A method for the treatment of patients with autoimmune thyroiditis

 

(57) Abstract:

The invention relates to medicine, namely, endocrinology, and can be used to treat patients with autoimmune thyroiditis (AIT). The method includes hormone replacement therapy in combination with the introduction of cyclo 3 Fort. This ensures that the recovery process is broken feedback hypothalamus, thyroid gland, which increases the effect of treatment and prevents complications of the disease. table 1.

The invention relates to medicine, namely to endocrinology, and can be used to treat patients with autoimmune thyroiditis (AIT).

There is a method of treatment of patients with AIT, including the introduction of the drug L-thyroxine for hormone replacement therapy (Balabolkin M. I. Endocrinology.-M.: Medicine, 1989 - S. 416).

This method does not have sufficient efficiency and has no direct effect on venous and neurological complications that occur in patients with autoimmune thyroiditis.

The objective of the invention is to provide a method of treatment of patients with autoimmune thyroiditis, allowing to increase the efficiency of treatment of the disease and its complications.

stielow hormonal therapy, according to the invention additionally assign cyclo 3 Fort.

In the pathogenesis of autoimmune thyroiditis plays an important role in the feedback function of the hypothalamus - thyroid. The revealed correlation between increased lipid parameters in plasma and violation of feedback hypothalamus - thyroid. The authors first proposed a method of treating autoimmune thyroiditis, allowing a direct impact on the restoration of disturbed feedback hypothalamus-thyroid gland through the use of a therapeutic agent cyclo 3 Fort. At the same time the product cyclo 3 Fort has a direct impact on venous disorders and neurological complications that occur in patients with autoimmune thyroiditis.

The method is carried out, for example, as follows.

Patients AIT prescribe the drug L-thyroxine in a dose of 50 mg daily and cyclo 3 Fort 1 capsule 2 times a day. After 3 months of treatment there were significant improvements in clinical, hormonal, biochemical, electrophysiological, Doppler indices.

The method is illustrated by the following examples.

Example 1. Patient K., 37 years old, diagnosed with autoimmune thyroiditis, hypothyroidism. Complaints about headaches, diffuse in nature, and the study of blood on thyroxine (T3), triiodothyronine (T4), thyroid-stimulating hormone (TSH) has identified the following indicators T3=1.9 nmol/l, T4=52 nmol/l, TSH= 3,7 mIU/l, the level of antibodies to thyroid tissue = 1:257. In the biochemical study indicated an increased level of O. cholesterol to 8.2 mmol/l, low density lipoprotein (LDL) = 5.7 mmol/l, very low density lipoprotein (VLDL) = 2.5 mmol/L. the Patient received L-thyroxine in a dose of 50 mg daily, cyclo 3 Fort, 1 capsule 2 times a day for 3 months. After the treatment regressed headaches, decreased swelling of periorbital areas eyeballs and limbs, improved memory and attention. When a blood test revealed the following indicators T3=2,31 nmol/l, T4=99,1 nmol/l, TSH=4.2 mIU/l, antibodies to thyroid tissue 1: 224. In the biochemical study were recorded decline O. cholesterol = 6,9 mmol/l, LDL = 3.25 mmol/l, VLDL = 1.13 mmol/l

Example 2. Sick,, 43,, the diagnosis of autoimmune thyroiditis, hypothyroidism. Complaints about headaches, diffuse in nature, edema periorbital areas, poor memory, weight gain, swelling of extremities, numbness on the Palmar surface 3 fingers of the right hand. In the study of blood T3=0.8 nmol/l, T4=51 nmol/l, TSH= 2,6 mIU/l, the level of 6.1 mmol/l, VLDL = 2.8 mmol/L. the Patient received L-thyroxine in a dose of 50 mg for 3 months. After the treatment has been little positive dynamics of clinical, electrophysiological, biochemical, and hormonal parameters. In particular, slightly decreased headaches, decreased swelling of periorbital areas eyeballs and limbs. In the study of blood T3=1.9 nmol/l, T4=97.8 nmol/l, TSH=to 3.5 mIU/l, the level of antibodies to thyroid tissue 1:258. In the biochemical study of the level of O. cholesterol = 7.5 mmol/l, LDL = 5.3 mmol/l, VLDL = 2.0 mmol/l

The proposed method was treated 37 patients. All patients were women aged 39 years to 51 years with a comparable duration and severity of disease. Had complaints of General weakness and fatigue, poor memory, diffuse in nature headache, dizziness, hearing loss. In the biochemical study indicated an increased level of cholesterol, low density lipoprotein, very low density lipoprotein. All patients were recorded decrease in positively FCS in the study of the basal vein of Rosenthal's method dopplerography and a decrease in the rate of holding vosburgh on thyroxine, triiodothyronine, thyroid stimulating hormone was demonstrated decreased levels of T3, T4 and increased levels of TSH. The level of antibodies to thyroid tissue 1:42823,5. Ultrasonography of the thyroid gland revealed the seal of the gland tissue.

Among the examined patients were allocated to 2 groups. the 1st group consisted of 19 persons treated within 3 months of the treatment by the proposed method, namely hormone replacement therapy and treatment of cyclo 3 Fort. The 2nd group consisted of 18 patients, who in the course of these 3 months received only hormone replacement therapy. For comparison, chose the 3rd group, which included 20 healthy women.

The table below presents the dynamics of biochemical, neurophysiological and Doppler indices depending on the method of treatment and in comparison with the norm.

The table shows that in patients of the 1st group after treatment there was a significant improvement in biochemical, electrophysiological, Doppler indices. In patients of the 2nd group, these changes are less significant.

The proposed method of treatment improves the efficiency of treatment of patients with autoimmune thyroiditis and prevent oslognenija, characterized in that it further designate cyclo 3 Fort.

 

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