The way bioacoustic correction of psycho-physiological state of the organism
(57) Abstract:Invention refers to medicine, namely to psychophysiology. Record the electroencephalogram signals from at least two leads. Transpondeur these signals in the audible range of sound frequencies separately for each of the leads and at the same time for all leads. Act simultaneously received audio signals to the patient through the organization of biological acoustic feedback through one or more sound sources. The sound sources are placed side corresponding to the abstraction. The electroencephalogram signals recorded in one or more points located in the longitudinal plane through the midline of the head, placement of sound sources to the left and right of the head of the patient, or at points located in the transverse plane of the head to the left and to the right. The sound sources are placed side corresponding to these points. With each oscillation of the recorded signal electroencephalogram transported separately and sequentially. The method allows to increase the efficiency of the recovery processes of the body in case of functional disorders. 4 C.p. f-crystals. Oblastnaya body using electroencephalographic biological acoustic feedback (EEG-BOS), and can be used in various fields of medicine in the treatment of a wide range of diseases, such as functional disorders of the Central nervous system, psychosomatic diseases and effects of organic brain damage.Art
It is known that currently there is increasing interest in non-pharmacological methods of treatment and rehabilitation of patients with various pathologies. One of the most rapidly developing methods of correction of the functional state of individual systems and the organism as a whole are methods of biofeedback (BFB). The use of biofeedback in clinical practice helps to normalize the functional state of the organism, thereby facilitating the recovery of disordered physiological processes (Alekseev, A. S., Daskalov, I. E. biofeedback in psychotherapy practice. KN. "The seventh Congress of neuropathologists and psychiatrists". M, so 1, S. 9-11.).There is a method of correction of psychophysiological state of a person, including the registration of physiological parameters, the presentation of the patient, the comparison with the reference physiological parameters, conducting psychotherapeutic vozdeistvie on one part of the display screen, on the second part which reproduces a reference thermogram of a healthy person and simultaneously carry out a video of the patient and display the video image on the second screen, then perform hetero - and autosuggestive effect, fill the contour of the color video image corresponding to the display pattern, and conduct monitoring of the patient on the dynamics of changes in thermogram in comparison with the reference, and in identifying differences, the procedure was repeated (RF Patent 2012364, And 61 M 21/00, 1994)
In this way elements of biofeedback (BFB) in combination with the techniques of psychotherapy when exposed to the patient a strictly defined sequence of techniques, while the patient tries to influence some of their functions to correct them, while he is in therapeutic contact with a doctor, by changing parameters of thermal image in the "desired" direction and bringing them to the specified standards. This approach allows the impact on psychogenic personal side of illness and somatic component that provides a relatively high therapeutic effectiveness of the method.However, in the known method of organogenesis (Century. N. Chernihiv and other Arbitrary regulation of EEG rhythms person. The journal "Physiology" 5, T. 8, 1982, S. 817-821), which is effective against techniques biofeedback, abridged from such physiological indicators such as heart rate, blood pressure, respiration, but not effective when using EEG biofeedback, which has attracted more attention in the clinic of neurosis. This is because the concept of arbitrary regulation functions require you to specify those "desirable" options to which you want to lead a physiological process, and at the organization of EEG biofeedback is very difficult. First, the parameters of the EEG largely individual (Rusyn B. C. Potentials of the human brain. M.: Medicine, 1987) and, secondly, given the integrity of the spatial-temporal patterns of brain electrical activity in humans, such "desirable" options may be several, which greatly complicates the procedure barefoot. (Livanov, M. N. Spatial-temporal organization of the potentials and the systemic activity of the brain. M.: Nauka, 1989).The known correction method TS the external environment, for example, light or sound, providing a comfortable condition, and in the correction mode perform discrete change of selected parameters at which the patient suffers minimum deviation biosignal, including EEG signal, and adjust the deviation of the latter from the empirical parameters through the organization of biofeedback, including sound or light signals (ed. mon. The USSR 1706568, And 61 M 21/00, 1991).There is also known a method of control and correction of psychophysiological state of a person, in which the recorded EEG signals transform using the synthesizer in the modulated sound (music) signals, and the converted signals affect the individual through the organization of biological acoustic feedback (BAOS).Common to the above methods is the use of biofeedback, abridged from EEG, monitoring