The method of obtaining the substance for the destruction of the microvasculature local skin lesions

 

(57) Abstract:

Hold addition to the salt of benzylpenicillin selected from a rate of 1 million to 2 million UNITS, 250-500 mg plasticized polyvinyl chloride. The volume was adjusted to 10 ml 78-82% solution of sulfuric acid and incubated until complete dissolution of the antibiotic. Then add in it of 0.8-1.0 ml of 10% aqueous solution platifillina. The total volume of the final product was adjusted to 10 ml 78-82% sulfuric acid. The invention allows to increase the penetrating ability of the drugs and thus increase therapeutic effect. table 1.

The present invention relates to medicine, more precisely to pharmacology, and can be used in clinical practice and cosmetology to remove the local skin diseases by destroying feeding them microcirculation and subsequent natural rejection of dying skin lesions types of moles, melanomas, Nepesov, atheroma, hemangiomas, etc.

Known compositions and methods of their application for removal of these skin lesions. For example, strong solutions of sulphuric, nitric acid, acetic acid, liquid nitrogen, nitrate silver, etc. /see bed, 1974, T. 3, S. 336. . . 338/. However, when applying any necrotic necrotic masses formed inflammatory focus through the development of pathogenic flora. As a consequence, the healing of the wound after removal of the local skin lesions is secondary tension and on-site chemical burn is formed colloidal and fibrous scar. In this case, if the skin lesions were located on the face or other exposed places and had a significant size, there is an unpleasant cosmetic effect.

Closest to the claimed is "a Set of tools for removal of benign skin lesions containing a vial with 72...78% sulfuric acid solution of penicillin based 800 thousand to 1 million UNITS per 10 ml and 0.2% plasticized polyvinyl chloride /see the description of the utility model to the testimony of the Russian Federation 1628, M CL 6 And 61 M 35/00, publ. 16.02.96, BI 2/.

This drug is partially eliminates these drawbacks. Obviously adding penicillin to a strong solution of sulfuric acid retains the antiseptic effect after applying the acid solution on the skin for a time sufficient to prevent inflammation in necrotic tissues.

It is found experimentally that increasing the dose of penicillin in solution up to 1...2 million IU per 10 ml of solution is optimal to reduce healing time and the suit is the plastic plasticized polyvinyl chloride, it dissolves and changes the viscosity of the solution so that the drop caused by skin lesions, does not spread, and remains at the application site. In this case, reduced the lesion border of healthy tissue.

However, the surrounding healthy tissue is still affected by the treatment of the boundary layer, though to a lesser extent.

The main disadvantage of the known means is that the increase in solution viscosity affects the penetration of it to nourish skin lesions microcirculatory bed. With a relatively deep location of the root feeding system /microcirculation/ possibly incomplete blocking and subsequent destruction of her due to surface disturbance thin lymphatic and blood capillaries due to increased viscosity of the sulfuric acid solution that can cause relapse of the new education. Further, when applying the known means for skin lesions there is a burning sensation and redness of the tissues around the site causing the liquid. When strong chemical burn or very sensitive skin redness lasts for quite some time and sometimes goes in pigmentation that is amintirea with various additives, we found that the introduction into the solution platifillina can significantly reduce the side effects known means.

After using specified tools hyperemia is observed only in the area of application of the drug, does not affect healthy tissue and subaverage that observed in almost all patients. Turned out to be unexpected and decreasing time of healing of skin wounds. On average, they amounted to 2,5...3,0 week against 3.0...3.5 weeks.

In the available literature we did not find fame outdoor applications platifillina for the treatment of localized skin lesions. Platifilin - cholinolytic, is used as a spasmolytic agent of the Central and peripheral actions. Known for its use in spastic colitis, cholecystitis, hypertension, renal colic, etc. Use of this drug topically in dermatology is not known. However, a drug long used in medical practice, shows its harmlessness in oral use and found that it is included in the body tissues /M. D. Mashkovsky. Medicinal product. - M., 1978, T. 2 S. 223...231/.

Apparently, the addition platifillina provides the TBA;

- elimination of pain, in particular, a burning sensation when applying the medicinal substance painful hearth.

Without testing it could not be asserted. First, it was unknown that will keep their properties platifilin in strong sulfuric acid. Secondly, in what proportions it should be included in the solution to achieve these effects. Thirdly, was unknown to the extension of these properties over time.

All known methods of application of drugs for skin lesions have one significant drawback. They do not protect the border with local skin formations skin from chemical burns tissue. We offer a way to remove the local skin lesions by using prepared according to the described method of substance for the destruction of the microvasculature, which together will eliminate the mentioned disadvantages of the known means and methods of removal of local skin lesions.

It was found that if prior to treatment border region of contact between the local skin lesions with healthy skin should be treated by means of neutral sulfuric acid, for example vaseline, it's about helping to accelerate its destruction and subsequent healing of wounds. When experimentation established that, in addition to the vaseline, the most appropriate means of neutral sulfuric acid, is a medical adhesive "Lancelot".

