Way of correcting impaired immune homeostasis and drug

 

(57) Abstract:

The invention relates to medicine, in particular to immunology, and for the correction of impaired immune homeostasis accompanied by changes psychosomatic functions and/or biological reactions. To do this, enter the drug on the basis of potentiated form of antibodies to the substance involved in the regulation of the mentioned functions and/or reactions, obtained by repeated dilution and shaking or rubbing on the homeopathic method. It also injected a drug on the basis of potentiated forms of antibodies, involved in the regulation of the mentioned functions and/or reactions received on the same technology. The method provides an increase in the intensity of immunocorrective. 3 S. and 4 C.p. f-crystals.

The invention relates to medicine, in particular: to immunology, and can be used for the correction of impaired immune homeostasis accompanied by changes psychosomatic functions and/or biological reactions.

The prior art method immune correcting treatment by injection of a medicinal product containing antibodies ( see "Clinical immunology and is tetela to antigenic determinants, causing change psychosomatic functions and /or biological reactions (see ed. St. USSR 1131508, class a 61 K 39/00, 1984)

However, this method of immunotherapy is not in all cases provide an effective therapeutic result, especially in the treatment of immunodeficiency diseases with unknown etiology.

Know the use of antibodies as drugs for the treatment of various infectious diseases, viral diseases (see R. I. Meshkov, L. C. Kovalchuk, M. I. Konovalov "Clinic, diagnostics, treatment of some forms of immunodeficiency and allergic diseases with the organization of the services of clinical immunology". Smolensk, "PolyGram", 1995, S. 56-64; ed. St. USSR 1131508, class a 61 To 39 /00, 1984). However, the effect of these drugs based on antibodies strictly specific and caused by passive immunity lasts for a relatively short time.

Closest to the invention is a medicinal product on the basis of antibodies modified to improve the efficiency of the immune response 1-2 residues of fatty acids (see ed. St. USSR 1730144, CL C12 N 7/00, 1992 ). The disadvantage of this preparation containing antibodies with covalently attached thereto residues of fatty acids, the public funds.

The invention is directed to increasing the intensity of restoring immune homeostasis, the violation of which is accompanied by a change of psychosomatic functions and/or biological reactions, and the development of drugs based on antibodies.

The solution of the problem provided by the fact that the method of correction of impaired immune homeostasis accompanied by changes psychosomatic functions and/or biological reactions, comprising the administration of a medicinal product on the basis of the antibodies according to the invention as a drug ispolizuyut potentiated form of antibodies to the substance involved in the regulation of the mentioned functions and/or reactions, obtained by repeated dilution and shaking or rubbing on homeopathic method.

Alternatively, the solution of the problem provided that the method of correction of impaired immune homeostasis accompanied by changes psychosomatic functions and/or biological reactions, comprising the administration of a medicinal product on the basis of the antibodies according to the invention as a drug use potentiated form of antibodies, participating or rubbing on homeopathic method.

In accordance with the invention, a drug for the correction of impaired immune homeostasis based on the processed antibodies is a potentiated form, obtained by repeated dilution and shaking or rubbing on homeopathic method of source specific antibodies to the substance associated with impaired immune homeostasis.

At the same time as the original antibody potentiated form using antibodies to the substance of the polypeptide structure;

at the same time as the source of antibodies used antibody to the substance of lipopolysaccharide structure;

at the same time as the source of antibodies used antibody to the substance of the polynucleotide structure;

at the same time as the original antibody potentiated form using antibodies to the substance of the prion structure.

To prepare potentiated form of antibodies to receive an antigen is a substance associated with a specific immune homeostasis, and prepare a mixture of the antigen with the adjuvant (complete beta-blockers), which is injected subcutaneously laboratory animal (rabbit) back into the region in the amount of 1-3 ml in 2 weeks refresher incollecting antibodies to the antigen. From the obtained serum, which are soluble in neutral solvents (distilled water, saline, alcohol, etc) substance (e.g., lyophilized protein, dry lipopolysaccharide and so on), produce a uniform decrease in the concentration by serial dilution of 1 part of the above mentioned substances in 9 parts (tenfold dilution) or 99 parts (for centesimal dilution) or in 999 parts (for the thousandth breeding) neutral solvent with multiple vertical shaking ("dynamic") each received cultivation and use separate containers for each subsequent breeding until you get the desired potency - ratio cultivation in homeopathic method (see for example, C. Schwabe "Homeopathic medicinal product", M, 1967, C. 14-29) taken in homeopathic practice, pharmaceutical forms and dilutions, mainly centesimal (C1-S).

Example 1.

Patient S. , 37 years old, was admitted to the narcotic hospital with a diagnosis of "Chronic alcoholism Art. II, acute alcohol withdrawal". Within 3 days of hourly patient received oral potentiated the preparation of antibodies to undiluted is ervah days the patient's condition improved markedly: normalized sleep, vanished hand tremor, headache and diarrhoea illnesses. Over the next 2 days the patient is fully normalized. Additional medicamental therapy was not carried out. Was discharged in good condition.

Example 2.

Patient A. , 25 years old, was admitted to the addiction unit with a diagnosis of Acute opiate abstinence severe". The chemotherapy the patient has not appointed, but every 30 min patient received potentiated the preparation of antibodies to the undiluted fraction mezhoperatorskogo protein S - 100 in potency With 1000 - 5-8 drops of a 40% alcohol solution in a tablespoon of distilled water. State abstinence controlled completely within three days. After 5 days was discharged in satisfactory condition.

1. Way of correcting impaired immune homeostasis accompanied by changes psychosomatic functions and/or biological reactions, including the introduction of drugs based on antibodies, characterized in that as a drug use potentiated form of antibodies to the substance involved in the regulation of the mentioned functions and/or reactions, obtained by repeated cultivation and Strajitsa, accompanied by the change of psychosomatic functions and/or biological reactions, including the introduction of drugs based on antibodies, characterized in that as a drug use potentiated form of antibodies, involved in the regulation of the mentioned functions and/or reactions, obtained by repeated dilution and shaking or rubbing on homeopathic method.

3. Remedy for the correction of impaired immune homeostasis based on the processed antibodies, characterized in that use potentiated form, obtained by repeated dilution and shaking or rubbing on homeopathic method of source specific antibodies to the substance associated with impaired immune homeostasis.

4. Drug under item 3, characterized in that as the source of antibodies for potentiated form using antibodies to the substance of the polypeptide structure.

5. Drug under item 3, characterized in that as the source of antibodies for potentiated form using antibodies to the substance of lipopolysaccharide structure.

6. Drug for p. Wu polynucleotide structure.

7. Drug under item 3, characterized in that as the source of antibodies for potentiated form using antibodies to the substance with prion structure.

 

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33 cl, 5 dwg, 1 ex

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