Tool-hydrosulphate of graphite and method for the treatment of patients with benign and malignant skin tumors (options)

 

(57) Abstract:

The invention relates to medicine and for the creation of a means and method for the treatment of patients with benign and malignant skin tumors. The invention lies in the fact that the tool is a hydrosulfate graphite formula24+SO4-H2SO4containing 1 g of graphite 1 g of sulfuric acid at a density fluid 1,815 g/cm3. In addition, the claimed preparation containing hydrosulfate graphite and filler in volume ratios of 1:2 to 1:1. A method of treating patients is characterized by applying to the affected skin area remedies in the form of liquid or ointment. The invention has a selective effect on tumor vessels without destruction of the connective tissue adjacent to the skin and at the same time provides a high penetrating ability. 4 C. and 5 C.p. f-crystals.

The invention relates to medicine, namely to oncodermatology, medical cosmetology, pharmacology, biochemistry, and can be used in clinical medicine for elimination of benign and malignant skin tumors (papillomas, melanoma, pigmented nevi, hemangiomas, squamous cell skin cancer and other swollen the data skin tumor formations, which can be divided into chemical, physical and physico-chemical. For example, a chemical method effects are different ways of destruction of tumors using concentrated solutions of sulphuric, nitric and acetic acids, liquid nitrogen, nitrate of silver and other (bed, 1974, T. 3, pp. 336-338). When removing skin tumors acids occurs necrosis with the formation of local inflammatory focus, which contributes to the development of pathogenic flora and education cosmetic defect.

It should be noted that the chemical effect of corrosive acids accompanied by a pronounced destruction of the connective tissue of the skin, especially thin bundles of collagen, elastic and reticular fibers. (CME, T. 1, M.: 1994, pp. 461-463.)

In this regard, the destruction of collagen fibers, forming the border of the epidermis with interstitial substance of the basal membrane, leads to disruption of metabolic processes between epidermis and dermis. In addition, the dermis contains cellular elements of fibroblasts and histiocytes, which play an important role in implementing the immune function of the skin. Note that in the connective tissue of the skin has a large number of shelter is edrea is located on the border between the dermis and hypodermis and leave the smaller blood vessels in the reticular layer of the dermis. Lymphatic vessels located in the dermis in the form of superficial and deep networks, so after direct exposure to concentrated chemicals on tumor formation of the skin occurs a chemical burn, causing keloid and fibrotic scars with simultaneous violation of microcirculation and lymph circulation in the surrounding areas of healthy skin. In cases of localized skin lesions on the face or other open spaces in the application of chemical treatments is unpleasant cosmetic defect in the form of disruption of the natural structure of the skin, because it is destroyed basal membrane, which plays a major role in the regeneration of the dermis. Therefore, when the chemical is corrosive effect on tumor cells and connective tissue and blood vessels of the skin that causes structural defects of the dermis surrounding tumor tissue.

Existing physical methods of treatment, such as laser or cryosurgery (O. S. Ozersky, Cosmetology, St. Petersburg, 2000, pp. 310-313, 326-327, can be applied without cosmetic effects only when Troubleshooting tumors of small size, while pigmented nevi, melanoma, exophytic forms Ronnie physico-chemical methods are also causing a lesion adjacent to the tumor of connective tissue structures and therefore are accompanied by keloid and fibrous scars.

Known treatment for patients with tumors of the skin is graphite. In homeopathic medicine, graphite is used for the removal of various growths of the skin (J. of Sharett. Practical homeopathic lekarstovedenie. Homeopathic medicine, Smolensk, 1997, pp. 227-230). Pharmacological effect of graphite due to its ability to penetrate into the vascular matrix of the tumor with subsequent mummification and rejection (ischemic effect).

A significant drawback of graphite as a medicinal substance is its only surface effects and the inability to penetrate into the deeper structures of the skin, and therefore in the microcirculatory system of the tumor itself.

Thus, each of the above funds in individual possesses a specific destructive effect, but none of them alone provides a satisfactory therapeutic effect.

The present invention is the creation of a therapeutic agent, which should combine a selective action on the vessels of the tumor without destroying the connective tissue adjacent to the skin and at the same time have a high penetrating power.

