The method of correction of immune disorders in patients with genital endometriosis

 

(57) Abstract:

The invention relates to medicine, and gynecology. After a day spend radon baths, gynecological irrigation and micro using radon waters. Exercise EHF-therapy on point RN22. EHF-therapy in the days free from hydrotherapy, or with an interval of 2 h after conducting baths. Act 20 minutes Method promotes early normalization of immunogenesis. 3 table.

The invention relates to medicine, namely to gynecology and for the treatment of women suffering from genital endometriosis.

There is a method of treatment of patients with genital endometriosis using radon concentration radon water 40 NCI/L. the Method provides for the appointment of radon baths temperature 36oWith a duration of 10 minutes, 8-10 procedures according to the scheme: 2 days bath, 3rd day or every other day, and gynecological irrigation in the days of bathing at a temperature of 36oC for 10 min during the 1st procedures and exposure time 10 min follow-up procedures, the course of 8-10 treatments. Under the influence of radon was observed a slight tendency to decrease of lysozyme, a clear trend toward increased the Ki main classes of immunoglobulins, there is a tendency to increase at the end of treatment. Application of radon led to some stimulating the production of antibodies, resulting in increased formation of circulating immune complexes. The decreased activity of lysozyme contributed to the reduction processes of disintegration of the tissue, which was also referred to the positive effects of radon. However, not always immunomodulatory effects of radon was expressed significantly (L. P. meadow et al. The use of radon water in the complex treatment of patients with genital endometriosis. - Pyatigorsk.-1987).

Know the influence of EHF-radiation on cells and the organization of cellular systems. Experimental studies have demonstrated the stimulating effect of the electromagnetic field of millimeter range on the immune system in animals with induced hyperplasia of the uterus, which is of interest in the clinical aspect, since it is known that hyperplastic processes of the female reproductive organs are accompanied by multiple immune disorders. The results of immunological research in the group of patients with hyperplastic processes of the uterus treated with electromagnetic radiation of extremely high frequency, prodemonstrirovav-therapy in complex treatment of benign and malignant tumors of the uterus. //In Proc. : Millimeter waves of non-thermal intensity in medicine./Proceedings of the International Symposium. -Moscow. - 1991).

The essence of the invention is that, using EHF-therapy in combination with radon procedures in terms of remission increased on average by 2-3 months in comparison with pure radon.

The method is as follows. The patient receives basic medical complex, including a training mode, the internal intake of mineral water, diet, physical therapy. Radon was administered according to the scheme: bath, gynecological irrigation, microclysters with the concentration of radon water 1,5 CVR/l (40 NCI/l), have a marked analgesic, sedative, immunomodulatory, anti-inflammatory and normalizing the function of the endocrine system action and EHF-therapy on biologically active corporeal point RN 22, which was administered on days free from hydrotherapy or with an interval of 2 hours from the receipt of radon. EHF-therapy was carried out, for example, by the "True-1" with a wavelength of 7.1 mm or 5.6 mm (individually), the power flux-density 10 mW/see the Mouthpiece of the instrument with the area revealed a 2 cm was located in the area above the point; expoilt temperature of 35-37oWith a duration of 10-15 minutes Gynecological irrigation and micro appointed in the days of bathing with the same parameters. The course shall also 8-12 treatments. The course of treatment is 24 days.

The method is illustrated by the following examples.

Excerpt from history of the disease

Sick Elena To the Islands, 30 years old, was admitted to the hospital with a diagnosis of genital endometriosis (adenomyosis of the uterus, Posadsky endometriosis). The woman suffered with pain in the lower abdomen before and during menstruation, growing up intense in the first 2-3 days of the cycle; before menstruation - chromazone within 2-6 days, pain during sexual intercourse, weakness, fatigue, irritability, loss of ability to work. Considers herself a patient menarche, when there was pain and all associated syndrome. The diagnosis of endometriosis exhibited for the first time after the beginning of sexual life. In treatment were used synthetic progestins with a short-term decrease in pain and improvement in General condition.

Bimanual study indicated an increase in the size of the uterus up to 7-8 weeks., multiple painful testovaty seal in the thickness of the myometrium, the appendages on both sides of heterogeneous malopodvalnaya: clinical blood and urine tests - without pathology. ECG violations of repolarization processes in the posterior wall of the left ventricle. Ultrasound of the genital findings are in accordance with bimanual examination.

