The method of complex treatment of acute pyelonephritis puerperas

 

(57) Abstract:

The invention relates to medicine, namely to obstetrics and urology. The proposed comprehensive treatment, including antibacterial, diuretic, desensitized, together with immunomodulating and detoxication therapy. From the first day after birth as an immunomodulator used in the preparation of spirulina 3-5 g/day, a rate of 4-6 months with breaks in 10 days after every 20 receptions. On the second day after birth once intramuscularly injected with one dose of human immunoglobulin. Detoxification therapy is carried out, starting from the seventh day after birth, using continuous membrane plasmapheresis, consisting of 2-3 sessions with breaks in between 4-5 days. The method allows a timely manner and quickly to stop homeostasis: syndromes of systemic inflammatory response, endogenous intoxication and immunodeficiency. 2 C.p. f-crystals, 1 table.

The invention relates to medicine, more specifically to obstetrics and urology.

Acute pyelonephritis (PN) puerperas occurs in 5-10% of cases. An important feature of the woman in the postpartum period is the availability of powerful spectrum of compensatory processes, capable of support the I in immune status. Under the action of an infectious agent, decisive in the development of acute MON, on the basis of violations of the adaptive capabilities of the organism parturients undergoing major changes in metabolism and blood circulation systems macro - and microcirculation. The latter leads to the cessation of normal functioning of the systems of natural detoxification of the body and development of the syndrome of endogenous intoxication (see Bagni H. I. Kompleksni prospective enterosorbent Szilard-P TA monomodular ena purple at lkuhn portl C gestating planificare//Liky.-1997.- 6.-S. 43)

According to literature data from childbirth in the normal course of delivery for 2-3 days reduced immune status, and when purulent-inflammatory complications, including acute MON, occurs secondary immunodeficiency (see Kreminski J. M. Prospective monocalendar s meta profilaktiki Gino-zapolni skladany at portl // PAG.-1995.- 6.-S. 40).

Causal factor for acute MON remains infection with pathogenic bacteria, viruses, Mycoplasma, fungi, along with a significant role in the pathogenesis of this disease immunological factors. Bacterial agents are leading in the development of endogenous intoxication. As the temperature is on the microflora antigens in this pathology of the kidney (see Tiktinsky O. A., Kalinin S. M. Pyelonephritis. - SPb.: At St. Petersburg Maps Media.-1996.-C. 90-92).

There is a method of prophylactic treatment of acute MON in puerperas with immunomodulators splenin and quercetin (see Kreminski J. M. Prospective monocalendar s meta profilaktiki Gino-zapolni skladany at portl // PAG.-1995.- 6.-C. 40-43).

The disadvantage of this method is the low efficiency of treatment, because it is directed only to one causal factor in the occurrence of acute MON in puerperas - immunological.

Known closest to the claimed method of complex treatment of acute MO postpartum, including antibacterial, diuretic, desensitized therapy drugs (antibiotics, sulfonamides, saluretics, desensibilization), and detoxifying the enterosorption with sorbent Szilard-P and immunomodula lapsed therapy in the form of receiving infusions of the roots of Echinacea purpurea, mixed with the aqueous suspension of the Szilard-P (see Bagni H. I. Obgruntuvannya monocore enterosorbents the complex lkuhn portl C gestating planificare // Liky.-1998.- 1.-S. 17-20).

The disadvantage of this method of complex treatment Ostia and clinical and laboratory parameters. Cases full recovery with the help of this method was not observed (see ibid., S. 19). The disease becomes chronic, which requires very long-term drug therapy.

Causes of low efficiency of this method is the use of only limited by the intestine detoxification therapy, and herbal remedies is Echinacea purpurea, possessing weak for this pathology immunomodulatory properties. In addition, the effect of Echinacea is reduced due to the simultaneous reception of the sorbent and immunomodulator.

The basis of the invention is the task in the method of complex treatment of acute MON puerperas by changing the tools and techniques of immunomodulatory therapy on the background of detoxification of the blood by means of a continuous membrane plasmapheresis (PA) to achieve timely and rapid relief of homeostasis: syndromes of systemic inflammatory response, endogenous intoxication and immunodeficiency. This dramatically improves the function of all vital organs: there is more rapid, significant and stable clinical effect compared to the prototype. Using the proposed method improves the perfor who was udalos. An important advantage of the proposed method of treatment is the preservation of lactation in the puerperium in 100% of cases, while in the treatment method-prototype - only in 24% of cases. Treatment in hospital is reduced with 22,00,6 to 12,30,7 day. Antibiotics, diuretics, desensibilization limited to 5-7 days.

