A method for the diagnosis of epilepsy
(57) Abstract:The invention relates to medicine, namely, neurology, and can be used for the diagnosis of paroxysmal States epileptic and nonepileptic Genesis. Spend stimulation reversing checkerboard pattern and the registration of induced visual potentials. Determine the amplitude of the rhythmic polarised as the average of the amplitudes of the peaks of the potential difference in the range of 400-1000 MS during stimulation of the separate right and left eye. Additionally calculate the critical value of the amplitude of polarized (AK) in Áv according to the formula: Ato= TO ANP100where atocritical value of the amplitude of polarized, Áv, K - factor, equal to 0.61, AND NP100- the average value of the amplitude of the positive component R in healthy subjects, MKV, compare the values and, if the average amplitude of polarized higher than the critical value, establish the diagnosis of epilepsy. The method improves the accuracy of diagnosis. The invention relates to the field of neurology and can be used for the diagnosis of paroxysmal States epileptic and nonepileptic Genesis, in particular, ill. unctionally diagnosis of nervous diseases. M.: Medicine, 1991, S. 293 - 304), which is in registration are visual evoked potentials (SGP) of the cerebral cortex in 8-lead located at symmetric points in the occipital, parietal, Central and frontal areas in response to visual stimulation with a flash of light, which is supplied to the closed eyes studied from a distance of 30 cm with subsequent visual quality rating components VIZ for epilepsy patients based on the presence or absence of increasing amplitude and shape changes of the potential of converting it into a complex peak-wave. The presence of increasing amplitude and a transformation of the form of the potential was regarded as a sign of epilepsy, and the absence of these changes was regarded as a sign of lack of epileptic disorders.However, this method does not provide accurate diagnosis of epilepsy, as assessed VIZ without quantifying the exact criteria of presence of epileptic disorders.The task of the invention is to improve the accuracy of diagnosis of paroxysmal States in patients with ischemic stroke in order to timely identify the decision accuracy of diagnosis.The technical result is achieved in that in the method for the diagnosis of epilepsy, including visual stimulation reversing checkerboard pattern with the size of the cells 30' and the light patter of 60 kJ/m2then determine the average amplitude of polarized as the arithmetic average of the amplitudes of the peaks in the potential difference between the active electrode placed in the Central occipital point, and a reference electrode located in sredneobsky point in the range of 400-1000 MS during stimulation of the separate right and left eye, and comparing the obtained value with a critical value of the amplitude of polarized, which is calculated by the formula
where AK is a critical value of the amplitude of polarized, Áv;
K - coefficient, equal to 0.61;
ANDNP100- the average value of the amplitude of the main positive component R in healthy subjects, Laq,
thus, if the average amplitude of polarized higher than the critical value, then establish the diagnosis of epilepsy.The method is as follows. A survey carried out on the device for recording evoked potentials, in particular Conterpoint ("Dantec Medtronic, US. USA-Denmark). The patient impose an active electrode in the center of the frontal point-Fz. (Zenkov L. R. , Ronkin, M. A., 1991. lliday A., 1982). Then spend a full screen monocular stimulation reversing checkerboard patter (separate left and right eye). In accordance with standard procedure (alliday A. Evoked potentials in clinical testing. Edinburg et.c: Churchill Liningstone, 1982, 575 p.) the frequency of treatment of a putter is 1 Hz, the size of the cells 30', the average brightness of the screen - 60 kJ/m2the number of averagings - 100. Epoch analysis is 1000 MS.Defined components VIZ-R, 145, P200, 250, and then touch polarized in the range of 400-1000 MS. The average amplitude of polarized is determined by calculating the average value of the amplitudes of the ten most pronounced component of polarized (after the main peaks actually PEL - P200, 250, i.e., starting with 400 MS). Then