Dietary supplement for the prevention of rheumatic fever and rheumatic arthritis "antirheumatic"

 

(57) Abstract:

The invention relates to the pharmaceutical industry. Dietary Supplement contains burdock, Valerian, hawthorn, sage, raspberries, oats, ascorbic acid and rutin, each active ingredient 0.1-rate of 99.0 wt. %. As excipients tablet of the drug may contain starch, water, calcium stearate, and as filler - sugar. The invention allows to expand the range of action of the drug. 2 C.p. f-crystals, 2 tab.

The invention relates to pharmaceutical industry that manufactures drugs therapeutic and prophylactic purposes, and can be used for the prevention of rheumatic fever and rheumatic arthritis as biologically active additive - BAA.

The treatment of rheumatic diseases is a long process that is associated with a wide spectrum of pharmacological preparations. Long folk medicine for the treatment of rheumatism used medicinal plants that contain a balanced complex of biologically active substances that have diverse therapeutic effect on the patient's body, detoxify tissues from toxins, art is ukta for strengthening the nervous system (see, e.g., S. I. Sokolov and others, "Handbook of medicinal plants", 1984, M., S. 408, 409). Use oats in the form of cereals, teas, soups.

Closest to the invention (the prototype) is a dietary Supplement that includes as a component burdock (see L. C. Nikolaychuk "diabetes Treatment plants", Minsk, 1997, S. 135-137). Burdock has anti-microbial activity has protivomigrenoznoe (antipyretic), diuretic and diaphoretic action. It can be used in the form of infusions and decoctions for rheumatism.

A significant disadvantage of this drug is narrow action spectrum, allowing its use only in certain rheumatic diseases. In addition, it has a tonic effect and does not have immunostimulating and anti-inflammatory effects.

The aim of the invention is to eliminate these shortcomings by expanding the range of action of the drug and giving it a tonic, immunostimulatory and anti-inflammatory properties.

The invention consists in that the biologically active additive for the prevention of rheumatic fever and rheumatic arthritis, including the quality of LFA, raspberries, oats, ascorbic acid and rutin 0.1-rate of 99.0 wt.% each active component.

One of the technological form of SUPPLEMENTS may be the tablet additionally contains as excipients starch and calcium stearate, and as filler - sugar.

Biologically active additive can be performed also in the form of infusions, tinctures, extracts, powders, syrups and other technological forms.

The main factors influencing the choice of technological forms of run BAD, are the production technology, the specific conditions of use and convenience, the value of a single dose of the drug.

The optimal quantity of each component determined experimentally to ensure the most effective action of the drug.

All active components in the composition of the SUPPLEMENTS that have relevant therapeutic effect.

Elecampane belongs to the means, invigorating and strengthening the heart. It has anti-inflammatory, inhibits the growth of streptococci. Used in the form of infusions and decoctions, is included in herbal preparations.

Effect of biologically active componence injured by inflammation of the tissues.

Hawthorn has long been used for functional cardiac disorders, palpitation, heart weakness, the initial forms of hypertension. Expands coronary vessels, reduces cholesterol, strengthens the heart muscle. Applied in the form of tinctures and extracts, produced in the form of briquettes. Sage leaves is effective in the treatment of articular rheumatism, have a marked anti-inflammatory and antiseptic action.

Antimicrobial properties associated with essential oil, anti - tannins, flavonoid compounds and vitamin P, which condense epithelial tissue, reduce the permeability of cell membranes, walls of blood and lymphatic vessels. The antiseptic properties of sage leaves due to herbal antibiotic - salvina, which not only impedes the development of coccoid microorganisms and inactivates their toxins, inhibits the hemolytic properties. Used as part of the fees in the form of infusions.

Antirheumatic activity raspberry due to it contains salicylic acid, providing protivomigrenoznoe, analgesic and protivovospalitel the impact of the pathological process excitability thermoregulatory centers of the intermediate brain.

The pharmacological activity of medicinal plants in BAD potentiaries ascorbic acid and rutin. Biological properties of these vitamins due primarily to their participation in redox processes. They stimulate tissue respiration, have antihypoxic and antioxidant action to prevent damage to the capillaries, reducing their permeability and increase the strength.

