A method of treatment of soft tissue sarcomas

 

(57) Abstract:

The invention relates to medicine, namely to Oncology, and can be used in the treatment of malignant soft tissue tumors with an unfavorable course of the disease. A method of treatment involving the introduction of anticancer drugs, in three of the vial with 50 ml of pulizia produce fence in 100-150 ml of the patient's blood from a peripheral vein in each bottle add one of the chemotherapy drugs doxorubicin 60-90 mg, methotrexate 30 mg, cyclophosphamide 600 to 800 mg, the mixture is then incubated for 30 min at a temperature of 36.6-37oWith and injected alternately intravenous drip, two weeks after drug administration perform surgery. The method allows to reduce the size of tumors, to achieve its mobility, significantly reduce side effects of chemotherapy.

The invention relates to medicine, more specifically to Oncology, and can be used in the treatment of malignant soft tissue tumors with an unfavorable course of the disease, recurrence and early metastasis.

There is a method of treatment of malignant soft tissue tumors of different stages, combining the introduction prosodists in the form of continuous daily 24-hour infusion from the first to the third day. Anticancer drugs are injected in the decreasing order of their therapeutic value. Each schema drug administration is carried out within 3 weeks. ("Cancer therapy", a reference under. Ed. Prof. Perevozchikova N. And., M: Medicine. 1993).

Suggested by the author of the route of administration of chemotherapy drugs is a long-term infusion of a single dose of 24 hours, which is poorly tolerated in patients. In addition, the entire course is 3 weeks, and given the emergent adverse toxic effects of anticancer drugs longer. Interruptions in treatment postpone surgical removal of the tumor, which enables further development of the malignant process and the deterioration of the patient, his long stay in the hospital.

There is a method of treatment of malignant tumors of soft tissues, when lengthy introduction anticancer chemotherapy additionally conduct oral administration, subcutaneous or intravenous immunostimulatory drugs and hormones. Treatment for up to 6 months or more in the preoperative period. ("Cancer chemotherapy Handbook. N. And. Perevozchikova. M.: Medicine, 1993).

Application Edinoverie is somewhat reduces the severity of toxic side effects of chemotherapy. But not shortening the time of the preoperative phase of treatment, does not exclude the occurrence of relapse and the symptoms of metastases. The main disadvantage of this method is the length and complexity of course preoperative anticancer therapy, which does not exclude toxic complications.

The aim of the present invention is to improve the immediate results of treatment of soft tissue sarcomas.

This goal is achieved by the fact that after diagnosis and stage of the distribution process in a patient from a peripheral vein is the blood in quantities of 100 to 150 ml in three of the vial with 50 ml of pulizia, then in each vial enter one of the anticancer drugs doxorubicin 60-90 mg, methotrexate 30 mg, cyclophosphamide 600-800 mg, then the bottles with the mixture incubated in the incubator for 30 min at a temperature of 36.6-37oS, after which the mixture alternately injected, drip, two weeks after drug administration perform surgery.

Comparative analysis of the proposed "treatment of soft tissue sarcomas with known methods of treatment for this malignancy will allow contaisn the developed method is unconventional method of introduction of anticancer drugs using natural fluid of the patient - blood incubation mixture and then reinfused.

The proposed method for the treatment of soft tissue sarcoma involves an inventive step, since it is not obvious from the known level of development of medicine in this field for a specialist oncologist-medical physicist. In the available known sources of public information of Russia, CIS and abroad indicate this method of treatment are missing.

The described method is industrially applicable, as may be repeatedly reproduced in institutions with special profile and medical-preventive institutions of General medical network.

A method of treatment of soft tissue sarcomas is as follows. Three vial with 50 ml of pulizia each produce a fence from a peripheral vein in 100-150 ml of the patient's blood. Then vials add one of the anticancer drugs doxorubicin 60-90 mg, methotrexate 30 mg, cyclophosphamide 600-800 mg After that, the bottles with the mixture incubated in a thermostat at a temperature of 36.6-37oC for 30 min, the mixture is injected drip from each bottle in turn. Two weeks after drug administration operational stage of complex treatment.

A. S., 4869, 47 years old, was admitted to the Department of breast tumors, soft tissue and bone 5.05.99 with complaints about the presence of a soft tissue tumor in the left shoulder, which appeared 2 weeks before admission, pain in the left shoulder joint and the peace of mind when driving with irradiation to the left hand, requiring the appointment of analgesics, numbness, 1, 2, 3 and 4 partially fingers of the left hand, impaired range of motion in the left shoulder. When entering the area of the left shoulder joint in the projection head of the left humerus defined tumor 58 cm thick consistency, motionless, without distinct outlines. The skin over the tumor is not changed. Regional lymph nodes are not defined. Range of motion both passive and active in the left shoulder joint is limited: abstraction - 60othe flexion - 90o, extension - 10o. Cytological analysis: chondrosarcoma. Radiographically: chondrosarcoma of the head of the humerus.

The indicators of the General analysis of blood from 6.05.99: hemoglobin 130 g/l, erythrocytes - 4,21012/l, leukocytes 5,0109. ECG data within the age norm. Blood biochemical parameters before treatment: urea 7,49 mmol/l, creatinine 132,5 mmol/l, ACT - 0.5 mmol/l, ALT - 0.4 m is pulizia taken in 100-150 ml of the patient's blood. In each of the vials entered one of three chemotherapy: doxorubicin 60 mg, methotrexate 30 mg, cyclophosphamide 600 mg After incubation in a thermostat at a temperature of 36.6-37oC for 30 min the contents of the bottles alternately transferred to the patient intravenously. The immediate effect was assessed two weeks after drug administration, and was regarded as a partial regression of the tumor. The size of the soft tissue component decreased to 1,53 cm, significantly reduced pain in the hand (the patient did not need analgesics), fully recovered the sensitivity of the fingers, almost fully recovered full range of motion in the left shoulder. Radiographically two weeks after chemotherapy compared to 2.05.99 positive dynamics - partial restoration of normal bone structure. The decrease in periosteal reaction. Any complications chemotherapy have been identified. Blood counts remained within the normal range, the dynamics of ECG signs and level of enzyme activity and the nitrogenous bases was not, complaints related to treatment, were not.