Immunological studies have shown that the values of Ig A and Ig M was the patient at the lower limit of normal; Ig G the patient also did not exceed normal values.

Treatment. The complex treatment consisted of destination gynecological irrigation (30 degrees, 15 min), public baths (30 degrees, 15 min), microenemas (30 degrees, 15 min). Procedures of radon water concentration of 40 NCI/L. They spent one day on the scheme: 2 days admission, day break; in the course of 10 treatments. In addition to the Spa treatment the patient was prescribed EHF-therapy on biologically active corporeal point RN 22. Used machine "Yav-1 with a wavelength of 7.1 mm flux density of 10 mW/cm, exposure time 20 min Exposure was carried out through the day, with an interval of more than 2 hours from the receipt of hydrotherapy or free days, a total of 10 treatments. After treatment disappeared headaches, irritability, weakness, significantly decreased pain. Clinical blood and urine tests remained within normal limits. D is ur myometrium.

Immunological studies have shown that the values of Ig A and Ig M after treatment increased from 1.26 to 3.2 and from 0.72 to 1.52m (positive impact applied medical complex), Ig G concentration in serum decreased from 9 to 8.

The patient was discharged with improvement in General condition and gynecological status. After 1 year, the woman re-examined in the clinic. Favorable clinical changes, positive dynamics of objective data, including immunological parameters were maintained during the entire period has elapsed after the Spa treatment.

Summary. Thus, the patient genital endometriosis adopted in the clinic treatment radon concentration radon 40 NCI/l and EHF-therapy on biologically active corporeal point RN 22, endured the procedure well, was noted positive dynamics of the overall condition, data gynecological status, objective research and immunological indices on the background of receipt procedures and in the analysis of remote results of treatment after 1 year.

Excerpt from the history.

Patient Natalia And society, 35 years old, was admitted to the hospital with a diagnosis of genital the PTA, growing up intense before menstruation and krivomazova within 1-3 days in the same period, frequent pain during sexual intercourse, weakness, irritability and fatigue, reduced work capacity. Considers herself a patient menarche, when at the first menstruation pains until loss of consciousness or twilight state of consciousness, weakness. Endometriosis was first diagnosed at the age of 29 after multiple courses of anti-inflammatory treatment for chronic salpingoophoritis. In treatment were used synthetic progestins, electrophoresis of potassium iodide, vitamin therapy, symptomatic obezbolivaushee therapy with a short-term effect.

Bimanual study indicated an increase in the size of the uterus up to 6-7 weeks., heterogeneity of its structure and the tenderness, the appendages on both sides tyazhistye, spinach, in the region of Sacro-uterine ligament is palpated rounded, uneven, sharply painful education, size 2.5 cm in diameter.

Studies: clinical blood and urine tests - without a pathology. ECG - without a pathology. Ultrasound of the genital organs - the uterus is enlarged HH mm, mosaic structure, behind the cervix-immunological studies revealed, the values of Ig a and Ig M the patient were increased, respectively, 4,32, and 3.38, Ig G, the patient did not exceed the norm (18,03).

Treatment. Were appointed gynecological irrigation, public baths, microenemas of radon water concentration 180 NCI/l (36 C, 15 min). All procedures were performed in one day, according to the scheme: 2 days admission, interval 1 day or every other day, the patient received 10 treatments. In combination with balneotherapy woman took EHF-therapy according to the methods described above. After the treatment significantly decreased pain, irritability and fatigue have become less pronounced. Clinical blood and urine tests remained within normal limits. Data bimanual and ULTRASONIC studies showed a reduction in the size of the uterus (5-6 weeks), the tendency to normalization of the structure of the myometrium.

Immunological studies have shown that the value of Ig A decreased to 3.87, a Ig M after treatment to 2.5, the concentration of the same Ig G in the serum remained the same - 18,03.

The patient was discharged with improvement in General condition and gynecological status. After 1 year the patient is re-examined in the clinic. Favorable clinical changes, positive dynamics of objective data, including imnogo treatment.

Summary. Thus, the patient genital endometriosis adopted in the clinic course EHF and radon (180 NCI/l, physiotherapy biologically active corporeal point RN 22), endured the procedure well, was noted positive changes in General condition, data gynecological status, objective research and immunological parameters directly after receiving procedures and in the analysis of remote results of treatment after 1 year.

