Method of treating psoriasis in combination with chronic opisthorchiasis

 

(57) Abstract:

The invention relates to medicine, dermatology, to methods of treating psoriasis in combination with chronic opisthorchiasis. Enter praziquantel at a dose of 30 mg/kg during the first days of treatment, cancel it, and then, one day, in addition to therapy administered biologically active food Supplement "Holegon" 2 tablets 3 times daily before meals for 5 days, which should be repeated after 7 days on 2 tablets 3 times daily before meals. This method allows to reduce the number of complications and high efficiency deworming.

The invention relates to the field of medicine, dermatology and relates to methods of treating psoriasis in combination with chronic opisthorchiasis.

There is a method of treatment of patients with combined pathology using praziquantel, appointed in the usual dose of 60 mg/kg of body weight on the night circuit 3 times with an interval of 4 hours deworming Efficiency was 100%. However, for patients with psoriasis this treatment causes complications of skin lesions in the form of appearance of new lesions, especially in the first days after deworming, itchy that necessitate psoriasis, the state of the stomach and biliary system when combined with chronic opisthorchiasis". The dissertation on competition of a scientific degree of candidate of medical Sciences. Tomsk, 1999).

The technical result of the invention is to reduce the number of complications and high efficiency deworming achieve application of a new method of treating psoriasis in combination with chronic opisthorchiasis, including deworming praziquantel during the stationary phase of psoriasis, and praziquantel is administered in a dose of 30 mg/kg of body weight, and a day appointed additional reception of biologically active food supplements "Holegon" in a dose of 2 tablets 3 times daily before meals for 5 days, after 7 days appoint the reception of biologically active food supplements "Holegon" 2 tablets 3 times daily before meals for 5 days.

The method is as follows.

Before entering in gastroenterology hospital for translation an advanced stage of psoriasis in inpatient ambulatory patient receives the following treatment: detoxification therapy (solution of sodium thiosulfate and 30% at 10 ml/N 10), antihistamines (trexel 1 tabletki 20 days). Outer: cream Unna.

Also the patient is undergoing physical examination (complete blood count, urinalysis, biochemical analysis of blood), liver ultrasound, duodenal intubation or ELISA test for opisthorchiasis.

When in duodenal bile eggs opistorhisov or higher titer by ELISA test, the patient is sent for deworming in gastroenterology hospital EDO.

In the hospital the patient receives praziquantel on the night circuit at a dose of 30 mg/kg body weight, 3 times with an interval of 4 hours (10 PM to 2 am, 6 am). The next day continuing treatment by a preparation "Holegon" 2 tablets 3 times daily before meals for 5 days. Then after 7 days additionally receives the drug "Holegon" 2 tablets 3 times a day for 5 days.

Biologically active food Supplement "Holegon" is a tablet weighing 1.3 g, each of which contains the aspen bark extract 200 mg, peppermint 100 mg, immortelle 100 mg, Valerian 100 mg, MCC (microcrystalline cellulose) 740 mg, yarrow 25 mg.

Peppermint (leaf) has anti-inflammatory, antispasmodic, astringent, diuretic and antimicrobial action.

Yarrow (herb and inflorescences) has anti-inflammatory, antimicrobial, choleretic and diuretic.

Valerian (root rhizome) has antispasmodic, sedative, choleretic and analgesic effect.

MCC (microcrystalline cellulose) is a source of dietary fiber derived from natural raw materials of plant origin, has the ability to absorb and excrete toxic compounds, contributes to the normalization of the functions of the gastrointestinal tract, the blood sugar level.

The aspen bark extract is effective as a choleretic, anti-inflammatory, antibacterial, parasitogenic tools.

Indications for use: recommended as a tonic and mild anti-inflammatory, choleretic, detoxification remedy for gallstones, chronic cholecystitis, hepatitis, biliary dyskinesia (especially due to parasitic diseases: opisthorchiasis, giardiasis). Adults: 2 tablets 3-4 times a day, a course of 7 days. Form release: pills. The drug "Holegon" - Russia, LLC "ArtLife" 001172. R. 643.11.99, biologically, octahydro-4 H-pyrazino (2,1-a) isoquinoline-4 he - white crystalline powder, bitter taste. Quickly absorbed by ingestion. Peak concentrations in plasma observed after 1-2 hours. Metabiliziruetsya quickly and displays up to 80% in the form of metabolites by the kidney within 4 days., with 90% of output in the first 24 hours. The mechanism of action is important to increase his influence permeability of cell membranes of parasites for calcium ions. The drug causes a reduction in muscle parasites, passing in spastic paralysis. It is highly effective for the treatment of schistosomiasis and trematodozov. Internally within 1-2 days. Usually take a day to 25 mg/kg of body weight 3 times or 30-40 mg/kg 2 times. The product gives a high therapeutic effect (100%). Form release: pills. (Mashkovsky M. D. Lekarstvennye funds. - M.: Medicine, 1993, I. 2., S. 448.).

