A method of treatment of peritonitis

 

(57) Abstract:

The invention relates to medicine, in particular to surgery, and for the treatment of peritonitis. To do this, in the complex therapy during and after surgery include lycopene in the form of washing the abdominal cavity during surgery and oral administration after surgery. For washing use a solution of lycopene in a dilution of 1: 4000, and after surgery, the dose of lycopene is 1-2 g/day. The method provides a significant improvement of results of treatment of peritonitis, including by improving tissue tolerance to hypoxia.

The invention relates to medicine, specifically to methods of treatment of purulent-septic diseases of the abdominal cavity, including peritonitis.

Known application in peritonitis other suppurative diseases of the abdominal cavity preparations radioactive actions aimed at bacterial intervention [1], and correction of internal environments of the body, including acid-base balance [similar - 2], and correction of violations of the motor-evacuation activity intestine [3].

Despite the seemingly most modern of products, aimed at eliminating bacterial absement the th disease, causing constant anxiety surgeons. Moreover, peritonitis with wartime injuries, lesions during disasters and other emergencies. The mortality in this disease continues to be high, and the treatment time is relatively long.

There is a method of treatment of peritonitis adopted for the prototype, including the elimination of the source of infection by surgical intervention or distinguishing it with adequate drainage, the suppression of infection in the abdominal cavity and the outside of it with antibiotics and wash (lavage), combating intestinal obstruction, correction of violations of water-electrolyte balance, protein metabolism and acid-base balance [4].

The aim of the invention is the reduction in the duration of treatment.

This goal is achieved by the fact that as a drug use lycopene, and in the intraoperative period lycopene used in a dilution of 1:4000, and in the postoperative period in a dose of 1-2 grams per day.

The drug lycopene is one of the species of carotenoids, chemical structure contains a chain hydrocarbons with a large number of blank dual SV in 1996 According to the certificate the product contains 99.9% of pure lycopene. As is evident from the certificate to the present time, lycopene was used as a food Supplement solely for the prevention of coronary heart disease and atherosclerosis.

Pure lycopene produced from natural tomato using an ether-less extraction. In the form of liposomes, the drug is soluble in water and physiological solution. In surgery lycopene to date have not been applied.

We first proposed the use of the drug lycopene in surgical pathology as a method of treatment of peritonitis by intraoperative lavage of the abdominal cavity in a concentration of 1:4000 and drug inside in the postoperative period in a dose of 1-2 grams per day.

The method is as follows.

On admission the patient with a diagnosis of peritonitis noted a sharp pain in the abdomen, aggravated by movement, change of position of a body and the coughing of the patient; note the forced position of the patient, increased heart rate, fever. Upon examination of the abdomen reveals the limited mobility of the abdominal wall, palpation reveals protective muscles of the anterior abdominal wall is about, the acceleration of ESR, the syndrome of hypercoagulability.

During the operation, determine the attack of the abdominal cavity, the presence of deposits of fibrin on the swollen bluish loops of the small intestine. Surge vessels sluggish, Vienna expanded.

After surgical removal of the primary site of infection and perform a standard toilet abdominal cavity with its lavage with saline, a solution of antibiotics and antiseptics abdominal cavity at the final stage of the surgery (intraoperative) washed with two liters of saline solution containing lycopene at a dilution of 1:4000. After processing the abdomen is sutured, leaving the drainage in the lateral channels. In the postoperative period in addition to antibiotics, drugs, supporting the cardiovascular system, and detoxification therapy, the patient is administered at 1-2 g of lycopene through the mouth in the form of a solution in the probe for 2-3 days and then up to 10 days of the postoperative period in capsules.

The postoperative course without complications, restoration of intestinal peristalsis for 2-3 days with simultaneous disappearance of the symptoms of inflammation and irritation of the peritoneum. The patient will be discharged for 8-9 days after surgery. The average duration of treatment sokrascheniyami.

Example 1. Patient B. 43 years old was admitted to the surgical Department with the diagnosis: acute appendicitis, diffuse peritonitis. Was urgently operated. During the operation, in addition to effusion in the abdominal cavity of pus and deposits of fibrin on the swollen loops of the small intestine revealed numerous small hemorrhages, which also extended to the mesentery. Themselves loops of intestine were cyanotic, with signs of apparent swelling. The pulsation of the vessels was somewhat sluggish, Vienna expanded. The clinical picture corresponds razlitom purulent peritonitis as a complication of acute gangrenous appendicitis with perforation of the Appendix. After appendectomy and perform a standard toilet abdominal cavity by rinsing it with saline peritoneal cavity washed intraoperative two liters of saline solution containing lycopene at a dilution of 1:4000. After processing the abdomen is sutured, leaving the drainage in the lateral channels. In the postoperative period in addition to antibiotics (gentamicin 2 g/day, ampioks 1 g/day), drugs, supports the cardiovascular system, and detoxification therapy the patient received 2 g of lycopene through the mouth in the form of a solution in the probe for 3 days and then teenage removed on the 3rd day. Restore peristalsis occurred on the 2nd day of the postoperative period. The symptoms of inflammation and irritation of the peritoneum disappeared at the same time. The patient was discharged 9 days after surgery in satisfactory condition. Further complications were observed.

In the patient application of lycopene, obviously, has had a positive impact on the resolution of paresis of the intestine, which occurred much earlier than in patients with similar severity of peritonitis, which allowed to reduce the time of stay of the patient in hospital and to avoid complications.

