Method for the treatment and prevention of immunologic deficiency

 

(57) Abstract:

The invention relates to medicine, namely to methods for treatment and prevention of immunological failure. As media use the extract of the fresh pork donor spleen. The extract prepared by placing the splenic sections of diameter 0.3-0.5 cm in isotonic sodium chloride solution. The extract obtained is the inside of 10-15 ml 3 times daily on an empty stomach. Treatment 1-4 weeks. The method allows us to simplify the procedure for obtaining sediment and to minimize the risk of complications. 2 C.p. f-crystals.

The invention relates to the field of therapeutic and preventive medicine and can be used for the treatment and prevention of diseases with secondary immunological failure, respiratory diseases in clinical practice.

Known method of immune and detoxification in the treatment of sepsis, septic surgical complications and other serious diseases, which consists in intravenous infusion xenoplanet obtained by perfusion of saline solution through the vascular system of the isolated porcine spleen (see Methodological recommendations lungs and pleura with complicated course", Novosibirsk, the health Department of the Novosibirsk region administration, 1992).

The disadvantages of this method are the complexity, the need to respect the rules of asepsis and antisepsis during intravenous infusion of a solution.

The known method immune (see Russian Federation Patent 2131257, class a 61 K 35/28, publ. 10.06.99, bull. 16), including application of sediment, which is used as the powder of pig spleen obtained by the method of freeze-drying, which is the inside of 0.1-3.0 g / day in 1-4 weeks.

The disadvantages of this method, taken as a prototype, is the high economic cost and complexity of production media.

The essence of the invention lies in the fact that according to the method of treatment and prevention of immunologic deficiency, consisting of enteral intake sediment donor spleen of a pig, as the media use the extract of the fresh pork donor spleen, obtained by extraction through the splenic sections. The extract produced by extraction through the splenic sections of diameter 0.3-0.5 cm isotonic salt. EXT the proposed method of treatment and prevention of immunologic deficiency shows a high therapeutic effect, extends the use of xenoculture, minimizes the risk of complications associated with the violation of asepsis, combined well and prevents the negative effects of antibiotics and other anti-inflammatory drugs, which increases therapeutic potential of used drug combinations available to a wider range of physicians, including non-surgical profile (internists, pediatricians), reduces the time of preparation of the extract with a minimum participation of employees, cost-effective.

The method is as follows: delivered with the meat fresh pork spleen crush on slices of 0.3-0.5 cm, pour 1 liter of isotonic sodium chloride solution and then for 30 min mix thoroughly. Filtered. Obtained after filtering the extract is used to treat. The extract is taken internally (enterline) 10-15 ml 3 times daily on an empty stomach. Treatment 1-4 weeks. The duration of treatment is determined by the disease and its severity. The dosage may be individual - above or below.

Example 1. Patient A. the Diagnosis of exacerbation of chronic cholecystitis, chronic pancreatitis, XP.pyelonephritis, XP.bronchiale not come. Prescribed course of speleotherapy - extract fresh pork donor spleen enterline 10 ml 3 times a day. The course of treatment is 3 weeks. Gradually the patient's condition has improved, the phenomenon disappeared endotoxemia and renal-hepatic insufficiency, improved laboratory values. The patient was discharged from the hospital within 24 days of receipt in good condition.

Example 2. Patient M. the Diagnosis of peptic ulcer 12 duodenal ulcer and stomach, exhaustion, chronic hepatitis. In the postoperative period developed intestinal obstruction, duodenal fistula, diffuse serous peritonitis, total right-sided pneumonia, postoperative suppuration of wounds, progressive emaciation. In this case, in the complex treatment was applied enteral administration of the extract of the fresh pork spleen 15 ml 3 times daily on an empty stomach for 2 weeks. Positive dynamics in the condition of the patient (pain reduction, improvement of appetite) appeared after inclusion in the comprehensive treatment of the extract of spleen.

1. Method for the treatment and prevention of immunologic deficiency, consisting of enteral intake sediment donor spleen pigs, characterized in that the image quality is through the splenic sections.

2. The method according to p. 1, characterized in that the extract is obtained by extraction through the splenic sections of diameter 0.3-0.5 cm isotonic salt.

3. The method according to p. 2, characterized in that the extract is taken orally for 10-15 ml 3 times daily on an empty stomach, treatment 1-4 weeks.

 

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FIELD: medicine, surgery, transplantology.

SUBSTANCE: embryonic spleen should be sampled, washed in nutritive medium № 199 to be placed into fresh medium № 199 to obtain homogenate in teflon homogenizer followed by centrifuging; then one should isolate the upper, medium and inferior layers, suck off medium layer and the upper part of inferior layer; the cell mixture obtained should be diluted in nutritive medium № 199 to be then introduced by injections into mesentery of small intestine or rectus muscle of abdomen. The present innovation favors the activation of immune system in patients undergone splenectomic operation and in those in case of surgical immunodefficient state due to high functional and regenerating activity of transferred embryonic splenic cells.

EFFECT: higher efficiency of prophylaxis.

6 dwg, 2 tbl

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