Dose of praziquantel reduced in 2 times against commonly used by combining with a drug of plant origin. Dose and sequence of use of the drug selected on the basis of clinical observations. After a course of treatment performed control sensing, according to which determined the efficacy of deworming. Rate if deworming during the period of less than 5 days reduces the effectiveness of deworming, and the lengthening of the course of treatment for more than 5 days, resulting in additional side effects that are undesirable to patients with psoriasis. In the daytime, the drug is administered for easy monitoring of patients 3 times to increase the concentration of the herbal drug to be more effective deworming. The dose of 2 tablets 3 times a day 5 days is necessary and sufficient for the clinical observations for effective deworming. Additionally in 7 days "Holegon" is prescribed as a tonic and anti-inflammatory. The dose of 2 tablets 3 times a day 5 days selected on the basis of clinical observations.

Example

The patient is Smooth, A. A., 23, was admitted to the gastroenterology Department Bureau with a diagnosis of Chronic opisthorchiasis. Chronic acalculous cholecystitis under mild exacerbation. Biliary dyskinesia on hyponatremia type. Concomitant diagnosis: Psoriasis, guttate-plaque, stationary phase, common, autumn and winter.

Upon receipt complained of heaviness in the right hypochondrium, a constant bitter taste in the mouth, nausea, decreased appetite.

From history revealed that PAC is abusee treatment:

detoxification therapy (sodium thiosulfate and 30% at 10 ml/N 10), antihistamines (trexel 1 tablet a day 7 days), vitamins (aevit 1 capsule 2 times a day, 30 days), sedatives (sibazon 1 tablet at night 20 days). Outer: cream Unna.

The last 2 years have trouble heaviness in the right hypochondrium, periodic pain in this area, fatty food intolerance, nausea.

Performed outpatient physical examination, ultrasound, duodenal intubation, ELISA test opisthorchiasis.

In General, the analysis of blood eosinophilia of up to 5%. In General urine analysis showed no pathological changes. Biochemical analysis of blood within normal limits. The titer by ELISA test 1:200 (at a rate of 1:64).

According to chromatic miotroponogo duodenal intubation revealed dyskinesia of the gallbladder on hyponatremia type: gallbladder bile were due in large volume to 100 ml (normal 60 ml) and time to expiration was extended to 45 min (at a rate of 21 min). Revealed hypotonia of the sphincter of Oddi.

Microscopy bile found eggs of opisthorchis (3-4 per field).

By ultrasound volume gall is one process in the stationary phase was admitted to the hospital Bureau for the treatment of chronic opisthorchiasis.

Objective: Asthenic physique. On the skin of the scalp, torso, elbows, and knees papules pink-brown coalescing into plaques covered with silvery-white scales. Psoriatic triad positive (the phenomenon of stearic spots, the phenomenon of psoriasis of the film, the phenomenon of the point of bleeding). Tongue coated white bloom. In the lungs, the heart and without pathology. The abdomen is soft, with tenderness in the right hypochondrium moderately painful. Positive symptoms and Kera Murphy.

For the treatment of chronic opisthorchiasis and Hyper motility gallbladder dyskinesia was appointed a combined method of treatment: praziquantel at a dose of 30 mg/kg, and in a day "Holegon" 2 tablets 3 times daily before meals for 5 days.

Treatment the patient endured well. After deworming praziquantel side effects were noted. The appearance of new lesions on the skin, itching were observed. 5 day use "Holigan" (end of treatment) disappeared a feeling of heaviness in the right hypochondrium, bitter taste in the mouth, not bothered by the feeling of nausea. After treatment of chronic opisthorchiasis held control duodenal intubation, ELISA test, ultrasonic issledovanii and 60 ml (normal 60 ml) and 20 min (at a rate of 21 min). Violations in the activity of the sphincter apparatus have been identified. Microscopy revealed bile opisthorchis single egg. By ultrasound gallbladder volume was 54 cm3that is the norm. However, the patient complained of poor appetite. Within a week after treatment was achieved regression of psoriasis. 7 days after the end of treatment the patient was additionally prescribed course of drug treatment "Holegon" 2 tablets 3 times daily before meals for 5 days. One month after the treatment, the patient noted a good health, complaints from the side of the abdomen did not show, nausea disappeared and normal appetite. A repeated duodenal intubation. Microscopy bile eggs of opisthorchis not identified. ELISA test 1:64 (which is the norm). The skin was at the stage regression.

The efficiency of the method

Combined method treated 7 patients with psoriasis in combination with chronic opisthorchiasis. Side effects of the skin, confirming the worsening of the underlying pathological process was not observed. Gastro-intestinal tract in the treatment of this sposato, the proposed method allows the authors to treat patients with combined pathology with optimally balanced combination of high anthelminthic drug with biologically active additive "Holegon" produced from local raw materials. This gave the opportunity to halve the dose highly effective, but highly toxic praziquantel and more smoothly with high efficiency (85,8%) to treat patients suffering from psoriasis.

Method of treating psoriasis in combination with chronic opisthorchiasis, consisting in deworming praziquantel during the stationary phase of the process, characterized in that designate the first day of treatment praziquantel at a dose of 30 mg/kg, and a day appointed additional biologically active food Supplement "Holegon" 2 tablets 3 times daily before meals for 5 days, after 7 days appoint a biologically active food Supplement "Holegon" 2 tablets 3 times daily before meals for 5 days.

 

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