Way immune disorders in children
(57) Abstract:The invention relates to medicine, namely to immunology, and concerns the increase of non-specific anti-infective resistanceat organism children. For this enterline injected the drug, which is a polysaccharide kefir fungus, 2-5 doses, each containing 200 mg of the drug, 2-3 times a day for 10-12 days. The method allows to increase the effectiveness of therapy in reducing adverse reactions. 2 C.p. f-crystals. The invention relates to medicine, in particular to the enhancement of nonspecific anti-infective resistance children by immune.It is known that children, especially very early age, most often exposed to various, including infectious diseases, occurring against a background of violations of these or other factors of immune protection of the body, deepening the pathological process.To a greater extent this applies to children closed-organized groups, weak, sickly, having a variety of factors, aggravating the status of the child.Known methods of non-specific stimulation of immune response, consisting in the introduction of drugs is gjevik cells". Riga, 1990, 152 S.).One of these drugs is zymosan, which is used primarily for the treatment of patients with dysentery and hepatitis C.Application zymosan provides the normalization of immunological response of the organism of patients.Closest to the proposed method is immune disorders in children, including the introduction of a drug (M. D. Mashkovsky. Medicinal product. - M.: Medicine, Volume 2, 1993, p . 201-202.This drug is prodigiozan - high-polymeric polysaccharide complex, dedicated Yves bacteria prodigiosum. Action prodigiozana linked to the stimulation of the endogenous immune system of the body, activate interferon education. Prodigiozan used as stimulants in the complex of various diseases accompanied by a reduction in the immunological reactivity of the organism in chronic infectious and inflammatory processes. Prodigiozan - colorless, slightly opalescent liquid - applied in the form of sterile 0.005% solution for injection, isotonic sodium chloride solution. For holding immune children prodigiozan administered in doses of 10-20 mcg. Treatment is 3-6 the I possibility of pyrogenic reactions, temperature rise 2-3 hours after injection, General malaise, the occurrence of headaches, aches in the joints, the occurrence of leukopenia followed by leukocytosis, chronic bowel disease - acute, increased abdominal pain, diarrhea, which significantly reduces the efficiency of the method.According to this task, aimed at improving the efficiency of immunostimulation and anti-infective resistance children due to the absence of adverse reactions, good endurance and is absolutely harmless.To achieve this objective in the way of immune disorders in children, including the introduction of a medicinal product, enterline enter polysaccharide kefir fungus 2-5 doses 2-3 times a day for at least 10-12 days. While children up to three years imposed polysaccharide kefir fungus 2 doses 2 times a day, children over the age of three years imposed polysaccharide kefir fungus 5 doses for three meals a day.Polysaccharide kefir fungus is a natural dietary Supplement (TU VES VNIMI 9228-096-00419785-94), which has an immunomodulatory effect, the ability to induce local immune response.The form is] kefir fungus in a capsule (one dose).The method is as follows. For immune and increase nonspecific resistance of the organism of the child for children up to three years is prescribed 400 mg/day polysaccharide kefir fungus, i.e. two doses for receiving two times a day. Children older than three years is prescribed 1 g/day of polysaccharide kefir fungus, that is five doses, three times a day (2 times 2 doses and 1 times 1 dose).The drug is taken by mouth 30 minutes before a meal, drink boiled water at room temperature for 10-12 days.A specific example of the method.In November 1988 at the orphanage, child 8, Moscow polysaccharide kefir fungus received 20 children aged 3 to 5 years. All children had dramatically burdened status, number of children combine 2-3 different aggravating factor (repeated colds and intestinal infections, certain deviations from the Central nervous system, allergodermatit, malnutrition and others). Welcome kefir fungus was carried out for 30 minutes before a meal two doses (400 mg) twice a day and a single dose (200 mg) once a day, daily dose was 1.0 g per day. At impossibility of the use of the drug in the capsule he fell from it, was diluted with boiled water at room temperature. Prepro fungus were used to define the concentration of secretory immunoglobulin class And in the saliva and koprofilia before taking the drug and 5 days after administration of the polysaccharide kefir fungus. This revealed a reliable increase in the content of secretory immunoglobulin a in saliva of the surveyed children, the average concentrations to which the drug was 0,0907+0,0305 and 0,1205+0,0673 after administration, p<0.08 to.Thus, this method is immune exerts immunomodulatory effect on the local immune system of the child. Restoring the deficiency of secretory immunoglobulin a in saliva, polysaccharide kefir fungus promotes the protection of the oral mucosa children, constantly exposed to a variety of foreign substances and microbes: a pathogens of various diseases, allergens, food antigens, microbial antigens. 1. Way immune disorders in children, including the introduction of a drug, characterized in that enterline enter polysaccharide kefir fungus 2-5 doses, each containing 200 mg of the drug, 2-3 times a day for 10-12 days.2. The way immune, 2 times a day.3. Way immune disorders in children under item 1, characterized in that children over the age of three years imposed polysaccharide kefir fungus 5 doses 3 times a day, in three doses.
where Z is-C(R1R2)-CH2or-C(R1)=CH-; R1- phthalimid, when Z is-C(R1R2)-CH2- or one - or twofold substituted by hydroxy, methoxy or amino groups phtalimide radical when Z represents-C(R1)=CH-, R2is hydrogen or C1-6alkyl group; R3is hydrogen, C1-6an alkyl group or aromatic ring system; R4- C1-6alkyl or aromatic ring
FIELD: medicine, hematology, pharmaceutical technology, pharmacy.
SUBSTANCE: medicinal agent represents hydroxyethylated starch an aqueous solution containing 5-10% of hydroxyethylated starch with the optimal ratio of substituted hydroxyethyl groups at atoms C2/C6 up to 6:1 in glucose residue, average value of molecular mass 130-450 kDa, narrowed molecular-mass distribution at the substitution degree 0.35-0.70 and 0.80-1.00% of sodium chloride. Agent is prepared using maize or potato starch as the raw with the content of amylopectin 95%, not less. Starch is subjected for alkaline purification, acidic or enzymatic hydrolysis up to preparing products with molecular mass 400-900 kDa up to the required degree of substitution of hydroxyethyl groups. The solution is purified from impurities by ultrafiltration and/or reverse osmosis and purification is carried out using apyrogenic activated carbon and/or by sterilizing filtration and the following thermal sterilization of the end product. Invention provides preparing a new agent for rapid blood pressure recovery after blood loss.
EFFECT: improved preparing method, valuable medicinal properties of agent.
9 cl, 6 ex