The method of correction of immune disorders

 

(57) Abstract:

The invention relates to the field of medicine, relates to a method for correction of immune disorders and can be used in clinical practice to restore the immune system. This involves a complex water-soluble salts of calcium, copper, zinc, magnesium, iron and selenium. The drug is administered orally in droplets that provides individual adjustment of doses. This leads to multiple effects on different parts of the immune circuit, which dramatically enhances the immunomodulatory effect.

The invention relates to the field of medicine, relates to a method for correction of immune disorders and can be used in clinical practice to restore the immune system.

The immune system controls the normalization of the functions of the microcirculatory network, and functions of all human organs and tissues. Cell and tissue immunity play a leading role in the regulation of what is happening in the tissues and organs of the processes. Control over the activity of the cells, tissue regeneration, removal of decay products through the mutual influence of phagocytes, histiocytes, plasma cells and lymphocytes in the system issledovaniya in the field of micronutrients person, which showed a close relationship of trace elements to immune and microcirculatory systems of different cells, tissues and functions of man (A. P. Avtsin, A. A. Zhavoronkov, M. A. riche, HP Struchkova, Microelementoses person, Moscow, "Medicine", 1991).

Currently in medical practice for immune mostly use the tools of natural origin. It is a well known adjuvant, taktivin, timoptic, mielopid, timogen and others (M. D. Mashkovsky, Medicines, Moscow, "Medicine", 1993, so 2, S. 193-204).

All these drugs are mainly organotropic action, have side effects in the form of toxic and mutagenic violations, and most importantly - have a relatively low activity effects on molecular energy and biochemical processes.

For the prototype accepted way immune described in the patent of the Russian Federation 2138271. The method consists in the following. Pre-receive proteogenomic complex, which is an organic low molecular weight component derived from proteincoding plant materials, and ionized organic salt of selenium. The drug protocellular complex is a solution of Lex administered orally, intramuscularly, intravenously, intraarterially, as well as externally in the form of a suspension in an oil solution or in the form of ointment with oil-alcohol filler. The duration of treatment can vary from 1 to 3 months and over.

The disadvantage of the above method is the following. When calculating doses were not taken into account the average daily requirement of the human body in selenium and, most importantly, the authors do not use the integrated application of metal-immunomodulators, which reduces the effectiveness of the treatment.

At the same time immunomodulatory metals in the body: calcium, copper, zinc, magnesium, iron, selenium (Century. So Long. Fundamentals of immunology. M, Honey.book N.Novgorod, Ed. The C 2000, - 204 C., S. 99 I).

Also known average daily demand for these metals and their salts for humans, respectively (Emsley, J. Items: Per s angl. - M.: Mir, 1993. - 256 S. C. 84, 112, 220, 108, 64, 172), determining the existence of optimal immune systems.

The aim of the invention is to increase the efficiency of influence on the immune and autoimmune processes.

This goal is achieved by the use of convenient dosage form solution is a water - soluble salts of calcium, copper, zinc, magneta water-soluble salts of metals of immunomodulators in a convenient dosage form - the solution in doses given daily requirement of these trace elements with individual correction depending on treatment goals, weight, portability drugs and corrective facilities physician.

The method is as follows. The patient takes the water-soluble salts include chlorides of calcium and copper, sulphate of zinc, magnesium, iron and sodium selenate in a mixture of oral drops in daily dosages of 58.9 mg/kg, 0,186 mg/kg, 1.4 mg/kg 27 mg/kg, 1.5 mg/kg, 0.006 mg/kg, respectively. This leads to multiple effects on different parts of the immune circuit, which dramatically enhances the immunomodulatory effect. The reception drops is carried out at intervals depending on the severity of the condition and treatment goals, and monitored laboratory parameters.

Criteria normalization of immune disorders, we chose the level of immunoglobulin (hyperimmune reaction), the level of antinuclear antibodies (AHA) and the analysis of immunological indexes.

In the experimental group 30 different patients with different immune and autoimmune disorders were given aqueous solution in the droplets of a mixture of the above-mentioned salts of calcium, copper, zinc, magnesium, iron, selenium in the above-mentioned doses daily needs per kg of body weight.

During the 26-day treatment, the reduction of immunoglobulin E in the middle, antinuclear antibodies and normalization of immunological indexes in the experimental group positively above the control on 693,2% in the absence of other treatments, and the number of side effects such as anemia and hypercupremia was practically absent.

The advantage of the proposed method is the following. Drops of water-soluble salts are cheap, stable during storage, do not have side effects and contraindications, easily dosed, drip schemes easily increase or decrease depending on the treatment goals or the sensitivity of the patient.

Thus, the proposed method of correction of immune disorders is effective and safe for patients.

The method of correction of immune disorders, characterized in that is used in a complex water-soluble salts of calcium, copper, zinc, magnesium, iron and selenium in the form of drug - drops orally in daily dosages corresponding to the average human needs in these micronutrients.

 

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