Tool-hydrosulphate gravitationaly complex and method for the treatment of patients with inflammatory and trophic disturbances of the skin

 

(57) Abstract:

The invention relates to medicine, namely to dermatology, venereology and medical cosmetology. The invention lies in the fact that the tool contains a hydrosulfate gravitationaly complex, obtained by treating graphite with concentrated sulfuric acid in a ratio of 1:1 in the presence of kontsentrirovannoy nitric acid, in which is dissolved 1 g of selenium per 1 g of the metalloid in 50 ml of nitric acid, and a filler having colloidal properties, with volume ratios of filler and chemical complex 25:1-12,5:1. In addition, a method for treatment of inflammatory and trophic disturbances of the skin by application of the specified funds to the affected skin. The invention also has a biological effect on the whole structure of the skin - cells-phagocytic system, connective tissue and microcirculation and lymph circulation. 2 S. and 4 C.p. f-crystals.

The invention relates to dermatology and venereology, medical cosmetology, pharmacology, biochemistry, and can be used in clinical medicine for the removal of various inflammatory skin diseases, such as pustular lesions (pyoderma what about the follicle, various forms of fungal diseases of the skin (ringworm), as well as those forms of acne, which are accompanied by long flowing inflammation associated with an autoimmune reaction leading to the formation of trophic disorders and keloid scars.

Currently in medical cosmetology uses a variety of tools to normalize blood circulation and restore the function of the immune and lymphatic systems to address inflammatory and trophic disorders. Used both local and other treatments that have a General effect on the body. In inflammatory processes apply antiseptic and cauterizing agents, antibiotics, anti-inflammatory, disinfectant, antibacterial and keratolytic substances in the form of ointments, gels, creams and other preparations, which have a beneficial effect. However, when expressed pathological processes involving lesions of the connective tissue of the skin - the dermis, inflammation often leads to poor circulation and change structures of collagen fibers, which causes the formation of keloid and fibrotic scars with cosmetic defects (O. S. Ozersky, Cosmetology, M., 2000, S. 22 the th tissue immunity sufficiently Autonomous, but at the same time, anatomically and physiologically connected with dermis, and the lymphatic system.

In the implementation of immune activity, as is known, a greater role for the population of lymphocytes, mainly T cells. In connection with the autonomy of tissue immunity of skin cells can undergo differentiation of immunocompetent, participate in antibody production and to allocate lymphokines. However, cellular immunity of the skin mainly built on the phagocytic reactions of the type carried out by Langerhans cells and skin tissue histiocytes - macrophages. In the epidermis the function of macrophages perform Langerhans cells, which constitute about 5% of the total number of epidermal cells. This population of tissue macrophages has a characteristic feature, because due to the long processes of these cells increases the area of reactivity and enhanced immune response. For example, during the development of contact dermatitis, the skin always increases the number of Langerhans cells and activated phagocytic reaction. The generally accepted point of view, according to which in case of inflammatory processes in the skin this kind of cells can grow due to the influx of their lymph nodes.

Desorptive activity and ability to intense immune response. It should be noted that the interaction of T cells with histiocytes dramatically increases their bactericidal activity. Dermatobia population of macrophages selects a number of mediators and enzymes, interferon and lysozyme. On the surface these tissue histiocytes, like all macrophages have receptors for immunoglobulin G and C3the complement. Along with intracellular digestion of antigen histiocytes produce factor to increased phagocytic activity. In addition to macrophages in the skin are also fat cells, which are sources of heparin and histamine, so that they actively participate in immune reactions immediate and delayed type. Recently, the epidermal cells was identified factor acting like polypeptide of the thymus in relation to T cells. In addition, it was also revealed phagocytic activity of keratinocytes.

Thus, the immune system of the skin is basically reactive-phagocytic and presented by Langerhans cells, tissue histiocytes and keratinocytes.

The immune system of the skin is the epidermis and in the middle part of the skin directly into the dermis, making inextricably linked immune cleto possibility to perform its various immunological reactions, showing the ability to anamnestic immune response and at the same time participating in barrier protective functions.

From the positions of clinical anatomy the skin is a multicomponent tissue system formed by the epidermis, dermis and subcutaneous fat (LMEs, so 2, Moscow, 1994, S. 461-462). In the basal or core layer of the epidermis are melanocytes and Langerhans cells, arranged in a single row on the basal membrane. In the main layer, spinous, are confinally fiber protoplasm, penetrating from one cell to another. In the granular layer are cells, a characteristic feature of which is the presence in the cytoplasm keragialin masses associated with bunches of monofiber (monofilare-keragialin complexes).