the functional state of one or more physiological parameters and their regulation and use in the organization EEG biofeedback amplitude-frequency modulation of the sound signal in the audible frequency range different rhythms of electrical activity in golosistymi, forcing the brain to produce primarily a specific type of EEG activity during this physiological effect is that the brain responds to music feedback and actively changes the current EEG activity, leading her to a certain resonance with the submitted music.However, in all known ways in organizing this kind of biofeedback, the latter is used in the framework of "traditional" biological feedback with cognitive self-regulation, which is carried by an artificial (forced) the correction algorithm. For example, there are the "desirable" or "undesirable" areas EEG and present them as "pleasant" or "unpleasant" melodies, the appearance of which the patient ucamae his volitional effort. This leads to the complication of the sessions of biofeedback and the treatment of the patient. In addition, in the above EEG biofeedback particular parameter is replaced with an artificial signal, which significantly distorts the information about the true physiological state of the patient. Large distortion in the circuit EEG biofeedback arise either due to too simplified conversion of the signal, such as amplitude and frequency modulation of simple tones EEG rhythms, either by making large the violation occurs the original time-frequency structure of the signal, leading to decreased accuracy of information transfer in bare outline, and, therefore, reduce the effectiveness of the correction of psychophysiological state of a person.The closest to the invention, the technical essence and the achieved result is a method of correction of psychophysiological state of a person, including the recording of signals on the electroencephalogram (EEG) of the brain from one lead of the registration points of the forehead, the neck on the patient's head, the transposition of EEG signals in the audible sound frequency range (spectrum shift of the EEG signal in the audio frequency range while maintaining the original ratio of the amplitudes, frequencies and phases) and the impact on human transposed the EEG signals in the circuit EEG-BOOS through the sound sources, while the transposition of EEG signals in the audio signals is carried out by decomposing them into several quasi-periodic signals using comb filters and record periods of EEG signals with subsequent accelerated reading and adding the last (RF Patent 2071361, And 61 M 21/00, 1997).The known method chosen for the prototype of the present invention allows for the transposition of the original low-frequency Gar is increase the accuracy of the transfer of information about the current state of the Central nervous system in the form available for the perception of sensory systems. This makes it possible to provide a different approach to EEG-BIOS, which you can accept that the body regardless of its current state has a benchmark of its functioning, and functional disorders are a consequence of loss or disorder of the inner channels of information that provides a comparison of actual and reference States. This approach provides correction of the functional state through EEG biofeedback.The disadvantages of this method include low degree of implementation of non-cognitive regulation when creating contour EEG-BOS because of restrictions on the flow of information about the current state of the human body, caused by a single registration of EEG signals from one lead of the registration points of the forehead, the neck on the head of the patient, and lack of accurate reflection of the parameters of the original EEG signals in its transposed audio signal. All of this ultimately leads to a reduction in the efficiency of correction of psycho-physiological condition of the patient.The invention
The aim of the proposed invention is to improve the efficiency of the process>This goal is achieved by the fact that the method of correction of psychophysiological state of the organism in which the recorded signals electroencephalogram transpondeur in the sound signal in the audible frequency range and affect patient transposed signals through the organization of biological acoustic feedback, according to the invention the signals of the EEG recorded from at least two leads from the point of registration, transpondeur separately for each of the leads and at the same time for all leads and received audio signals simultaneously affect the patient through one or more sound sources. While the sound sources used for each of the leads can be placed from the side corresponding to the abstraction and registration of EEG signal can be performed at one or more points located in the longitudinal plane of the center line of the head or in the transverse plane of the head to the left and to the right. In addition, each change recorded signal electroencephalogram transpondeur separately and sequentially.Registration of EEG signals simultaneously from multiple abstraction points registration is allows you to get transposed the EEG signals, spatial parameters of brain potentials, and the implementation of the spatial acoustic impact on the patient circuit EEG-BOS organized the specified location of sound sources transposed EEG signals, allows you to create a spatial sound image own EEG. Ultimately, this contributes to