calculated the arithmetic mean of the amplitudes of polarized obtained during stimulation of the separate right and left eyes.If the amplitude of polarized value is larger than the critical value of the amplitude AK, these changes are consistent with epilepsy.Taking into account the individual characteristics of the devices developed system of calculation of the threshold amplitude polarized by the formula: AK = KANP100where AK is the desired level of cu is NP100 - the average value of the amplitude of the main positive component R in healthy subjects (obtained in the study of this particular device), calculated as the arithmetic mean of the amplitudes R obtained by separate stimulation of the right and left eye (for our device, this value amounted to 6.377 Áv).Example 1.Patient P., 53.The diagnosis of encephalopathy with 3 tbsp. residual moved ischemic stroke in the left hemisphere of the brain. Symptomatic locally due to epilepsy.From the anamnesis it is known that in 1994, he suffered a cerebral blood flow in ischemic type in the cortical branches of the left middle cerebral artery, with a slight paresis in the right limbs, and items of motor aphasia with incomplete recovery. 8 months after a stroke, the patient developed sudden attack of vertigo, followed by loss of consciousness. Ill attack was antinovel.When viewed in the neurological status was observed: cerebral and meningeal symptoms are not present. Acuity and field of view approximately not changed. Movement of the eyeballs in full. Eyes rounded D = S. O. Mild right-sided hemiparesis to 4.5 points. Muscle tone in the right extremities slightly elevated by spastic type. Tendon and periosteal reflexes D > S, the symptom Babinski on the right. Sensitivity is not compromised. Coordinatorsee sample performs satisfactorily.The proposed method after the registration of the PEL for noise reduction in the hardening 0zwas identied according to the results of stimulation of the right and left eye And polarized, which was 7,12 Áv. Since this value exceeds the critical AK= 0,61 7,377 = 2,09 Áv, was diagnosed with epilepsy. Further observation of the patient and re-EEG confirmed the diagnosis.The proposed method was examined 120 patients with post-stroke epilepsy and patients with ischemic stroke and in 80 cases diagnosed epilepsy. A method for the diagnosis of epilepsy, including the assessment of the visual analyzer through visual stimulation and registration of induced visual potentials, characterized in that the conduct stimulation of the reversing checkerboard pattern with the size of the cells 30' and the illumination pattern 60 kJ/m2then determine the average amplitude Posleen in the Central occipital point, in the range of 400-1000 MS during stimulation of the separate right and left eye, and comparing the obtained value with a critical value of the amplitude of polarized, which is calculated by the formula:
ANDto= TO ANP100,
where atocritical value of the amplitude of polarized, Áv;
K - coefficient, equal to 0.61;
ANDNP100- the average value of the amplitude of the positive component R in healthy subjects, Laq,
thus, if the average amplitude of polarized higher than the critical value, then set the diagnosis "epilepsy".
SUBSTANCE: method involves carrying out clinical and diagnostic examination and additionally measuring latent period of III peak on invoked potential curve from acoustic invoked stem potentials. Cerebral stem injuries are determined from neuromuscular electrodiagnostic data. Latent period III peak value being above or below a norm and injured medial cerebral stem region allover the stem thickness or totally injured lateral and caudal stem regions or all said regions injury taking place, high intraoperation trigeminocardial reflex risk degree is diagnosed in patients suffering from vestibular neuroschwannoma. Latent period III peak value being above or below a norm and no injuries of cerebral stem or latent period III peak value corresponding to norm and totally injured lateral and caudal stem regions at the same time or only medial cerebral stem regions taking place, moderate risk degree is diagnosed. Normal latent period III peak value and no injuries of cerebral stem being the case, low risk degree is to be diagnosed.
EFFECT: high accuracy of diagnosis.
FIELD: medical engineering.