Average, or connective tissue of the skin - the dermis, takes the bulk of the skin. It is limited from the epidermal basal membrane and built of collagen, elastic and argyrophilic fibers arranged in a generally amorphous substance. In the dermis are the main mass of fibroblasts, histiocytes, mast cells, melanocytes and leukocytes. The main amorphous substance of the dermis is a gel and consists of gyaru elochnye elements and fibrillar proteins.

Skin microcirculation consists of superficial and deep vascular networks. The first is located under the basal membrane in the papillary layer and performs gas exchange and nutrient function. The second deep network is on the border with subcutaneous fat and consists of arterial-venous plexus, poor capillaries, which eliminates the possibility of unregulated intensive exchange of substances between blood and tissue. With the circulatory system of the skin is closely related lymphatic system, which is divided by the surface network and subdermal lymphatic plexus, located on the lower border of the skin.

Presents data on histophysiology skin suggests that cellular immune education - phagocytes and fibroblasts together with the collagen of the skin, vascular and lymphatic networks integrated into a holistic biological mechanism that provides a variety of functions. In this regard, new ways of treating these or other drugs should combine the simultaneous action on the immune, reparative and structure-forming system, representing a single multifunctional integrative mechanism.

The proposed method of lacreta and simultaneously chemicals which will simultaneously act on the immune mechanisms, connective tissue and blood vessels with the conservation of the structures of the epidermis, the basement membrane, blood and lymphatic systems. This substance should be presented component permeability, substance effects on connective tissue and a means to stimulate phagocytic cells.

It is now known that the number of aggressive acids (e.g., sulfur) has high penetrating through the epidermis and dermis, and therefore they are used to eliminate cancerous ulcers, boils, and various inflammatory processes. In homeopathic medicine these substances are used to normalize the blood circulation in the skin to eliminate pathological processes (James Tyler Kent Lectures on homeopathic medicine Materia Medica, so 2. "Homeopathic medicine", Moscow, 1999, S. 1248-1253).

Medicine elective acting on connective tissue and phagocytic system is graphite. It is known that graphite, which is widely used in homeopathic medicine, has long been used as a means skin, lymphatic and venous (William Berik, homeopathic Materia Medica, prepaie on the skin tissue, including onto the skin surface, especially on the blood and lymphatic capillaries (Doctor Diamon, Homeopathic physiology, Kharkov, 1993, S. 248-257). This medication has a profound effect, as all compounds of carbon, and is used to treat cancerous ulcers, chronic scarring of the skin and cancerous growths. Pharmacodynamic properties of graphite show that he has an immunostimulating property. Pharmacological effect of graphite based on its ability to penetrate through the microcirculation and the lymphatic system in various structures of the skin. The mechanism of action of graphite as a medicinal substances was studied in inflammatory skin diseases, as well as with erysipelatous inflammation with marked clinical effect, indicating a stimulation of cellular immunity in the skin and responsible fibroblasts and histiocytes. At the same time, a significant drawback of this method is the inability of finely ground graphite powder or granulated, deeply penetrate the capillary or lymphatic system of the skin in the microcirculatory bed.

Currently, research on immunopharmacology trace elements showed that Simonetta, including on the cell. Selenium performs a crucial role in activation of the immune system. Deficiency of this trace element is associated with a variety of immunodeficiencies. Selenium stimulates the activity of T-cells and tissue phagocytes, has an indirect anti-inflammatory properties, increases the production of interleukins, potentional cellular and humoral immune responses, suppresses immediate hypersensitivity and delayed type, modulate the phagocytic function of polymorphonuclear leukocytes. Now firmly established that the use of food additives and organic selenium products leads to a significant reduction in the incidence of cancer of the breast, skin and lung (Kudrin, A. C., Rocky A. C., lark A. A., Rock, M. G., Gromova, O. A. "Immunopharmacology trace elements", Moscow, 2000, S. 354-357).

Each of the above substances separately has a certain physiological and pharmacodynamic effects, but at the same time does not have a single common biological effect on phagocytic system cells, connective tissue and microcirculation and lymph.

The present invention is PP the touch skin - phagocytic system cells, connective tissue and microcirculation and lymph.

