The drug popovic", which has anti-inflammatory and antimicrobial properties

 

(57) Abstract:

The invention relates to medicine, namely pharmacology, in particular to drugs on the basis of propolis, and can also be used as a biologically active food Supplement. The proposed "Popovic", which has anti-inflammatory and antimicrobial properties, includes alcohol tincture of propolis, citric acid, tincture of sweet clover and an excipient, contains the following ratio of components per tablet, g: alcohol tincture of propolis - 0,04-0,25; tincture of clover - 0,003-0,010; citric acid - 0,004-0,020; excipients - 0,002-0,006; filler - the rest. As auxiliary substances the product contains talc, starch, calcium stearate, and as filler - sugar. The drug has a high therapeutic effect without the allergic reactions. 1 C.p. f-crystals, 2 tab.

The invention relates to medicine, namely pharmacology, in particular to drugs on the basis of propolis, and can also be used as a biologically active food additive.

Propolis is a natural product produced by bees, consisting of substances of rastitel atuomobile, analgesic effect. On its basis, prepare a variety of drugs to medical and cosmetic fields.

Known drug, possess anti-microbial, anti-inflammatory, analgesic action on the basis of propolis (Tikhonov A. I., Sokolov, I. C., Budnikova I.e., Sonin B. C. Composition and technology sublingual tablets with hydrophobic phenolic product propolis // pharmacy, 1991, - 1. - S. 24-27).

Closest to the invention (prototype) is a drug that has anti-inflammatory and antimicrobial properties, analgesic, including 10% alcohol tincture of propolis, citric acid. Excipient and filler (Provisional patent RK 5879, 1998).

The disadvantages of this drug is inadequate therapeutic efficacy. Object of the invention is a drug that has anti-inflammatory and antimicrobial properties, which have great therapeutic activity, a more convenient form for use.

The invention consists in that the drug is "Popovic" in its composition in addition to alcohol tincture of propolis and citric acid contains the tincture of sweet clover, spoa tincture of propolis - 0,04-0,25

Tincture of clover - 0,003-0,010

Citric acid is of 0.004-0.020

Excipients - 0,002-0,006

Filler - Rest

As auxiliary substances the product contains talc, starch (100%), calcium stearate, and as filler - sugar.

Optimal specified number of components obtained experimentally.

In clinical practice, drugs clover is used as the outer irritating and distracting funds, as an expectorant and a softening agent in inflammatory diseases of the respiratory system.

Quantitative introduction propolis in the composition optimally, as less than 0.04 g the effect is insufficient for the manifestation of it as anti-inflammatory and antimicrobial agent, and at more than 0.15 g is impractical, because the dose is not accompanied by the increase of therapeutic action and the possibility of allergic reactions.

Therapeutic effect of the drug is enhanced by the introduction of tincture of sweet clover. In amount less than 0.001 g therapeutic effect is not observed, and more than 0.003 g apply irrational, because it is impossible to specify the desired form for sublingual application.

As auxiliary components, ensuring the reliability of the time raspadaemosti and baled used talc, starch (100%) and to improve the flowability of the granules and increase the strength of the pressing - calcium stearate. As the filler used sugar. The selected mixture is the most affordable, comfortable and cheap.

To obtain tablets propolis, sugar, citric acid, calcium stearate is crushed in a mill to form a powder, sift and introduced into the granulator. There, add the tincture of sweet clover and pre-prepared with 10% starch paste and damp granulation. The obtained granules are dried at 40-50oC for 4-6 hours the Dried granulate is placed in a mixer and add outrivals mixture of talc + calcium stearate) and stirred. The resulting mixture is subjected to pelletizing.

To obtain a preparation according to the invention, the components must meet the requirements of the relevant farmakopejnyh (FS) and temporary farmakopejnyh (VFS), the state standards (GOST).

An experimental study of the properties of the obtained preparation is conducted who's anti-inflammatory pharmacological substances".

Experimental study of anti-inflammatory activity was carried out on outbred mice 20-26 g of both sexes. The drug was administered intragastrically in the form of a 2% aqueous solution and a 2% starch paste (pill) in doses from 50 to 500 mg/kg, single and multiple times depending on the nature of the inflammatory process in the experiment.

Determination of anti-inflammatory activity was carried out on a model of acute inflammatory edema caused subplanetary introduction to the hind leg of the rat 0.1 ml of 2% aqueous solution of formalin. Measuring volume of the foot was performed after 2, 4, 8 and 24 h at the moment of maximum development of edema. Experimental rats were injected repeatedly intragastric the proposed drug substance in doses of 100, 200 and 500 mg/kg 1 h prior to the introduction of phlogogenic agent. Antiphlogistics activity of the preparations was estimated at a maximum of inflammatory edema in control (1, 2, 7).

As the main indicators of the intensity of the inflammatory response and anti-inflammatory effect of study drug used indicator of growth paws (% by source) and % inhibition of inflammation by the formula

< / BR>
where V is the volume of swollen paws in the control minus the initial volume of this (when administered intragastrically) to increase the paws of rats with formalin edema (in each group, 12 rats-males) are presented in table 1.

Antimicrobial activity of the drug was studied using twofold serial dilutions in liquid nutrient medium (in experiments with bacteria used the broth, Hottinger, in experiments with mushrooms environment Saburo). Confidence interval microbiological tests 095 (GFH, vol. 1, S. 199). Activity against bacteria and protivogribkova activity was studied on the strains presented in table 2.

Thus, the preparation according to the invention has a specific anti-inflammatory and antimicrobial activity (drug at various concentrations from 0.5 to 10% active against gramopolozhitelnyh and grammaticalising bacteria and fungi dermatophytes). Selected excipients and used in the pharmaceutical factors correlate with processes tabletting of propolis with the manifestation of therapeutic activity.

1. The drug has anti-inflammatory and antimicrobial properties, including alcohol tincture of propolis, citric acid, excipients and a filler, characterized in that it additionally contains the tincture of sweet clover in the following ratio of components per tablet, g:

Spirtually substances - 0,002 - 0,006

Filler - Rest

2. The drug under item 1, characterized in that the auxiliary substances used starch, talc and calcium stearate, and as filler - sugar.

 

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