One of the main forms of dietary SUPPLEMENTS is a tablet, in which, in addition to the active components should include excipients, starch (100%) and calcium stearate, and as filler - sugar. The following is an example of the manufacture of the drug in tablet form.

Components shall meet the requirements of the relevant Pharmacopoeia (FS) and temporary Pharmacopoeia (VFS), the state standards (GOST).

Components for preparation of the drug in a tablet weighing 0,550,005 g were taken in the following proportions (see table.1).

The amount of each component is within the limits specified in the claims.

The drug is prepared as follows.

Sugar and oat flakes weigh, isolet, add distilled water and insist in a boiling water bath with frequent stirring for 15 minutes, then add the weighted sage leaves and insist on a water bath for another 15 min, then cooled for 45 minutes, the Broth is filtered, pressing plant material is filtered.

In decoction of plant materials when boiling add the sugar. Separately cook the starch, dissolved in a small part of the vegetable broth. Add to the boiling syrup. Stirred to obtain a clear solution mixture.

Crushed oats, rutin, ascorbic acid, remaining sugar, calcium stearate is sifted. Tincture of hawthorn, raspberry syrup is filtered through 4 layers of gauze. All these components are stirred for 15 minutes Wet weight granularit collected in a receiver and pass on drying, which is carried out for 10 hours to a constant weight at periodic stirring. The humidity of the product - not more than 2%.

The finished tablet weight is directed to a dry granulation.

The dried mixture is loaded into the device for producing granules from dry tablespace.

The dry granulate is collected in the receiver and sent for tableting and obespylivanie through a hole diameter of 12 mm, weighed and Packed.

The sequence of operations is the same regardless of the number of prepared composition.

As auxiliary components, ensuring the reliability of the time raspadaemosti and baled used starch and calcium stearate, and to improve the flowability of the granules and increase the strength of the pressing - sugar and distilled water.

Clinical trials of biologically active food additives was carried out in the clinic 5, Alma-ATA. Were conducted clinical trial in 20 patients with rheumatoid arthritis. The age of the patients was on average (362,3) years. Predominant among them were women (63%). The duration of disease ranged (1,50,5) years. All patients admitted to the hospital in the acute stage, about which they were prescribed therapy, including aminoquinoline drugs, D-penicillamine and cytostatics. Patients of the first group as an additional drug was assigned claimed the drug in a dose of 3 tablets 3 times a day. Patients of the second group received only chemotherapy.

When assessing the effects of therapy on the course of the disease was assessed by indicators such as the size of the Kie indicators as the volume of the affected joints, pain, mobility, presence of morning stiffness. Observations were carried out within 3 months with a monthly check of the studied parameters.

Before treatment, the patients of both groups was assessed as moderate. They complained about the pain, swelling and limitation of motion in interphalangeal (12%), ankle (5%), knee (2%) and elbow (1%) joints. All patients reported morning stiffness (up to 12 hours a day). The joints of the affected limb were increased in volume, the local temperature is increased, the amplitude of movement was severely restricted. In 5% of patients differed rheumatoid nodules on the arms and chest.

In the dynamics of treatment there was a gradual reduction of all morbid manifestations, which by the end of the 3rd month of treatment have made it possible to observe a significant improvement in 8 patients of the first group and 3 in the second; the improvement in 2 patients first and 3 patients in the second and, finally, no effect of treatment in 4 patients of the second group.

Table 2 presents the dynamics of laboratory parameters in patients with rheumatoid arthritis during treatment.

These data indicate that the additional inclusion in Microbiology were noted following objective changes: there was a clear and significant reduction in the value of leukocytosis, the number of erythrocytes was increased to normal, and the value of the ESR and indicators osterrath proteins reached normal values.

The proposed biologically active food additive has a wide range of preventive actions as auxiliary health resources in rheumatic conditions.

1. Dietary Supplement for the prevention of rheumatic fever and rheumatic arthritis, comprising as an active ingredient burdock, characterized in that as the active components, it additionally contains Valerian, hawthorn, sage, raspberries, oats, ascorbic acid and rutin 0.1-rate of 99.0 wt.% each active component.

2. Biologically active additive under item 1, characterized in that it is made in the form of tablets additionally contain as excipients starch and calcium stearate, and as filler - sugar.

3. Biologically active additive under item 1, characterized in that it can be made in the form of infusions, tinctures, extracts, powders, syrups.

 

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