To achieve the objectives of the proposed group of inventions, United by a common inventive concept. For the treatment of patients with inflammatory and trophic disturbances of the skin includes chemical composition C24+HSO4-H2SO4- hydrosulphate of graphite, in which the substance is carried out by the permeability is sulfuric acid, and the active therapeutic impinging molecules of graphite. This chemical complex polarized selenium ions obtained by dissolving 1 g of the metalloid in 50 ml of concentrated nitric acid. This substance is called the hydrosulfate gravitationaly complex, in which graphite limits the aggressiveness of the action of sulphuric acid and at the same time, synergistic with sulfuric acid has a selective effect on microcirculation and lymph circulation. Obtained by the chemical complex is formed during the processing of graphite with concentrated sulfuric acid in the presence of oxidant - concentrated nitric acid, in which is dissolved 1 g of selenium. This chemical substance is connection inclusions grecheskiy graphite lattice. As is known, the distance between carbon atoms in the layer of graphite is 1,42 relationship between carbon atoms in one plane are covalent in nature. The interlayer distance between carbon atoms more ~ 3,35 and communication between the interstitial carbon atoms is much weaker. In these interlayer voids graphite and can, under certain conditions, to diffuse the atoms and molecules of some compounds, including molecules of sulfuric acid. The process is spontaneous, but kinetically long enough. At different time intervals can be embedded variable amount of sulfuric acid, but in the limit formed by the compound [C24+HS4-H2SO4] containing 1 g of graphite 1 g of sulfuric acid. This complex is partially ionic character and by dissolving it in excess acid is formed conductive solution. Graphite has a density equal to 2.2 g/cm3; concentrated sulphuric acid is 1.84 g/cm3. The resulting liquid has a density equal 1,815 g/cm3. The purpose of the almost complete elimination of the corrosive action of sulfuric acid volume ratio of acid and graphite is 1:1.

The tool further comprises a filler, with the b treatment of patients with inflammatory and trophic disturbances of the skin, characterized in that on the affected areas it is applied tool in ointment form, if slightly severe inflammation use the tool in volumetric proportions of filler and a set of 25: 1, and in inflammatory processes involving keloid scars is 12.5:1.

Example of getting the wax forms a hydrosulfate gravitationalwave complex.

In a glass container with a capacity of 700 cm3make a volume of 350 cm3graphite, pour 350 ml of concentrated sulfuric acid solution by adding 50 ml of concentrated nitric acid, in which is dissolved 1 g of selenium. Tightly sealed and put in a dark warm place, withstanding chemical ingredients at a temperature of 20oWith in a month. During this time, the sulfuric acid reacts with the crystal lattice of graphite, so that the liquid becomes intense brown color. Upon expiration of the above period, the liquid is poured into another container, tightly corked and stored in a dark place at normal room temperature.

To 25 g of vaseline or any other ingredient having colloidal properties and is used in the treatment cosmetol colloidal substances to liquid hydrosulfate gramitsidinova complex is 25:1 or 12.5:1). The contents thoroughly mixed with a glass rod to evenly distribute the hydrosulfate gravitationalwave complex in vaseline or other colloidal substances. After this ointment, a mixture of vaseline and chemical complex, tightly corked and placed in the refrigerator for seal patterns obtained substances.

Examples of the method for the treatment of patients with inflammatory and trophic disturbances of the skin

Example 1. Patient S. T. I., 48 years old. The diagnosis of relapsing erysipelas skin brush both hands.

Considers himself to be patient for 3 years, when after suffering erysipelatous limfangoita in the area of the skin of the fingers and the back surface of the wrists of both hands noted when the symptoms of the disease, which appeared from time to time every six months. Inflammatory lesions were accompanied by redness and swelling of tissues adjacent to the lesions. Applied topical application of antibiotic therapeutic effect is not given. Contact of the skin with water caused discomfort in the places of old lesions and relapse.

With the consent of the patient treatment ointment form the hydrosulfate gravitationalwave is and 2 hours in the morning and evening, treatments were carried out daily for 2 weeks. After 4 days of treatment, the rash began to dry up, in some places there was even a resorption of vesicles. After 2 weeks, the patient noted normalization of skin color and the disappearance of signs of inflammation. In subsequent re-emerged erysipelas, which was fixed with the ointment during the week. Relapses in the future not occurred, the observation period is 2 years.

Example 2. Patient A. A. N., 19. Diagnosis: common abrasions of the skin of the neck and zadziorny departments neck.

Considers himself ill for several months, when after suffering follicular tonsillitis noted the appearance of inflammatory nodes with sizes up to several centimeters in the skin of the neck and rear upper parts of the neck. The disease wore pronounced, accompanied by high fever and malaise. As a student of the higher military school, was admitted to the hospital, where it was held specific treatment. However, in the next there was a recurrence furunkuleze inflammation of the skin near the foci of previous lesions.

With the consent of the patient treatment ointment form the hydrosulfate graffiti, adjacent to the lesions, in the morning and in the evening was applied a thin layer of ointment for 1.5 hours In the period of treatment was noted slight burning and tingling in the skin of the head and upper neck from behind. There were 2 courses of treatment, each lasting 3 weeks with a break in 2 months. The observation year, relapse was not.

Example 3. Patient D., 28 years. Diagnosis: ugrevidnye form of skin inflammation of the face and back with the formation of keloid scars.