The problem is solved in that in the known method of complex treatment of acute MO postpartum, including antibacterial, diuretic, desensitized, together with immunomodulating and detoxication therapy, new spend together with immunomodulating therapy with the help of new tools: preparation of spirulina and human-immunoglobulin (-IgG), and starting from the first day after birth, appointed reception 3-5 grams per day of the drug spirulina oral and on the second day a single intramuscular injection, 1 dose human-IgG, and detoxification therapy using continuous membrane PA on the seventh day after birth.

In addition, the difference of the proposed method is that the drug spirulina is prescribed for 4-6 months with breaks in 10 days after each 20 days of admission.

Another difference is that in the treatment wire is th features of the invention and the technical result, which can be obtained in the proposed method, there is a causal relationship.

Research has shown that acute MON childbirth is not only pronounced syndrome of systemic inflammatory response, but also the syndrome of endogenous intoxication, which is manifested by high fever, chills, headaches, weakness, thirst, lack of appetite, presence of toxic changes in clinical blood tests. Therefore, the main condition for the treatment of acute MON is timely correction of homeostasis and the creation of optimal conditions to ensure adequate immune response against the background respectively assigned to antibiotic therapy.

However, after the treatment by using well-known integrated methods (including the prototype) was achieved in only temporary improvement in the status of women in labour: in the future, all women will be relapses, because it is not completely eliminated toxic products of endogenous metabolism and therefore cannot be corrected by changes in the immune status.

The complex treatment of acute MON puerperas on a background of antibacterial, diuretic, desensitizing (Batia) pathogenetically justified and promotes more rapid, than traditional therapy, relief of the inflammatory process in the kidneys, reducing the level of endogenous intoxication patients on the basis of which improves the function of the vital organs and, consequently, increases the efficiency of the treatment.

Coming in acute MON in the body postpartum women and adolescent girls violations of the internal environment - "biochemical homeostasis - can't be reflected in the systems security organs of detoxification, immunity, and breeding. Evolving toxic press causes a cascade of subsequent disorders with the emergence of a number of vicious circles, tear that the body alone is no longer able even with medication and chelators, which leads to the formation of chronic incurable process in the kidneys. Most effectively and safely in this case, the use of PA, especially continuous membrane, because it is aimed at removing very small portions (15 ml) of whole blood is the liquid part of the plasma, the components of which are restored in the body much faster and blood corpuscles. The formed elements of blood, immediately returns into the bloodstream. After a session of PA observed a significant reduction in concentration is at the level. This suggests that in the bloodstream entered toxic substances present in the intercellular space and in cells. Experiments have shown that the optimal number of procedures PA must match 2-3. Subsequent sessions PA assists in the removal of almost all toxic substances from the vascular bed. Among the methods of efferent (from the Latin efferens - delete) therapy PA is the most versatile and effective, and continuous membrane PA is easy and affordable for any medical institution, easily tolerated by patients.

According to the claimed method as immunomodulator use human-IgG, which combine with the preparation of spirulina, made of black sea algae containing protein (60-70%), carbohydrates (10-20%), fat (5%), vitamins, amino acids, minerals. According to who (see instructions for use of the drug) spirulina strengthens the immune system, compensates for vitamin and mineral deficiency, increases the body's resistance to diseases. Reduces the period of rehabilitation after childbirth, increases lactation, exhibiting the properties of enterosorption for removal of toxic substances from the body, strengthens the cardiovascular and nervous sitsta relapses during 1-3 years of follow-up). It can be assumed that this effect is due not only to the detoxification of the body by removal using PA toxins, bacteria, aggressive metabolites, but no less powerful complex (immune stimulating, antihypoxic and other) procedures PA in combination with therapy-IgG and drugs spirulina. Effect full cure occurs only when the combination of the basic therapy with PA-IgG and spirulina (see table).

