Way to treat myxomatosis and viral haemorrhagic disease of rabbits

 

(57) Abstract:

The invention relates to veterinary medicine. The method consists in the fact that the treatment as a medicinal substance use 1-aminoadamantane hydrochloride, which is injected at a dose of at least 20 mg per 1 kg body weight twice a day, two days in a row. The method allows to increase the effectiveness of treatment of rabbits when the disease myxomatosis and/or viral haemorrhagic disease (WGBC). table 1.

The invention relates to veterinary medicine and can be used to treat myxomatosis and viral haemorrhagic disease of rabbits.

From the literature of veterinary medicine it is known that "...myxomatosis is OSTROBRAMSKA, highly contagious viral disease of rabbits characterized by inflammation of the mucous membranes and the emergence of gelatinous edema in the head region, anus, genitals and skin. In the former USSR disease is logged in animal husbandry since 1989 and causes great economic damage. . . . Mortality the number of rabbits when it reaches 100% and the infection is spreading rapidly. (see Surin Century. N. and other Viral diseases of animals", M: UNITEMP, 1998, S. 742).[1].

Ibid at page 485 described viral haemorrhage: "GBq - OSTROBRAMSKA, highly contagious disease, characterized by phenomena of hemorrhagic diathesis in all organs."

Since both diseases are caused by viruses, infectious and vysokokvalitne, with the disease of several rabbits these diseases spread quickly and grow to the size of the epidemic.

As control measures put diseases Century. N. Syurin al. proposes the introduction of a vaccine or serum, which are the only means of prevention and the development of immunity against diseases of new individuals, the methods of treatment for already sick rabbits are not identified and mortality reaches 100%.

From another literary source, taken as the closest analogue, it is known that "...effective treatments for myxomatosis was not found. Attempts at treatment terramicina, dihydrostreptomycin, aureomycin, penicilina (drugs from the group of antibiotics) did not effect." (see Leonchuk C. C. and others"Disease of rabbits", M.: Kolos, 1974, S. 33).[2].

The main drawback of the nearest analogue is that drugs used to not have a pronounced antiviral activity, but only prevent the development of secondary microflora and traces ublico).

The technical result of the invention is the finding of the drug with pronounced antiviral activity and the development of effective treatment of rabbits when the disease myxomatosis and/or viral haemorrhagic disease.

The essence of the invention lies in the fact that intramuscularly injected drug, which is used as 1 aminoazo-Montana hydrochloride at a dose of at least 20 mg per 1 kg body weight twice a day, two days in a row.

The drug 1-aminoadamantana hydrochloride (other names: midantan, amantadine, interestat M-90) is known in medicine as a drug for treatment of diseases of people, in particular as an antiviral agent effective against influenza viruses of type a 2. In the future discovered its effectiveness in Parkinson's disease." (see Mashkovsky M. D. "Drug" M: Medicine, 1973, S. 176). [3].

In veterinary wide application not found.

The authors of the present invention discovered the high efficiency of the above mentioned medicinal product in the treatment of diseases of rabbits, namely, myxomatosis and viral haemorrhagic disease.

Myxomatosis - OST the rabbits (VGBC) - an acute infectious disease caused by RNA-containing viruses.

The mechanism of therapeutic effect in these diseases, by definition, the authors of the invention lies in the fact that 1-aminoadamantana hydrochloride has an inhibitory effect on the reproduction not only of RNA-containing viruses, but also to the reproduction of DNA-containing viruses, and at the same time the drugs are based on the increased activity of monoamine oxidase.

In intramuscular maximum concentration midantana in the blood and tissues is achieved in two hours.

Because metabolism in rabbits is faster for them, according to the invention, the treatment is effective only in the introduction of this drug substances 2 times a day, two days in a row, at a dose of at least 20 mg per 1 kg of live weight.

In the table "comparison of methods of treatment myxomatosis of rabbits and UGBC prototype and according to the invention the data set empirically in the treatment of livestock rabbits 100 species of medicinal substances from the group of antibiotics (the prototype) and midantanom (according to the invention).

Sources of information taken into account

1. Syurin Century. N. and others, 974, S. 33.

3. Mashkovsky, M. D. "Drug", M.: Medicine, 1993, S. 176.

Way to treat myxomatosis and viral haemorrhagic disease of rabbits, including the introduction of drugs intramuscularly, characterized in that, as a medicinal substance use 1-aminoadamantane hydrochloride, which is injected at a dose of at least 20 ml per 1 kg of body weight twice a day, two days in a row.

 

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Cytotoxic agents // 2187499

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