Immunomodulator

 

(57) Abstract:

The invention relates to medicine, namely to treatment-and-prophylactic means of plant origin, and can be used as an immunomodulator. The product contains Royal jelly, rosehip extract dry extract, beet dry and excipients necessary for obtaining a tablet form. The tool has a high therapeutic activity, non-toxic, convenient for application. 3 table.

The invention relates to herbal medicines and can be used as a therapeutic and prophylactic agent for increasing the body's resistance to various infectious diseases, improve metabolism, improve the elasticity of blood vessels, prevent allergic reactions and other adverse conditions.

Known stimulatory effect of fetal serum (Pathological physiology, 1986, 5, S. 28-31), due to its major protein component of the protein (AFP). The immune response of the organism to actively participate in the process of reparative regeneration under humoral vozdeistviem in tissue repair.

Known pharmacological regulation of adaptive and compensatory reactions of the organism with the use of immune-active compounds. Among them, of particular interest are polysaccharides of plants, such as polysaccharide palustre, which is used for invoking the induction of cytological T-lymphocytes in unidirectional culture. In his introduction to animals in doses and modes that cause maximum stimulation of the release into the blood cytological T-lymphocytes, palustrine effectively inhibits the growth of sarcoma-180, mammary adenocarcinoma CA-755.

The known method (A. S. USSR 1028335, 1981) to obtain the fraction of iridoids from the plant mullein Jungar, with the ability to improve the physical condition of healthy people in specific conditions (for example, in zero-gravity conditions, harsh climate, and so on), as well as diseases involving reduced efficiency, lethargy, weakness.

It is known tool that has the ability to increase the efficiency of the organism (A. C. the USSR 858833, 1980), on the basis of polyphenolic compounds derived from the roots and rhizomes of medicinal Burnet Sanguisorba off. The tool has also antihypoxic and stimulating effect.

The described tool has low toxicity, it can be used to stimulate immunity in infectious diseases, pathogenetically related to the failure of the immune system.

The disadvantages of the known means possessing immunomodulatory activity are: the limited resource base of plant material, slain these shortcomings as a dietary means, having the ability to stimulate the physiological functions of the body by affecting the immune response through complex mechanisms of humoral regulation, it is proposed a composition containing Royal jelly extract, rose fruit dry extract, beet dry milk sugar, starch, calcium stearate and water in the following ratio, wt. %:

Royal jelly - 1,0-2,0

Rosehip extract dry - 13,0-18,0

Extract beet dry - 6,5-8,0

Milk sugar - 40,0-46,0

Sugar - 13,-16.0

Starch - 13,5-16,0

Calcium stearate - 0,7-1,4

Purified water - the Rest

The proposed tool has been tested for toxicity in accordance with the Requirements of pre-clinical study of the General toxic action of new pharmacological substances" (1985). The results showed that the proposed tool is not toxic.

The pharmacological activity of the proposed drug was defined as follows.

Together with immunomodulating activity of the proposed drug was tested on mice. Mouse lines LB/C, were divided into 4 groups (20 mice). The first group received food within 6 weeks of the inventive tool, the second group rosehip extract to dry, the third of which was assessed by proliferative activity of lymphocytes of the spleen (splenocytes), namely their ability to be transformed into blast cells in vitro under the influence of phytohemaglutinin (PHA). The degree of besttransport lymphocytes was determined by the inclusion H3- thymidine into DNA of the cell.

The proliferation index (PI) was determined by the formula

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The results are presented in table 1

As follows from the data presented in table 1, the inventive tool stimulates proliferating activity of spleen lymphocytes of mice in the 2-fold compared with control, rosehip extract dry - 1.5 times, Royal jelly + extract beet dry 1.37 times compared to control.

Together with immunomodulating activity of the proposed drug has been evaluated also on the cytolytic activity of T-lymphocytes (T-cells) in the model unidirectional mixed culture of lymphocytes. The tests were carried out on mice LB/C Mice were divided into 4 groups (20 mice in each group). The first group received food within 6 weeks of the inventive tool, the second group rosehip extract to dry, the third group - Royal jelly with extricom beet in the ratio of 1:0,025 accordingly, the fourth group of control.

The cytolytic activity of T-killer cells was determined by their sposobnostey 2.

As follows from the data presented in table 2, the inventive tool stimulates activity of spleen lymphocytes of mice in the 2-fold compared with control, rosehip extract dry - 1.5 times, Royal jelly + extract beet dry 1.37 times compared to control.

The tests were carried out on mice CBA (weighing approximately 25 g). Mice were divided into 3 groups. Experimental group (40 mice) received food declared remedy 2 times a week throughout life until natural death (50-60 weeks). The control group (40 mice) received placebo in the number equivalent to the experimental group. The second control group (60 mice) did not receive any supplements in the diet. All animals were injected subcutaneously carcinogen dimethylhydrazine (DMH) 8 mg/kg of body weight weekly for 10 weeks.

Preventive activity was assessed by survival of animals and number of tumors have 2 lifetime: 30.5 weeks and 40 weeks.

The results are presented in table 3.

As follows from the data presented in table 3, the inventive tool increases survival of animals 10 times (40 weeks) compared with the control. Thus, there is a delayed onset of houhoulis in the first half of animal life, in the experimental group in this period there were no single tumor.

All these data indicate that the inventive tool increases the body's defenses to the effects of carcinogens and other environmental factors, because some of the animals in the control groups in the early stages died from infection (without tumor).

The inventive tool is obtained as follows.

The source components are thoroughly mixed in the claimed proportions and subjected to granulation, the granulate is dried, tabletirujut, the target product is obtained in the form of tablets weight 0.65 g, Packed in bottles. Technological scheme of production provides for the exclusion of potentially harmful excipients or processes accompanying the formation of such substances. As the ingredients of the proposed drug used only in medical practice substance.

The claimed tool created as a result of the search of new immunomodulators based on natural ingredients and natural products, it is designed to enhance the natural resistance of the organism to unfavorable factors of internal and external environment.

Saleimoa important biologically active compounds and natural products in doses below or equal to the minimum physiological needs.

Any change in the qualitative composition of the funds is not achieving the stated technical result.

An example of obtaining funds.

Mixing 1.2 g of Royal jelly, 14.0 g rosehip extract dry and 6.9 g of the extract of beet dry, of 45.7 g of milk sugar, 14.0 g of sugar, 15.0 g of starch, 0.8 g of calcium stearate and water in the required quantity, the mixture granularit, the granulate is dried, tabletirujut, the target product is obtained in the form of tablets with a weight of 0.65,

Immunomodulator on the basis of extracts of plant materials, characterized in that it is a tablet form and additionally contains Royal jelly, milk sugar, starch, calcium stearate and water, as well as extracts of plant materials - rosehip extract dry extract dry beet in the following ratio, wt. %:

Royal jelly - 1,0-2,0

Rosehip extract dry - 13,0-18,0

Extract beet dry - 6,5-8,0

Milk sugar - 40,0-46,0

Sugar - 13,5-16,0

Starch - 13,5-16,0

Calcium stearate - 0,7-1,4

Purified water - the Rest

 

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