Comparative effectiveness of the proposed method of treatment and prototype, as well as recommended products and methods was tested on 120 postpartum, have developed acute MON (4 groups of 30 women) (see table). The first group of mothers were treated according to the method prototype: applied basic therapy (antibiotics, sulfonamides, diuretics, desensibilization), enterosorbent Szilard-P, mixed with a tincture of the root of Echinacea purpurea. According to our observations the improvement in puerperas with acute MON in the first group came through br220.6 days of treatment by the method prototype. The second group was treated in the same way, except that detoxification was performed using 3 runs of continuous membrane PA. Treatment continued until 20-21 days. The third group was treated with th, and as provided by the proposed method: a single injection of human IgG and a course of oral medication spirulina. The improvement in this group of patients occurred on 21-22 day. Spirulina patients took home another 4-6 months with breaks in 10 days after each 20 days of admission. In the fourth group treated according to the claimed method: basic therapy, PA-IgG, spirulina. A significant improvement in parturients were observed after 2-3 sessions PA. From obstetric clinics were discharged to the 11-15 day. At home the patient continued taking spirulina for another 4-6 months. The table below shows the indicators defined in puerperas at discharge from the hospital, except the number of relapses, which were taken into account in the next 1-3 years. The effectiveness of the treatment was tested on indicators: the number of red blood cells, white blood cells, molecules average molecular weight (MSM), hemoglobin concentrations, the magnitude of leukocyte index of intoxication (LII), erythrocyte sedimentation rate (ESR), the level of the CEC, the onset of clinical improvement in patients, the number of days of inpatient treatment and the number of relapses MO of the year (see table). As shown by the results of clinical trials, the efficiency of complex treatment of acute MO new immunomodulator (group 3) and only the new method of detoxification (2nd group).

So there is an unexpected jump in efficiency - sverhsummarny. Especially demonstrated sverhsummarny effect on the main indicator is the number of disease relapses in the year: the 4th group is 0,30,1 (was 1 case of recurrence in the group during 3 years of observation). Using the proposed method it is possible to substantially complete cure of acute MO postpartum (without transition in the chronic stage). With basic therapy the puerperium spend only 5-7 days, therefore it is lactation, and through the action of spirulina and supported by the necessary time.

Showing synergistic mechanism of action, the combination of three such powerful healing factors, as PA-IgG and spirulina, as well as carefully selected experienced by treatment quickly and effectively to normalize the homeostasis of the organism postpartum women and adolescent girls in acute MON - pain syndromes, systemic inflammatory response, endogenous intoxication and immunodeficiency. And long-term (4-6 months) receiving spirulina strengthens the immune system and stabilizes the state of homeostasis. As the table shows, there has been a sharp increase in all indicators in the 4th group compared with the others. Single injection of human IgG in the second day the village is x acute MON. In parallel, starting from the first day after delivery, patients take 3-5 grams per day of the drug spirulina. In the future the house of a female patient taking spirulina for 4-6 months with breaks in 10 days after each 20 days of admission. Such dose and mode of administration established empirically, given the nature of the disease and the condition of the parturient women and are the best.

PA prescribe exactly 7 days after giving birth to stabilize hemodynamic parameters of the body postpartum women and adolescent girls. The number of sessions PA, equal to 2-3, sufficient for effective removal of blood toxins. A break between sessions of the PA, is equal to 4-5 days required to ensure that bloodstream received toxic elements from the cell and intercellular space and there was a balance in their blood.

The inventive method of complex treatment of acute MO postpartum is as follows.

The clinical diagnosis of acute MON, starting with the first day after birth, postpartum women assign basic treatment: antibiotics, sulfa, nitrofuranovye, diuretic, antisense funds made according to traditional methods. The basic course of treatment lasts 5-7 days depending times a day (see Mashkovsky M. D. Medicines. - M.: Medicine, 1993.-T. 2.-S. 352-355); as sulfa and nitrofuranovye drugs - Biseptol and furadonin, respectively, 0.8 g and 0.3 g, 2 times a day (see ibid., S. 335, 364); desensitizer - suprastin, pipolphen, diasorin 0,025 g 1-2 times a day (see ibid., T. 1, S. 352-354); as diuretics - a decoction of the leaves of bearberry, horsetail grass, knotweed (see ibid., T. 1, S. 591, 602). Treatment with the appointment of bed rest and diet 7a, then 7.

From the first day after birth prescribe the drug spirulina "Spirulina Crimean iodine", which produces LLC JV "Algotherm" (, Simferopol) together with the Institute of Biology of the Southern seas NASU (, Sevastopol) by TUU 23665400.001-97. Spirulina is in the form of tablets or powder for 3-5 g / day in 3 divided doses.

On the second day after birth, the patient is injected intramuscularly injection, 1 dose human-IgG produced by the firm "Biomed", the Russian Federation (see Reference Vidal. Drugs in Russia. ): Astra Pharm Service, 1997.-C. In-64).

