(57) Abstract:The invention relates to the protection of building materials and structures from biodegradation by microscopic fungi. For expanding the resource base of receipt of fungistatic substances, reduction of toxicity, cost, and efficiency actions, as well as expand the market by the waste industry as a fungistatic substance use salt of caprolactam General formula
< / BR>where n = 1-5 and X-the acid anion Cl-; NO-3, HSO-4. Production of fungistatic substances simple, does not require scarce, expensive solvents and components, the degree of biostability treated them with high-quality products. table 2. The invention relates to the protection of building materials and structures, flooring products, equipment and structures from biodegradation by microscopic fungi.As fungistatic or fungicidal substances used various classes of organic compounds.Known fungistatic substance which protects the construction materials from damage by microorganisms in the conditions of operation, such as o-h is W hen fell sharply, the effectiveness of their practical usage is low, the selectivity is high, many of them have not been mastered by the industry, and, for example, pyrocatechin requires expensive solvents such as ethyl alcohol.In addition, some of the above fungistatic substances initially toxic to the environment and humans.At the same time, the majority of the building materials and, in particular, on the basis of gypsum, phosphogypsum, chitragupta and others, as well as the most used technique in polymer materials and coatings (LCR) do not have sufficient decay resistance and are easily damaged by microscopic fungi such as As. niger and otherThese lesions cause irreversible structural changes in the materials and further lead to loss of strength and destruction.It is known that when operating in conditions of high humidity and temperature of the gypsum product is particularly often affected by microscopic fungi. And this, in turn, affects the ecological situation in the buildings, the surface of the products covered by spots, the material becomes loose and destroyed.Therefore, the research problem fungistatic substances shall Britanie aimed at finding substances not toxic to the environment and humans, cheap, affordable, effective for use as a fungistatic substances, as well as expand the market technogenic waste industry.This is achieved by apply salt caprolactam derivatives of General formula
< / BR>where n=1-5, X-anion of a mineral acid (Cl-, NO3-, SO3-as fungistatic substances.The salt derivatives of the caprolactam obtained by acid modification of the still bottoms from the distillation of the caprolactam (MCTC)  are dense homogeneous mediobrunneus mass, capable of a long time not to crystallize, with density 1325-1357 kg/m3and the electrical conductivity (1,5-3,2)10-31/OSM, soluble in water.Thus, it is proposed the use of a known substance for a new purpose.To use salts of derivatives of caprolactam (MCTC) as a fungistatic substance is prepared from 0.05 to 10% aqueous solutions, the water temperature should be not less than 50oWith and carry out the application of surface structures, products of gypsum, phosphogypsum, chitragupta and others who Yessei directly with the mixing water.Penetrating into the pores, the surface roughness of structures and building materials, salt derivatives of caprolactam during cooling clog them, protecting the surface as the external and internal from the biodegradation of microscopic fungi and their spores. In addition, studies have shown that with the introduction of MCTC in the construction mixture, for example of plaster, chitragupta, phosphogypsum and other, they increase the coefficient of giprostoymost (Kg), the ratio of the strength of the samples in compression, stored in water, and the strength of the samples stored in air-dry conditions, and thereby prevent the penetration of water in the finished product, and thus increase their giprostoymost.First proposed the use of salts of derivatives of caprolactam as a fungistatic substance, thus the proposed solution has the criterion of "novelty".The absence in the patent and scientific literature on this and related fields of technology the same or similar to the technical nature of solutions, and that first discovered previously unknown properties of salts derived caprolactam, allowing them to use as fungistatic substances, results in the este fungistatic substances salt derivatives of caprolactam in the indicated concentrations inhibit the development of viable (active) microgroove, previously identified in the operating conditions, and prevent their development in the case of repeated contact of spores or mycelium on the surface of the structure. The trial offer and other known substances was carried out on a mixture of strains of fungi, identified and deposited with the collection of cultures INMN the Russian Academy of Sciences by well-known methods .Comparative data on the effectiveness of the proposed and known substances in points (percent) growth of microscopic fungi are shown in table 1.From table 1 it follows that we offer as a fungistatic substance salt derivatives of caprolactam (MCTC) have a high biocidal efficacy.In addition, it was held biotesting extracts of materials with additives MCTC and known substances of different concentrations, to determine the toxicity of their actions on the environment.To determine the toxicity of building materials with the addition of fungistatic substances known and proposed as a test object were selected Daphnia species Daphnia Magna Straus.Aqueous extract of samples of building materials treated with a fungistatic substances were filtered and the filtrate was placed a t gibet, the material is considered toxic. The results of the biological testing are presented in table 2.As follows from table 2, used as a fungistatic substance salt derivatives of caprolactam (MCTC) is not toxic to the environment. Use in the industry, we offer salt derivatives of caprolactam will reduce environmental tensions in the region, will effectively protect building materials from biodeterioration.In addition, the proposed fungistatic substance produced from waste products of caprolactam, so its cost is much lower than the known. Production of fungistatic substances simple, does not require scarce, expensive solvents and components, and the degree of biological products, processed data fungistatic substance is high, which is consistent with the objectives of the present invention.Thus, we offer a fungistatic substance allows to expand the raw material base, to refuse deficient, toxic materials, it is cheap, domestic, and can solve the environmental problem of the region for disposal of industrial waste, expanding their market. The use of salts of product3-, HSO3-)
as fungistatic substances.