Example 2. Patient S. 55 years was hospitalized in the Department of emergency surgery with a diagnosis of acute gangrenous cholecystitis, diffuse peritonitis. In operation, the presence of the patient gangrenous modified gallbladder perforation, generalized biliary peritonitis. Produce cholecystectomy, evacuation of the effusion in the abdominal cavity, washed with recent physiological solution, which was added lycopene in a dilution of 1:4000. The abdomen is sutured, to the bed of the gallbladder and into the right lateral channel enter drains. In the postoperative period administered antibiotics (gentamicin 2 g/day, ampioks 1 g/day), spend uchet drug lycopene 1.5 g/day by mouth in the form of a solution within 2 days and over the next 6 days in capsules. The postoperative period was uneventful. The patient 3 days after surgery fully normalized function of the intestines. The wound healed by first intention. On day 7 were removed skin seams, and on the 8th day the patient was discharged in good condition.

In this patient a smooth postoperative period largely due to the use of lycopene as during surgery and the immediate postoperative period. Postoperative wound healing by first intention.

Example 3. Patient C. 82 years old was admitted to the surgical Department with the diagnosis: blunt abdominal trauma, diffuse peritonitis. Operations identified gap in the wall of the small intestine, diffuse peritonitis. When revision of a loop of intestine is vastly overblown, cyanotic, serous cover multiple petechial haemorrhages. In all departments of the abdominal cavity muddy effusion, applying fibrin. Produce resection of 5 cm of the small intestine. After sanation of abdominal cavity in the last injected 1.5 liters of saline solution with lycopene at a dilution of 1:4000. Spend peritoneal dialysis. In the postoperative period prescribed drugs, supporting the cardiovascular system, assign detoksikatsionnuyu lycopene at a dose of 1 g/day in the form of a solution on the probe within 3 days within 7 days of the postoperative period in capsules. Postoperative period was without significant complications. Intestinal peristalsis had recovered by day 3 post-operative period. Laparotomic wound healed by first intention.

In this case, the introduction of lycopene resulted in the recovery of the sick elderly with very severe pathology to a 10-day postoperative period.

Observation of the operated patients showed reduction of terms of treatment of patients with peritonitis by 25-40% due to the use of lycopene in comparison with the previously known methods of doing this category of surgical patients.

The drug of lycopene obvious to experts in the field of abdominal surgery and, moreover, the preparation of lycopene were not used in surgery, and was only used as a food additive for the prevention of atherosclerosis and prevention of myocardial infarction.

The drug lycopene by direct injection into the abdominal cavity produced for the first time, with a pronounced positive effect is based on a previously unknown property of the direct effects of lycopene in improving tissue tolerance to hypoxic injury and extend periilanent drug lycopene, its use since 1996 as a dietary Supplement makes a real implementation of the proposed method for the treatment of peritonitis, almost directly under the description of the invention for surgeons specialized hospitals, and the accumulation of clinical material for widespread distribution, including in the military field surgery.

The method is directly ready for use and has important socio-medical and economic importance.

Sources of information

1. Kanshin N. N. The treatment of purulent peritonitis. Bulletin of surgery, 1980, I. 125, 9, S. 108-113.

2. Ryabov, A. Syndromes critical States. M.: Medicine, 1994, 368 S.

3. Shalimov A. A., Shaposhnikov, C. I., M. Pinchuk, Acute peritonitis. Kiev, 1981, 265 S.

4. Kuzin, M. I. and others Peritonitis. Bed, M, 1982, S. 91-102.

A method of treatment of peritonitis, characterized in that during the operation when the washing of the abdominal cavity using likacin in a dilution of 1: 4000, and in the postoperative period lycopene is administered in a dose of 1-2 grams per day.

 

Same patents:
The invention relates to medicine, namely anesthesiology, and can be used in highly traumatic, involving massive blood loss operations in patients with baseline impaired vital functions of the body
The invention relates to medicine, namely to surgery, and can be used for the treatment of chronic duodenal obstruction

The invention relates to medicine, namely to surgery, and can be used for the treatment of paraproctitis

The invention relates to solutions for surgical irrigation and methods of use thereof, in particular to anti-inflammatory, analgesic and anticonvulsant solutions

The invention relates to medicine and can be used to inhibit the hemolytic activity of pathogenic strains of E. coli
The invention relates to medicine, namely to the General treatment of purulent peritonitis in the terminal stage

The invention relates to medicine, particularly surgery, gynecology, traumatology, and concerns the application of perfluorocarbon emulsions as a means for the prevention of connective tissue binding between the bodies and the walls of the organs
The invention relates to medicine, specifically to methods of treatment of trophic ulcers and purulent-necrotic lesions of the lower extremities in patients with diabetes mellitus
Medical center // 2195954
The invention relates to medicine and refers to compositions that have anti-stress effect, relieving emotional stress and normalizing sleep
Medical center // 2195953
The invention relates to medicine and relates to compositions for the prevention and correction of disorders due to exposure to stress and other adverse environmental factors
The invention relates to medicine and refers to compositions that have adaptogenic action

The invention relates to medicine and pharmaceutical industry, in particular to the creation, production and application of funds for the treatment of menopausal disorders

The invention relates to pharmakologie, namely, toning, adaptogenic, immune modulating, hypoglycemic, antihypoxic, anti-inflammatory, neuroprotective, radioprotective, thermoprotection, act-protective drug

The invention relates to medicine, in particular to therapy, and can be used for the treatment and prevention of atherosclerosis

The invention relates to the field of medicine, pharmacology, and can be used as a means of having bactericidal and fungicidal action for the treatment of diseases caused by pathogenic viruses, fungi(yeast) and microorganisms

The invention relates to apitherapy and is designed for warming up the ear and nose holes as hygiene, restorative, and improving sleep remedy
The invention relates to medicine, namely to compositions for the treatment of varicose veins
Balm "grace" // 2195484
The invention relates to alcoholic beverage industry
Up!