SUBSTANCE: device has means for acting upon object under study, means for recording responses having transducers connected to computer via signal input/output unit, photorecorder unit having programmed control mechanism and frame marker unit having in series connected control desk, frame marker, superposed responses photorecorder, programming unit and switchboard connected to control desk, means for acting upon object, means for recording responses and computer. Photorecorder programming unit has cam mechanism, the switchboard has relay circuits, the frame marker unit has means for recording treatment protocol and means for recording current events being tape drive with transparent tape coupled with tape drive with exposed film. The means for recording responses have magnetic tape recorder connected to control desk and transducers via switchboard. Tape recorder signal input is connected to microphone for recording vocal data describing current experiment condition and testee data.
EFFECT: enhanced effectiveness in recording biopotentials and creating feedback links among testees; wide range of functional applications.
2 cl, 6 dwg
FIELD: medicine, neuroophthalmology.
SUBSTANCE: it is necessary to register electroencephalogram (EEG) and at disorganized low-amplitude EEG, when amplitude of alpha-rhythm is below 30 mcV or is not detected at all it is necessary to prescribe nystenon per os per 1 tablet twice/d daily for 2 wk. In case of high-amplitude hypersynchronous EEG at amplitude of alpha-rhythm being 100 mcV and more one should prescribe glycin per 1 tablet 100 mg sublingually twice/d daily for 2 wk. Then comes video-training with the help of "Amblyocor-01" device for 2 wk along with simultaneous intake of earlier prescribed preparations. In case of disorganized low-amplitude EEG one should fulfill training in the mode of "relaxation", in case of high-amplitude hypersynchronous EEG - in the mode of "activation". The innovation enables to affect central departments of optic analyzer.
EFFECT: higher efficiency of correction.
FIELD: medicine; physiology and therapy.
SUBSTANCE: patient's cardiointervalograms are registered and analysed in real time mode. Respiratory movements are synchronised with own heart rate. Command information to man on inspiration-expiration is generated by microcontroller on basis of analysis of ongoing cardiointervalogram, and inspiration command is generated by microcontroller upon registration of cardiointervalogram's maximum and provided the time interval of analysis lockout is completed, when microcontroller's commands are pending even at extremum. Expiration command is generated upon registration of cardiointervalogram's minimum and the time interval of analysis lockout starts at expiration command with duration of three cardio cycles, or at inspiration command with duration of one cardio cycle.
EFFECT: method increases efficacy of systems of diagnostics and correction of human functional condition.
SUBSTANCE: method involves successively electromiographic (EMG) training of ischiocavernosus muscles on initial electromiographic signals of biological feedback (BF), causing alternating contraction of 5 seconds long and relaxation of 10 seconds long of perineum muscles during 15 minutes. Then follows an alternating contraction to 30% of maximal EMG level of 10 seconds long and relaxation of 10 seconds long during 15 minutes. After that electric stimulation of ischiocavernosus muscles and between segments of spinal cord S2-S4 and S4-S5-C1 of spine is performed, laser irradiation of segments S2-S4 of spinal cord, spine segments S4-S5-C1 and upper surface of penis body is performed. Laser exposure is performed with low-intensive infra-red waves with amplitude-frequency modulation with frequency to 3 Hz and modulation depth to 30 per cent, energy to 50 joule, wavelength 960 nm. Electric stimulation of ischiocavernosus muscles is performed bipolarly by pulse current with their weak titanic contraction, duration of burst and pause being 2 seconds with frequency of burst filling 3000 Hz, and bipolar electric stimulation between segmentsS2-S4 of spinal cord and S4-S5-C1 of spine with infra-low electric waves with frequency to 3 Hz and amplitude to 100 mcA is performed. Time of laser exposure on each region is 5 minutes, time of exposure to pulse current is 30 minutes, time of exposure to infra-low current is 24 hours, course of treatment is 15 days.
EFFECT: extended arsenal of means for treatment of erectile dysfunction.