On the seventh day cancel all medication, except spirulina, and hold the first session of continuous membrane PA. During the procedure happens the CSOs membrane PA is carried out using an apparatus "Gemos-PA", produced by SPE "biotech-M" of the Ministry of health of the Russian Federation in accordance with BTM 00.03.00 THAT, through the membrane plasmofilter FPM-800 (filtration area of 800 cm2), which meets the requirements of OMI 941.152.001 specifications and developed by JSC "Optics" in St. Petersburg. Per session remove 80050 ml expurgate, i.e. plasma 60050 ml. Course consists of two or three sessions with an interval of 4-5 days. Standard plasmodesmata when apheresis consists of 100-200 ml of 10 or 5% solution of albumin, 200 ml reopoligliukina, 400-500 ml of physiological solution (the ratio of remote plasma and plasma substitutes is 1-1,4).

These solutions and their value, in our opinion, are best for continuous membrane PA in puerperas with acute MON. The duration of one procedure continuous membrane PA average 1,30,15 hour.

After 2-3 sessions PA postpartum women carry out blood tests and 11-15 day it is typically discharged from the hospital. At home the woman is still the drug of spirulina in the same doses for 4-6 months with breaks in 10 days after each 20 days of admission.

Clinical blood analysis is carried out using a diagnostic instrument and reagent kits analyzers brand "environmental techniques". Under. as amended, Rimmele. - M.: Medicine, 1987. -S. 148-152); MSM - spectrophotometrically at a wavelength of 254 nm (see Winds centuries Plasmapheresis in combination with laser irradiation of blood in the treatment of acute pyelonephritis pregnant / Efferent therapy. 1998.-So 4, 2. -S. 18); LEAH expect in a known manner (see Wroblewski O. P., Ivanova N. E. Role of calculation by computer leukocyte index of intoxication in the study of the dynamics of infectious and septic processes / Anest. and Reanimator. - 1985.- 5.-S. 45-47).

Specific examples of implementation of the proposed method.

Example 1. The puerperal L., 22 years old, delivered in the obstetric clinic for 5 hours prior to delivery, gestational age 41 weeks. In history there were indications 2 spontaneous abortion, vaginitis. During pregnancy suffered double-acute respiratory infections, at 26 weeks of gestation was admitted to the Department of pathology of pregnancy about the threat of miscarriage. Was diagnosed with severe gestational MO. The Department was an appropriate treatment. The girl was discharged with improvement. In the obstetric clinic puerperal L. gave birth to a boy weighing 3300 g and estimation on Apgar scale 7-8 points. Childbirth is normal, in time.

In the first su is back pain, the radiation of pain in the lower abdomen in the course of the ureter, dysuric disorders in the form of a quick and painful urination, pale skin, headaches, changes in blood tests:

erythrocytes, 1012/l: 3,00 (N: 3,90 - 5,70);

hemoglobin, g/l: 100,1 (N: 120,0 - 160,0);

leukocytes, 109/l: 23,0 (N: 3,6 - 9,0);

ESR, mm/h: 70 (N: 2 - 15);

LII,.E.: 6,2 (N: 1,0 - 1,5);

MSM, in.E.: 381,2 (N: 220,0 - 250,0);

The CEC.E.: 153,3 (N: 40,00 - 70,00).

The urine culture is marked true bacteriuria: more than 100000 microbial cells in 1 ml of urine.

Diagnosis: acute MON, which is confirmed by ultrasound investigation (USI) of the kidneys.

Travaileth L. were given a comprehensive treatment of acute MO according to the claimed method, which included antibacterial, dysuric, desensitized therapy:

- norfloxacin 0.25 g 2 times a day, 7 days;

- diasorin 0,025 g 2 times a day, 7 days;

- furadonin 0.3 g, 2 times a day, 5 days;

- decoction of leaves of bearberry, 1 table. spoon 6 times a day, 7 days;

- a decoction of the herb of knot-grass and horsetail 150 ml 3 times a day, 7 days.

Prescribed diet 7a and bed rest.

Starting from the first day postpartum, puerperal principle is of 1 dose of human-IgG.

On the seventh day after birth was taken off all medications except spirulina, and held the first session of continuous membrane PA. The session lasted for 80 minutes. Just removed 550 ml of plasma. Plasmodesmata consisted of 100 ml of 10% aqueous solution of albumin, 200 ml reopoligliukina, 400 ml of physiological solution.