the efficiency of recovery of the parameters of bioelectrical brain activity. Separate and sequential transposition of each oscillation of the recorded EEG signal can significantly reduce the distortion introduced in the EEG signals while converting them into audio signals, which in turn increases the accuracy of the display parameters of the EEG signals in its integrated sound manner.Comparative analysis of known and proposed methods of correction of psycho-physiological state of the body shows that the differences are the last in the conditions of registration and subsequent transposition of EEG signals, as well as in the implementation of the impact transposed the EEG signals in the circuit EEG-BAOS and, therefore, the proposed method meets the criterion of "novelty."Compliance with the proposed method the criterion of "industrial applicability" is confirmed by the implementation in devices, medical equipment.The most preferred implementation of the invention.During therapeutic procedure on the patient perform acoustic effects transposed the EEG signals. The average session duration EEG-BOS is 20-30 minutes.The inventive method is implemented by using a device that contains the sound sources, the EEG sensors located at points of registration on the patient's head, the amplifiers of the recorded EEG signals, blocks transpose blocks of power amplifiers, the unit of visual and acoustic monitoring and control unit. The block transpose contains the Converter of EEG oscillations in the acoustic signals.During the treatments recorded EEG signals by which you can judge the quality of the patient's condition, are displayed to a workplace of the operator and serves to block visual and acoustic monitoring. Completion of the education on the appropriate blocks transpose. After converting the EEG signals in units of transposition, where each change in EEG transpondeur separately and sequentially, the audio signals are sent to the power amplifiers, the mix mode which sets the control unit. System acoustic control allows the operator to hear what the patient.In the Institute of Experimental medicine, St. Petersburg) in the physiological Department of them. I. Pavlov preliminary results of studies applying this method in the treatment of patients with neurasthenic disorders of varying severity. In the course of the research with each patient was held from 3 to 7 sessions acoustic biofeedback. On the basis of the tests was determined by a "successful" and "unsuccessful" sessions. "Good" was considered to be the session in which the sound image EEG was perceived by the patient as euphonic, "failed" was considered to be the session in which the sound is transposed EEG signal was perceived as disharmonious. Individual spectral EEG characteristics of patients were combined in groups 'successful" and "unsuccessful" sessions, and thus was determined the averaged dynamics of spectral EEG signals in groups these sessions. Most Celestica chaotic, unstructured set of sounds, like those settings Symphony orchestra before the concert. "Successful" often turned out to be the fourth session. However, many patients reported the structure and sonority as a separate moments, and the entire session as a whole. Often patients were able to split the session into separate phases (up to 3 - 4) with its characteristic sound. It was found that in a number of sessions of this method is estimated to patients is a significant improvement in sound touch the image of their own EEG, which corresponds to the improvement of psychophysiological indicators: the level of reactive and personal anxiety on Spilberger-Hanina, the compliance rate of autologous normal vegetative coefficient on Lusero, subjective evaluation of the sound image, time, simple motor responses, individual moments, assessment of health, activity and mood test SAN.Thus, the proposed method is compared with the prototype helps to restore the physiological state of the organism in case of functional disorders by increasing the conversion accuracy of brain potentials in audio signals.Premedicine institutions of different profiles. 1. Method of correction of psychophysiological state of the body, including the registration of electroencephalogram signals, the transportation of these signals in the audible range of sound frequencies and the influence of the latter on the patient through the organization of biological acoustic feedback, characterized in that the signals of the EEG recorded from at least two leads from the point of registration, transpondeur separately for each of the leads and at the same time for all leads and received audio signals simultaneously affect the patient through one or more sound sources.2. The method according to p. 1, wherein the sound sources for each lead post side, the corresponding abstraction.3. The method according to p. 1, characterized in that the signals of the EEG recorded in one or more points located in the longitudinal plane through the midline of the head, and the sound sources have the left and right of the head of the patient.4. The method according to p. 1, characterized in that the signals of the EEG recorded in the points located in the transverse plane of the head to the left and to the right, and the sound-sources Rainie recorded signal electroencephalogram transpondeur separately and sequentially.
FIELD: medicine, neurology, psychopathology, neurosurgery, neurophysiology, experimental neurobiology.