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The curative effect of the compound of graphite with sulfuric acid. It is a complex of hydrosulphate of graphite and is expressed by the formula C24+HS4-H2SO4. This substance aggressive bearing component is sulfuric acid, and the active therapeutic current - molecules of graphite. The graphite in this connection limits the aggressiveness of the action of sulphuric acid and at the same time, synergistic with sulfuric acid has an elective action on microcirculation and lymph circulation. This chemical complex is obtained in the processing of graphite with concentrated sulfuric acid in the presence of oxidant - concentrated nitric acid. This chemical substance is formed by the introduction of atoms, ions or molecules of sulfuric acid between the carbon layers of the crystal lattice of graphite. As is known, the distance between carbon atoms in the layer of graphite is of 1.42 A. the Link between carbon atoms in one plane are covalent in nature. The interlayer distance between carbon atoms more ~ 3,35, And communication between the interstitial carbon atoms is much weaker. In these interlayer voids graphite and can, under certain conditions, to diffuse the atoms and mo the sky long enough. At different time intervals can be embedded variable amount of sulfuric acid, but in the limit formed by the compound [C24+HSO4-H2SO4] containing 1 g of graphite 1 g of sulfuric acid. Graphite has a density equal to 2.2 g/cm3; concentrated sulphuric acid is 1.84 g/cm3. The resulting liquid has a density equal 1,815 g/cm3.

In addition, the proposed remedy for the treatment of patients with benign and malignant formations containing skin-hydrosulphate of graphite and filler with a colloidal properties, with a volumetric ratio of 1: 2-1:1.

When treating patients with benign and malignant tumors of the skin in the affected areas affected by hydrosulphate of graphite - C24+HS4-H2SO4containing 1 g of graphite 1 g of sulfuric acid and having a density of 1,815 g/cm3. The liquid is applied in a dose of 0.05 ml and the surrounding tissue smeared with vaseline. Large skin lesions treated 2 to 3 times with an interval of 10-20 minutes; Ceratophyllum and pigmented nevi treated 2 to 3 times with an interval of 3 days within 2-6 weeks. Additionally, when treating patients with benign is about 1.5-2 hours for 2-8 weeks. While the treatment of patients with aggressive cancer leaking ulcers is carried out by applying to the affected skin products containing hydrosulfate graphite and filler (having colloidal properties) in volume ratios of 1:1, and in the treatment of melanoma tumor sites cuticles daily for 6-8 weeks.

Examples of receiving liquid and ointment forms of hydrosulphate of graphite

Example 1. Obtaining a liquid form.

In a glass container with a capacity of 700 cm3make a volume of 100 cm3graphite, pour in 500 ml of concentrated sulfuric acid solution by adding 50 ml of concentrated nitric acid. Tightly sealed and put in a dark warm place, withstanding chemical ingredients at a temperature of 20oWith in a month. During this time, the sulfuric acid reacts with the crystal lattice of graphite, so that the liquid becomes intense brown color. Upon expiration of the above period, the liquid is poured into another container, tightly corked and stored in a dark place at normal room temperature.

Example 2. Getting the ointment form of hydrosulphate of graphite

25 mitologia, added 12.5 ml or 25 ml of hydrosulphate of graphite (volume ratio vaseline or any colloidal substance to the hydrosulphate of graphite are 2:1 or 1:1). The contents thoroughly mixed glass cane to uniform distribution of hydrosulphate of graphite in vaseline or other colloidal matter. After this ointment, which is a mixture of vaseline and hydrosulfate graphite, tightly corked and placed in the refrigerator for seal patterns obtained substances.

The proposed method of treatment in contrast to the above is as follows: when applying a liquid form of hydrosulphate of graphite on the tumor of the skin with a glass rod at a dose of 0.05 ml of the drug in the skin surrounding the tumor, smeared with vaseline, which eliminates the defeat of surrounding tissue and the access of air through them to the microcirculatory bed. It accelerates tumor destruction and subsequent wound healing. In cases of local large skin lesions they need to be two to three times a day treatment interval of 10-20 minutes is Clinically established that when removing hard skin tumors - Ceratophyllum or pigmented nevi, they should be treated 2-3 requestone substance is applied to the tumor for 1.5-2 hours a day or 1 every 3 days within 2-6 weeks. The impact of liquid and ointment forms of hydrosulphate of graphite is in the supine position to avoid spreading liquid or ointment.

Examples of the method for the treatment of patients with benign and malignant skin tumors

Example 1. Patient C., I., 47 years old. Diagnosis: multiple melanoma outer surface of the upper third of the leg.

After diagnosis, the course of radiation and chemotherapy, radiation caused skin burns and minor reducing tumor formation. A few weeks after the treatment was the emergence of additional tumors in the radiation zone and the increase of the former tumors (up to the size of large peas). With the consent of the patient was treated with hydrosulphate of graphite (ointment form) - 25 ml of hydrosulphate of graphite on 25 g of vaseline. The ointment was applied in the supine position and remained on the surface of melanoma formations within two hours. During treatment was seen a slight burning sensation in the area of the skin of the upper third of the leg. Within 40 days ointment drug hydrosulphate of graphite was applied daily on the skin tumors. The primary size of tumors initially remained unchanged and only starting with 10-12 days of treatment were. Despite the fact that the patient has been removed inguinal lymphogenous metastasis, recurrence of the growth of malignant melanoma of the skin outer surface of the upper third of the leg in the next did not happen. The observation period of 1.5 years.