Two weeks after drug administration 24.05.99 resection of the upper third of levidia and distant metastases (last turnout 22.03.2000).

2. Patient F., 1933 birth, 4424, was admitted to the Department of breast tumors, soft tissue and bone Rostov cancer research Institute 20.04.99 with complaints about the tumors in the upper third of the anterior surface of the right thigh, pain in the region of the tumor extending to the knee. From the anamnesis of the disease: tumor noticed 2 months ago, notes the rapid growth. Related diseases - hypertension stage 2A. When entering in the upper third of the right thigh on the front surface of the tumor 810 cm thick consistency with the softening in the center, fixed, painless on palpation. The skin over the tumor is not changed. Regional lymph nodes are not defined. Cytological analysis 7699-700 from 20.04.99 among the blood and interstitial mucous substance detected individual cell sarcoma. The indicators of the General analysis of blood from 21.04.99: hemoglobin 144 g/l, erythrocytes 4,51012/l, leukocytes 7,0109/HP ECG Data within the age norm. Blood biochemical parameters before treatment: urea 5.83 mmol/l, creatinine 81,1 mmol/l, ACT - 0.6 mmol/l, ALT - 0.4 mmol/L. 23.04.99 initiated the introduction of anticancer drugs, for which 3 of the vial with 50 ml of pulizia taken in 100-150 ml of the AOC is lifespan 600. After incubation in a thermostat at a temperature of 36.6oC for 30 min the contents of the bottles alternately transferred to the patient intravenously. On the first day after chemotherapy was observed nausea and single vomiting, which were stopped on their own, increasing the temperature up to 37.5oWith in two days. Cardiotoxic complications according to ECG and biochemical studies of the enzymatic activity have been identified. Blood counts remained within the normal range. The immediate effect was evaluated 2 weeks after drug administration and was regarded as a partial regression of the tumor. Tumor size decreased to 57 cm, significantly reduced pain in the region of the tumor, the tumor became much softer, more vigorous, swelling of surrounding tissue decreased by about 50%. In further performed to remove the tumor. Cytological analysis of the operational material 8630-8634 from 6.05.99 among necrotic masses detected dystrophica modified round cell sarcoma. Conducted post-operative radiation therapy.

Up to the present time within 11 months the patient was observed without signs of recurrence and distant metastases (last turnout 20.03.2000).

3. The patient P. the research oncological Institute 25.10.99 with complaints about the presence of tumors of the anterior chest wall. According to the patient, the tumor appeared 5 years ago. In may 1999 rapid growth. In June 1999 by place of residence made surgical intervention, but a week after surgery, the tumor started to grow rapidly again.

When entering the right half of the anterior chest wall is determined by the moving tumor soft-elastic consistency, rounded 610 cm, without distinct outlines. The skin over the tumor bluish color. Around the tumor tissue swelling up to 1 cm Regional lymph nodes are not defined. Cytological analysis - sarcoma. Radiographically before treatment: in the area of projection of the anterior chest wall, between 2 and 4 ribs at the level of the mid-clavicle line is determined by the inhomogeneous soft tissue component with fragmented contours of sizes up to 10 see Indicators of the General analysis of blood from 26.10.99 hemoglobin 96 g/l, erythrocytes 3,51012/l, leukocytes 3,9109/HP 28.10.99 started a course of autohemotherapy. Patient 3 a bottle logician from a peripheral vein taken in 100-150 ml of blood. In each of the bottles put one of the 3 drugs: doxorubicin 80 mg, methotrexate 30 mg, cyclophosphamide 800 mg After incubation in a thermostat at a temperature of 36.6-37oC for 30 min, the contents of the bottle the week after drug administration and was regarded as a partial regression of the tumor. The size of the soft tissue component decreased to 1,52,5 cm, significantly decreased cyanosis over the tumor. On x-ray data, the regression of tumors was 70%. To 4 days after drug administration radiation to 2,5109/l, which were stopped after 5 days by appointment haemostimulating therapy. Other complications were not. The dynamics of ECG characteristics and enzyme activity was not. 14.11.99 performed surgery. Postoperative radiation therapy. 1.03.2000 at the next follow-up examination the patient feels well, recurrence and distant metastasis was not observed.

Technical and economic efficiency of the application of the Method of treatment of soft tissue sarcomas is possible

to accelerate the pre-treatment stage without amplification toxic side effects of chemotherapy;

to avoid the necessity of forced interruptions in treatment to mitigate the side effects of chemotherapy and the use of additional medications;

- to carry out organ-saving operation;

- to increase disease-free period and to reduce the frequency of metastasis.

A method of treatment of sarcomas of marciene anticancer drugs in three of the vial with 50 ml of pulizia produce fence in 100-150 ml of the patient's blood from a peripheral vein, in each bottle add one of the chemotherapy drugs doxorubicin 60-90 mg, methotrexate 30 mg, cyclophosphamide 600 to 800 mg, the mixture is then incubated for 30 min at a temperature of 36.6-37oWith and injected alternately intravenous drip, two weeks after drug administration perform surgery.

 

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