SUBSTANCE: one should simultaneously register electroencephalogram (EEG) to detect the level of constant potential (LCP). At LCP negativization and increased EEG power one should detect depolarizational activation of neurons and enhanced metabolism. At LCP negativization and decreased EEG power - depolarized inhibition of neurons and metabolism suppression. At LCP positivation and increased EEG power - either repolarized or hyperpolarized activation of neurons and enhanced metabolism. At LCP positivation and decreased EEG power - hyperpolarized suppression of neurons and decreased metabolism of nervous tissue. The method enables to correctly detect therapeutic tactics due to simultaneous LCP and EEG registration that enables to differentiate transition from one functional and metabolic state into another.
EFFECT: higher accuracy of diagnostics.
5 dwg, 1 ex, 1 tbl
FIELD: medicine, neurology.
SUBSTANCE: one should establish neurological status, bioelectric cerebral activity, availability of perinatal and ORL pathology in patients, establish their gradations and numerical values followed by calculation of prognostic coefficients F1 and F2 by the following formulas: F1=-31,42+1,49·a1-2,44·a2+0,2·а3+1,63·a4+0,62·а5+3,75·a6+1,8·а7-3,23·a8-0,8·а9-1,32·а10+3,26·а11+8,92·a12-2,0·a13+3,88·а14+1,79·a15+0,83·a16-2,78·a17; F2=-27,58+1,43·a1+3,31·а2+0,08·а3+3,05·а4-0,27·а5+2,69·а6+3,11·а7-6,47·a8-6,55·a9+1,99·а10+5,25·а11+7,07·a12-0,47·a13+0,13·a14+4,04·a15-1,0·a16-1,14·а17, correspondingly, where a1 - patient's age, a2 - studying either at the hospital or polyclinic, a3 - duration of stationary treatment (in days), a4 - unconscious period, a5 - terms of hospitalization since the moment of light close craniocerebral trauma, a6 - smoking, a7 - alcohol misuse, a8 - arterial hypertension, a9 - amnesia, a10 - close craniocerebral trauma in anamnesis, a11 - psychoemotional tension, a12 - meteolability, a13 - cervical osteochondrosis, a14 - ORL pathology, a15 - availability of perinatal trauma in anamnesis with pronounced hypertension-hydrocephalic syndrome, a16 - availability of paroxysmal activity, a17 - availability and manifestation value of dysfunction of diencephalic structures. At F1 ≥ F2 on should predict the development of remote aftereffects in young people due to evaluating premorbid background of a patients at the moment of trauma.
EFFECT: higher reliability of prediction.
2 ex, 1 tbl
FIELD: medicine; medical engineering.
SUBSTANCE: method involves doing multi-channel recording of electroencephalogram and carrying out functional tests. Recording and storing rheoencephalograms is carried out additionally with multi-channel recording of electroencephalogram synchronously and in real time mode in carotid and vertebral arteries. Electroencephalograms and rheoencephalograms are visualized in single window with single time axis. Functional brain state is evaluated from synchronous changes of electroencephalograms, rheoencephalograms and electrocardiograms in response to functional test. The device has electrode unit 1 for recording bioelectric brain activity signals, electrode unit 2 for recording electric cardiac activity signals, current and potential electrode unit 3 for recording rheosignals, leads commutator 4, current rheosignal oscillator 5, synchronous rheosignal detector 6, multi-channel bioelectric brain activity signals amplifier 7, electrophysiological signal amplifier 8, demultiplexer 9, multi-channel rheosignal amplifier 10, multi-channel analog-to-digital converter 11, micro-computer 12 having galvanically isolated input/output port and personal computer 13 of standard configuration.
EFFECT: enhanced effectiveness of differential diagnosis-making.
11 cl, 6 dwg
FIELD: medicine; medical engineering.