After 4 days of continuous session of the membrane PAS repeated. The status of postpartum women and adolescent girls have improved significantly: body temperature and urine normal, the headaches disappeared and lumbar, improved appetite. Lactation is normal. Prescribed diet 7.

Postpartum women held a blood test:

erythrocytes, 1012/l: 4,00 (N: 3,90 - 5,70);

hemoglobin, g/l: 122,0 (N: 120,0 - 160,0);

leukocytes, 109/l: 9,0 (N: 3,6 - 9,0);

ESR, mm/h: 16 (N: 2 - 15);

LII,.E.: 1,6 (N: 1,0 - 1,5);

MSM, in.E.: 246,8 (N: 220,0 - 250,0);

The CEC.E.: 65,25 (N: 40,00 - 70,00).

On the 13th day of the puerperal L. was discharged from the hospital. Her condition good, baby feeding breast milk. It is recommended to take spirulina to 20 days followed by a break of 10 days. Further, the intake of spirulina in the same mode to continue up to 4 months. Recommended not too cold, keep in nutrition diet 7, to be followed up by a urologist. Over the next Goa in the obstetric clinic for two days before delivery. In history there are instructions on chronic tonsillitis, frequent respiratory infections. During pregnancy were two hospitalizations for acute gestational MO. The puerperal M gave birth to a boy weighing 3600 g and estimation on Apgar scale 6-7 points. Childbirth is normal. In the first days after birth the status of postpartum women and adolescent girls Feet was complicated with acute MON: the patient noted a high body temperature (up to 39.5oC), paleness of skin, chills, shortness of breath, tachycardia, weakness, back pain, headaches, lack of appetite, thirst, dysuria, marked changes in blood test results:

erythrocytes, 1012/l: 2,80 (N: 3,90 - 5,70);

hemoglobin, g/l: 95,8 (N: 120,0 - 160,0);

leukocytes, 109/l: 21,8 (N: 3,6 - 9,0);

ESR, mm/h: 72 (N: 2 - 15);

LII,.E.: 6,7 (N: 1,0 - 1,5);

MSM, in.E.: 385,4 (N: 220,0 - 250,0);

The CEC.E.: 159,00 (N: 40,00 - 70,00).

The urine culture is marked true bacteriuria: more than 100000 microbial cells in 1 ml of urine. The diagnosis of acute MON confirmed by ultrasound of the kidneys.

Postpartum women Feet were given a comprehensive treatment of acute MO according to the claimed method, which included antibacterial, dysuric, desensitized therapy:

- Palin 0.4 g, 2 times a day, 7 days;

- Biseptol 0.8 g, 2 times Wei;

- a decoction of the herb of knot-grass and horsetail 150 ml 3 times a day, 7 days.

Postpartum women M assigned to bed rest and diet 7a power.

Spirulina and-IgG postpartum women were taken as in example 1, except that the dose of spirulina was increased to 5 g per day. On the seventh day after birth was taken off all medications except spirulina, and held the first session of continuous membrane PA. The session lasted 85 minutes. Just deleted 650 ml of plasma. Plasmodesmata when apheresis consisted of 200 ml of a 5% solution of albumin, 200 ml reopoligliukina, 500 ml of physiological solution.

After 5 days session PA was repeated, and after 4 days spent 3rd session PA. The status of postpartum women and adolescent girls Feet has improved significantly: normalized body temperature and urination, nausea disappeared, headaches, lumbar pain, improved appetite. Lactation is normal. Prescribed diet 7.

Postpartum women M Held a blood test:

erythrocytes, 1012/l: 3,90 (N: 3,90 - 5,70);

hemoglobin, g/l: 120,0 (N: 120,0 - 160,0);

leukocytes, 109/l: 8,5 (N: 3,6 - 9,0);

ESR, mm/hour: 12 (N: 2 - 15);

LII,.E.: 1,7 (N: 1,0 - 1,5);

MSM, in.E.: 230,0 (N: 220,0 - 250,0);

The CEC.E.: 63,10 (N: 40,00 - 70,00).

On the 16th day of the postpartum women Feet and her baby vypis edusim break in 10 days. Further, the intake of spirulina in the same mode to continue up to 6 months. Recommended not too cold, keep in nutrition diet 7 for 6 months, to be followed up by a urologist. Over the next 3 years recurrence MO, the patient was not observed.