NH - OC6H13where R is H, CH3with insect - and aerorepublica activity
FIELD: chemistry of lactams' derivatives.
SUBSTANCE: the present innovation deals with obtaining N-(2-chloroalkyl)- and N-alkyl-aromatic derivatives of lactams of the following general formula: , where R=H, Cl, R'=(CH2)3, (CH2)5 which could be modifiers of unsaturated carbon-chain caoutchoucs and rubber mixtures based upon them. The suggested method for obtaining the mentioned N-substituted lactams deals with combining N-chlorolactams and allyl benzene, moreover, as N-lactams one should apply either N-chlorobutyrolactam or N-chlorocaprolactam. The process should be carried out at molar ratio of N-chlorolactam to allyl benzene being equal to 1-1.15:1, at availability of a catalyzer as mono-tertiary-butylperoxy-α-methylmethoxyethoxyethyl ether of ethylene glycol taken at the quantity of 0.4-4.0% weight, in the medium of inert solvent, for example, chlorobenzene at 100-125° C for about 15-20 min. The innovation enables to shorten terms of reaction by 20-30 times, simplify the way for obtaining target products and widen the assortment of the obtained compounds, as well.
EFFECT: higher efficiency.
FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to technology for preparing caprolactam by the cyclization reaction of derivatives of aminocaproic acid. Method is carried out by cyclizing hydrolysis of compound chosen from the group comprising aminocaproic acid esters or amides, or their mixtures. The process is carried out in the presence of water, in vapor phase at temperature 200-450°C in the presence of a solid catalyst comprising of aluminum oxide that comprises at least one macroporosity with pores volume corresponding to pores with diameter above 500 Å taken in the concentration 5 ml/100 g of above. Preferably, the specific square of catalyst particles is above 10 m2/g and the total volume of pores is 10 ml/100 g or above wherein pores volume corresponds to pores with diameter above 500 Å is 10 ml/100 g or above. Invention provides improving the process indices due to the improved properties of the solid catalyst.
EFFECT: improved preparing method.
5 cl, 2 ex
FIELD: organic chemistry, medicine, biochemistry, pharmacy.
SUBSTANCE: invention relates to novel azaheterocycles of the general formula (I): possessing inhibitory effect on activity of tyrosine kinase and can be used in treatment of different diseases mediated by these receptors. In compound of the general formula (1) W represents azaheterocycle comprising 6-13 atoms that can be optionally annelated with at least one (C5-C7)-carbocycle and/or possibly annelated with heterocycle comprising 4-10 atoms in ring and comprising at least one heteroatom chosen from oxygen (O), sulfur (S) or nitrogen (N) atom; Ra 1 represents a substitute of amino group but not hydrogen atom, such as substituted (C1-C6)-alkyl, possibly substituted aryl and possibly substituted 5-10-membered heterocyclyl comprising at least one heteroatom chosen from O, S or N; Rb represents carbamoyl group -C(O)NHRa wherein Ra represents a substitute of amino group but not hydrogen atom, such as possibly substituted alkyl, possibly substituted aryl, possibly substituted 5-10-membered heterocyclyc comprising at least one heteroatom chosen from O, S or N; Rc represents a substitute of cyclic system, such as possibly substituted (C1-C6)-alkyl, possibly substituted aryl and possibly substituted 5-6-membered heterocyclyl comprising at least one heteroatom chosen from O, S or N; or Rb and Rc form in common aminocyanomethylene group [(=C(NH2)CN], or their pharmaceutically acceptable salts. Also, invention relates to methods for synthesis of these compounds (variants), a pharmaceutical composition, combinatory and focused libraries.
EFFECT: valuable medicinal properties of compounds and pharmaceutical composition, improved methods for synthesis and preparing.
35 cl, 16 sch, 13 tbl, 43 ex
SUBSTANCE: invention refers to bengamide derivatives produced by fermented microorganism Myxococcus virescens ST200611 (DSM 15898), to application in cancer therapy and/or prevention, to medical products containing bengamide derivatives, making process of bengamide of formula . In addition, the invention refers to compound of formula .
EFFECT: new bengamide derivatives are characterised with useful biological properties.