Example 2. Patient N. T. And., 51, the Diagnosis of multiple papillomas of the skin of the lower third of the chest (directly under the Breasts).

In order to remove skin tumors within 14 days daily for papillomas was applied ointment form of hydrosulphate of graphite (volume ratio of vaseline and hydrosulfate graphite 2:1) - the application time 30 minutes a week papilloma darkened, cringed, turned into crust and subsequently disappeared. At the location of papillomas remained poorly pigmented areas of the skin. Complete recovery occurred by 15-th date of application of the ointment form of hydrosulphate of graphite.

Example 3. Patient C. I. S., 32, Diagnosis: pigmented nevus inner surface of the skin of the upper third of the nose.

Turned in SIC dermatovenerologic Institute of health Ministry with a request to conduct the destruction of education, which was a cosmetic defect. Lying on tumor formation in a period of 4 weeks was applied a thin layer of liquid hydrosulfate around pigmented nevus had an ischemic area of the skin (pronounced whitening and reduce sensitivity in this area). The phenomenon of spasm of the microvasculature of the skin around the tumor continued for 5 minutes, then came hyperemia adjacent to the nevus of the skin lasting for 20 minutes Lubrication pigmented nevus was carried out 2 times during the treatment session every three days and were held regularly until the complete destruction of the tumor. Resorption of tumors occurred at the end of 4 weeks, the wound healed by first intention. After regeneration of the skin was observed weak pigmentation in the location of the nevus. Toxico-allergic or other reactions during treatment were observed.

Example 4. Patient T. C. A., 56 years. Diagnosis: cancer skin ulcer supraclavicular area on the right.

Turned in SIC dermatovenerologic Institute of health Ministry about the long-term unhealed ulcer of the right supraclavicular region. Considers himself ill for 6 years, when he noted a small nodule in the skin supraclavicular area on the right. Oncodermatology diagnosed patient endophytic form of squamous cell skin cancer. After the course of chemotherapy and radiation tumor formation resorbed, however, remained small size of the ulcer, which continued to increase. Held in techinicans area found a large cancerous skin ulcer size 8 x 2 cm with no evidence of granulation, the bottom of the ulcer dirty grey colour. Within one month the patient lying on the affected area was applied a thin layer of ointment of hydrosulphate of graphite at the rate of 25 ml of the substance to 25 g of vaseline (volume ratio 1:1). Since the surface of cancerous ulcers was quite a large area, then turn smeared as the outer, and inner parts. There were 8 topical applications. A week later, the regeneration of the skin was noted in the inner parts of cancerous ulcers. After 3 weeks regeneration occurred over the entire surface of the inner half of the ulcers and showed signs of recovery of the skin structure in the outer part. After 30 days from the start of treatment there was a full restoration of the natural structure of the skin.

1. For the treatment of patients with benign and malignant tumors of the skin, characterized by the fact that it is a complex of hydrosulphate of graphite formula24+SO4-H2SO4containing 1 g of graphite, approximately 1 g of sulfuric acid and having a density of 1,815 g/cm3.

2. For the treatment of patients with benign and malignant tumors of the skin, characterized in that it contains hydro is by approximately 1 g of sulfuric acid at a density fluid 1,815 g/cm3and the filler in volume ratios of hydrosulphate of graphite and filler, respectively, 1:1 or 1:2.

3. Means under item 2, characterized in that the filler it contains petrolatum.

4. The method of treatment of patients with benign and malignant tumors of the skin, characterized by the fact that on the affected area of the skin put the tool under item 1 at a dose of 0.05 ml and the surrounding tissue smeared with vaseline.

5. The method according to p. 4, characterized in that the large skin lesions subjected to 2-3 single treatment with an interval of 10-20 minutes

6. The method according to p. 4, characterized in that Ceratophyllum, pigmented nevi, and other types of tumors treated with daily 2-3 times at intervals of 3 days, treatment 2-4 weeks.

7. The method of treatment of patients with benign and malignant tumors of the skin, characterized by the fact that in the affected areas of skin (cancerous ulcers) put the tool on p. 2 daily or every three days for 1.5-2 hours for 2-6 weeks.

8. The method according to p. 7, characterized in that in the treatment of patients with cancer, aggressive leaking sores on the affected skin put the tool on p. 2 at volume ratios of hydrosulphate of graphite and nab abayat daily for 6-8 weeks.

 

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