Considers herself a patient for 5 years, when he noted the emergence of ugrevidnye rashes in the skin of the cheeks and forehead. Being a specialty dermatologist, used a variety of anti-inflammatory, including disinfectants and antibacterial ointments, in combination with antibiotics. After treatment usually occurred a temporary remission of the disease, however, after six months there was a relapse of the disease and ugrevidnye skin cover not only the face, but the skin of the back. After the disappearance ugrevidnye rashes in the skin began to appear cosmetic defects in the form of small keloids. Methods of therapeutic effect was not given, and topical application of skin with hormonal therapy and keratolytic substances not treosulfan gravitationalwave complex (volume ratio of the substance and filler 1:12,5). Lying on the lesions of the skin of the face and back were applied topical application of 1 times in 2 days, the duration of treatments was 2 o'clock in 30 days ugrevidnye rash disappeared and 3 months later, the patient noted a flattening and softening of keloid scars. Six months later recovered natural healthy color of skin, were also observed resorption of keloid scars in the affected areas of the skin of the face and back.

At the beginning of the disease were expressed in the phenomenon of immune-depression - decreased levels of T-helper cells, the decrease in antibody titer, the coefficient of immunoregulation was equal to 0.8. At the end of treatment significantly increased the number of T-helper cells, increased antibody titer, the coefficient of immunoregulation was equal to 1.7. In the above observation the favorable anti-inflammatory and keratolytic effect of restoring the activity of tissue immunity came from the joint action of hydrosulphate of graphite and selenium.

1. For the treatment of patients with inflammatory and trophic disturbances of the skin, characterized in that it contains a hydrosulfate gravitationaly complex obtained by treating graphite with concentrated sulfuric acid in a ratio of 1: 1 in presence the of islote, and a filler having colloidal properties, with volume ratios of filler and chemical complex 25: 1-12,5: 1.

2. Means under item 2, characterized in that the filler it contains petrolatum.

3. The method of treatment of patients with inflammatory and trophic disturbances of the skin, characterized by the fact that the affected skin put the tool under item 1, if slightly severe inflammation of the use of the tool containing the filler and the hydrosulfate gravitationaly complex in the ratio of 25: 1, and in inflammatory processes involving kolloidnyi scars - in volume ratios of 12.5: 1.

4. The method according to p. 3, characterized in that in the treatment of patients with recurrent erysipelatous inflammation of the skin tool, containing a filler and hydrosulfate gravitationaly complex in volume ratios of 25: 1, applied daily for 2 hours in the morning and evening for 2 weeks.

5. The method according to p. 3, characterized in that in the treatment of patients with ugrevidnye form of skin inflammation with the formation of kolloidnyi scars tool, containing a filler and hydrosulfate gravitationaly complex in volume ratios of 12.5: 1, is applied on the affected areas of spalling with abrasions on the field of rashes and skin, adjacent to the affected areas morning and evening put on 1,5-2,0 h a thin layer of ointment containing filler and hydrosulfate gravitationaly complex in volume ratios of 25: 1, the course of treatment up to 3 weeks.

 

Same patents:

The invention relates to solutions for surgical irrigation and methods of use thereof, in particular to anti-inflammatory, analgesic and anticonvulsant solutions
The invention relates to pharmaceutical industry and veterinary

The invention relates to medicine and concerns the establishment of a drug for the treatment of purulent skin infections

The invention relates to medicine and can be used for the treatment of venous leg ulcers

The invention relates to medicine, namely to the treatment of ulcers in the diabetic foot syndrome
The invention relates to medicine, to surgery, to a method of treatment of fistulous dermatitis
The invention relates to medicine, in particular to plastic surgery, and can be used for the treatment of burn wounds

The invention relates to medicine and can be used to stimulate wound healing
The invention relates to medicine and can be used for treatment of burns
The invention relates to the field of biotechnology, and in particular to compositions of plant origin with a positive normalizing effect on living organisms, and can be used in food industry, medicine, veterinary

The invention relates to preparations of nimesulide for local use based gel systems

The invention relates to the field of medicine and pharmacology and applies to new effectors of interferon against viruses genital herpes and human papilloma

The invention relates to the field of hygienic tools used in the field of intimate human relationships, and in particular to means external use

The invention relates to medicine and concerns the establishment of a drug for the treatment of purulent skin infections

The invention relates to medicine and relates to antiviral agents for external use, with anti-herpes activity, wound healing and antiviral action

The invention relates to the field of medicine, veterinary medicine and for the composition with antiseptic, reparative and analgesic properties

The invention relates to the field of pharmacology, and relates to a wound healing drug for the treatment of purulent wounds, burns and skin diseases

The invention relates to medicine, specifically to pharmaceutical compositions for the treatment of viral diseases of the skin and mucous membranes caused by a simple virus or herpes zoster, and prevention of these diseases in patients with immune system disorders

The invention relates to the field of medicine
Enterosorbent // 2180231
The invention relates to medicine and can be used as enterosorbent
Up!