrics and gynecology: science and practice". - Moscow, 2000. - S. 55. (prototype).

Method for the treatment of psoriatic arthritis, including traditional drug therapy and the influence of a magnetic field, wherein the magnetic field with induction on the surface of the body 80-100 MT performed twice during the day, and the first exposure is carried out in the morning from 9 to 11 h, and the second from 13 to 15 h, the moving magnetic system over the affected joints in a circular motion clockwise with a speed of 3-4 cm/s, for 0.5-1.5 min at action on the area of the small joints and 3-4 min - action on the area of the large joints, in the course of 7-9 days.

 

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SUBSTANCE: method involves making incision in conjunctiva and Tenon's capsule of 3-4 mm in size in choroid hemangioma projection to sclera 3-4 mm far from limb. Tunnel is built between sclera and Tenon's capsule to extrasclerally introduce flexible polymer magnetolaser implant through the tunnel to the place, the choroid hemangioma is localized, after performing transscleral diaphanoscopic adjustment of choroid hemangioma localization and size, under visual control using guidance beam. The implant has permanent ring-shaped magnet in the center of which a short focus scattering lens of laser radiator is fixed. The lens is connected to light guide in soft flexible envelope. The permanent implant magnet is axially magnetized and produces permanent magnetic field of 2-3 mTesla units intensity. It is arranged with its north pole turned towards the choroid hemangioma so that extrascleral implant laser radiator disposition. The other end of the implant is sutured to sclera 5-6 mm far from the limb with two interrupted sutures through prefabricated openings. The implant is covered with conjunctiva and relaxation sutures are placed over it. Light guide outlet is attached to temple using any known method. 0.1-1% khlorin solution is injected in intravenous bolus dose of 0.8-1.1 mg/kg as photosensitizer and visual control of choroid hemangioma cells fluorescence and fluorescent diagnosis methods are applied. After saturating choroid hemangioma with the photosensitizer to maximum level, transscleral choroid hemangioma laser radiation treatment is carried out via laser light guide and implant lens using divergent laser radiation at wavelength of 661-666 nm with total radiation dose being equal to 30-120 J/cm2. The flexible polymer magnetolaser implant is removed and sutures are placed on conjunctiva. Permanent magnet of the flexible polymer magnetolaser implant is manufactured from samarium-cobalt, samarium-iron-nitrogen or neodymium-iron-boron system material. The photosensitizer is repeatedly intravenously introduced at the same dose in 2-3 days after the first laser radiation treatment. Visual intraocular neoplasm cells fluorescence control is carried out using fluorescent diagnosis techniques. Maximum level of saturation with the photosensitizer being achieved in the intraocular neoplasm, repeated laser irradiation of the choroid hemangioma is carried out with radiation dose of 30-60 J/cm2.

EFFECT: enhanced effectiveness of treatment.

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EFFECT: wide range of functional applications.

2 cl, 2 dwg

FIELD: medicine.

SUBSTANCE: method involves building tunnel to posterior eyeball pole in inferoexterior and superexterior quadrants. The tunnel is used for implanting flexible polymer magnetolaser implant to the place, the subretinal neovascular membrane is localized. The implant has a permanent magnet shaped as a cut ring and is provided with drug delivery system and a short focus scattering lens of laser radiator connected to light guide. The permanent implant magnet is axially magnetized and produces permanent magnetic field of 5-7 mTesla units intensity. It is arranged with its north pole turned towards sclera at the place of the subretinal neovascular membrane projection with extrascleral arrangement of laser radiator lens membrane being provided in the subretinal neovascular membrane projection area. The other implant end is sutured to sclera 5-6 mm far from the limb via holes made in advance. The implant is covered with conjunctiva and retention sutures are placed thereon. Light guide and drug supply system lead is attached to temple with any known method applied. Drugs are supplied via the implant drug supply system in retrobulbary way in any order. Triombrast is given in the amount of 0,4-0,6 ml and dexamethasone or dexone in the amount of 0,4-0,6 ml during 3-4 days every 12 h. 0.1-1% aqueous solution of khlorin is intravenously introduced at the third-fourth day after setting the implant as photosensitizer, selected from group containing photolon, radachlorine or photoditazine, at a bolus dose of 0.8-1.1 mg/kg. Visual control of subretinal neovascular membrane cells fluorescence is carried out by applying fluorescent diagnosis methods. After saturating the subretinal neovascular membrane with the photosensitizer to maximum saturation level, intravitreous, transretinal laser radiation of 661-666 nm large wavelength is applied at general dose of 30-120 J/cm2. The flexible polymer magnetolaser implant is removed and sutures are placed on conjunctiva. Permanent magnet of the flexible polymer magnetolaser implant is manufactured from samarium-cobalt, samarium-iron-nitrogen or neodymium-iron-boron system material. The photosensitizer is repeatedly intravenously introduced at the same dose in 2-3 days after the first laser radiation treatment. Visual intraocular neoplasm cells fluorescence control is carried out using fluorescent diagnosis techniques. Maximum level of saturation with the photosensitizer being achieved in the subretinal neovascular membrane via laser light guide and implant lens, repeated laser irradiation of the subretinal neovascular membrane is carried out with radiation dose of 30-60 J/cm2.

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FIELD: medicine.

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EFFECT: enhanced effectiveness of treatment.

3 cl, 2 dwg

FIELD: medicine, narcology.

SUBSTANCE: one should pre-detect the frequency of magnetic field ranged 1.0-15.0 Hz at which one should observe the shift of bioelectric activity waves towards deceleration, the decrease of motor thresholds, amplitude, the decrease of rhythmic disorders, and the increase of dopamine level in blood and/or liquor. Stimulation should be performed with magnetic field of certain frequency at induction being 0.5-1.2 Tl in projection of cerebral hemispheres. Simultaneously, one should carry out visual stimulation at frequency of stimuli presentation of 3-25/sec. Moreover, valuable visual stimuli should be presented at 0.1-20 msec, and invaluable ones at 35-350 msec. Seances take place every day for 30-60 min, therapeutic course consists of 10-20 seances. The method applies magnetic field at optimal induction for every patient in combination with psychotherapeutic impact.

EFFECT: higher efficiency of therapy.

1 ex

FIELD: medicine.

SUBSTANCE: on should perform ultrasound inhalation of 1%-ABISIB for 5-7 min followed by impact of impulse low-frequency magnetic field at induction up to 35 mTl onto projection of pulmonary radix from MAG-30 apparatus for 10-15 min daily, 10 procedures/course.

EFFECT: higher efficiency of therapy.

2 ex, 2 tbl

FIELD: medical engineering.

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EFFECT: enhanced effectiveness of treatment.

5 dwg

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