In addition, we discovered that large local skin lesions are guaranteed to be removed only when the repeated processing with interval 15. . . 20 minutes. Experimentally also found that the optimal is the three-fold repetition. Thus the need for multiple processing occurs if at least one linear size of the skin lesions is four or more millimeters. To accelerate healing of the treated surface after removal of vaseline applied drugs for the treatment of burns and means to reduce inflammation and speed up the regeneration of the skin.

Thus, we propose an agent for the destruction of terminal vascular beds local skin lesions, obtained by adding to the dry benzylpenicillin selected from calculation 1...2 million IU 250...500 mg plasticized polyvinyl chloride, bringing the volume up to 10 ml 78...82% sulfuric acid solution and kept in a tightly sealed glass container in the dark at a temperature of 18...20oWith up to complete dissolution of the anti-Christ. CSO solution platifillina and bringing the total volume of the final product up to 10 ml 78...82% sulfuric acid.

In addition, we offer and the usage of the obtained substances, namely, that before applying it on skin lesions bordering area cover neutral to acid substance, then moisten the local skin lesions are offered by the substance, starting from the center of its surface with a gradual transition to the limit of its contact with healthy skin tissue, and for skin lesions, at least one of the linear dimensions of which exceeds 4...5 mm, repeat the wetting several times with an interval of 15...20 minutes, then remove the tool-neutral sulfuric acid, and cause the tool to reduce inflammation and speed up the regeneration of skin area, 3...5 times the size of skin lesions, and as substances, neutral sulfuric acid, is used, for example, vaseline.

Examples of obtaining the substance

Example 1

In a glass container with a capacity of 10 ml make 1 million UNITS of sodium salt of benzylpenicillin and 250 mg plasticized polyvinyl chloride, is then poured 80% solution of sulfuric acid to the level of 10 mm. Tightly sealed and put in a dark place, maintaining the solution at a temperature of 18oWith two days. For astrochronology plasticized polyvinyl chloride. In the remaining volume of medical pipette add 0.8 ml of 10% aqueous solution platifillina and bring the total solution volume to 10 ml of 80% sulfuric acid. The container tightly sealed and store in the refrigerator. Substance when properly stored retains therapeutic properties during the year.

Example 2

In a glass bowl put 2 million UNITS of dry sodium salt of benzylpenicillin and 500 mg plasticized polyvinyl chloride and brought the solution to 10 ml of 82% sulfuric acid. Tightly kuprili capacity and placed in a dark place, maintaining at the temperature of 18oC to dissolve the antibiotic. After about two days penicillin is completely dissolved, the liquid acquires a dark-brown colour, the plastic swells and becomes loose. It is removed with tweezers and reduced fill volume of 1 ml of 10% aqueous solution platifillina and 82% solution of sulfuric acid /optionally, up to 10 ml and Then the container tightly sealed and store in the refrigerator.

Conducted patent research in medicine allow us to conclude that our proposal with the specified set of essential features unknown to the level of medical technology and Nanami not detected offer with the set of essential features, set forth in the claims, from which it follows that for specialists in the field of medicine it is not obvious from the level of medical technology and scientific research, and therefore meets the criterion of invention - "inventive step".

In the claimed proposal upon receipt of the substances used is known ingredients permitted for use, namely salts of benzylpenicillin, strong sulfuric acid brand CHP /chemically pure/ production Olaine chemical plant, plasticized polyvinylchlorid made from selling child instance nipples and powder platifilin.

In the method of removing local skin lesions there are no unknown or impossible without the development of new technology operations. In addition, manufactured according to the proposed method of therapeutic substance and treated with it a few dozen patients.

All this proves the compliance of the proposal with the criterion of "industrial applicability".

Examples of the use of therapeutic agents

Patient S 38 years. A diagnosis of multiple papillomas armpit. Papilloma disc-shaped, ranging in size from 3 to 6 mm in diameter, therapeutic substance. Papilloma darkened, there is a very slight burning sensation and slight redness of the skin. A week later, all papillomas turned into crust and were rejected. On the location of papillomas remained slabopigmentirovannyh skin. Papilloma fell all. Other results of the treatment are shown in table.

No patient was complaining of severe pain. Burning was noted, but barely noticeable. Complete removal of skin lesions occurred after up to 14 days, i.e. two weeks, which indicates the acceleration of the healing process in comparison with the prototype. Residual effects of pigmentation is poorly expressed.

All this testifies to the achievement of goals and performance of the claimed methods.

The method of obtaining the substance for the destruction of the microvasculature local skin lesions, consisting in the fact that in the sulfuric acid solution make salt of benzylpenicillin and plasticized polyvinyl chloride, wherein the salt of benzylpenicillin selected from a rate of 1 million to 2 million UNITS. add 250-500 mg plasticized polyvinyl chloride, the volume was adjusted 78-82% solution of sulfuric acid to 10 ml and the mixture was kept in tightly) is removed degraded polyvinyl chloride and the solution is further added to 0.8-1.0 ml of 10% aqueous solution platifillina, and the total volume of the final product was adjusted to 10 ml 78-82% sulfuric acid.

 

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