Example 3. (For comparison, the treatment of the prototype).

The puerperal K. , 39 years old, birth of the second. Delivered in the obstetric clinic the day before expected birth.

In history there are instructions on chronic cholecystitis, chronic tonsillitis. During pregnancy underwent treatment for exacerbations of gestational MO. The puerperal K. gave birth to a girl weighing 3450, the Child is evaluated on a scale of Apgar scores 8 points. Childbirth is normal. In the first days after birth, the postpartum women and adolescent girls signs of acute MON: chills, fever, loss of appetite, nausea, dysuria, fatigue, headaches and back pain. Blood in the acute phase showed:

erythrocytes, 1012/l: 2,75 (N: 3,90 - 5,70);

hemoglobin, g/l: 97,9 (N: 120,0 - 160,0);

leukocytes, 109/l: 24.5cm (N: 3,6 - 9,0);

ESR, mm/h: 69 (N: 2 - 15);

LII,.E.: 6,6 (N: 1,0 - 1,5);

MSM, in.E.: 376,4 (N: 220,0 - 250,0);

The CEC.E.: 158,9 (N: 40,00 - 70,00).

The urine culture is marked true bacteriuria: more than 150,000 microbial cells in 1 ml of urine. The diagnosis of acute MO(equivalent to the treatment of the prototype). Detoxification and together with immunomodulating therapy was also appointed to the prototype method: in parallel with the basic therapy for 6-7 days used enterosorbent Szilard-P in the form of a previously prepared suspension of the calculation: 1 tablespoon of sorbent in 50 ml of water 3 times a day 30 minutes before meal. Echinacea purple appointed to apply 15-20 drops 3 times per day in conjunction with the sorbent in the form of a tincture of the root (1: 10 to 70% alcohol) dissolved in water suspension of the Szilard-P. (see Bagni H. I. Obgruntuvannya monocrats enterosorbents the complex lkuhn portl C gestating planificare // Liky.-1998.- 1. -S. 18). The patient's condition after 7 days of treatment has improved a little. Therefore, basic therapy continued up to 20 days. The status of postpartum women and adolescent girls to the 20-th day has improved. However lactation has ceased. Spent a blood test:

erythrocytes, 1012/l: 2,99 (N: 3,90 - 5,70);

hemoglobin, g/l: 100,3 (N: 120,0 - 160,0);

leukocytes, 109/l: 11,9 (N: 3,6 - 9,0);

ESR, mm/h: 34 (N: 2 - 15);

LII,.E.: 2,3 (N: 1,0 - 1,5);

MSM, in.E.: 300,0 (N: 220,0 - 250,0);

The CEC.E.: 71,38 (N: 40,00 - 70,00).

On the 23rd day of the puerperal K. and the child was discharged from the hospital in satisfactory condition. The child is artificial of any the AUX intermittent antimicrobial therapy.

As seen from the above examples, after the complex treatment of postpartum by the claimed method (unlike the prototype) recurrence MO within 1-3 years is not observed. Lactation does not stop. The reception of pharmaceuticals is limited to only the first 5-7 days. In-patient treatment postpartum women and adolescent girls are 11-15 days (prototype 23).

1. The method of complex treatment of acute pyelonephritis postpartum, including antibacterial, diuretic, desensitized, together with immunomodulating and detoxication therapy, characterized in that together with immunomodulating therapy is performed with the use of the drug spirulina and human-immunoglobulin, and starting with the first day after birth, appointed reception 3-5 grams per day of the drug spirulina oral and on the second day a single intramuscular injection of one dose of human immunoglobulin, and detoxication therapy is carried out, starting from the seventh day after birth, using continuous membrane plasmapheresis.

2. The method according to p. 1, characterized in that the drug spirulina is prescribed for 4-6 months with breaks in 10 days after each 20 days of admission.

3. The method according to p. 1, characterized in that the course is

 

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The invention relates to medicine, namely to methods of in vitro adoptive immunotherapy, especially in the treatment of patients with viral hepatitis C

The invention relates to medicine, namely to Oncology, and can be used to treat breast cancer

The invention relates to biotechnology and immunology, and can be used to generate neutralizing antibodies against different strains and clinical isolates of HIV-1
The invention relates to medicine, in particular to the treatment of various diseases

The invention relates to veterinary medicine, namely to epizootiology and veterinary immunology and AIDS for specific passive prophylaxis and treatment of associated viral-bacterial infections
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