15 cl, 7 tbl, 18 ex
SUBSTANCE: invention relates to derivatives of 3-aminocaprolactam of formula (I): , where X represents -CO-R1 or -SO2-R2, R1 represents alkyl (with the exception of 5-methylheptanyl and 6-methylheptanyl, where radical R1 is bonded to carbonyl in position 1), halogenalkyl, alkoxy (with the exception of tret-butyloxy), alkenyl, alkinyl or alkylamino radical from 4-20 carbon atoms (for example, from 5-20 carbon atoms, 8-20 carbon atoms, 9-20 carbon atoms, 10-18 carbon atoms, 12-18 carbon atoms, 13-18 carbon atoms, 14-18 carbon atoms, 13-17 carbon atoms) and R2 is alkyl radical from 4-20 carbon atoms (for example, from 5-20 carbon atoms, 8-20 carbon atoms, 9-20 carbon atoms, 10-18 carbon atoms, 12-18 carbon atoms, 13-18 carbon atoms, 14-18 carbon atoms, 13-17 carbon atoms); or to its pharmacologically acceptable salt. Invention also relates to application and pharmacological composition, which has anti-inflammatory activity, based on said compounds.
EFFECT: obtaining new compounds and based on them pharmacological composition, which can be applied for obtaining medications for treatment, relief or prevention of inflammatory disease symptoms.
57 cl, 62 ex
SUBSTANCE: present invention relates to a method for synthesis of caprolactam from alkylcyanovalerate which involves bringing alkylcyanovalerate into contact with hydrogen in gaseous state in the presence of a hydrogenation catalyst and a ring formation catalyst, and treatment after condensation of a gaseous stream containing the formed lactam in order to separate ammonium which may be present, the formed alcohol and/or the caprolactam solvent and extraction of caprolactam, where the hydrogenation catalyst includes a metal element or a mixture of metal elements selected from a group containing an active metal element in form of iron, ruthenium, rhodium, iridium, palladium, cobalt, nickel, chromium, osmium and platinum or several metals from this list, and the ring formation catalyst is porous aluminium oxide.
EFFECT: obtaining caprolactam without intermediate separation of alkylaminocaproate.
10 cl, 5 ex, 1 tbl
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to compounds of general formula
where there are R3/R3', R4/R4' and R5/R5' where at least one of either R4/R4' or R5/R5' always represents a fluorine atom, and the other radical values are disclosed in the description.
EFFECT: making the compounds which are γ-secretase inhibitors, and can be effective in treating Alzheimer's disease or advanced cancers, including but not limited to carcinoma of uterine cervix and breast carcinoma and malignant tumours of hematopoietic system.
15 cl, 3 tbl, 18 ex
SUBSTANCE: invention relates to an improved method of purifying crude ε-caprolactam obtained from cyclohexanone oxime via gas phase Beckmann rearrangement, comprising a step for crystallisation of ε-caprolactam from the solution of crude ε-caprolactam in ether or halogenated hydrocarbon, a step for washing the crystalline ε-caprolactam obtained from the crystallisation step with a solvent and a step for hydrogenation of the crystalline ε-caprolactam through contact with hydrogen in the presence of a hydrogenation catalyst.
EFFECT: high purity of the product, high absorption of potassium permanganate and extraction coefficient at wavelength 290 nm equal to or less than 0,05, which meets all requirements for commercial products.
19 cl, 12 ex
SUBSTANCE: invention relates to methods of producing a prepolymer with functional groups via chemical modification of oligodiene diols, which are used in chemical industry as the basis for making tyres, industrial rubber articles and paint materials. Described is a method of producing a prepolymer with terminal amino groups, involving treating oligodiene diol with a modifier, followed by separation of the reaction product, via an oligomerisation reaction of ε-caprolactam with oligodiene diol in the presence of catalytic amounts of benzoic acid with reagents in molar ratio 4:1:0.005, respectively, in a vacuum-sealed ampoule at 170°C and reaction time of 180 minutes.
EFFECT: shorter reaction time and lower temperature and, as a result, fewer thermal-oxidative and destructive processes, possibility of using industrially available starting reagents.
SUBSTANCE: invention relates to a redox ammoximation method, wherein a ketone or aldehyde reacts with ammonia and oxygen in the presence of a catalyst, where the catalyst is a redox catalyst based on aluminophosphate, having a qualitative general formula M1M2AlPO-5 (I), where M1 denotes at least one transition metal selected from Co(III), Mn(III), Fe(III), Cr(VI), Cu(III), V(V) and Ru(III); M2 denotes a metal selected from Ge(IV), Sn(IV), Re(IV), V(IV) and mixtures thereof; M1 and M2 are different from each other; and a certain portion of phosphorus atoms in the structure of the type M1M2AlPO-5 is substituted with atoms of M2. Also disclosed is a redox ammoximation catalyst.
EFFECT: providing a selective ammoximation method.
11 cl, 5 tbl, 6 dwg, 16 ex