On this way (radon baths, gynecological irrigation, microclysters with a radon concentration of 1.5 CVR/l (40 NCI/l) in combination with EHF-therapy on biologically active corporeal point RN 22), was treated 51 patients suffering from genital endometriosis (adenomyosis of the uterus and pozavcherashnym forms of endometriosis). The control group consisted of 32 patients receiving only radon, according to the above method. Both groups in clinical terms were identical. All patients had pain, most pronounced in the premenstrual and menstrual periods, chromazone before menstruation, General malaise, was determined by the increase of the uterus, presence of lesions pozavcherashnego endometriosis bimanual and ULTRASONIC studies the lo was diagnosed in 11 patients, secondary - 6. General characteristics of patients are presented in table. 1.

All patients were observed immunological study of blood serum. We have identified deviations from normal values: IgA and IgM. 17 women in the study group they were at the lower limit of normal (concentration of IgA in an average of 1,263+0,54, IgM - 0,72+0,87), IgG in these patients was almost unchanged.

In 34 patients of the main group values of IgA And IgM to treatment were increased (average IgA -4,03+0,04; IgM -3,38+0,57). When determining the values of IgG abnormalities of this indicator was not, which was probably connected with the localization of endometriotic foci we observed patients (patient suffered from endometriosis Sacro-uterine ligaments and internal).

7 patients in the control group IgA and IgM were at the lower limit of normal (concentration of IgA in an average of 1,113+0,67, IgM -0,86+0,54), IgG in these patients was within normal limits. The remaining 25 women in this group the values of IgA and IgM to treatment were increased (average IgA -3,98+0,72; IgM -3,41+0,65). When determining the values of IgG in the observed deviations from the norm of this indicator was not, or was slightly above normal (average to 19.2+0,34 5 patients).

After combinemode, gynecological examination - shrinking endometrioid neoplasms, which was confirmed by the data of ultrasound; the reduction of adhesions. All these positive changes were noted in both groups equally. However, it should be noted that balneology women who received the combined treatment, proceeded almost asymptomatic, while in the control group noted the General symptoms and alopecia baldereschi.

Patients of the control group under the influence of radon reliable dynamics of emission of the main classes of immunoglobulins were observed; there was a trend to increase at the end of treatment. Application of radon led to some stimulating the production of antibodies that during the initial high level of immunoglobulins could create a situation development baldereschi and contribute some shortening of the period of remission in the future.

The patients of the main group were observed shifts in the immunological, and the nature of these changes was different: in 17 patients with concentrations of IgA and IgM at the lower limit of normal after treatment, these figures increased (IgA - up to 3.2+0,22, IgM - through 1.52 +0,3 the deposits under the influence of complex radon and EMR EHF was determined significant tendency to normalization of these indicators (average IgA decreased to a 3.87+0,72, IgM -2,87+0,44). After treatment in these patients IgG was slightly decreased (which is positive), therefore, decreased the degree of involvement in the pathological process of autoimmune component (Dynamics of the immunological and clinical parameters are shown in table. 2 and 3).

In the analysis of remote results in both groups of women were stable remission: disappearance or decrease pain, shortening of the period spotting before menstruation, good overall health. However, it should be noted that patients of the control group after 6-8 months. there were complaints of increased pain before and during menstruation, although still in pain intensity was not reached. Patients of the main group had a longer duration of remission (10-12 months).

In addition, preserved the character of changes of immunological indexes only in patients who received combined treatment.

Thus, the effectiveness of the treatment approach in patients with genital endometriosis was higher than that using only the radon 27.3%. Positive dynamics of indicators of immunological indexes in complex effects of radon and EMR UHF testified to by the program.

A method for the treatment of patients with genital endometriosis involving the use of radon water, characterized in that are used radon water in combination with EHF-therapy on biologically active corporeal point RN 22, with radon baths appoint a temperature of 35-37oC 10-15 min, every other day, gynecological irrigation and micro appointed in the days of bathing the same temperature and exposure to the days free from hydrotherapy, or with an interval of 2 hours from the receipt of hydrotherapy, conduct of EHF-therapy at the specified point, exposure time 20 min, at the rate of 8-12 treatments.

 

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