Antiseptic tablets

 

(57) Abstract:

The invention relates to the field of medicine and relates to antiseptic tablets, which can be used to treat diseases of the throat and mucous membranes of the oral cavity. Antiseptic tablets for sucking include caramel mass, menthol, peppermint and eucalyptus oil, thymol and Miramistin in a certain ratio. Tablets showed a pronounced antimicrobial properties, the absence of toxic effects on the mucous membranes and body, as well as high efficiency in inflammatory diseases of the mucous membrane of the oral cavity and throat. table 2.

The invention relates to medicine and can be used for the treatment of inflammatory diseases of the throat and mucous membranes of the oral cavity.

Antiseptic tablets for sucking (ATS) in the form of drops or pastilles contain one or more active antiseptic substances in carmelitani or caramel mass. Known use as active ingredients Anatol and 2,4-dichlorobenzaldehyde (Antisept Dr. tice, the Register of medicines of Russia, M., "radar-2000", 1999, S. 935), liquid extract of thyme (Bronchicum lozenges cough, where W is the same S. 980), dyclonine hydrochloride (Coldrex Lary Plus, ibid, S. 1033), 4-amyl-metacresol and amylmetacresol (Parigoris, ibid, S. 701).

The disadvantage of these drugs is the development of allergic reactions contained organochlorine and low efficiency of the extracts. In addition, some of these drugs cause disorders of the function of gastrointestinal tract, nausea, vomiting.

Closest to the claimed technical solution are essentially sucking tablets Septolete, including, wt.%: benzalconi chloride 0,08; menthol 0,1; mint oil 0,08; eucalyptus oil 0.05; thymol 0,05; caramel mass to 100. The disadvantage of this quality tablets is relatively high toxicity benzalconi chloride, resulting in vomiting and nausea overdose of daily nutrient intake, as well as allergic reactions of people on this drug.

The aim of the present invention is to expand the range of PBX, increasing their effectiveness and safety.

This objective is achieved in that in a pill (Lollipop, toffee), representing caramel mass containing antiseptic, menthol, mint oil, eucalyptus oil and thymol, in what,10

Menthol - 0,08 - 0,12

Peppermint essential oil - 0,06 - 0,1

Eucalyptus essential oil - 0,04 - 0,06

Thymol - 0,04 - 0,06

Caramel mass Up to 100.

From this mass of formed tablets (lozenges, lozenges) weighing from 1 g to 1.5 g

Miramistin (FS 42-3498-98) approved for use in a 0.01% aqueous solution as a means to prevent sexually transmitted diseases, by introducing into the urethra, vagina, and treatment of external genital organs (VFS 42-2048-91). It is antiseptic from the group of Quaternary ammonium compounds (QAC) and acts as kationaktivnaya detergent. Thanks to the emulsifying properties Miramistin depolarized membrane cell membrane of microorganisms and increases their permeability. It has bactericidal activity against gram-positive and gram-negative bacteria and fungi on a wide range of fungi, and has virucidal activity against complex viruses: influenza, adeno-, herpes, HIV.

Miramistin not have an irritating effect on the mucous membranes of the mouth, nose, throat, urethra, vagina, abdomen, eyes, does not violate the mucociliary clearance of the ciliated epithelium of the respiratory tract. The Miramistin identified cue range of biological activity and low toxicity (LD50for mice 1400 mg/kg) confirms the feasibility of using Miramistin in the inventive quality. This is also possible because the Miramistin highly stable at a temperature of 180oC.

Menthol and peppermint essential oil show a taste and a mild analgesic effect. Thymol has an additional antiseptic effect, and eucalyptus essential oil - purifying effect, facilitating the phlegm.

The antiseptic effect of the proposed structure and its variants (table.1) was checked by conventional microbiological methods (serial dilutions, disks and method of wells) on liquid and dense nutrient media in relation to the test cultures of gram-positive (Staphylococcus aureus R), gram-negative (Escherichia coli) and fungi (Candida albicans).

In table.2 shows the results of these studies, which show that the antiseptic properties of Miramistin in the inventive composition does not decrease. At the same time, the content of Miramistin higher than 0.1% changes the taste, so use it in such concentrations is inappropriate.

Test the effectiveness of the claimed PBX conducted on a limited number of people-volunteers (7 men), who had simpres 2-3 hours. In all subjects there was a significant improvement within 1-3 days. Two people (authors-applicants) had used a day for 10 tablets within 2 weeks (14 days) in order to identify side effects associated with overdose. No discomfort or manifestations on the part of the mucous membrane of the oral cavity and gastrointestinal tract have been identified.

Thus, as can be seen from the above data, the optimum ratio of components within, claimed in the claims.

Antiseptic tablets for sucking, including caramel mass, menthol, peppermint and eucalyptus oil, thymol and antiseptic, characterized in that they contain an antiseptic Miramistin in a ratio of components, wt. %:

Miramistin - 0,05-0,10

Menthol - 0,08-0,12

essential oil:

Mint - 0,06-0,1

Eucalyptus - 0,04-0,06

Thymol - 0,04-0,06

Caramel mass Up to 100

 

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