SUBSTANCE: method involves recording multichannel electroencephalogram, electrocardiogram record and carrying out functional test and computer analysis of electrophysiological signals synchronously with multichannel record of electroencephalogram and electrocardiogram in real time mode. Superslow brain activity is recorded, carotid and spinal artery pools rheoelectroencephalogram is recorded and photopletysmogram of fingers and/or toes is built and subelectrode resistance of electrodes for recording bioelectrical cerebral activity is measured. Physiological values of bioelectrical cerebral activity are calculated and visualized in integrated cardiac cycle time scale as absolute and relative values of alpha-activity, pathological slow wave activity in delta and theta wave bandwidth. Cerebral metabolism activity dynamics level values are calculated and visualized at constant potential level. Heart beat rate is determined from electrocardiogram, pulsating blood-filling of cerebral blood vessels are determined from rheological indices data. Peripheral blood vessel resistance level, peripheral blood vessel tonus are determined as peripheral photoplethysmogram pulsation amplitude, large blood vessel tonus is determined from pulse wave propagation time data beginning from Q-tooth signal of electrocardiogram to the beginning of systolic wave of peripheral photoplethysmogram. Postcapillary venular blood vessels tonus is determined from constant photoplethysmogram component. Functional brain state is determined from dynamic changes of physiological values before during and after the functional test. Device for evaluating functional brain state has in series connected multichannel analog-to-digital converter, microcomputer having galvanically isolated input/output ports and PC of standard configuration and electrode unit for reading bioelectric cerebral activity signals connected to multichannel bioelectric cerebral activity signals amplifier. Current and potential electrode unit for recording rheosignals, multichannel rheosignals amplifier, current rheosignals generator and synchronous rheosignals detector are available. The device additionally has two-frequency high precision current generator, master input of which is connected to microcomputer. The first output group is connected to working electrodes and the second one is connected to reference electrodes of electrode unit for reading bioelectrical cerebral activity signals. Lead switch is available with its first input group being connected to potential electrodes of current and potential electrodes unit for recording rheosignals. The second group of inputs is connected to outputs of current rheosignals oscillator. The first group of outputs is connected to current electrodes of current and potential electrodes unit for recording rheosignals. The second group of outputs is connected to inputs of synchronous detector of rheosignals. Demultiplexer input is connected to output of synchronous detector of rheosignals and its outputs are connected to multichannel rheosignals amplifier inputs. Outputs of multichannel bioelectrical cerebral activity signals amplifier, multichannel rheosignals amplifier and electrophysiological signal amplifier are connected to corresponding inputs of multichannel analog-to-digital converter. Microcomputer outputs are connected to control input of lead switch, control input of multichannel demultiplexer, control input of multichannel analog-to-digital converter and synchronization inputs of current rheosignals oscillator and synchronous detector of rheosignals. To measure subelectrode resistance, a signal from narrow bandwidth current generator of frequency f1 exceeding the upper frequency fup of signals under recording is supplied. A signal from narrow bandwidth current generator of frequency f2≠ f1>fup is supplied to reference electrode. Voltages are selected and measured at output of each amplifier with frequencies of f1, f2 - Uf1 and Uf2 using narrow bandwidth filtering. Subelectrode resistance of each working electrode is determined from formula Zj=Ujf1 :(Jf1xKj), where Zj is the subelectrode resistance of j-th electrode, Ujf1 is the voltage at output from j-th amplifier with frequency of f1, Kj is the amplification coefficient of the j-th amplifier. Subelectrode resistance of reference electrode is determined from formula ZA=Ujf2 :(Jf2xKj), where ZA is the subelectrode resistance of reference electrode, Ujf2 is the voltage at output from j-th amplifier with frequency of f2, Jf2 is the voltage of narrow bandwidth current oscillator with frequency of f2.
EFFECT: wide range of functional applications.
15 cl, 10 dwg
FIELD: medicine, psychiatry.
SUBSTANCE: one should conduct EEG-testing to detect total value of the indices of spectral power or percentage spectral power of delta- and teta-rhythms due to spectrometric technique in frontal, parietal, central and temporal areas both before and during emotional-negative loading when visual emotionally negative stimuli are presented followed by their imaginary reproduction. In case of higher indices to visual stimuli being above 15% against the background one should diagnose epilepsy. The method enables to increase the number of diagnostic means, increase accuracy and objectivity in predicting epilepsy with polymorphic paroxysms at dissociation of clinical and EEG-values.
EFFECT: higher efficiency of diagnostics.
1 ex, 1 tbl