SUBSTANCE: invention relates to psychology, medicine, namely to symptomatic psychotherapy of diseases associated with disturbances of person's psychoemotional state. Estimation of patient's psychoemotional state is carried out by performing clinical-psychological examination with formulation of diagnosis. After that in accordance with psychotherapeutical aims, musical background is created, carrying and modulating frequency of sound vibrations are added for rhythm impact in spectrum of frequencies of natural electroencephalographic processes, and in colour images determined are predominating colour gamut, succession and frequency of colour image change for rhythm impact in spectrum of frequencies of natural electroencephalographic processes. Selected material is presented in form of videofilm, taking into account obtained patient's diagnostic data, after which it is shown to the patient.
EFFECT: method increases efficiency of impact on person's psychoemotional state, which takes into account presence in etiopathogenesis of biological, psychological and social factors, each of which needs correcting impacts, corresponding to its nature.
13 cl, 4 tbl, 4 dwg
SUBSTANCE: duration, amplitude and form of each continuous brain signal wave are matched with parameters of each sensory signal. Recording each continuous brain signal wave, forming a matched sensory signal and exposing a patient to this signal are consistent and immediate. During the procedure, the patient is suggested to pay attention that the sensory signals perceived reflect brain work.
EFFECT: method enables more efficient process normalising psychophysiological state following stress load, psychoemotional and mental strain, and while treating functional disorders of central nervous system, psychosomatic diseases and consequences of organic cerebral affections.
SUBSTANCE: invention relates to field of medicine, namely to obstetrics. Cardiointervalography (CIG) is performed. Analysis of heart rate variability (HRV) is carried out. Value of the following indices is estimated: standard deviation, pRR50,coefficient of variation, total power of HRV (TP), power of slow LF-waves, mode amplitude, index of adequacy of regulation processes (IARP), voltage index (VI), value of maximal R-R interval, mean-square difference between duration of neighbouring cardiointervals (RMSSD), normalised power of slow LF-waves, normalised power of fast HF-waves, vegetative index of rhythm (VIR). On the basis of obtained data each of the above mentioned indices is given points from 0 to 2. Also evaluated is value of systolic and diastolic arterial pressure with assigning points. Degree of cervix "maturity" is determined by Bishop scale with giving points. Obtained points are summed up. If sum of points equals 7 or more woman is related to group of risk in of uterine inertia development.
EFFECT: method makes it possible to carry out prediction of uterine inertia before beginning of urgent delivery, which gives possibility to take measures for prevention of initial uterine inertia, in addition, method is non-invasive and safe for parturient woman and newborn baby.
4 ex, 2 tbl
SUBSTANCE: patient is trained by challenging to imagine a paretic limb movement and controlling the imagined movement. An electroencephalography is recorded; the recorded data are transferred to a computer for synchronous processing, and arousal reaction signals of a sensorimotor rate responsible for the imagined movement are isolated by means of an EEG pattern classifier according to the Bayes method. Identification results of the mental challenge are presented to the patient by a visual feedback in the form of a mark on a monitor. The mark re-position testifies to accuracy of the challenge. The imagined movement challenge is presented for 10 seconds. The training course makes 6-12 days, one training a day, of the length of 20-30 minutes every 1 to 4 days.
EFFECT: method provides more effective rehabilitation that is ensured by the feedback training in the conditions enabling the patient controlling the imagined paretic limb movement visually.
3 dwg, 4 tbl, 2 ex
SUBSTANCE: pulse electric activity of sensorimotor central neurons is recorded in experimental animals adapted to hypoxia. The recorded activity frequency is modulated by a multivibrator and an electroacoustic transducer; the signals are copied and transferred onto a carrier. The patient is exposed to distant acoustic signals with the use of the laser generator. The exposure is sequential and starts with sessions at frequency 5-8 Hz for 5-7 minutes and follows with sessions at frequency 10-15 Hz for 5-8 minutes. The sessions are daily, one session a day; the therapeutic course is 10-14 sessions.
EFFECT: method enables using the drug-free modalities and normalise the blood pressure that is ensured by providing the mode and sequence of acoustic signal flow.
2 tbl, 3 ex