Biologically active food supplement "liver"

 

(57) Abstract:

The invention relates to pharmaceutical industry. Biologically active food Supplement for the prevention and auxiliary treatment for liver diseases on the basis of immortelle contains ascorbic acid, citric acid and excipients including sugar. It also contains extract of corn silk, oats, decoction of burdock roots. Immortelle used in a tincture of the flowers, in the following ratio of components, g: infusion of flowers of immortelle 0,002 extract, corn silk 0,01, decoction of burdock roots of 0.002, ascorbic acid 0,025, citric acid 0,005, oats 0,1, auxiliary substances, including sugar - the rest to 0.55. The invention improves therapeutic activity and shelf life of the product. 1 C.p. f-crystals, 2 tab.

The invention relates to pharmaceutical industry that manufactures drugs therapeutic and prophylactic purposes, and can be used for the prevention and auxiliary treatment for liver diseases.

Known drug "Flamin", has a choleretic effect, on the basis of immortelle [M. D. Mashkovsky. Lekai concentrate immortelle (0.18 g), pectin (1 g), citric acid (0.1 g), ascorbic acid and sugar (up to 18.4 g).

The disadvantage of this drug is used in the form of a suspension, the lack of therapeutic activity, small storage period.

Known application of extract of corn silk as a cholagogue with cholecystitis, violations of function of the gastrointestinal tract. Liquid extract includes corn silk, water, alcohol. [M. D. Mashkovsky. Medicinal product. Kharkov: Torsing, 2 T., 1998, T. 1,S. 511].

The disadvantage of these drugs is the liquid form, the lack of therapeutic activity, small storage period.

These drugs have limited preventive effect.

The objective of the invention is the development of a new food additive, with a wide range of preventive actions and improving functional status in the treatment of chronic liver diseases, convenient for use inside and with a long shelf life.

This result is achieved in that the biologically active nutritional food Supplement for the prevention and auxiliary treatment for liver diseases at osnovopolozheniya substances, including sugar, she introduced extract of corn silk, oats, decoction of burdock roots in the following ratio of components, g:

Infusion of flowers of immortelle - 0,002

Extract of corn silk - 0,01

A decoction of burdock roots - 0,002

Ascorbic acid - 0,025

Citric acid - 0,005

Oats - 0,1

Excipients including sugar - the Rest is up to 0,55

As auxiliary substances it contains starch, water, sugar, and calcium stearate.

Burdock root is used as a diuretic and diaphoretic, and also as a tool that improves metabolism.

Use the specified purpose combination previously used substances has become possible as a result of established authors more pronounced qualities, providing cholagogue, diaphoretic, diuretic, spasmolytic effect, leading to increased secretion of bile, promotes the discharge of small stones from the gall bladder.

Optimally determined number of components obtained experimentally.

And while the impact of these drugs on the human body are known, but their application in new capacity and in small doses it is a new effect that allows you to use the way.

Cook in a water bath with frequent stirring decoction of burdock root. Prepare an infusion of the flowers of immortelle. Sugar, oatmeal is ground in the mill. Separately cook the starch paste.

Powdered sugar, oats, ascorbic acid sieved through a sieve with the hole diameter of 1 mm, calcium stearate through a sieve with the hole diameter of 0.5 mm, a Decoction of burdock root, infusion of flowers of immortelle, the citric acid solution is filtered through 4 layers of gauze.

In the mixer load of crushed oatmeal, powdered sugar, starch paste, include a mixer and thoroughly mixed for 3 minutes.

To the resulting mixture add the decoction of burdock, infusion of immortelle, a solution of citric acid, extract of corn silk and stirred for 10 minutes. Ready tablet mass transfer in wet granulation.

The wet mass is loaded into the device for producing granules from wet tablespace. Include a screw device, in which the mixture is forced through the mesh holes with a diameter of 4-5 mm Wet granules are collected in the receiver. From the receiver the wet granulate is passed for drying. Protus not more than 4 %.

Dry tablet weight is directed to a dry granulation. The dried mixture is loaded into the device for producing granules from dry tablespace. The dry granulate is collected in the receiver. From the receiver the dry granules are loaded into the mixer, add ascorbic acid and sifted calcium stearate. Include a stirrer and stirred for 10 minutes. The dry granulate is directed to tableting. At the end of the process the tablets are collected in the receiver and sent to the dust. The finished tablets are sieved by the vibrating screen through a hole 10 mm in diameter, weighed and Packed.

The sequence of operations is the same regardless of the number of prepared composition.

Biologically active food Supplement "Liver" contains the famous permitted for use in medical practice medicines which are in the specified combination (see table. 1) ensure the reduction or disappearance of symptoms of biliary tract and liver.

With the introduction of these components in amounts less than the indicated doses, the preventive effect is not observed.

If the dose is not increasing preventive dei is ASS="ptx2">

As auxiliary components, ensuring the reliability of the time raspadaemosti and baled used calcium stearate to improve the flowability of the granules and increase the strength of pressing, sugar and distilled water.

Available in tablet form, which is convenient to use, has a long shelf life (2 years).

Clinical trials of biologically active food supplements was conducted in an urban Advisory-territorial clinic of Moscow.

The study included 22 children with dyskinesia of the biliary tract (6 boys and 16 girls) aged 5 to 8 years.

During clinical testing for months due to a fractional power limitation mechanical and chemical food stimuli, fats patients of the experimental group was additionally appointed tested biologically active additives (BAA) 1-3 tablets 3-4 times a day. 10 children in the control group received the same diet without the inclusion of BAD at the same time.

Since 2-3 days after the start of the study decreased the number of patients in the experimental group with such symptoms of diseases of the gallbladder and biliary tract: diarrhoeal phenomenon, b the clinical symptoms of the disease could not be detected.

Table 2 presents the number of cases of improvement of the second portion of bile in %.

As a result of conducted research it can be concluded that the use of dietary SUPPLEMENTS promoted normalization of bile in patients. Since patients with chronic acalculous cholecystitis increased amount of bile, which has become transparent with alkaline reaction. In patients with dyskinesia of the biliary tract disappeared or became less pronounced intermittent secretion of bile, reduces its density.

The proposed biologically active food additive to food "Liver" is a newly available drug with a wide range of preventive actions and improving functional status in the treatment of chronic liver diseases, convenient for use inside and with a long shelf life.

1. Biologically active food Supplement for the prevention and auxiliary treatment for liver diseases on the basis of immortelle, containing ascorbic acid, citric acid and excipients including sugar, characterized in that it further comprises the extract of corn silk, oats, broth to the R> Infusion of flowers of immortelle - 0,002

Extract of corn silk - 0,01

A decoction of burdock roots - 0,002

Ascorbic acid - 0,025

Citric acid - 0,005

Oats - 0,1

Excipients including sugar - the Rest is up to 0,55

2. Additive under item 1, characterized in that the quality of excipients contains starch, water, and calcium stearate.

 

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